2024
Randomized in error in pragmatic clinical trials
Tong G, Coronado G, Li C, Li F. Randomized in error in pragmatic clinical trials. Contemporary Clinical Trials 2024, 148: 107764. PMID: 39603383, DOI: 10.1016/j.cct.2024.107764.Peer-Reviewed Original ResearchPragmatic clinical trialsElectronic health record dataHealth record dataPatient-reported dataExclusion of participantsSelection biasPatients' medical recordsAverage treatment effectOutcomes of participantsUsual carePragmatic trialTreatment effectsIntervention effectsIntention-to-treatOutcomes frameworkPost-randomization exclusionsPotential outcomes frameworkRecord dataCovariate-adjusted estimatesMedical recordsParticipantsClinical trialsInterventionTrialsArm being
2023
Health equity considerations in pragmatic trials in Alzheimer's and dementia disease: Results from a methodological review
Nicholls S, Al‐Jaishi A, Niznick H, Carroll K, Madani M, Peak K, Madani L, Nevins P, Adisso L, Li F, Weijer C, Mitchell S, Welch V, Quiñones A, Taljaard M. Health equity considerations in pragmatic trials in Alzheimer's and dementia disease: Results from a methodological review. Alzheimer's & Dementia Diagnosis Assessment & Disease Monitoring 2023, 15: e12392. PMID: 36777091, PMCID: PMC9899766, DOI: 10.1002/dad2.12392.Peer-Reviewed Original Research
2021
Methodological challenges in pragmatic trials in Alzheimer’s disease and related dementias: Opportunities for improvement
Taljaard M, Li F, Qin B, Cui C, Zhang L, Nicholls SG, Carroll K, Mitchell SL. Methodological challenges in pragmatic trials in Alzheimer’s disease and related dementias: Opportunities for improvement. Clinical Trials 2021, 19: 86-96. PMID: 34841910, PMCID: PMC8847324, DOI: 10.1177/17407745211046672.Peer-Reviewed Original ResearchConceptsPragmatic trialAlzheimer's diseasePrimary outcomeSample size calculationGroup treatment trialsPairs of reviewersDementia researchSize calculationCluster Randomized TrialGroup treatment designRandomized trialsTreatment trialsIntracluster correlationMethodological qualityTrial reportsBaseline assessmentDiseaseTrialsDementiaKey methodological characteristicsOutcomesType IMethodological quality indicatorsUnique methodological challengesSame individual