2025
Power calculation for cross-sectional stepped wedge cluster randomized trials with a time-to-event endpoint
Baumann M, Esserman D, Taljaard M, Li F. Power calculation for cross-sectional stepped wedge cluster randomized trials with a time-to-event endpoint. Biometrics 2025, 81: ujaf074. PMID: 40557765, PMCID: PMC12188223, DOI: 10.1093/biomtc/ujaf074.Peer-Reviewed Original ResearchConceptsSW-CRTsCluster randomized trialStepped wedge cluster randomized trialTime-to-event endpointsTime-to-event outcomesRobust sandwich varianceMarginal Cox modelSandwich varianceWithin-periodElectronic reminder systemSW-CRTRandomized trialsBinary outcomesPower calculationsPower formulaReminder systemR Shiny applicationHospital settingCorrelation parametersSample sizePlanned trialsCox modelWaldFormulaTrials
2022
Effect of intravenous antihypertensives on outcomes of severe hypertension in hospitalized patients without acute target organ damage
Ghazi L, Li F, Simonov M, Yamamoto Y, Nugent J, Greenberg J, Bakhoum C, Peixoto A, Wilson F. Effect of intravenous antihypertensives on outcomes of severe hypertension in hospitalized patients without acute target organ damage. Journal Of Hypertension 2022, 41: 288-294. PMID: 36583354, PMCID: PMC9799038, DOI: 10.1097/hjh.0000000000003328.Peer-Reviewed Original ResearchConceptsAcute target organ damageTarget organ damageSevere hypertensionOrgan damageIntravenous antihypertensivesBP elevationClinical outcomesMyocardial injuryTarget end-organ damageOverlap propensity scoreSevere BP elevationAcute kidney injuryBlood pressure reductionEnd-organ damageRisk of strokeInpatient hypertensionCardiovascular eventsIndex hospitalizationKidney injuryRetrospective studyHypertensionAntihypertensivesHospitalizationCox modelPatients
2019
Predicting the Risk of Huntington’s Disease with Multiple Longitudinal Biomarkers
Li F, Li K, Li C, Luo S, Group P. Predicting the Risk of Huntington’s Disease with Multiple Longitudinal Biomarkers. Journal Of Huntington's Disease 2019, 8: 323-332. PMID: 31256145, PMCID: PMC6718328, DOI: 10.3233/jhd-190345.Peer-Reviewed Original ResearchConceptsEnroll-HDRisk of Huntington's diseasePREDICT-HDRisk of HDMultiple longitudinal markersTime to diagnosisHuntington's diseasePatient's risk categoryPrognostic indexPrognostic scorePrognostic modelHD diagnosisRisk predictionPublic health threatCox modelRisk categoriesLongitudinal measurementsHealth threatRiskLongitudinal biomarkersScoresBiomarker measurementsPatient selectionClinical trialsClinical biomarkers
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