2025
Pre-implementation findings on the barriers and potential solutions to initiate same-day antiretroviral therapy among people who inject drugs in Malaysia
Oliveros D, Jenarun G, Salleh N, Saifi R, Earnshaw V, Madden L, Bromberg D, Sutherland R, Nikitin B, Kamarulzaman A, Altice F. Pre-implementation findings on the barriers and potential solutions to initiate same-day antiretroviral therapy among people who inject drugs in Malaysia. International Journal Of Drug Policy 2025, 145: 104967. PMID: 40865440, DOI: 10.1016/j.drugpo.2025.104967.Peer-Reviewed Original ResearchCommunity health workersNominal group techniqueHIV specialistsPre-implementationHighest-ranked barrierSame-day ARTSame-day antiretroviral therapyHIV treatment servicesPre-implementation findingsFear of policeInjected drugsAntiretroviral therapyHIV servicesInterpersonal stigmaHealth workersHIV providersMixed-method research strategyPre-implementation activitiesSocioecological modelImplementation barriersFocus groupsHarm reductionTreatment servicesGreater Kuala LumpurNGO partnershipsDevelopment and evaluation of an online HIV pre-exposure prophylaxis (PrEP) training program for community pharmacists to implement pharmacy-led PrEP services in Malaysia
Gan Y, Zaki R, Hafidzar S, Koh K, Nizaruddin M, Noh R, Khalid K, Yap A, Altice F, Lim S, Azwa I. Development and evaluation of an online HIV pre-exposure prophylaxis (PrEP) training program for community pharmacists to implement pharmacy-led PrEP services in Malaysia. PLOS ONE 2025, 20: e0328713. PMID: 40824910, PMCID: PMC12360552, DOI: 10.1371/journal.pone.0328713.Peer-Reviewed Original ResearchConceptsHIV pre-exposure prophylaxisPre-exposure prophylaxisCommunity pharmacistsTraining programPrEP servicesExploration-Preparation-Implementation-SustainmentKnowledge testOnline training programSimulation-based learningPrEP knowledgeClinical decision-makingPaired t-testKnowledge scoresPatient communicationParticipant feedbackBaseline assessmentDaily PrEPPharmacistsEligibility assessmentPrEP efficacyPrEPScore differencesPercentage scorePatient counselingClinical contraindicationsFacilitators and barriers to scaling up methadone maintenance therapy in Malaysian prisons: using nominal group technique with custodial staff
Mobley A, Shenoi S, Ahmad A, Ravie N, Bromberg D, Madden L, Long J, Pang J, Kamarulzaman A, Altice F. Facilitators and barriers to scaling up methadone maintenance therapy in Malaysian prisons: using nominal group technique with custodial staff. International Journal Of Prison Health 2025 PMID: 40787851, DOI: 10.1108/ijoph-11-2024-0064.Peer-Reviewed Original ResearchCustodial staffCustody officersMethadone maintenance treatmentMalaysia’s largest prison.Opioid use disorderMixed-methods strategyVital perspectiveLargest prisonPrison settingMalaysian prisonsPrisonTop-ranked barriersMiddle-income countriesHealth-care programsEase-of-accessTreatment of opioid use disorderMethadone maintenance treatment programsMonths employmentNominal group techniqueMethadone maintenance therapyOfficeMMT programDecision-makingStaffUse disorderA Dyad-Based Intervention to Improve Adherence to Antiretroviral Therapy among People with HIV who Inject Drugs in Kazakhstan: Results of a Randomized Controlled Trial
