2025
Prevalence of metabolic syndrome in people living with HIV and its multi-organ damage: a prospective cohort study
Tang J, Chen L, Pan W, Lu L, Liu X, Zhang L, Zheng L, Song X, Guo F, Lv W, Cao W, Hsieh E, Li T. Prevalence of metabolic syndrome in people living with HIV and its multi-organ damage: a prospective cohort study. BMC Infectious Diseases 2025, 25: 351. PMID: 40075301, PMCID: PMC11905433, DOI: 10.1186/s12879-025-10735-7.Peer-Reviewed Original ResearchConceptsRisk factors of MetSFactors of MetSPooled Cohort EquationsProspective cohort studyAssociated with higher riskBone mineral densityGlobal scale-upMulti-organ damageRisk factorsAssociated with unfavorable health outcomesAntiretroviral therapyAlcohol consumptionCohort studyConclusionThe incidenceChina Diabetes SocietyPrevalence of metabolic syndromeScale-up of antiretroviral therapyMetabolic syndromeAssociated with multi-organ damageOrgan damageGlobal scale-up of antiretroviral therapyUnfavorable health outcomesIncidence of MetSLow HDL-C concentrationsAssociated with MetS
2022
Management of rheumatoid arthritis in China: a study of the implementation of 2019 EULAR recommendations
Jin S, Jiang N, Huo Y, Duan X, Fang Y, Zhao C, Li H, Yang M, Huang Z, Yang P, Zhang H, Zhan F, Wang Y, Wang Y, Wu C, Wang Q, Hsieh E, Li M, Tian X, Zhao Y, Zeng X. Management of rheumatoid arthritis in China: a study of the implementation of 2019 EULAR recommendations. Annals Of The Rheumatic Diseases 2022, 81: 1052-1054. PMID: 35168947, DOI: 10.1136/annrheumdis-2021-221841.Peer-Reviewed Original Research
2021
Bone mineral density and microarchitecture among Chinese patients with rheumatoid arthritis: a cross-sectional study with HRpQCT
Jin S, Li M, Wang Q, Zeng X, Xia W, Yu W, Guan W, Hsieh E. Bone mineral density and microarchitecture among Chinese patients with rheumatoid arthritis: a cross-sectional study with HRpQCT. Arthritis Research & Therapy 2021, 23: 127. PMID: 33894786, PMCID: PMC8067377, DOI: 10.1186/s13075-021-02503-0.Peer-Reviewed Original ResearchConceptsBone mineral densityRheumatoid arthritisRisk of fractureCross-sectional studyMineral densityFragility fracturesDistal radiusHealthy controlsBone microarchitectureBone strengthHigh-resolution peripheral quantitative computed tomographySex-matched healthy controlsPeripheral quantitative computed tomographyDual-energy X-ray absorptiometryVolumetric bone mineral densityFemale reproductive factorsRA-related characteristicsThoracolumbar X-rayTraditional risk factorsQuantitative computed tomographyX-ray absorptiometryCortical bone thicknessThin cortical boneGroup of ageChinese RegistryValidation of a six-item dietary calcium screening tool among HIV patients in China
Tseng LY, Xie W, Pan W, Lyu H, Yu Z, Shi W, He Y, Chen W, Li T, Hsieh E. Validation of a six-item dietary calcium screening tool among HIV patients in China. Public Health Nutrition 2021, 24: 4786-4795. PMID: 33820577, PMCID: PMC8600937, DOI: 10.1017/s1368980021001427.Peer-Reviewed Original ResearchConceptsSix-item toolAdjacent quartilesClinical practiceScreening toolClinical risk factorsFollow-up screeningModerate relative validityTime-point studyHIV patientsAverage BMIBone healthMean ageOutpatient settingNutritional assessmentRisk factorsRoutine screeningDietary CaHealthy dietDisease preventionHIVFurther assessmentRelative validityAdequate CaChinese individualsTarget populationLong-term trabecular bone score and bone mineral density changes in Chinese antiretroviral-treated HIV-infected individuals
