2025
Facilitators and barriers to scaling up methadone maintenance therapy in Malaysian prisons: using nominal group technique with custodial staff
Mobley A, Shenoi S, Ahmad A, Ravie N, Bromberg D, Madden L, Long J, Pang J, Kamarulzaman A, Altice F. Facilitators and barriers to scaling up methadone maintenance therapy in Malaysian prisons: using nominal group technique with custodial staff. International Journal Of Prison Health 2025 PMID: 40787851, DOI: 10.1108/ijoph-11-2024-0064.Peer-Reviewed Original ResearchCustodial staffCustody officersMethadone maintenance treatmentMalaysia’s largest prison.Opioid use disorderMixed-methods strategyVital perspectiveLargest prisonPrison settingMalaysian prisonsPrisonTop-ranked barriersMiddle-income countriesHealth-care programsEase-of-accessTreatment of opioid use disorderMethadone maintenance treatment programsMonths employmentNominal group techniqueMethadone maintenance therapyOfficeMMT programDecision-makingStaffUse disorderRetention and dropout from sublingual and extended-release buprenorphine treatment: A comparative analysis of data from a nationally representative sample of commercially-insured people with opiod use disorder in the United States
Ivasiy R, Madden L, Johnson K, Machavariani E, Ahmad B, Oliveros D, Tan J, Kil N, Altice F. Retention and dropout from sublingual and extended-release buprenorphine treatment: A comparative analysis of data from a nationally representative sample of commercially-insured people with opiod use disorder in the United States. International Journal Of Drug Policy 2025, 138: 104748. PMID: 40020306, PMCID: PMC12045481, DOI: 10.1016/j.drugpo.2025.104748.Peer-Reviewed Original ResearchConceptsOpioid use disorderSL-BUPXR-BUPUse disorderRetrospective cohort studyExtended-release buprenorphineReduce treatment discontinuationDays of supplyTreatment discontinuationSublingual buprenorphineReduce overdose riskBuprenorphine treatmentCohort studyHigh dosesPrimary outcomeImpact of dosagePatientsBuprenorphineMonthsMg/dayCommercially-insured individualsProportion of individualsOpioidOverdose riskImprove health outcomesExploration of the multi-level barriers to scaling up methadone for HIV prevention among people who inject drugs in Kazakhstan
Liberman A, Rozental Y, Ivasiy R, Kussainova A, Primbetova S, Madden L, Terlikbayeva A, Altice F. Exploration of the multi-level barriers to scaling up methadone for HIV prevention among people who inject drugs in Kazakhstan. Journal Of Substance Use And Addiction Treatment 2025, 172: 209640. PMID: 39986387, PMCID: PMC12009200, DOI: 10.1016/j.josat.2025.209640.Peer-Reviewed Original ResearchNominal group techniqueHIV preventionCommunity health workersMulti-level barriersIn-depth interviewsHealth workersPWID clientsSocioecological modelCommunity stakeholdersOpioid use disorderFocus groupsHIV epidemicClinical directorsClinical sitesEducating clientsOpioid agonist therapyImprove implementationGroup techniqueResearch teamCHWsPolicy levelUse disorderCliniciansAlternative medicationsEligibilityPredicting antiretroviral medication adherence among substance-using people with HIV: test and extension of the information-motivation-behavioral skills model
Krishnan A, Ranjit Y, Zhou X, Altice F. Predicting antiretroviral medication adherence among substance-using people with HIV: test and extension of the information-motivation-behavioral skills model. Journal Of Behavioral Medicine 2025, 48: 403-413. PMID: 39924604, DOI: 10.1007/s10865-025-00557-y.Peer-Reviewed Original ResearchCocaine use disorderSubstance use disordersBehavioral skillsInformation-motivation-behavioral (IMB) skills modelSkills modelInformation-motivation-behavioral skills modelAntiretroviral medication adherenceUse disorderAntiretroviral therapyART adherenceMedication adherenceDaily adherenceImprove ART adherenceMotivational barriersDisordersAntiretroviral therapy adherenceMotivational factorsPractical barriersReduce HIV transmissionEnhance ART adherenceSuboptimal adherenceVirological failureHIV transmissionCocaineAdherencePrescribing methadone in prison predicts linkage to HIV care after release from prison: A randomized and patient preference trial
Mobley A, Wegman M, Bazazi A, Shenoi S, Bromberg D, Ahmad A, Kamarulzaman A, Altice F. Prescribing methadone in prison predicts linkage to HIV care after release from prison: A randomized and patient preference trial. International Journal Of Drug Policy 2025, 137: 104733. PMID: 39923270, PMCID: PMC11875876, DOI: 10.1016/j.drugpo.2025.104733.Peer-Reviewed Original ResearchConceptsLinkage to HIV careHIV careIncrease linkage to HIV careTreatment-as-prevention strategiesHIV treatment cascadeHIV treatment outcomesOpen-label trialCox proportional hazards modelsPatient preference trialOpioid use disorderMalaysia’s largest prison.Impact of methadoneProportional hazards modelTreatment cascadeInverse probability weighted Cox proportional hazards modelAnalytic sampleStudy participantsCareTreatment outcomesPrescribed methadoneOpioidConfounding variablesHIVUse disorderHazards modelRationale and design of a randomized clinical trial of integrated eHealth for PrEP and medications for opioid use disorders for women in the criminal legal system. The Athena study
Meyer J, Brunson S, Price C, Mulrain M, Nguyen J, Altice F, Kyriakides T, Cropsey K, Eaton E. Rationale and design of a randomized clinical trial of integrated eHealth for PrEP and medications for opioid use disorders for women in the criminal legal system. The Athena study. Addiction Science & Clinical Practice 2025, 20: 4. PMID: 39825419, PMCID: PMC11742507, DOI: 10.1186/s13722-024-00534-x.Peer-Reviewed Original ResearchConceptsCriminal legal systemOpioid use disorderLegal systemStandard of careStructural barriersUse disorderEnhanced standard of careRates of opioid use disorderDelivery of PrEPPre-exposure prophylaxisWomen's abilityRandomized clinical trialsLife-saving interventionsRandomized Controlled TrialsHealth disparitiesImplementation outcomesPrEP initiationPreventive servicesClinical outcomesIntegrated deliveryFollow-upDelivery modelsClinical trialsDecision aidPrEP
2024
Trajectory and progress of opioid agonist therapy programs in the Kyrgyz Republic
Liberman A, Kurmanalieva A, Biibosunova D, Shumskaya N, Ivasiy R, Bromberg D, Madden L, Altice F. Trajectory and progress of opioid agonist therapy programs in the Kyrgyz Republic. Global Health Economics And Sustainability 2024, 2: 2536. PMID: 40212662, PMCID: PMC11985161, DOI: 10.36922/ghes.2536.Peer-Reviewed Original ResearchOpioid agonist therapyHuman immunodeficiency virusMortality of human immunodeficiency virusOpioid agonist therapy programsOpioid use disorderMethadone programsHIV prevention strategiesAgonist therapyImmunodeficiency virusClinical protocolsEffective treatmentUse disorderNeighboring countriesHIV preventionKyrgyz RepublicMethadoneOpioidCentral AsiaIncreased state supportCentral Asian countriesDrugCarceral systemInternational donorsLocal news coveragePolitical challengesThe cascade of care for commercially-insured persons with opioid use disorder and comorbid HIV and HCV infections
Ivasiy R, Madden L, DiDomizio E, Johnson K, Machavariani E, Ahmad B, Oliveros D, Ram A, Kil N, Altice F. The cascade of care for commercially-insured persons with opioid use disorder and comorbid HIV and HCV infections. Drug And Alcohol Dependence 2024, 263: 112410. PMID: 39159600, PMCID: PMC12045330, DOI: 10.1016/j.drugalcdep.2024.112410.Peer-Reviewed Original ResearchOpioid use disorderXR-NTXUse disorderHCV infectionPrescribed MOUDOpioid use disorder cascadePrevalence of opioid use disorderRetrospective cohort studyHigher treatment retentionCascade of careConcurrent infectious diseasesSix-month retentionHCV/HIV coinfectionComorbid HIVCohort studyHospital-based settingPrescribed methadoneHCVMOUD initiationHIVHCV epidemicOpioidMethadoneMOUD prescriptionsTreatment retentionPrevalence and Correlates of Depression and Bipolar Disorder Among Patients Maintained on Methadone and Buprenorphine in Ukraine
Morozova O, Dvoriak V, Dumchev K, Machavariani E, Bromberg D, Dvoriak S, Altice F. Prevalence and Correlates of Depression and Bipolar Disorder Among Patients Maintained on Methadone and Buprenorphine in Ukraine. International Journal Of Mental Health And Addiction 2024, 1-18. PMID: 40823203, PMCID: PMC12356126, DOI: 10.1007/s11469-024-01353-6.Peer-Reviewed Original ResearchCorrelates of depressionBipolar disorderUse disorderPrevalence of psychiatric disordersBurden of mental health disordersCo-occurring disordersAlcohol use disorderSubstance use disordersMental health disordersIntegrated care strategiesCluster randomized trialAnalyzed baseline dataOpioid use disorderPsychiatric disordersMethadone dosageDepression diagnosisStigma levelsPHQ-9Moderate/severe depressionHealth disordersDepressionCare strategiesPhysical healthDrug injectionDisordersAlcohol Use Disorder and HIV Risk in a National Survey of Men Who Have Sex with Men in Ukraine
Gabriel W, Sazonova Y, Kulchynska R, LaMonaca K, Salyuk T, Smyrnov P, Altice F. Alcohol Use Disorder and HIV Risk in a National Survey of Men Who Have Sex with Men in Ukraine. International Journal Of Behavioral Medicine 2024, 1-17. PMID: 38914921, DOI: 10.1007/s12529-024-10272-8.Peer-Reviewed Original ResearchHIV transmission riskAssociated with HIV transmissionAlcohol use disorderHIV transmissionAlcohol consumptionTargeted HIV prevention strategiesPotential alcohol use disordersBehaviors associated with HIV transmissionRisk behaviors associated with HIV transmissionUnknown HIV statusHIV prevention strategiesPrevalent HIV infectionAssociated with increased likelihoodLikelihood of HIV acquisitionPre-exposure prophylaxisMultivariate regressionProblematic alcohol consumptionUse disorderConclusionThe high prevalenceMSM participantsHIV testingProblematic alcohol useHIV incidenceHIV statusHIV riskHigher methadone dose at time of release from prison predicts linkage to maintenance treatment for people with HIV and opioid use disorder transitioning to the community in Malaysia
Ahmad A, Bromberg D, Shrestha R, Salleh N, Bazazi A, Kamarulzaman A, Shenoi S, Altice F. Higher methadone dose at time of release from prison predicts linkage to maintenance treatment for people with HIV and opioid use disorder transitioning to the community in Malaysia. International Journal Of Drug Policy 2024, 126: 104369. PMID: 38484531, PMCID: PMC11056294, DOI: 10.1016/j.drugpo.2024.104369.Peer-Reviewed Original ResearchMethadone maintenance treatmentNational Institute of Drug AbuseMethadone dosePost-releaseOpioid dependenceMaintenance treatmentMethadone maintenance treatment doseHigher doses of methadoneProspective trialsHighest methadone dosagePost-release outcomesHigher methadone dosesMalaysia’s largest prison.Levels of depressionTreatment of opioid use disorderMonths of releaseDose of methadoneOpioid use disorderLargest prisonHigher dosageIncarcerated peopleIncarceration periodUse disorderMethadone dosageTime-to-event analysisPreferences and decisional considerations relating to opioid agonist therapy among Ukrainian people who use drugs: A conjoint analysis survey.
Bromberg D, Madden L, Fraenkel L, Muthulingam D, Rhoades D, Dvoriak S, Dumchev K, Pykalo I, Altice F. Preferences and decisional considerations relating to opioid agonist therapy among Ukrainian people who use drugs: A conjoint analysis survey. PLOS Global Public Health 2024, 4: e0002725. PMID: 38277422, PMCID: PMC10817130, DOI: 10.1371/journal.pgph.0002725.Peer-Reviewed Original ResearchOpioid agonist therapyWithdrawal symptomsAdverse side effectsAgonist therapySide effectsOpioid use disorderQuality-of-life improvementUse disorderCombined HIVHIV incidenceClinical decision-makingDosing frequencyRespondent-driven samplingOpioidOpioid epidemicAssess preferencesClinical concernPatient preferencesPatientsDelivery strategiesTherapyDisordersHIVPatient concernsWithdrawal
2023
Qualitative exploration of the early experiences of opioid use disorder patients from private clinics after Russia’s invasion of Ukraine in five major cities in Ukraine
Mazhnaya A, Meteliuk A, Pykalo I, Altice F. Qualitative exploration of the early experiences of opioid use disorder patients from private clinics after Russia’s invasion of Ukraine in five major cities in Ukraine. Frontiers In Public Health 2023, 11: 1238188. PMID: 38162610, PMCID: PMC10756895, DOI: 10.3389/fpubh.2023.1238188.Peer-Reviewed Original ResearchConceptsPrivate clinicsOpioid use disorder patientsInvasion of UkraineOpioid use disorderDosage reductionTreatment optionsFull-scale invasion of UkraineHealth system navigationQualitative explorationExperiences of patientsQualitative semi-structured interviewsMOUD treatmentUse disorderPatientsRussia's invasion of UkraineFull-scale invasionDisorder patientsClinicState-funded clinicsSemi-structured interviewsMOUDMOUD deliveryMedication availabilityState-funded facilitiesPatient experience
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