2025
Depression and Low Social Support Mediate the Association of Marital Stress and 12-Month Cardiac-Specific Quality of Life in Young Adults With Acute Myocardial Infarction
Zhu C, Dreyer R, Li F, Spatz E, Caraballo C, Mahajan S, Raparelli V, Leifheit E, Lu Y, Krumholz H, Spertus J, D’Onofrio G, Pilote L, Lichtman J. Depression and Low Social Support Mediate the Association of Marital Stress and 12-Month Cardiac-Specific Quality of Life in Young Adults With Acute Myocardial Infarction. Biopsychosocial Science And Medicine 2025, 87: 129-137. PMID: 39909011, DOI: 10.1097/psy.0000000000001363.Peer-Reviewed Original ResearchConceptsLow social supportCardiac-specific quality of lifeNatural direct effectSocial supportMonths post-AMIQuality of lifeAcute myocardial infarctionMarital stressComprehensive secondary preventive strategySignificant depressive symptomsPost-AMISecondary prevention strategiesYoung adultsMyocardial infarctionSociodemographic factorsDepressive symptomsAMI survivorsCovariate adjustmentPrevention strategiesSelf-reportContinuous scoresQoLBaseline QoLCategorical depressionDepression
2023
A randomized clinical trial assessing the effect of automated medication-targeted alerts on acute kidney injury outcomes
Wilson F, Yamamoto Y, Martin M, Coronel-Moreno C, Li F, Cheng C, Aklilu A, Ghazi L, Greenberg J, Latham S, Melchinger H, Mansour S, Moledina D, Parikh C, Partridge C, Testani J, Ugwuowo U. A randomized clinical trial assessing the effect of automated medication-targeted alerts on acute kidney injury outcomes. Nature Communications 2023, 14: 2826. PMID: 37198160, PMCID: PMC10192367, DOI: 10.1038/s41467-023-38532-3.Peer-Reviewed Original ResearchConceptsAcute kidney injuryUsual care groupKidney injuryCare groupAcute Kidney Injury OutcomesAlert groupNon-steroidal anti-inflammatory drugsComposite of progressionHours of randomizationMedications of interestAldosterone system inhibitorsClasses of medicationsProton pump inhibitorsRandomized clinical trialsAnti-inflammatory drugsClinical decision support systemNephrotoxic medicationsHospitalized adultsDiscontinuation ratesCertain medicationsPrimary outcomeSubstantial morbiditySystem inhibitorsPump inhibitorsParallel group
2022
Effect of intravenous antihypertensives on outcomes of severe hypertension in hospitalized patients without acute target organ damage
Ghazi L, Li F, Simonov M, Yamamoto Y, Nugent J, Greenberg J, Bakhoum C, Peixoto A, Wilson F. Effect of intravenous antihypertensives on outcomes of severe hypertension in hospitalized patients without acute target organ damage. Journal Of Hypertension 2022, 41: 288-294. PMID: 36583354, PMCID: PMC9799038, DOI: 10.1097/hjh.0000000000003328.Peer-Reviewed Original ResearchConceptsAcute target organ damageTarget organ damageSevere hypertensionOrgan damageIntravenous antihypertensivesBP elevationClinical outcomesMyocardial injuryTarget end-organ damageOverlap propensity scoreSevere BP elevationAcute kidney injuryBlood pressure reductionEnd-organ damageRisk of strokeInpatient hypertensionCardiovascular eventsIndex hospitalizationKidney injuryRetrospective studyHypertensionAntihypertensivesHospitalizationCox modelPatientsBlood pressure response to commonly administered antihypertensives for severe inpatient hypertension
Ghazi L, Li F, Chen X, Simonov M, Yamamoto Y, Biswas A, Hanna J, Shah T, Peixoto AJ, Wilson FP. Blood pressure response to commonly administered antihypertensives for severe inpatient hypertension. PLOS ONE 2022, 17: e0265497. PMID: 35385506, PMCID: PMC8985959, DOI: 10.1371/journal.pone.0265497.Peer-Reviewed Original ResearchConceptsHTN developmentSevere hypertensionOral hydralazineOral carvedilolIntensive care unit patientsBlood pressure elevationCare unit patientsAssociation of treatmentSingle healthcare systemAntihypertensive treatmentCommon antihypertensivesInpatient hypertensionOral amlodipinePrescribed antihypertensivesOral metoprololClinical characteristicsCohort studyUnit patientsBP responseHospitalized patientsPressure elevationBP changesLower BPHypertensionHydralazine
2021
Black Women Are More Likely Than White Women to Schedule a Uterine-Sparing Treatment for Leiomyomas
Wegienka G, Stewart E, Nicholson W, Zhang S, Li F, Thomas L, Spies J, Venable S, Laughlin-Tommaso S, Diamond M, Anchan R, Maxwell G, Marsh E, Myers E, Vines A, Wise L, Wallace K, Jacoby V. Black Women Are More Likely Than White Women to Schedule a Uterine-Sparing Treatment for Leiomyomas. Journal Of Women's Health 2021, 30: 355-366. PMID: 33524308, DOI: 10.1089/jwh.2020.8634.Peer-Reviewed Original ResearchConceptsUterine fibroidsWhite womenBlack womenUterine-sparing treatmentClinical sitesTertiary care centerPatients' medical recordsRandom effects logistic regressionTreatment RegistryHysterectomyUF symptomsSubgroup analysisTreatment selectionConclusion:</i></b>Quality of lifeWorse symptomsMedical recordsCare centerMyomectomyLogistic regressionWomenResults:</i></b>Evaluate differencesTreatmentWhite counterparts
2019
Predicting the Risk of Huntington’s Disease with Multiple Longitudinal Biomarkers
Li F, Li K, Li C, Luo S, Group P. Predicting the Risk of Huntington’s Disease with Multiple Longitudinal Biomarkers. Journal Of Huntington's Disease 2019, 8: 323-332. PMID: 31256145, PMCID: PMC6718328, DOI: 10.3233/jhd-190345.Peer-Reviewed Original ResearchConceptsEnroll-HDRisk of Huntington's diseasePREDICT-HDRisk of HDMultiple longitudinal markersTime to diagnosisHuntington's diseasePatient's risk categoryPrognostic indexPrognostic scorePrognostic modelHD diagnosisRisk predictionPublic health threatCox modelRisk categoriesLongitudinal measurementsHealth threatRiskLongitudinal biomarkersScoresBiomarker measurementsPatient selectionClinical trialsClinical biomarkers
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