Guan W, Pan W, Yu W, Cao W, Lin Q, Zhang Z, Song X, Li Y, Tian J, Xu Y, Li T, Hsieh E. Long-term trabecular bone score and bone mineral density changes in Chinese antiretroviral-treated HIV-infected individuals. Archives Of Osteoporosis 2021, 16: 41. PMID: 33624129, PMCID: PMC9675940, DOI: 10.1007/s11657-021-00890-0.Peer-Reviewed Original ResearchConceptsTrabecular bone scoreBone mineral densityTH bone mineral densityNormal bone mineral densityAntiretroviral therapyBone scoreART initiationFemoral neckMineral densityBone microarchitectureTotal hip (TH) BMDLumbar spine (LS) BMDBone mineral density changesFN bone mineral densityLarge tertiary care hospitalRetrospective chart reviewTertiary care hospitalMineral density changesMean percent decreaseResultsFour hundred fiftyPercent decreaseAdult PWHChart reviewCare hospitalBMD changes
2020
Time to sputum culture conversion and its predictors among patients with multidrug-resistant tuberculosis in Hangzhou, China
Li Q, Lu M, Hsieh E, Wu L, Wu Y, Wang M, Wang L, Zhao G, Xie L, Qian HZ. Time to sputum culture conversion and its predictors among patients with multidrug-resistant tuberculosis in Hangzhou, China. Medicine 2020, 99: e23649. PMID: 33327347, PMCID: PMC7738096, DOI: 10.1097/md.0000000000023649.Peer-Reviewed Original ResearchConceptsInitial sputum culture conversionSputum culture conversionPoor treatment outcomesSuccessful treatment outcomeTreatment outcomesCulture conversionMDR-TBMultidrug-resistant tuberculosis patientsCox proportional hazards regressionMDR-TB treatmentMDR-TB patientsRetrospective cohort studyKaplan-Meier methodTreatment success rateInitiation of treatmentMultidrug-resistant tuberculosisProportional hazards regressionConsecutive negative culturesRisk of transmissionCohort studyTuberculosis patientsTreatment failureHazards regressionOutpatient treatmentInpatient treatmentChinese registry of rheumatoid arthritis (CREDIT): III. The transition of disease activity during follow‐ups and predictors of achieving treatment target
Xiang Y, Wang Q, Li H, Duan X, Fang Y, Yang P, Li Q, Wu R, Huo Y, Shi X, Wu Z, Wang Y, Jiang N, Hsieh E, Li M, Tian X, Zeng X, co‐authors C. Chinese registry of rheumatoid arthritis (CREDIT): III. The transition of disease activity during follow‐ups and predictors of achieving treatment target. International Journal Of Rheumatic Diseases 2020, 23: 1719-1727. PMID: 33034424, DOI: 10.1111/1756-185x.13996.Peer-Reviewed Original ResearchConceptsBiologic disease-modifying anti-rheumatic drugsDisease activityTreatment responseChinese RegistryRheumatoid arthritisDisease-modifying anti-rheumatic drugsBaseline Disease Activity ScoreConventional DMARD therapyLower baseline DAS28Baseline disease activityDisease Activity ScoreAnti-rheumatic drugsBaseline DAS28DMARD therapyLDA ratesPrednisolone usageSynthetic DMARDsEarly RADisease durationActivity scoreTreatment strategiesTreatment targetsYounger agePatientsBaselineLongitudinal change in bone mineral density among Chinese individuals with HIV after initiation of antiretroviral therapy
Guo F, Song X, Li Y, Guan W, Pan W, Yu W, Li T, Hsieh E. Longitudinal change in bone mineral density among Chinese individuals with HIV after initiation of antiretroviral therapy. Osteoporosis International 2020, 32: 321-332. PMID: 32803316, PMCID: PMC9509525, DOI: 10.1007/s00198-020-05584-w.Peer-Reviewed Original ResearchConceptsTenofovir disoproxil fumarateLong-term clinical managementBone mineral density lossMineral density lossAntiretroviral therapyDisoproxil fumarateClinical managementRisk factorsGreater bone mineral density lossInitiation of TDFDual-energy x-ray absorptiometry testingHIV-specific parametersNon-TDF groupUndetectable viral loadOutpatient HIV clinicRelated risk factorsLarge tertiary hospitalBone mineral densityDensity lossAntiretroviral initiationTDF groupWeek 96HIV clinicWeek 48HIV diagnosisAge‐, Site‐, and Sex‐Specific Normative Centile Curves for HR‐pQCT‐Derived Microarchitectural and Bone Strength Parameters in a Chinese Mainland Population