Davis A, Rozental E, Bolger N, Gulyayev V, Gulyayev P, Denebayeva A, Wen H, Cui J, Terlikbayeva A, Primbetova S, Samandas J, Altice F, Remien R, Mergenova G. A Dyad-Based Intervention to Improve Adherence to Antiretroviral Therapy among People with HIV who Inject Drugs in Kazakhstan: Results of a Randomized Controlled Trial. AIDS And Behavior 2025, 1-13. PMID: 40773102, DOI: 10.1007/s10461-025-04841-5.Peer-Reviewed Original ResearchAntiretroviral therapy adherencePost-interventionIntervention armSelf-reported ART adherenceAntiretroviral therapySocial support interventionsImmediately post-interventionLargest HIV clinicStandard of careFollow-upMultilevel mixed modelsOne-month follow-upInjected drugsSix-month follow-upRandomized Controlled TrialsDyad-level factorsSupport interventionsPre-interventionSuboptimal antiretroviral therapyIntervention sessionsART adherenceSupportive partnersHIV clinicNo significant differenceHIV epidemicCombined response to commentaries regarding Ivasiy et al. (2025)
Ivasiy R, Madden L, Johnson K, Machavariani E, Ahmad B, Oliveros D, Tan J, Kil N, Altice F. Combined response to commentaries regarding Ivasiy et al. (2025). International Journal Of Drug Policy 2025, 145: 104935. PMID: 40752295, DOI: 10.1016/j.drugpo.2025.104935.Peer-Reviewed Original ResearchHepatitis C Virus (HCV) Clearance Cascade for Persons With Human Immunodeficiency Virus (HIV)/HCV Coinfection Using Health Department Surveillance Data Among 7 US Jurisdictions Highlights the Role of HIV Care Engagement
Wegener M, Brooks R, Nichols L, Altice F, Villanueva M. Hepatitis C Virus (HCV) Clearance Cascade for Persons With Human Immunodeficiency Virus (HIV)/HCV Coinfection Using Health Department Surveillance Data Among 7 US Jurisdictions Highlights the Role of HIV Care Engagement. Open Forum Infectious Diseases 2025, 12: ofaf412. PMID: 40799793, PMCID: PMC12342353, DOI: 10.1093/ofid/ofaf412.Peer-Reviewed Original ResearchHuman immunodeficiency virusHepatitis C virusDirect-acting antiviralsHepatitis C virus outcomeImmunodeficiency virusHuman immunodeficiency virus care engagementHuman immunodeficiency virus viral suppressionC virusHepatitis C virus monoinfectionHCV-monoinfected individualsHepatitis C virus care continuumCare engagementHIV care engagementHCV clearanceCoinfected populationHealth department jurisdictionsViral suppressionBlack/African American personsPublic health strategiesStudy endMultivariate analysisPublic health infrastructureRisk factorsClinical modelCare continuumPilot randomized controlled trial to reduce HIV-related stigma among clinicians in Malaysia via project ECHO®
Earnshaw V, Collier Z, Wong P, Saifi R, Chong N, Ng R, Azwa I, Basri S, Hassan A, Mousavi M, Omar S, Walters S, Haddad M, Kamarulzaman A, Altice F. Pilot randomized controlled trial to reduce HIV-related stigma among clinicians in Malaysia via project ECHO®. AIDS Care 2025, 37: 1313-1331. PMID: 40736373, DOI: 10.1080/09540121.2025.2534539.Peer-Reviewed Original ResearchConceptsHIV-related stigmaClinical-related outcomesClinical Trial Registration:Scalable interventionsPilot randomized controlled trialQualitative focus groupsFocus group resultsQuantitative survey resultsSubgroup of participantsStigma reductionProject ECHOHIV testingIndividual healthcare facilitiesHIV preventionTrial Registration:Structural stigmaFocus groupsIntervention conditionHealthcare facilitiesStigmaGlobal disparitiesPotential benefitsRegistration:InterventionCliniciansStrengthening HIV Activism Among Clinicians in Malaysia: A Randomised Controlled Trial
Chong N, Azwa I, Hassan A, Mousavi M, Wong P, Ng R, Saifi R, Basri S, Omar S, Walters S, Collier Z, Haddad M, Altice F, Kamarulzaman A, Earnshaw V. Strengthening HIV Activism Among Clinicians in Malaysia: A Randomised Controlled Trial. AIDS And Behavior 2025, 1-9. PMID: 40691430, DOI: 10.1007/s10461-025-04829-1.Peer-Reviewed Original ResearchRandomised controlled trialsHIV training programsPrimary care physiciansYears of practiceStigma reductionGeneral practitionersCare physiciansActivist identitiesStatistically significant mean differencePreliminary impactSignificant mean differencesHIV activityStructured activitiesKey populationsTraining programGeneral populationProgrammatic experienceControlled TrialsStatistically significant changesStudy armsMean differenceHIVCompare groupsStigmaCliniciansEvaluating the Usability of an HIV Prevention Artificial Intelligence Chatbot in Malaysia: National Observational Study
