2025
Selecting the optimal longitudinal cluster randomized design with a continuous outcome: Parallel-arm, crossover, or stepped-wedge.
Liu J, Li F, Sutcliffe S, Colditz G. Selecting the optimal longitudinal cluster randomized design with a continuous outcome: Parallel-arm, crossover, or stepped-wedge. Statistical Methods In Medical Research 2025, 9622802251360409. PMID: 40785501, DOI: 10.1177/09622802251360409.Peer-Reviewed Original ResearchSW-CRTsLongitudinal cluster randomized trialsStepped wedge cluster randomized trialCluster-period sizesTreatment effect estimatesCluster randomized trialContinuous outcomesGeneralized Estimating EquationsOptimal designCluster randomized designEffect estimatesFixed budgetCluster randomized trial designFormulaEquationsAlgorithmOptimal numberCross-sectional designGlobal optimal designEstimationRandomized trial designRandomized trialsStepped-wedgeCRXO trialsOD algorithm
2024
Sample size and power calculation for testing treatment effect heterogeneity in cluster randomized crossover designs
Wang X, Chen X, Goldfeld K, Taljaard M, Li F. Sample size and power calculation for testing treatment effect heterogeneity in cluster randomized crossover designs. Statistical Methods In Medical Research 2024, 33: 1115-1136. PMID: 38689556, PMCID: PMC11347095, DOI: 10.1177/09622802241247736.Peer-Reviewed Original ResearchCluster randomized crossover designSample size formulaTreatment effect heterogeneityAverage treatment effectHeterogeneity of treatment effectsSize formulaRandomized crossover designCluster-randomized crossover trialRandomized crossover trialEffect heterogeneitySampling schemeCluster randomized designTreatment effectsDifferential treatment effectsCrossover designFormulaContinuous outcomesLinear mixed modelsSample sizeCrossover trialInteraction testMixed modelsCovariatesClinical characteristicsStatistical methods
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