2025
Prevalence of metabolic syndrome in people living with HIV and its multi-organ damage: a prospective cohort study
Tang J, Chen L, Pan W, Lu L, Liu X, Zhang L, Zheng L, Song X, Guo F, Lv W, Cao W, Hsieh E, Li T. Prevalence of metabolic syndrome in people living with HIV and its multi-organ damage: a prospective cohort study. BMC Infectious Diseases 2025, 25: 351. PMID: 40075301, PMCID: PMC11905433, DOI: 10.1186/s12879-025-10735-7.Peer-Reviewed Original ResearchConceptsRisk factors of MetSFactors of MetSPooled Cohort EquationsProspective cohort studyAssociated with higher riskBone mineral densityGlobal scale-upMulti-organ damageRisk factorsAssociated with unfavorable health outcomesAntiretroviral therapyAlcohol consumptionCohort studyConclusionThe incidenceChina Diabetes SocietyPrevalence of metabolic syndromeScale-up of antiretroviral therapyMetabolic syndromeAssociated with multi-organ damageOrgan damageGlobal scale-up of antiretroviral therapyUnfavorable health outcomesIncidence of MetSLow HDL-C concentrationsAssociated with MetS
2024
BoneScore: A natural language processing algorithm to extract bone mineral density data from DXA scans
Fodeh S, Wang R, Murphy T, Kidwai-Khan F, Leo-Summers L, Tessier-Sherman B, Hsieh E, Womack J. BoneScore: A natural language processing algorithm to extract bone mineral density data from DXA scans. Health Informatics Journal 2024, 30: 14604582241295930. PMID: 39526751, PMCID: PMC11872221, DOI: 10.1177/14604582241295930.Peer-Reviewed Original ResearchConceptsT-score valuesT-scoreNLP algorithmsDXA scansFemoral neck T-scoreNatural language processing algorithmsBone mineral density dataLanguage processing algorithmsBone mineral densityExtract annotationsRegular expressionsTest dataProcessing algorithmsDXA reportsMineral densityAlgorithmMultivariate linear regressionClinical face validityRisk factorsPresence of informationDXANLPClinical validationClinical expertsAccuracy
2023
Incidence, Microbiological Studies, and Factors Associated With Prosthetic Joint Infection After Total Knee Arthroplasty
Weinstein E, Stephens-Shields A, Newcomb C, Silibovsky R, Nelson C, O’Donnell J, Glaser L, Hsieh E, Hanberg J, Tate J, Akgün K, King J, Re V. Incidence, Microbiological Studies, and Factors Associated With Prosthetic Joint Infection After Total Knee Arthroplasty. JAMA Network Open 2023, 6: e2340457. PMID: 37906194, PMCID: PMC10618849, DOI: 10.1001/jamanetworkopen.2023.40457.Peer-Reviewed Original ResearchConceptsPrimary total knee arthroplastyProsthetic joint infectionTotal knee arthroplastyIncidence rate ratiosLate prosthetic joint infectionsPostoperative periodIncidence rateCohort studyOverall cohortJoint infectionKnee arthroplastyVeterans Affairs Surgical Quality Improvement Program dataElective primary total knee arthroplastyEarly prosthetic joint infectionHepatitis C virus infectionQuality Improvement Program dataVeterans Affairs Corporate Data WarehouseAutoimmune inflammatory arthritisPostoperative antibiotic useC virus infectionRisk factor modificationChronic kidney diseasePeripheral artery diseaseLate postoperative periodYears of careGlobal Perspective on the Impact of the COVID‐19 Pandemic on Rheumatology and Health Equity
Hsieh E, Dey D, Grainger R, Li M, Machado P, Ugarte‐Gil M, Yazdany J. Global Perspective on the Impact of the COVID‐19 Pandemic on Rheumatology and Health Equity. Arthritis Care & Research 2023, 76: 22-31. PMID: 37277949, DOI: 10.1002/acr.25169.Peer-Reviewed Original ResearchConceptsRheumatic diseasesRheumatology practiceHealth service useHealth care utilizationCOVID-19 morbidityHealth care accessCOVID-19 pandemicMental health outcomesUptake of telemedicinePublic health emergencyPublic health communicationAcute phaseVaccine uptakeCare utilizationVaccination practicesRapid guidelinesWorse diseaseCare accessService useHealth outcomesPatient careDiseaseHealth equityHealth emergencyPandemic wanesPerformance of a modified fracture risk assessment tool for fragility fracture prediction among older veterans living with HIV
