2025
Exploring barriers and potential solutions before implementing a scale-up strategy to expand methadone coverage among people who inject drugs in Tajikistan
O'Hara G, Madden L, Burkhonov A, Alaei A, Mohsinzoda G, Bromberg D, Abdullozoda J, Yusufi S, Altice F. Exploring barriers and potential solutions before implementing a scale-up strategy to expand methadone coverage among people who inject drugs in Tajikistan. Journal Of Substance Use And Addiction Treatment 2025, 172: 209682. PMID: 40139416, DOI: 10.1016/j.josat.2025.209682.Peer-Reviewed Original ResearchConceptsOpioid agonist therapyNominal group techniquePre-implementationImplementation strategiesSecondary HIV prevention strategyHIV prevention strategiesPre-implementation studyAgonist therapyOpioid agonist therapy scale-upHIV epidemicPre-implementation activitiesMethadoneFocus groupsPrevention strategiesCentral Asian regionOpioidGroup techniquePWIDOrganizational factorsNIATxSocietal factorsRecipientsScale-up strategyDrugRetention and dropout from sublingual and extended-release buprenorphine treatment: A comparative analysis of data from a nationally representative sample of commercially-insured people with opiod use disorder in the United States
Ivasiy R, Madden L, Johnson K, Machavariani E, Ahmad B, Oliveros D, Tan J, Kil N, Altice F. Retention and dropout from sublingual and extended-release buprenorphine treatment: A comparative analysis of data from a nationally representative sample of commercially-insured people with opiod use disorder in the United States. International Journal Of Drug Policy 2025, 138: 104748. PMID: 40020306, PMCID: PMC12045481, DOI: 10.1016/j.drugpo.2025.104748.Peer-Reviewed Original ResearchConceptsOpioid use disorderSL-BUPXR-BUPUse disorderRetrospective cohort studyExtended-release buprenorphineReduce treatment discontinuationDays of supplyTreatment discontinuationSublingual buprenorphineReduce overdose riskBuprenorphine treatmentCohort studyHigh dosesPrimary outcomeImpact of dosagePatientsBuprenorphineMonthsMg/dayCommercially-insured individualsProportion of individualsOpioidOverdose riskImprove health outcomesPrescribing methadone in prison predicts linkage to HIV care after release from prison: A randomized and patient preference trial
Mobley A, Wegman M, Bazazi A, Shenoi S, Bromberg D, Ahmad A, Kamarulzaman A, Altice F. Prescribing methadone in prison predicts linkage to HIV care after release from prison: A randomized and patient preference trial. International Journal Of Drug Policy 2025, 137: 104733. PMID: 39923270, PMCID: PMC11875876, DOI: 10.1016/j.drugpo.2025.104733.Peer-Reviewed Original ResearchMeSH KeywordsAdultFemaleHIV InfectionsHumansMalaysiaMaleMethadoneMiddle AgedOpiate Substitution TreatmentOpioid-Related DisordersPatient PreferencePrisonersPrisonsProspective StudiesConceptsLinkage to HIV careHIV careIncrease linkage to HIV careTreatment-as-prevention strategiesHIV treatment cascadeHIV treatment outcomesOpen-label trialCox proportional hazards modelsPatient preference trialOpioid use disorderMalaysia’s largest prison.Impact of methadoneProportional hazards modelTreatment cascadeInverse probability weighted Cox proportional hazards modelAnalytic sampleStudy participantsCareTreatment outcomesPrescribed methadoneOpioidConfounding variablesHIVUse disorderHazards modelRationale and design of a randomized clinical trial of integrated eHealth for PrEP and medications for opioid use disorders for women in the criminal legal system. The Athena study
Meyer J, Brunson S, Price C, Mulrain M, Nguyen J, Altice F, Kyriakides T, Cropsey K, Eaton E. Rationale and design of a randomized clinical trial of integrated eHealth for PrEP and medications for opioid use disorders for women in the criminal legal system. The Athena study. Addiction Science & Clinical Practice 2025, 20: 4. PMID: 39825419, PMCID: PMC11742507, DOI: 10.1186/s13722-024-00534-x.Peer-Reviewed Original ResearchMeSH KeywordsAdultCriminal LawFemaleHIV InfectionsHumansMiddle AgedOpiate Substitution TreatmentOpioid-Related DisordersPre-Exposure ProphylaxisTelemedicineConceptsCriminal legal systemOpioid use disorderLegal systemStandard of careStructural barriersUse disorderEnhanced standard of careRates of opioid use disorderDelivery of PrEPPre-exposure prophylaxisWomen's abilityRandomized clinical trialsLife-saving interventionsRandomized Controlled TrialsHealth disparitiesImplementation outcomesPrEP initiationPreventive servicesClinical outcomesIntegrated deliveryFollow-upDelivery modelsClinical trialsDecision aidPrEP