Yu F, Xu Y, Hou Y, Lin Y, Jiajue R, Jiang Y, Wang O, Li M, Xing X, Zhang L, Qin L, Hsieh E, Xia W. Age‐, Site‐, and Sex‐Specific Normative Centile Curves for HR‐pQCT‐Derived Microarchitectural and Bone Strength Parameters in a Chinese Mainland Population. Journal Of Bone And Mineral Research 2020, 35: 2159-2170. PMID: 32564403, PMCID: PMC9719438, DOI: 10.1002/jbmr.4116.Peer-Reviewed Original ResearchConceptsHigh-resolution peripheral quantitative computed tomographyPeripheral quantitative computed tomographyVolumetric bone mineral densityCortical bone lossHR-pQCT parametersBone mineral densityHealthy Chinese menNormative reference rangesQuantitative computed tomographyHR-pQCT scansLatest-generation scannersYears of ageHR-pQCT measuresFracture risk assessmentBone strength parametersDifferent disease statesBone lossCortical porosityMineral densityBone microarchitectureEarly diagnosisComputed tomographyChinese menReference rangeNutritional statusMusculoskeletal ultrasound imaging training, use, and knowledge among rheumatologists in China
Wu M, Peng L, Donroe JH, Kohler MJ, Wang L, Zeng X, Li M, Hsieh E. Musculoskeletal ultrasound imaging training, use, and knowledge among rheumatologists in China. Clinical Rheumatology 2020, 40: 321-330. PMID: 32506316, PMCID: PMC11675347, DOI: 10.1007/s10067-020-05175-4.Peer-Reviewed Original ResearchIncidence of hypertension among persons living with HIV in China: a multicenter cohort study
Fan H, Guo F, Hsieh E, Chen WT, Lv W, Han Y, Xie J, Li Y, Song X, Li T. Incidence of hypertension among persons living with HIV in China: a multicenter cohort study. BMC Public Health 2020, 20: 834. PMID: 32487185, PMCID: PMC7268367, DOI: 10.1186/s12889-020-08586-9.Peer-Reviewed Original ResearchConceptsIncidence of hypertensionAntiretroviral therapyChinese PLWHIncident hypertensionInitiation of ARTProspective longitudinal multicenter studyReceipt of ARTCox proportional hazards modelART-naïve patientsDetectable HIV viremiaMulticenter cohort studyCox regression analysisBody mass indexRecent viral loadLongitudinal multicenter studyProportional hazards modelHIV viremiaMedian followZidovudine exposureChronic comorbiditiesHIV careViral suppressionCohort studyConclusionsThe incidenceMass indexAssociation between comorbidities and extraglandular manifestations in primary Sjögren’s syndrome: a multicenter cross-sectional study
Zhang Y, Li M, Zhang L, Li Q, Yang P, Kong X, Duan X, Zhang M, Li X, Wang Y, Xu J, Wang Y, Hsieh E, Zhao J, Xu D, Zhao Y, Zeng X. Association between comorbidities and extraglandular manifestations in primary Sjögren’s syndrome: a multicenter cross-sectional study. Clinical Rheumatology 2020, 39: 2677-2688. PMID: 32146615, DOI: 10.1007/s10067-020-04992-x.Peer-Reviewed Original ResearchConceptsExtraglandular manifestationsFragility fracturesCross-sectional studyThyroid disordersCardiovascular diseaseComorbidity burdenSjögren's syndromeMulticenter cross-sectional studyMethodThis cross-sectional studyComorbid cardiovascular diseasePrevalence of comorbiditiesPrimary Sjögren's syndromeAmerican-European criteriaMore comorbiditiesDisease durationBaseline prevalenceDisease characteristicsResultsA totalUnivariate analysisHigh prevalenceComorbiditiesHigh riskPatientsMultivariate analysisDemographic dataHIV/AIDS Among Female Sex Workers in China: Epidemiology and Recent Prevention Strategies