Womack J, Murphy T, Leo-Summers L, Kidwai-Khan F, Skanderson M, Gill T, Gulanski B, Rodriguez-Barradas M, Tien P, Yin M, Hsieh E. Performance of a modified fracture risk assessment tool for fragility fracture prediction among older veterans living with HIV. AIDS 2023, 37: 1399-1407. PMID: 37070536, PMCID: PMC10329997, DOI: 10.1097/qad.0000000000003566.Peer-Reviewed Original ResearchConceptsFracture Risk Assessment ToolMajor osteoporotic fractureRisk assessment toolCohort studyHip fractureOsteoporotic fracturesVeterans Aging Cohort StudyAging Cohort StudyMultivariable logistic regressionType of fractureRace/ethnicityAssessment toolGlucocorticoid useHIV cohortFragility fracturesPrevious fractureRheumatoid arthritisSmoking statusFracture riskModest discriminationOlder veteransLogistic regressionOccurrence of fracturesHIVAlcohol useAssessing the contributions of modifiable risk factors to serious falls and fragility fractures among older persons living with HIV
Womack J, Murphy T, Leo‐Summers L, Bates J, Jarad S, Gill T, Hsieh E, Rodriguez‐Barradas M, Tien P, Yin M, Brandt C, Justice A. Assessing the contributions of modifiable risk factors to serious falls and fragility fractures among older persons living with HIV. Journal Of The American Geriatrics Society 2023, 71: 1891-1901. PMID: 36912153, PMCID: PMC10258163, DOI: 10.1111/jgs.18304.Peer-Reviewed Original ResearchConceptsModifiable risk factorsFragility fracturesRisk factorsAlcohol use disorderSerious fallsPhysiologic frailtyAntiretroviral therapyOlder PWHUse disordersVeterans Aging Cohort StudyMeasures of multimorbidityAging Cohort StudyBody mass indexMultivariable logistic modelAverage attributable fractionSuccessful prevention programsKey risk factorsOpioid prescriptionsCohort studyMass indexModifiable factorsSixth decadeAttributable fractionElevated riskICD9 codesPrevalence of and risk factors for vertebral fracture and low bone mineral density among Peruvian women aging with HIV
Cabrera D, Cornejo M, Slotkin R, Pinedo Y, Yu W, Guan W, Garcia P, Hsieh E. Prevalence of and risk factors for vertebral fracture and low bone mineral density among Peruvian women aging with HIV. Archives Of Osteoporosis 2023, 18: 64. PMID: 37160770, PMCID: PMC10170032, DOI: 10.1007/s11657-023-01250-w.Peer-Reviewed Original ResearchConceptsBone mineral densityLow bone mineral densityThoracolumbar X-rayVertebral fracturesFemoral neckRisk factorsLumbar spineOsteoporosis treatmentTotal hipTreatment gapMineral densityTotal hip bone mineral densityPresence of VFsPeruvian womenTH bone mineral densityHip bone mineral densityFN bone mineral densityLower FN BMDSubset of patientsGenant semiquantitative methodLower femoral neckImportant treatment gapsKey risk factorsAntiretroviral therapyFRAX score
2022
Renal tubular acidosis and associated factors in patients with primary Sjögren’s syndrome: a registry-based study
Zhang Y, Qiao L, Zhang L, Li Q, Yang P, Kong X, Duan X, Zhang M, Li X, Wang Y, Xu J, Wang Y, Hsieh E, Zhao J, Xu D, Li M, Zhao Y, Zeng X. Renal tubular acidosis and associated factors in patients with primary Sjögren’s syndrome: a registry-based study. Clinical Rheumatology 2022, 42: 431-441. PMID: 36383239, DOI: 10.1007/s10067-022-06426-2.Peer-Reviewed Original ResearchConceptsRenal tubular acidosisPrimary Sjögren's syndromePSS patientsEarly disease onsetDisease onsetRenal involvementSjögren's syndromeKidney functionTubular acidosisEULAR Sjögren's Syndrome Disease Activity IndexSjögren's Syndrome Disease Activity IndexMethodThis case-control studyElevated alkaline phosphatase levelsSubjective dry mouthDisease activity indexHigh disease activityGlomerular filtration rateRegistry-based studyErythrocyte sedimentation rateYoung female patientCase-control studyLogistic regression analysisAlkaline phosphatase levelsAntibody positivityDisease activityPredictive Risk Model for Serious Falls Among Older Persons Living With HIV