2024
Decrease in provider stigma is associated with improved quality health indicators among individuals receiving methadone in primary care centers in Ukraine
Machavariani E, Bromberg D, Dumchev K, Esserman D, Earnshaw V, Pykalo I, Filippovich M, Ivasiy R, Ahmad B, Long J, Haddad M, Madden L, Oliveros D, Dvoriak S, Altice F. Decrease in provider stigma is associated with improved quality health indicators among individuals receiving methadone in primary care centers in Ukraine. International Journal Of Drug Policy 2024, 136: 104682. PMID: 39705875, PMCID: PMC11821433, DOI: 10.1016/j.drugpo.2024.104682.Peer-Reviewed Original ResearchConceptsPrimary care centersQuality health indicatorsProvider stigmaEvidence-based practiceGuideline-concordantPatient outcomesHealth indicatorsReduce provider stigmaCare centerInfluence healthcare utilizationSpecialty health servicesPatient-level outcomesTele-educationImprove patient outcomesProvider fearsImplementation trialHealthcare utilizationPreventive careHealth servicesPoor healthLinear mixed-effects modelsImprove attitudesStigmaIncrease accessMixed-effects modelsComparing the brief Holistic Health for HIV (3H+) to the Holistic Health Recovery Program (HHRP+) among people with HIV and opioid use disorder: Results from a randomized, controlled non-inferiority trial
Zelenev A, Huedo-Medina T, Shrestha R, Mistler C, Altice F, Sibilio B, Copenhaver M. Comparing the brief Holistic Health for HIV (3H+) to the Holistic Health Recovery Program (HHRP+) among people with HIV and opioid use disorder: Results from a randomized, controlled non-inferiority trial. PLOS ONE 2024, 19: e0312165. PMID: 39509356, PMCID: PMC11542883, DOI: 10.1371/journal.pone.0312165.Peer-Reviewed Original ResearchMeSH KeywordsAdultFemaleHIV InfectionsHolistic HealthHumansMaleMedication AdherenceMiddle AgedOpioid-Related DisordersRisk-TakingConceptsHolistic Health Recovery ProgramEvidence-based interventionsHolistic healthHIV treatmentRisk behaviorsReduce HIV risk behaviorsDifference-in-differencesEnd-of-interventionControlled non-inferiority trialHIV Epidemic goalsDrug treatment settingsAttainment of viral suppressionNon-inferiority trialRecovery programViral suppressionHigh ART adherenceHIV risk behaviorsNon-inferiorityHHRP+ART adherenceBehavioral interventionsReal-world settingsNon-parametric bootstrappingCondom useOpioid-dependent people
2023
Qualitative exploration of the early experiences of opioid use disorder patients from private clinics after Russia’s invasion of Ukraine in five major cities in Ukraine
Mazhnaya A, Meteliuk A, Pykalo I, Altice F. Qualitative exploration of the early experiences of opioid use disorder patients from private clinics after Russia’s invasion of Ukraine in five major cities in Ukraine. Frontiers In Public Health 2023, 11: 1238188. PMID: 38162610, PMCID: PMC10756895, DOI: 10.3389/fpubh.2023.1238188.Peer-Reviewed Original ResearchConceptsPrivate clinicsOpioid use disorder patientsInvasion of UkraineOpioid use disorderDosage reductionTreatment optionsFull-scale invasion of UkraineHealth system navigationQualitative explorationExperiences of patientsQualitative semi-structured interviewsMOUD treatmentUse disorderPatientsRussia's invasion of UkraineFull-scale invasionDisorder patientsClinicState-funded clinicsSemi-structured interviewsMOUDMOUD deliveryMedication availabilityState-funded facilitiesPatient experienceHigh perceived stress in patients on opioid agonist therapies during rapid transitional response to the COVID-19 pandemic in Ukraine
