Maintaining the validity of inference from linear mixed models in stepped-wedge cluster randomized trials under misspecified random-effects structures
Ouyang Y, Taljaard M, Forbes A, Li F. Maintaining the validity of inference from linear mixed models in stepped-wedge cluster randomized trials under misspecified random-effects structures. Statistical Methods In Medical Research 2024, 33: 1497-1516. PMID: 38807552, PMCID: PMC11499024, DOI: 10.1177/09622802241248382.Peer-Reviewed Original ResearchRandom effects structureVariance estimationComplex correlation structureRobust variance estimationFixed effects parametersDegrees of freedom correctionCluster randomized trialEstimates of standard errorsCorrelation structureRandom effectsStepped-wedge cluster randomized trialComprehensive simulation studyLinear mixed modelsStatistical inferenceRandom intercept modelSimulation studyMixed modelsMisspecificationValidity of inferencesRandom interceptContinuous outcomesEstimationComputational challengesIntercept modelStandard error
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