2024
Demystifying estimands in cluster-randomised trials.
Kahan B, Blette B, Harhay M, Halpern S, Jairath V, Copas A, Li F. Demystifying estimands in cluster-randomised trials. Statistical Methods In Medical Research 2024, 9622802241254197. PMID: 38780480, DOI: 10.1177/09622802241254197.Peer-Reviewed Original ResearchCluster randomised trialPotential outcomes notationTreatment effect estimatesOverview of estimationPublished cluster randomised trialsCluster-level summariesTarget estimandEstimandsTreatment effectsEffect estimatesInterpretation of treatment effectsOdds ratioEstimationRandomised trialsStudy objective
2022
Estimands in cluster-randomized trials: choosing analyses that answer the right question
Kahan BC, Li F, Copas AJ, Harhay MO. Estimands in cluster-randomized trials: choosing analyses that answer the right question. International Journal Of Epidemiology 2022, 52: 107-118. PMID: 35834775, PMCID: PMC9908044, DOI: 10.1093/ije/dyac131.Peer-Reviewed Original ResearchConceptsInformative cluster sizeCluster sizeCommon estimatorsCorrelation structureAlternative estimatorsEstimatorUnbiased estimatesBiased estimatesEstimandsDifferent estimandsTarget estimandAnalytic approachCareful specificationLarge clustersEquationsDifferent analytic approachesEstimatesMixed-effects models