2025
Selecting the optimal longitudinal cluster randomized design with a continuous outcome: Parallel-arm, crossover, or stepped-wedge.
Liu J, Li F, Sutcliffe S, Colditz G. Selecting the optimal longitudinal cluster randomized design with a continuous outcome: Parallel-arm, crossover, or stepped-wedge. Statistical Methods In Medical Research 2025, 9622802251360409. PMID: 40785501, DOI: 10.1177/09622802251360409.Peer-Reviewed Original ResearchSW-CRTsLongitudinal cluster randomized trialsStepped wedge cluster randomized trialCluster-period sizesTreatment effect estimatesCluster randomized trialContinuous outcomesGeneralized Estimating EquationsOptimal designCluster randomized designEffect estimatesFixed budgetCluster randomized trial designFormulaEquationsAlgorithmOptimal numberCross-sectional designGlobal optimal designEstimationRandomized trial designRandomized trialsStepped-wedgeCRXO trialsOD algorithm
2024
Optimal designs using generalized estimating equations in cluster randomized crossover and stepped wedge trials
Liu J, Li F. Optimal designs using generalized estimating equations in cluster randomized crossover and stepped wedge trials. Statistical Methods In Medical Research 2024, 33: 1299-1330. PMID: 38813761, DOI: 10.1177/09622802241247717.Peer-Reviewed Original ResearchConceptsMaximin optimal designsStepped wedge cluster randomized trialLocally optimal designsCluster-period sizesClosed-form formulaCluster-randomized crossover trialCross-sectional sampling schemeInteger estimationOptimal design algorithmDesign algorithmLongitudinal cluster randomized trialsWorking correlation structureCluster randomized trialMethod of generalized estimating equationsTreatment effect estimatesSAS macroVariance expressionsExact valueCorrelation structureMaximinSampling schemeBetween-clusterOptimal designOptimization design researchEstimating Equations
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