Zhang H, Hsieh E, Wang L, Liao S. HIV/AIDS Among Female Sex Workers in China: Epidemiology and Recent Prevention Strategies. Current HIV/AIDS Reports 2020, 17: 151-160. PMID: 32030600, PMCID: PMC9675938, DOI: 10.1007/s11904-019-00477-y.BooksConceptsFemale sex workersSex workersHIV prevalenceRisk factorsPrevention strategiesRecent prevention strategiesEpidemiology of HIVHIV prevention strategiesNational HIV prevalenceNational prevention programsCondom use practicesNew risk factorsSpread of HIVSex workHIV/AIDSRegional levelHIV infectionHIV transmissionSexual practicesHIV preventionHIV riskMale condomsPrevalence ratesReviewThis reviewPrevention programsHIV-1 CRF01_AE subtype and HIV-1 DNA level among patients with chronic HIV-1 infection: a correlation study
Lyu T, Yue Y, Hsieh E, Han Y, Zhu T, Song X, Cao W, Lyu W, Wang J, Li T. HIV-1 CRF01_AE subtype and HIV-1 DNA level among patients with chronic HIV-1 infection: a correlation study. BMC Infectious Diseases 2020, 20: 66. PMID: 31964364, PMCID: PMC6975045, DOI: 10.1186/s12879-020-4785-6.Peer-Reviewed Original ResearchConceptsHIV-1 DNA levelsAntiretroviral therapyHIV-1 subtypesHIV-1 DNAHIV-1Copies/106 PBMCWeek 96Baseline predictorsDNA levelsSubtype groupsBaseline HIV-1 DNA levelsHigher HIV-1 DNA levelLower HIV-1 DNA levelsTotal HIV-1 DNA levelsChronic HIV-1 infectionHIV-1 DNA decayWeeks of ARTHIV-1-infected patientsLarge multi-centre studySuppressive antiretroviral therapyT-cell countsIndependent risk factorProportion of patientsHIV-1 infectionPeripheral blood samplesOptimizing Treatment for Adults with HIV/AIDS in China: Successes over Two Decades and Remaining Challenges
Cao W, Hsieh E, Li T. Optimizing Treatment for Adults with HIV/AIDS in China: Successes over Two Decades and Remaining Challenges. Current HIV/AIDS Reports 2020, 17: 26-34. PMID: 31939111, PMCID: PMC6989417, DOI: 10.1007/s11904-019-00478-x.BooksConceptsNational Free Antiretroviral Therapy ProgramAntiretroviral therapyHIV/AIDSChinese patientsFree antiretroviral therapy (ART) programLong-term antiretroviral therapyHIV/AIDS patientsFree antiretroviral drugsLifelong antiretroviral therapyHIV care cascadeAIDS/STD ControlAntiretroviral therapy coverageAntiretroviral therapy programsHIV/AIDS diagnosisHIV/AIDS treatmentNumber of patientsMulti-center studyAvailable ART regimensART regimensCare cascadeChronic complicationsAntiretroviral treatmentOverall mortalityAIDS patientsChronic inflammation
2019
Short-term acceptability of female condom use among low-fee female sex workers in China: a follow-up study
Zhou C, Hsieh E, Rou K, Tillman J, Dong W, Feng XX, Yang YZ, Yang YJ, Sun XG, Zang HJ, Wu YZ, Wu Z. Short-term acceptability of female condom use among low-fee female sex workers in China: a follow-up study. BMC Women's Health 2019, 19: 77. PMID: 31200702, PMCID: PMC6570840, DOI: 10.1186/s12905-019-0773-7.Peer-Reviewed Original ResearchConceptsFemale condomCondom useFC useRegular clientsMale condom useOne-month followFemale sex workersFemale condom useFollow-up questionnaireShort-term acceptabilityEligible participantsResultsA totalMore frequent useBaseline questionnairePast monthLogistic regressionOne monthSex workersAppropriate candidatesFollowCondomsPrimary school educationFrequent useParticipantsQuestionnaire
2018
HIV-related stigma among people living with HIV/AIDS in rural Central China