Womack JA, Murphy TE, Leo-Summers L, Bates J, Jarad S, Smith AC, Gill TM, Hsieh E, Rodriguez-Barradas MC, Tien PC, Yin MT, Brandt CA, Justice AC. Predictive Risk Model for Serious Falls Among Older Persons Living With HIV. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2022, 91: 168-174. PMID: 36094483, PMCID: PMC9470988, DOI: 10.1097/qai.0000000000003030.Peer-Reviewed Original ResearchConceptsMiddle-aged veteransOlder PWHAntiretroviral therapySerious fallsOlder personsVeterans Aging Cohort StudyMeasures of multimorbidityAging Cohort StudyBody mass indexMultivariable logistic regressionPredictive risk modelCohort studyMass indexInjury codesElevated riskGeneral populationSix monthsPWHLogistic regressionPotential predictorsSubstance useRadiology reportsHIVExternal causesVeteransProlonged COVID-19 symptom duration in people with systemic autoimmune rheumatic diseases: results from the COVID-19 Global Rheumatology Alliance Vaccine Survey
DiIorio M, Kennedy K, Liew JW, Putman MS, Sirotich E, Sattui SE, Foster G, Harrison C, Larché MJ, Levine M, Moni TT, Thabane L, Bhana S, Costello W, Grainger R, Machado PM, Robinson PC, Sufka P, Wallace ZS, Yazdany J, Gore-Massy M, Howard RA, Kodhek MA, Lalonde N, Tomasella LA, Wallace J, Akpabio A, Alpízar-Rodríguez D, Beesley RP, Berenbaum F, Bulina I, Chock EY, Conway R, Duarte-García A, Duff E, Gheita TA, Graef ER, Hsieh E, Kibbi L, Liew DF, Lo C, Nudel M, Singh AD, Singh JA, Singh N, Ugarte-Gil MF, Hausmann JS, Simard JF, Sparks JA. Prolonged COVID-19 symptom duration in people with systemic autoimmune rheumatic diseases: results from the COVID-19 Global Rheumatology Alliance Vaccine Survey. RMD Open 2022, 8: e002587. PMID: 36104117, PMCID: PMC9475962, DOI: 10.1136/rmdopen-2022-002587.Peer-Reviewed Original ResearchConceptsSystemic autoimmune rheumatic diseasesCOVID-19 symptom durationSymptom durationAutoimmune rheumatic diseasesCOVID-19 onsetVaccines surveyRheumatic diseasesCOVID-19Test-confirmed COVID-19Complete symptom resolutionCOVID-19 severityCOVID-19 symptomsImmunomodulating medicationsComorbidity countSymptom resolutionBaseline characteristicsClinical characteristicsAcute symptomsVaccine dosesNovel viral variantsHigher oddsLower oddsDay 15Viral variantsLogistic regressionHealth-related quality of life among women aging with and without HIV in Peru
Cabrera DM, Chen M, Cornejo MP, Pinedo Y, Garcia PJ, Hsieh E. Health-related quality of life among women aging with and without HIV in Peru. PLOS ONE 2022, 17: e0269000. PMID: 35679332, PMCID: PMC9182248, DOI: 10.1371/journal.pone.0269000.Peer-Reviewed Original ResearchConceptsHealth-related qualityMental componentPhysical activityCell countLower health-related qualityShort Form Health SurveyComponent scoresHRQoL of womenLarge HIV clinicMental component scorePhysical component scoreForm Health SurveyStatistical significanceSummary component scoresCross-sectional studyRegression analysisChronic comorbiditiesHIV clinicHIV severitySF-36Mean ageRole limitationsPhysical functioningClinical dataHealth SurveySARS–CoV‐2 Infection and COVID‐19 Outcomes in Rheumatic Diseases: A Systematic Literature Review and Meta‐Analysis