Ni Z, Oh S, Saifi R, Azwa I, Altice F. Evaluating the Usability of an HIV Prevention Artificial Intelligence Chatbot in Malaysia: National Observational Study. JMIR Human Factors 2025, 12: e70034. PMID: 40663792, PMCID: PMC12283058, DOI: 10.2196/70034.Peer-Reviewed Original ResearchHIV self-test kitsPromote HIV testingSelf-test kitsHIV testingAI chatbotsObservational studyMSM-friendly clinicsFree HIV self-testing kitArtificial intelligenceDevelopment platformMental health servicesMiddle-income countriesPersonal health informationHuman-chatbot interactionsUpper middle-income countriesNational observational studyMachine learning algorithmsHealth servicesArtificial intelligence chatbotsHealth informationMental healthCommunity outreachSocial networking appsHealthcare systemHIV epidemicLoneliness among refugees: a neglected crisis in need of scalable innovation
Liu S, Bromberg D, Haucke M, Zhou X, Poole D, Bärnighausen T, Altice F. Loneliness among refugees: a neglected crisis in need of scalable innovation. The Lancet Regional Health - Europe 2025, 54: 101355. PMID: 40599742, PMCID: PMC12212147, DOI: 10.1016/j.lanepe.2025.101355.Peer-Reviewed Original ResearchThe viral playbook threatening the National Institutes of Health: a call to inoculate the immune system of American science
Altice F. The viral playbook threatening the National Institutes of Health: a call to inoculate the immune system of American science. The Lancet Regional Health - Americas 2025, 47: 101145. PMID: 40546883, PMCID: PMC12182333, DOI: 10.1016/j.lana.2025.101145.Peer-Reviewed Original ResearchOral pre-exposure prophylaxis (PrEP) receipt and persistence among opioid-dependent people who inject drugs initiating PrEP for HIV prevention
Khati A, Copenhaver M, Xu R, Altice F, Wickersham J, Gautam K, Paudel K, Shrestha R. Oral pre-exposure prophylaxis (PrEP) receipt and persistence among opioid-dependent people who inject drugs initiating PrEP for HIV prevention. Journal Of Substance Use And Addiction Treatment 2025, 173: 209693. PMID: 40222706, PMCID: PMC12477707, DOI: 10.1016/j.josat.2025.209693.Peer-Reviewed Original ResearchOpioid-dependent PWIDPre-exposure prophylaxisPrEP prescriptionPrEP useInjected drugsOral pre-exposure prophylaxisBehaviours related to sexFollow-up periodOpioid dependencePrEP continuum of careAssociated with higher persistenceFactors associated with persistenceMultivariable ordinal logistic regressionOpioid-dependent peopleDrug useAssess sociodemographic characteristicsPrEP persistenceRelated to sexHIV outbreakContinuum of careEarly 40sParticipantsPrEP continuumHIV preventionHIVDisease Intervention Specialist Field Experience in Re-engaging Out-of-Care People with HIV in Project CoRECT: A Mixed Methods Study
Macharaviani E, Altice F, Shrestha R, Truebig J, Carroll C, Nichols L, Ahmad B, Copenhaver M, Villanueva M. Disease Intervention Specialist Field Experience in Re-engaging Out-of-Care People with HIV in Project CoRECT: A Mixed Methods Study. AIDS And Behavior 2025, 29: 2451-2460. PMID: 40205311, PMCID: PMC12353047, DOI: 10.1007/s10461-025-04707-w.Peer-Reviewed Original ResearchDisease intervention specialistsRe-engagement effortsPatient-reported barriersControlled TrialsHIV care continuumCenters for Disease Control and PreventionExplanatory sequential mixed methods designSequential mixed methods designClinic operating hoursPatient-centered approachMixed methods studyDisease Control and PreventionPublic health interventionsMixed methods designStructured interactive sessionsControl and PreventionCare continuumCare engagementCare assessmentHealth interventionsSubstance use disordersAnti-retroviral treatmentMethods studyHIV statusSecondary analysisUsing nominal group technique to identify and prioritize barriers to decentralizing HIV care to primary health centers in Lima, Peru
