2025
How Should Parallel Cluster Randomized Trials With a Baseline Period be Analyzed?—A Survey of Estimands and Common Estimators
Lee K, Li F. How Should Parallel Cluster Randomized Trials With a Baseline Period be Analyzed?—A Survey of Estimands and Common Estimators. Biometrical Journal 2025, 67: e70052. PMID: 40302411, PMCID: PMC12041842, DOI: 10.1002/bimj.70052.Peer-Reviewed Original ResearchConceptsInformative cluster sizeIndependence estimating equationsCluster-period sizesParallel cluster randomized trialsTreatment effect estimatesCluster randomized trialInconsistent estimatesSimulation studyEstimandsEstimating EquationsCluster sizeContinuous outcomesEstimationTreatment effectsEffect estimatesImprove mental healthRandomized trialsConvergenceEquationsRural eastern IndiaMental healthMixed-effects modelsYouth teams
2023
Informative cluster size in cluster-randomised trials: A case study from the TRIGGER trial
Kahan B, Li F, Blette B, Jairath V, Copas A, Harhay M. Informative cluster size in cluster-randomised trials: A case study from the TRIGGER trial. Clinical Trials 2023, 20: 661-669. PMID: 37439089, PMCID: PMC10638852, DOI: 10.1177/17407745231186094.Peer-Reviewed Original ResearchConceptsCluster-randomised trialCluster-level summariesAcute upper gastrointestinal bleedingExchangeable correlation structureRed blood cell transfusionEQ-5D VAS scoreMixed-effects modelsUpper gastrointestinal bleedingBlood cell transfusionMixed effects modelsTreatment effectsCell transfusionGastrointestinal bleedingIschemic eventsVAS scoresOdds ratioMost outcomesTRIGGER trialTreatment effect estimatesEffect estimatesInformative cluster sizeTrialsOutcomesParticipant outcomesCorrelation structure
2022
Estimands in cluster-randomized trials: choosing analyses that answer the right question
Kahan BC, Li F, Copas AJ, Harhay MO. Estimands in cluster-randomized trials: choosing analyses that answer the right question. International Journal Of Epidemiology 2022, 52: 107-118. PMID: 35834775, PMCID: PMC9908044, DOI: 10.1093/ije/dyac131.Peer-Reviewed Original ResearchConceptsInformative cluster sizeCluster sizeCommon estimatorsCorrelation structureAlternative estimatorsEstimatorUnbiased estimatesBiased estimatesEstimandsDifferent estimandsTarget estimandAnalytic approachCareful specificationLarge clustersEquationsDifferent analytic approachesEstimatesMixed-effects models
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