Li Z, Morano JP, Khoshnood K, Hsieh E, Sheng Y. HIV-related stigma among people living with HIV/AIDS in rural Central China. BMC Health Services Research 2018, 18: 453. PMID: 29903006, PMCID: PMC6003113, DOI: 10.1186/s12913-018-3245-0.Peer-Reviewed Original ResearchConceptsHIV/AIDSRural PLWHAYoung PLWHAOpportunistic infectionsBerger HIV Stigma ScaleMethodsA cross-sectional studyMultivariable linear regression analysisBurden of HIVDisease-related factorsLevels of HIVCross-sectional studyHIV Stigma ScaleTotal HIVResultsA totalRural central ChinaPoor adherenceChinese PLWHAHIV stigmaHIVPLWHAChinese CenterStigma scoresLinear regression analysisStigma ScaleHigh levelsVertebral fractures among breast cancer survivors in China: a cross-sectional study of prevalence and health services gaps
Hsieh E, Wang Q, Zhang R, Niu X, Xia W, Fraenkel L, Insogna KL, Li J, Smith JS, Zhou C, Qiao YL, Zhang P. Vertebral fractures among breast cancer survivors in China: a cross-sectional study of prevalence and health services gaps. BMC Cancer 2018, 18: 104. PMID: 29378534, PMCID: PMC5789645, DOI: 10.1186/s12885-018-4014-5.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsVertebral fracturesCancer survivorsCross-sectional studyBreast cancerBone lossCancer treatment-induced bone lossHealthy community-dwelling postmenopausal womenProgesterone receptor-positive breast cancerHealth servicesBreast cancer survivor cohortCommunity-dwelling postmenopausal womenFracture-related risk factorsPeking Vertebral Fracture StudyTreatment-induced bone lossReceptor-positive breast cancerChinese breast cancer survivorsCancer survivor cohortLarge cancer hospitalThoracolumbar X-rayVitamin D supplementsPrevalent vertebral fracturesBone density scanInitiation of treatmentAdjusted odds ratio
2017
Delays in HIV diagnosis and associated factors among patients presenting with advanced disease at a tertiary care hospital in Beijing, China
Xie J, Hsieh E, Sun MQ, Wang HL, Lv W, Fan HW, Li TS. Delays in HIV diagnosis and associated factors among patients presenting with advanced disease at a tertiary care hospital in Beijing, China. PLOS ONE 2017, 12: e0182335. PMID: 28793312, PMCID: PMC5549987, DOI: 10.1371/journal.pone.0182335.Peer-Reviewed Original ResearchConceptsFirst medical visitHIV diagnosisAdvanced diseaseHIV testingMedical visitsAdvanced HIV diseaseEarly HIV testingPneumocystis jiroveci pneumoniaQuarter of patientsTertiary care hospitalCommon opportunistic infectionTimely HIV testingLogistic regression analysisMedian time delayHIV/AIDSAdvanced immunosuppressionJiroveci pneumoniaHIV diseasePatient characteristicsCare hospitalDiagnostic delayHIV infectionOpportunistic infectionsTertiary hospitalMedical recordsCardiovascular disease risk among Chinese antiretroviral-naïve adults with advanced HIV disease
Guo F, Hsieh E, Lv W, Han Y, Xie J, Li Y, Song X, Li T. Cardiovascular disease risk among Chinese antiretroviral-naïve adults with advanced HIV disease. BMC Infectious Diseases 2017, 17: 287. PMID: 28427339, PMCID: PMC5397830, DOI: 10.1186/s12879-017-2358-0.Peer-Reviewed Original ResearchConceptsCVD risk factorsFramingham risk scoreRisk factorsRisk scoreCVD riskAtherosclerotic cardiovascular disease risk scoreCommon CVD risk factorsCardiovascular disease risk scoreAdvanced HIV diseaseD risk scoreTreatment-naïve HIVLipid-Lowering TherapyPrevalence of hypertensionRisk factor treatmentBurden of CVDCardiovascular disease riskTreatment-naïve individualsMulticenter clinical trialAntiretroviral-naïve adultsDisease risk scoreRoutine clinical assessmentHIV providersAdverse eventsBackgroundCardiovascular diseaseHIV disease
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