Oliveros D, Konda K, Madden L, Montenegro-Idrogo J, Tafur Quintanilla K, Sosa Barbarán K, Nikitin B, Ponticiello M, Benites C, Sánchez J, Altice F. Using nominal group technique to identify and prioritize barriers to decentralizing HIV care to primary health centers in Lima, Peru. BMC Health Services Research 2025, 25: 466. PMID: 40156011, PMCID: PMC11954239, DOI: 10.1186/s12913-025-12618-8.Peer-Reviewed Original ResearchConceptsPrimary health centersNominal group techniqueDecentralized HIV careHIV careHealth centersHIV servicesGroup of healthcare providersDecentralization of HIV careNominal group technique groupsPatient's continuity of careContinuity of carePeruvian Ministry of HealthGroup techniqueEvidence-based strategiesMinistry of HealthHIV stigmaLack of confidenceHealthcare accessPerceived BarriersProvider groupsHealth outcomesHealthcare providersPatient continuityIdentified barriersEducational meetingsImpact of multi-level factors and partner characteristics on antiretroviral therapy adherence and access to HIV care during the COVID-19 pandemic
Neuenschwander P, Pala A, Altice F, Remien R, Mergenova G, Rozental E, Gulyayev V, Davis A. Impact of multi-level factors and partner characteristics on antiretroviral therapy adherence and access to HIV care during the COVID-19 pandemic. International Journal Of STD & AIDS 2025, 36: 568-576. PMID: 40155324, DOI: 10.1177/09564624251329626.Peer-Reviewed Original ResearchConceptsAntiretroviral therapy adherenceMental healthFactors associated with ART adherenceMethodsA cross-sectional surveyMultilevel generalized linear mixed modelsPoor mental healthAssociated with lower adherenceBackgroundAdherence to antiretroviral therapyAntiretroviral therapyMedication adherence ratesCross-sectional surveyCOVID-19 pandemicHIV treatment programsMulti-level factorsNegative emotional impactHIV carePublic health crisisSocial supportART adherenceSupportive partnersLinear mixed modelsAdherence ratesAssessed associationsLow adherenceAdherence levelsExploring barriers and potential solutions before implementing a scale-up strategy to expand methadone coverage among people who inject drugs in Tajikistan
O'Hara G, Madden L, Burkhonov A, Alaei A, Mohsinzoda G, Bromberg D, Abdullozoda J, Yusufi S, Altice F. Exploring barriers and potential solutions before implementing a scale-up strategy to expand methadone coverage among people who inject drugs in Tajikistan. Journal Of Substance Use And Addiction Treatment 2025, 172: 209682. PMID: 40139416, DOI: 10.1016/j.josat.2025.209682.Peer-Reviewed Original ResearchConceptsOpioid agonist therapyNominal group techniquePre-implementationImplementation strategiesSecondary HIV prevention strategyHIV prevention strategiesPre-implementation studyAgonist therapyOpioid agonist therapy scale-upHIV epidemicPre-implementation activitiesMethadoneFocus groupsPrevention strategiesCentral Asian regionOpioidGroup techniquePWIDOrganizational factorsNIATxSocietal factorsRecipientsScale-up strategyDrugCharacterisation of a syndemic of STI symptoms, substance use and violence among incarcerated Peruvian women
Cyrus E, Turpin R, Dyer T, Hashemi E, Ali S, Bazo A, Morgan-Lopez A, Scheidell J, Leon S, Sciaudone M, Altice F. Characterisation of a syndemic of STI symptoms, substance use and violence among incarcerated Peruvian women. Sexually Transmitted Infections 2025, sextrans-2024-056371. PMID: 40081910, DOI: 10.1136/sextrans-2024-056371.Peer-Reviewed Original ResearchSexually transmitted infection symptomsSexually transmitted infectionsIncarcerated womenSubstance usePopulation of incarcerated womenRisk of violenceSTI symptomsLatent profile analysisIncarceration ratesHigh school degreeSubstance misusePrisonSyndemic theoryViolenceYears of ageCross-sectional studyDeleterious health outcomesMedian ageSchool degreeSexual behaviorAt-risk populationsHealth outcomesGlobal trendsPeruvian womenEpidemiological dataRetention and dropout from sublingual and extended-release buprenorphine treatment: A comparative analysis of data from a nationally representative sample of commercially-insured people with opiod use disorder in the United States
Ivasiy R, Madden L, Johnson K, Machavariani E, Ahmad B, Oliveros D, Tan J, Kil N, Altice F. Retention and dropout from sublingual and extended-release buprenorphine treatment: A comparative analysis of data from a nationally representative sample of commercially-insured people with opiod use disorder in the United States. International Journal Of Drug Policy 2025, 138: 104748. PMID: 40020306, PMCID: PMC12045481, DOI: 10.1016/j.drugpo.2025.104748.Peer-Reviewed Original ResearchConceptsOpioid use disorderSL-BUPXR-BUPUse disorderRetrospective cohort studyExtended-release buprenorphineReduce treatment discontinuationDays of supplyTreatment discontinuationSublingual buprenorphineReduce overdose riskBuprenorphine treatmentCohort studyHigh dosesPrimary outcomeImpact of dosagePatientsBuprenorphineMonthsMg/dayCommercially-insured individualsProportion of individualsOpioidOverdose riskImprove health outcomesExploration of the multi-level barriers to scaling up methadone for HIV prevention among people who inject drugs in Kazakhstan
Liberman A, Rozental Y, Ivasiy R, Kussainova A, Primbetova S, Madden L, Terlikbayeva A, Altice F. Exploration of the multi-level barriers to scaling up methadone for HIV prevention among people who inject drugs in Kazakhstan. Journal Of Substance Use And Addiction Treatment 2025, 172: 209640. PMID: 39986387, PMCID: PMC12009200, DOI: 10.1016/j.josat.2025.209640.Peer-Reviewed Original ResearchNominal group techniqueHIV preventionCommunity health workersMulti-level barriersIn-depth interviewsHealth workersPWID clientsSocioecological modelCommunity stakeholdersOpioid use disorderFocus groupsHIV epidemicClinical directorsClinical sitesEducating clientsOpioid agonist therapyImprove implementationGroup techniqueResearch teamCHWsPolicy levelUse disorderCliniciansAlternative medicationsEligibilityPredicting antiretroviral medication adherence among substance-using people with HIV: test and extension of the information-motivation-behavioral skills model
Krishnan A, Ranjit Y, Zhou X, Altice F. Predicting antiretroviral medication adherence among substance-using people with HIV: test and extension of the information-motivation-behavioral skills model. Journal Of Behavioral Medicine 2025, 48: 403-413. PMID: 39924604, DOI: 10.1007/s10865-025-00557-y.Peer-Reviewed Original ResearchCocaine use disorderSubstance use disordersBehavioral skillsInformation-motivation-behavioral (IMB) skills modelSkills modelInformation-motivation-behavioral skills modelAntiretroviral medication adherenceUse disorderAntiretroviral therapyART adherenceMedication adherenceDaily adherenceImprove ART adherenceMotivational barriersDisordersAntiretroviral therapy adherenceMotivational factorsPractical barriersReduce HIV transmissionEnhance ART adherenceSuboptimal adherenceVirological failureHIV transmissionCocaineAdherence
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