2025
A Dyad-Based Intervention to Improve Adherence to Antiretroviral Therapy among People with HIV who Inject Drugs in Kazakhstan: Results of a Randomized Controlled Trial
Davis A, Rozental E, Bolger N, Gulyayev V, Gulyayev P, Denebayeva A, Wen H, Cui J, Terlikbayeva A, Primbetova S, Samandas J, Altice F, Remien R, Mergenova G. A Dyad-Based Intervention to Improve Adherence to Antiretroviral Therapy among People with HIV who Inject Drugs in Kazakhstan: Results of a Randomized Controlled Trial. AIDS And Behavior 2025, 1-13. PMID: 40773102, DOI: 10.1007/s10461-025-04841-5.Peer-Reviewed Original ResearchAntiretroviral therapy adherencePost-interventionIntervention armSelf-reported ART adherenceAntiretroviral therapySocial support interventionsImmediately post-interventionLargest HIV clinicStandard of careFollow-upMultilevel mixed modelsOne-month follow-upInjected drugsSix-month follow-upRandomized Controlled TrialsDyad-level factorsSupport interventionsPre-interventionSuboptimal antiretroviral therapyIntervention sessionsART adherenceSupportive partnersHIV clinicNo significant differenceHIV epidemic
2024
Influence of Stigma on Engagement in HIV Care and Adherence to Antiretroviral Therapy in Specialized HIV Clinics Targeting Men Who Have Sex with Men and Transgender Women in Lima, Peru
Oliveros Gómez D, Machavariani E, Altice F, Gálvez de León S, Earnshaw V, Montenegro-Idrogo J, Sánchez J, Seminario A. Influence of Stigma on Engagement in HIV Care and Adherence to Antiretroviral Therapy in Specialized HIV Clinics Targeting Men Who Have Sex with Men and Transgender Women in Lima, Peru. AIDS And Behavior 2024, 28: 2755-2768. PMID: 38878137, DOI: 10.1007/s10461-024-04401-3.Peer-Reviewed Original ResearchConceptsAdherence to antiretroviral therapyART adherenceTransgender womenHIV careSocial determinants of healthDeterminants of healthMultiple health outcomesInfluence of stigmaHIV-related outcomesViral suppression levelsGender minoritiesStigma subscaleAntiretroviral therapyHIV stigmaHealthcare engagementSocial determinantsHealth outcomesHIV clinicHIV epidemicStigmaVulnerable populationsCareOutcome variablesAssess factorsAdherenceUsing Data-To-Care Strategies to Optimize the HIV Care Continuum in Connecticut: Results From a Randomized Controlled Trial
Machavariani E, Miceli J, Altice F, Fanfair R, Speers S, Nichols L, Jenkins H, Villanueva M. Using Data-To-Care Strategies to Optimize the HIV Care Continuum in Connecticut: Results From a Randomized Controlled Trial. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2024, 96: 40-50. PMID: 38324241, PMCID: PMC11009056, DOI: 10.1097/qai.0000000000003391.Peer-Reviewed Original ResearchDisease intervention specialistsCare continuum outcomesHIV care continuum outcomesHIV care continuumRandomized Controlled TrialsHIV risk categoryCare continuumStandard-of-careData-to-CareViral suppressionRe-EngagementPredictor of re-engagementRisk categoriesHIV careRe-engage peopleMultivariate regression modelHIV clinicPredictors of retentionDetectable HIV-1 RNAIntervention specialistsControlled TrialsPre-randomizationPredictors of VSCareHIV-1 RNAImplementation of REDCap mobile app in an oral HIV clinical study
Seminario A, Karczewski A, Stanley S, Huamani J, Montenegro J, Tafur K, Julca A, Altice F. Implementation of REDCap mobile app in an oral HIV clinical study. BMC Public Health 2024, 24: 629. PMID: 38413910, PMCID: PMC10900554, DOI: 10.1186/s12889-024-17837-y.Peer-Reviewed Original ResearchConceptsAlcohol use disorderLow-middle income countriesOral healthAssociation of alcohol use disordersPerceived oral health statusAvailability of anti-retroviral therapyLevels of oral diseaseOral health statusAnti-retroviral therapyMobile appsElectronic data collection systemResultsThe mean ageHIV clinical studiesDietary supplement useClinical research staffHIV stigmaOral diseasesHIV clinicHIV casesHealth statusHIV statusMean ageClinical studiesParticipants' experiencesMedical history
2023
Psychometric Evaluation and Validation of the HIV Stigma Scale in Spanish Among Men Who Have Sex With Men and Transgender Women