Conway R, Grimshaw AA, Konig MF, Putman M, Duarte‐García A, Tseng LY, Cabrera DM, Chock YPE, Degirmenci HB, Duff E, Egeli BH, Graef ER, Gupta A, Harkins P, Hoyer BF, Jayatilleke A, Jin S, Kasia C, Khilnani A, Kilian A, Kim AHJ, Lin CMA, Low C, Proulx L, Sattui SE, Singh N, Sparks JA, Tam H, Ugarte‐Gil M, Ung N, Wang K, Wise LM, Yang Z, Young KJ, Liew JW, Grainger R, Wallace ZS, Hsieh E, Alliance T. SARS–CoV‐2 Infection and COVID‐19 Outcomes in Rheumatic Diseases: A Systematic Literature Review and Meta‐Analysis. Arthritis & Rheumatology 2022, 74: 766-775. PMID: 34807517, PMCID: PMC9011807, DOI: 10.1002/art.42030.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionMechanical ventilationRisk ratioOdds ratioMortality rateCOVID-19 disease severityJoanna Briggs Institute critical appraisal toolsCOVID-19Odds of hospitalizationNewcastle-Ottawa ScaleCOVID-19 outcomesRandom-effects modelCritical appraisal toolMantel-Haenszel formulaSystematic literature reviewAdjusted riskICU admissionRMD patientsClinical outcomesRheumatic diseasesMethodologic qualityRelative riskObservational studyGeneral populationLower riskIntersectionality of stigmas and health-related quality of life in people ageing with HIV in China, Europe, and Latin America
Hsieh E, Polo R, Qian HZ, Fuster-RuizdeApodaca MJ, Del Amo J. Intersectionality of stigmas and health-related quality of life in people ageing with HIV in China, Europe, and Latin America. The Lancet Healthy Longevity 2022, 3: e206-e215. PMID: 36098292, DOI: 10.1016/s2666-7568(22)00003-4.Peer-Reviewed Original ResearchManagement of rheumatoid arthritis in China: a study of the implementation of 2019 EULAR recommendations
Jin S, Jiang N, Huo Y, Duan X, Fang Y, Zhao C, Li H, Yang M, Huang Z, Yang P, Zhang H, Zhan F, Wang Y, Wang Y, Wu C, Wang Q, Hsieh E, Li M, Tian X, Zhao Y, Zeng X. Management of rheumatoid arthritis in China: a study of the implementation of 2019 EULAR recommendations. Annals Of The Rheumatic Diseases 2022, 81: 1052-1054. PMID: 35168947, DOI: 10.1136/annrheumdis-2021-221841.Peer-Reviewed Original ResearchPrevalence, Predictors, and Prognostic Benefits of Remission Achievement in Patients With Systemic Lupus Erythematosus: A Systematic Review
Yang Z, Cheng C, Wang Z, Wang Y, Zhao J, Wang Q, Tian X, Hsieh E, Li M, Zeng X. Prevalence, Predictors, and Prognostic Benefits of Remission Achievement in Patients With Systemic Lupus Erythematosus: A Systematic Review. Arthritis Care & Research 2022, 74: 208-218. PMID: 32986933, DOI: 10.1002/acr.24464.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusPrognostic benefitDisease activityRemission achievementLupus erythematosusRemission statusLower baseline disease activityMajor organ involvementBaseline disease activityClinical disease activityRisk stratification modelPositive serologic resultsDefinition of remissionSLE patientsAdult patientsOrgan involvementDrug withdrawalTreatment adjustmentEmbase databasesRemission definitionsRemissionSerologic activitySerologic resultsPatientsSystematic review
2021
Global Rheumatology Research: Frontiers, Challenges, and Opportunities
Bilsborrow JB, Peláez‐Ballestas I, Pons‐Estel B, Scott C, Tian X, Alarcon GS, Bucala R, Lewandowski LB, Hsieh E. Global Rheumatology Research: Frontiers, Challenges, and Opportunities. Arthritis & Rheumatology 2021, 74: 1-4. PMID: 34535973, PMCID: PMC8712358, DOI: 10.1002/art.41980.BooksHIV care using differentiated service delivery during the COVID‐19 pandemic: a nationwide cohort study in the US Department of Veterans Affairs