Galvez S, Altice F, Meteliuk A, Ivasiy R, Machavariani E, Farnum S, Fomenko T, Islam Z, Madden L. High perceived stress in patients on opioid agonist therapies during rapid transitional response to the COVID-19 pandemic in Ukraine. Frontiers In Public Health 2023, 11: 1231581. PMID: 38098837, PMCID: PMC10720365, DOI: 10.3389/fpubh.2023.1231581.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesics, OpioidCOVID-19HumansOpioid-Related DisordersPandemicsStress, PsychologicalSubstance Abuse, IntravenousUkraineConceptsOpioid agonist therapyOpioid use disorderAgonist therapyOAT patientsCOVID-19 pandemicSubstance useTake-home dosingAdditional psychosocial supportHigher perceived stressHigh riskPerceived Stress ScalePsychiatric disordersUse disordersPatientsPatient stressPsychosocial supportCertain subgroupsSevere levelsHigh levelsHealthcare deliveryStress ScalePerceived stressTherapyExtraordinary high levelsDisordersPreferences in medications for patients seeking treatment for opioid use disorder: A conjoint analysis
Muthulingam D, Hassett T, Madden L, Bromberg D, Fraenkel L, Altice F. Preferences in medications for patients seeking treatment for opioid use disorder: A conjoint analysis. Journal Of Substance Use And Addiction Treatment 2023, 154: 209138. PMID: 37544510, DOI: 10.1016/j.josat.2023.209138.Peer-Reviewed Original ResearchMeSH KeywordsBayes TheoremBuprenorphineCOVID-19Cross-Sectional StudiesHumansOpioid-Related DisordersPandemicsConceptsOpioid use disorderRoute of administrationPatient preferencesUse disordersSymptom reliefTreatment preferencesSide effectsCross-sectional observational studyTreatment-seeking peopleChi-squared analysisOral medicationsPublic health crisisOUD treatmentTreatment uptakeWithdrawal symptomsOpioid epidemicObservational studyTreatment decisionsSTROBE checklistSustainability of treatmentPatientsMedicationsHealth professionalsUtility scoresLarger studyDesign, implementation and preliminary results of a type-2 hybrid cluster-randomized trial of integrating screening and treatment for major depressive disorder into specialty clinics providing opioid agonist therapies in Ukraine
Machavariani E, Bromberg D, Dumchev K, Dvoriak S, Zeziulin O, Morozova O, Esserman D, Pykalo I, Saichuk N, Ivasiy R, Haddad M, Altice F. Design, implementation and preliminary results of a type-2 hybrid cluster-randomized trial of integrating screening and treatment for major depressive disorder into specialty clinics providing opioid agonist therapies in Ukraine. Contemporary Clinical Trials 2023, 131: 107248. PMID: 37263492, PMCID: PMC10527419, DOI: 10.1016/j.cct.2023.107248.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesics, OpioidDepressive Disorder, MajorHumansOpioid-Related DisordersSubstance Abuse, IntravenousUkraineConceptsOpioid agonist therapyMajor depressive disorderCo-occurring disordersAgonist therapyDepressive disorderSpecialty clinicPsychiatric disordersPatient-level outcomesPrevalent psychiatric disordersCluster-randomized trialPoor health outcomesProvider-level dataMDD treatmentTreatment algorithmExperimental armHigh prevalenceDelivery outcomesHealth outcomesSerial surveysClinicPatientsProject ECHOSubstance useMonthsDisordersResponding to health policy recommendations on managing opioid use disorder during Russia's invasion of Ukraine: Divergent responses from the frontline to the west
Ivasiy R, de Leon S, Meteliuk A, Fomenko T, Pykalo I, Bromberg D, Madden L, Farnum S, Islam Z, Altice F. Responding to health policy recommendations on managing opioid use disorder during Russia's invasion of Ukraine: Divergent responses from the frontline to the west. Frontiers In Public Health 2023, 10: 1044677. PMID: 36711398, PMCID: PMC9880308, DOI: 10.3389/fpubh.2022.1044677.Peer-Reviewed Original ResearchConceptsRussia’s invasionMartial lawRegions of UkrainePolicy recommendationsDepth interviewsHealth policy recommendationsEmergency policiesInternal displacementPolicyDistribution policyUkraineHealthcare servicesOpioid agonist treatment programExperienceWarSeries of adaptationsConflictInterviewsLegislationFrontlineCountriesDivergent responsesProvisionDirectorsPractice
2022
Impact of prerelease methadone on mortality among people with HIV and opioid use disorder after prison release: results from a randomized and participant choice open-label trial in Malaysia
