2025
Assessing Mediation in Cross‐Sectional Stepped Wedge Cluster Randomized Trials
Cao Z, Li F. Assessing Mediation in Cross‐Sectional Stepped Wedge Cluster Randomized Trials. Statistics In Medicine 2025, 44: e70175. PMID: 40662697, DOI: 10.1002/sim.70175.Peer-Reviewed Original ResearchConceptsStepped wedge cluster randomized trialSW-CRTsTreatment effect heterogeneityCluster randomized trialSW-CRTBinary mediatorEffect heterogeneityGeneralized linear mixed modelsNatural indirect effectLinear mixed modelsEstimationEffective structureExamplesMixed modelsType combinationsMediation proportionPractical implementation
2022
Is the Product Method More Efficient Than the Difference Method for Assessing Mediation?
Cheng C, Spiegelman D, Li F. Is the Product Method More Efficient Than the Difference Method for Assessing Mediation? American Journal Of Epidemiology 2022, 192: 84-92. PMID: 35921210, PMCID: PMC10144745, DOI: 10.1093/aje/kwac144.Peer-Reviewed Original Research
2021
Estimating the natural indirect effect and the mediation proportion via the product method
Cheng C, Spiegelman D, Li F. Estimating the natural indirect effect and the mediation proportion via the product method. BMC Medical Research Methodology 2021, 21: 253. PMID: 34800985, PMCID: PMC8606099, DOI: 10.1186/s12874-021-01425-4.Peer-Reviewed Original ResearchConceptsInterval estimatorsApproximate estimatorExact estimatorMultivariate delta methodFinite sample performanceProduct methodNon-negligible biasBinary outcomesRare outcome assumptionExact expressionDelta methodVariance estimationEmpirical performanceEstimatorCommon data typesBootstrap approachBinary mediatorNatural indirect effectSample size
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