Ranjit Y, Krishnan A, Earnshaw V, Weikum D, Ferro E, Sanchez J, Altice F. Psychometric Evaluation and Validation of the HIV Stigma Scale in Spanish Among Men Who Have Sex With Men and Transgender Women. Stigma And Health 2023, 8: 437-444. PMID: 38434589, PMCID: PMC10906740, DOI: 10.1037/sah0000302.Peer-Reviewed Original ResearchHIV Stigma ScaleTransgender womenStigma ScaleResource-limited settingsGood construct validityHIV clinicHIV stigmaDepressive symptomsMeasures of stigmaHIVInternalized stigmaPsychometric evaluationSociodemographic measuresMenSexMSMSocial supportConstruct validityEmployment statusSpanish versionConfirmatory factor analysisPsychometric propertiesWomenStigmaClinicCosts and cost‐effectiveness of a collaborative data‐to‐care intervention for HIV treatment and care in the United States
Shrestha R, Fanfair R, Randall L, Lucas C, Nichols L, Camp N, Brady K, Jenkins H, Altice F, DeMaria A, Villanueva M, Weidle P. Costs and cost‐effectiveness of a collaborative data‐to‐care intervention for HIV treatment and care in the United States. Journal Of The International AIDS Society 2023, 26: e26040. PMID: 36682053, PMCID: PMC9867888, DOI: 10.1002/jia2.26040.Peer-Reviewed Original ResearchConceptsCare armHIV careCare patientsIntervention armCare interventionsHealth departmentsHIV care interventionsHIV care outcomesHIV care providersHealthcare provider perspectiveHIV clinicHIV treatmentCare providersControl trialCare outcomesMicrocosting approachCare programCare servicesSurveillance dataSimilar interventionsIncremental costIntervention costsProvider perspectivesCareAverage cost
2022
Advancing data to care strategies for persons with HIV using an innovative reconciliation process
Villanueva M, Miceli J, Speers S, Nichols L, Carroll C, Jenkins H, Altice F. Advancing data to care strategies for persons with HIV using an innovative reconciliation process. PLOS ONE 2022, 17: e0267903. PMID: 35511958, PMCID: PMC9071117, DOI: 10.1371/journal.pone.0267903.Peer-Reviewed Original ResearchConceptsDisease intervention specialistsHIV care continuumCare continuumNon-randomized patientsPublic health surveillance dataOngoing HIV transmissionClinic visit dataHealth surveillance dataPublic health surveillanceHIV clinicHIV eliminationViral loadHIV transmissionCare engagementCopies/Clinic staffClinic dataYale University SchoolVisit dataHealth surveillancePWHSurveillance dataPatientsCells/Intervention specialists
2019
Impact of Abstinence and of Reducing Illicit Drug Use Without Abstinence on Human Immunodeficiency Virus Viral Load
Nance RM, Trejo MEP, Whitney BM, Delaney JAC, Altice F, Beckwith CG, Chander G, Chandler R, Christopoulous K, Cunningham C, Cunningham WE, Del Rio C, Donovan D, Eron JJ, Fredericksen RJ, Kahana S, Kitahata MM, Kronmal R, Kuo I, Kurth A, Mathews WC, Mayer KH, Moore RD, Mugavero MJ, Ouellet LJ, Quan VM, Saag MS, Simoni JM, Springer S, Strand L, Taxman F, Young JD, Crane HM. Impact of Abstinence and of Reducing Illicit Drug Use Without Abstinence on Human Immunodeficiency Virus Viral Load. Clinical Infectious Diseases 2019, 70: 867-874. PMID: 30994900, PMCID: PMC7319266, DOI: 10.1093/cid/ciz299.Peer-Reviewed Original ResearchConceptsMethamphetamine/crystalViral suppressionViral loadIllicit opioidsIllicit drug useDrug useRelative viral loadHuman immunodeficiency virus (HIV) viral loadNumber of PLWHSubstance useHIV viral loadHuman immunodeficiency virusLongitudinal cohort studyHarm reduction interventionsCrystal useCocaine/crackHIV clinicCohort studyVL suppressionImmunodeficiency virusImpact of abstinenceClinical studiesHigher oddsDrug categoriesOpioids
2017
Measuring Acceptability and Preferences for Implementation of Pre-Exposure Prophylaxis (PrEP) Using Conjoint Analysis: An Application to Primary HIV Prevention Among High Risk Drug Users
Shrestha R, Karki P, Altice FL, Dubov O, Fraenkel L, Huedo-Medina T, Copenhaver M. Measuring Acceptability and Preferences for Implementation of Pre-Exposure Prophylaxis (PrEP) Using Conjoint Analysis: An Application to Primary HIV Prevention Among High Risk Drug Users. AIDS And Behavior 2017, 22: 1228-1238. PMID: 28695388, PMCID: PMC5762432, DOI: 10.1007/s10461-017-1851-1.Peer-Reviewed Original ResearchConceptsPre-exposure prophylaxisSex-related risk behaviorsHigh-risk drug usersAcceptability of PrEPHigh-risk PWUDPrimary HIV preventionHIV prevention approachesDrug treatment settingsKey risk populationsHIV-negative PWUDHigh acceptabilityHIV clinicPrEP acceptabilityHIV testingPrEP uptakeMethadone clinicsHIV preventionRisk populationsSide effectsTreatment settingsDrug usersPrEP attributesRisk behaviorsPrEPUnderserved populations
2011
Improved Quality of Life for Opioid-Dependent Patients Receiving Buprenorphine Treatment in HIV Clinics
Korthuis PT, Tozzi MJ, Nandi V, Fiellin DA, Weiss L, Egan JE, Botsko M, Acosta A, Gourevitch MN, Hersh D, Hsu J, Boverman J, Altice FL. Improved Quality of Life for Opioid-Dependent Patients Receiving Buprenorphine Treatment in HIV Clinics. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2011, 56: s39-s45. PMID: 21317593, PMCID: PMC3073082, DOI: 10.1097/qai.0b013e318209754c.Peer-Reviewed Original ResearchConceptsSF-12 scoresGeneral US populationOpioid dependenceUS populationPoor health-related qualityShort Form Health SurveyBUP/NXBuprenorphine/naloxoneHIV care settingsOpioid-dependent patientsOpioid-dependent personsForm Health SurveyHealth-related qualityQuality of lifeBup/Mean HRQoLHIV clinicMaintenance therapyBuprenorphine treatmentHIV infectionPhysical HRQoLMental HRQOLHRQoL domainsMixed effects regressionHealth SurveyImproving Adherence to HIV Quality of Care Indicators in Persons With Opioid Dependence: The Role of Buprenorphine
Korthuis PT, Fiellin DA, Fu R, Lum PJ, Altice FL, Sohler N, Tozzi MJ, Asch SM, Botsko M, Fishl M, Flanigan TP, Boverman J, McCarty D. Improving Adherence to HIV Quality of Care Indicators in Persons With Opioid Dependence: The Role of Buprenorphine. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2011, 56: s83-s90. PMID: 21317600, PMCID: PMC3066190, DOI: 10.1097/qai.0b013e31820bc9a5.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveBuprenorphineBuprenorphine, Naloxone Drug CombinationCohort StudiesFemaleGuideline AdherenceHIV InfectionsHumansMaleMiddle AgedMultivariate AnalysisNaloxoneNarcotic AntagonistsOpiate Substitution TreatmentOpioid-Related DisordersPractice Guidelines as TopicQuality of Health CareConceptsBUP/NXHIV careOpioid dependenceHIV qualitySummary quality scoresCare indicatorsBuprenorphine/naloxone maintenance therapyHigh-quality HIV careOpioid-dependent HIVRole of buprenorphineObservational cohort studyOpioid-dependent patientsQuality scoresNondependent patientsHIV clinicMaintenance therapyCohort studyBuprenorphine treatmentClinical outcomesMultivariable analysisMedical recordsPatientsCareMonthsHIV
2001
Trust and the Acceptance of and Adherence to Antiretroviral Therapy.
Altice FL, Mostashari F, Friedland GH. Trust and the Acceptance of and Adherence to Antiretroviral Therapy. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2001, 28: 47. PMID: 11579277, DOI: 10.1097/00042560-200109010-00008.Peer-Reviewed Original ResearchConceptsInjection drug usersAntiretroviral therapyPotent new therapyStandardized chart reviewSocial isolationDrugs of abuseAntiretroviral regimenHIV clinicChart reviewHIV infectionHIV medicationsObserved therapyCorrelates of acceptanceHealth beliefsClinical informationHealth locusNew therapiesSide effectsPharmacy reviewDrug usersHealth statusInfected prisonersAIDS incidenceTherapyTherapeutic agentsTrust and the Acceptance of and Adherence to Antiretroviral Therapy
Altice F, Mostashari F, Friedland G. Trust and the Acceptance of and Adherence to Antiretroviral Therapy. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2001, 28: 47-58. DOI: 10.1097/00126334-200109010-00008.Peer-Reviewed Original ResearchInjection drug usersAntiretroviral therapyPotent new therapyStandardized chart reviewSocial isolationDrugs of abuseAntiretroviral regimenHIV clinicChart reviewHIV infectionHIV medicationsObserved therapyCorrelates of acceptanceHealth beliefsClinical informationHealth locusNew therapiesSide effectsPharmacy reviewDrug usersHealth statusInfected prisonersAIDS incidenceTherapyTherapeutic agents
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