Bazazi A, Culbert G, Wegman M, Heimer R, Kamarulzaman A, Altice F. Impact of prerelease methadone on mortality among people with HIV and opioid use disorder after prison release: results from a randomized and participant choice open-label trial in Malaysia. BMC Infectious Diseases 2022, 22: 837. PMID: 36368939, PMCID: PMC9652918, DOI: 10.1186/s12879-022-07804-6.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesics, OpioidHIV InfectionsHumansMalaysiaMaleMethadoneOpiate Substitution TreatmentOpioid-Related DisordersPrisonersPrisonsConceptsOpioid use disorderOpioid agonist therapyInfectious etiologyMost deathsUse disordersSample of menPrison releaseOpen-label trialT-lymphocyte countsPredictors of mortalityNational death recordsCrude mortality rateProportional hazards modelCovariate-adjusted modelsLow CD4Methadone initiationModified intentionAgonist therapySurvival benefitTreat analysisMethodsThis studyHIVHazards modelMortality rateMethadoneCollaborative learning and response to opioid misuse and HIV prevention in Ukraine during war
Altice FL, Bromberg DJ, Klepikov A, Barzilay EJ, Islam Z, Dvoriak S, Farnum SO, Madden LM. Collaborative learning and response to opioid misuse and HIV prevention in Ukraine during war. The Lancet Psychiatry 2022, 9: 852-854. PMID: 36244353, PMCID: PMC9806953, DOI: 10.1016/s2215-0366(22)00318-2.Peer-Reviewed Original ResearchUsing nominal group technique to identify barriers and facilitators to preventing HIV using combination same-day pre-exposure prophylaxis and medications for opioid use disorder
Eger WH, Altice FL, Lee J, Vlahov D, Khati A, Osborne S, Wickersham JA, Bohonnon T, Powell L, Shrestha R. Using nominal group technique to identify barriers and facilitators to preventing HIV using combination same-day pre-exposure prophylaxis and medications for opioid use disorder. Harm Reduction Journal 2022, 19: 120. PMID: 36307817, PMCID: PMC9616614, DOI: 10.1186/s12954-022-00703-8.Peer-Reviewed Original ResearchMeSH KeywordsAnti-HIV AgentsHIV InfectionsHumansOpioid-Related DisordersPre-Exposure ProphylaxisSubstance Abuse, IntravenousConceptsSame-day prescriptionPre-exposure prophylaxisOpioid use disorderHIV transmissionUse disordersClinical stakeholdersAvailability of providersSystems of careHealth care systemCoordinated careNew practice modelClinical careMedicationsPharmacy deliveryMOUDNominal group techniqueLocal prescribersPWIDSexual riskPrEPCare systemHealth benefitsCareMultiple visitsProphylaxisInterest without uptake: A mixed-methods analysis of methadone utilization in Kyrgyz prisons
Liberman AR, Bromberg DJ, Litz T, Kurmanalieva A, Galvez S, Rozanova J, Azbel L, Meyer JP, Altice FL. Interest without uptake: A mixed-methods analysis of methadone utilization in Kyrgyz prisons. PLOS ONE 2022, 17: e0276723. PMID: 36282864, PMCID: PMC9595522, DOI: 10.1371/journal.pone.0276723.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAnalgesics, OpioidHumansMethadoneOpiate Substitution TreatmentOpioid-Related DisordersPrisonersPrisonsConceptsKyrgyz prisonsCriminal justice systemDepth qualitative interviewsMethadone utilizationMethadone treatmentMixed-method analysisBrief interventionJustice systemPrison systemCriminal subcultureQualitative interviewsEastern EuropeEvidence-based HIV prevention strategiesCentral AsiaKyrgyz RepublicQualitative findingsPrison releaseHIV prevention strategiesPrisonInjection drug useMedication-Assisted TherapyMethadone uptakeInterpersonal relationshipsAttitudesHealth-related concernsStrengthening systems of care for people with or at risk for HIV, HCV and opioid use disorder: a call for enhanced data collection
Eller AJ, DiDomizio EE, Madden LM, Oliva JD, Altice FL, Johnson KA. Strengthening systems of care for people with or at risk for HIV, HCV and opioid use disorder: a call for enhanced data collection. Annals Of Medicine 2022, 54: 1714-1724. PMID: 35775786, PMCID: PMC9377256, DOI: 10.1080/07853890.2022.2084154.Peer-Reviewed Original ResearchMeSH KeywordsData CollectionHepacivirusHepatitis CHIV InfectionsHumansOpioid-Related DisordersUnited StatesConceptsCascade of careHuman immunodeficiency virusOpioid use disorderHepatitis C virusPublic health planningUse disordersCo-occurring opioid use disorderHealth planningBurden of diseaseSystems of careQuality improvement activitiesOUD cascadeTreatment initiationImmunodeficiency virusC virusPatient outcomesTreatment accessPayer sourceTreatment retentionHealth systemHealthcare systemCareSyndemicDisordersVirusPregnant Women and Opioid Use Disorder: Examining the Legal Landscape for Controlling Women's Reproductive Health.