McGinnis KA, Skanderson M, Justice AC, Akgün KM, Tate JP, King JT, Rentsch CT, Marconi VC, Hsieh E, Ruser C, Kidwai‐Khan F, Yousefzadeh R, Erdos J, Park LS. HIV care using differentiated service delivery during the COVID‐19 pandemic: a nationwide cohort study in the US Department of Veterans Affairs. Journal Of The International AIDS Society 2021, 24: e25810. PMID: 34713585, PMCID: PMC8554215, DOI: 10.1002/jia2.25810.Peer-Reviewed Original ResearchConceptsVeterans AffairsClinic visitsCohort studyVL testARV coverageCOVID-19 pandemicVeterans Aging Cohort StudyHIV healthcare deliveryNationwide cohort studyAging Cohort StudyViral load testsDifferentiated service deliveryHealthcare deliveryHIV careMost patientsPharmacy recordsVL testingCalendar periodHealthcare encountersOverall healthARVVirtual healthcareVirtual visitsVisitsService deliveryIncident Rheumatoid Arthritis in HIV Infection: Epidemiology and Treatment
Hanberg JS, Hsieh E, Akgün KM, Weinstein E, Fraenkel L, Justice AC, Team T. Incident Rheumatoid Arthritis in HIV Infection: Epidemiology and Treatment. Arthritis & Rheumatology 2021, 73: 2189-2199. PMID: 34042306, DOI: 10.1002/art.41802.Peer-Reviewed Original ResearchConceptsDisease-modifying antirheumatic drugsIncident rheumatoid arthritisDiagnosis of RARA patientsRheumatoid arthritisRheumatoid factorUninfected individualsRheumatology/European AllianceHigh titersVeterans Aging Cohort StudyRA-specific autoantibodiesRheumatology 2010 criteriaTenth Revision codesAging Cohort StudyIncidence rate ratiosHigh autoantibody titersICD-10 codesDMARD useUninfected veteransAntirheumatic drugsAutoantibody titersCohort studyImmunosuppressed populationHIV infectionMedical chartsBrief Report: Are Serious Falls Associated With Subsequent Fragility Fractures Among Veterans Living With HIV?
Womack JA, Murphy TE, Ramsey C, Bathulapalli H, Leo-Summers L, Smith AC, Bates J, Jarad S, Gill TM, Hsieh E, Rodriguez-Barradas MC, Tien PC, Yin MT, Brandt C, Justice AC. Brief Report: Are Serious Falls Associated With Subsequent Fragility Fractures Among Veterans Living With HIV? JAIDS Journal Of Acquired Immune Deficiency Syndromes 2021, 88: 192-196. PMID: 34506360, PMCID: PMC8513792, DOI: 10.1097/qai.0000000000002752.Peer-Reviewed Original ResearchConceptsSubsequent fragility fracturesFragility fracturesAntiretroviral therapySerious fallsRisk factorsVeterans Aging Cohort StudyAging Cohort StudyMultivariable logistic regressionUpper arm fracturesMiddle-aged populationYears of ageAlcohol use disorderCohort studyHip fractureVertebral fracturesArm fracturesInjury codesICD9 codesGeneral populationUse disordersLogistic regressionIntegrase inhibitorsOlder adultsRadiology reportsHIVEarly experience of COVID-19 vaccination in adults with systemic rheumatic diseases: results from the COVID-19 Global Rheumatology Alliance Vaccine Survey
Sattui SE, Liew JW, Kennedy K, Sirotich E, Putman M, Moni TT, Akpabio A, Alpízar-Rodríguez D, Berenbaum F, Bulina I, Conway R, Singh AD, Duff E, Durrant KL, Gheita TA, Hill CL, Howard RA, Hoyer BF, Hsieh E, Kibbi L, Kilian A, Kim AH, Liew DFL, Lo C, Miller B, Mingolla S, Nudel M, Palmerlee CA, Singh JA, Singh N, Ugarte-Gil MF, Wallace J, Young KJ, Bhana S, Costello W, Grainger R, Machado PM, Robinson PC, Sufka P, Wallace ZS, Yazdany J, Harrison C, Larché M, Levine M, Foster G, Thabane L, Rider LG, Hausmann JS, Simard JF, Sparks JA. Early experience of COVID-19 vaccination in adults with systemic rheumatic diseases: results from the COVID-19 Global Rheumatology Alliance Vaccine Survey. RMD Open 2021, 7: e001814. PMID: 34493645, PMCID: PMC8424419, DOI: 10.1136/rmdopen-2021-001814.Peer-Reviewed Original ResearchConceptsDisease-modifying antirheumatic drugsPatient-reported adverse eventsSystemic rheumatic diseasesCOVID-19 vaccinationRheumatic disease flareRheumatic diseasesDisease flareCOVID-19 vaccineAdverse eventsVaccine efficacyMuscle/joint painJanssen/JohnsonTime of vaccinationFever/chillsCommon rheumatic diseasePatient-reported dataOxford/AstraZenecaEarly experienceVaccines surveyAntirheumatic drugsMedication changesJoint painMost patientsPfizer-BioNTechRheumatoid arthritis
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