Madden L, Oliva J, Eller A, DiDomizio E, Roosa M, Blanchard L, Kil N, Altice F, Johnson K. Pregnant Women and Opioid Use Disorder: Examining the Legal Landscape for Controlling Women's Reproductive Health. American Journal Of Law & Medicine 2022, 48: 209-222. PMID: 36715261, DOI: 10.1017/amj.2022.26.Peer-Reviewed Original ResearchConceptsOpioid use disorderReproductive healthPregnant womenUse disordersPregnant women's useEvidence-based treatmentsReproductive health outcomesWomen's reproductive healthIntersection of HIVSystems of careHealth care choicesPostpartum womenChild healthTreatment policyUnintentional pregnancyHealth outcomesLarger studyWomenTransactional sexCare choicesMinority womenOutcomesOUDWomen's useDisordersA pilot implementation study to scale-up methadone in incarcerated persons with opioid use disorder and retain them on treatment after release in Moldova
Dorgay CE, Bromberg DJ, Doltu S, Litz T, Galvez S, Polonsky M, Dvoryak S, Altice FL. A pilot implementation study to scale-up methadone in incarcerated persons with opioid use disorder and retain them on treatment after release in Moldova. International Journal Of Drug Policy 2022, 104: 103683. PMID: 35417790, PMCID: PMC9827420, DOI: 10.1016/j.drugpo.2022.103683.Peer-Reviewed Original ResearchConceptsMethadone maintenance treatmentOpioid use disorderUse disordersBrief interventionPilot implementation studySBIRT interventionTreatment initiationMaintenance treatmentMethadonePotential implementation strategiesIncarcerated personsInterventionImplementation studyTreatment proceduresBaselineDisordersTreatmentParticipantsDays of releaseReleaseImplementation strategiesPre-trial detention facilitySessionsHIVReferralExtending a lifeline to people with HIV and opioid use disorder during the war in Ukraine
Altice FL, Bromberg DJ, Dvoriak S, Meteliuk A, Pykalo I, Islam Z, Azbel L, Madden LM. Extending a lifeline to people with HIV and opioid use disorder during the war in Ukraine. The Lancet Public Health 2022, 7: e482-e484. PMID: 35358424, PMCID: PMC9818031, DOI: 10.1016/s2468-2667(22)00083-4.Peer-Reviewed Original ResearchThe development and initial validation of the Russian version of the BASIS-24
Madden L, Farnum S, Bromberg D, Barry D, Mazhnaya A, Fomenko T, Meteliuk A, Marcus R, Rozanova J, Poklad I, Dvoriak S, Altice F. The development and initial validation of the Russian version of the BASIS-24. Addiction Science & Clinical Practice 2022, 17: 65. PMID: 36435811, PMCID: PMC9701377, DOI: 10.1186/s13722-022-00343-0.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesics, OpioidHIV InfectionsHumansOpioid-Related DisordersReproducibility of ResultsRussiaConceptsBASIS-24Addiction treatmentHIV prevention goalsSubset of patientsOpioid use disorderSymptom Identification ScaleMental health statusResultsCronbach’s alpha coefficientsMOUD patientsSeverity InstrumentTuberculosis epidemicEffective treatmentUse disordersHealth statusHealthcare professionalsMental healthPrevention goalsRelationships subscaleTreatment deliveryExploratory principal component analysisOpioidsHIVPatientsAlpha coefficientEECA region
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply