2025
Prevalence of metabolic syndrome in people living with HIV and its multi-organ damage: a prospective cohort study
Tang J, Chen L, Pan W, Lu L, Liu X, Zhang L, Zheng L, Song X, Guo F, Lv W, Cao W, Hsieh E, Li T. Prevalence of metabolic syndrome in people living with HIV and its multi-organ damage: a prospective cohort study. BMC Infectious Diseases 2025, 25: 351. PMID: 40075301, PMCID: PMC11905433, DOI: 10.1186/s12879-025-10735-7.Peer-Reviewed Original ResearchConceptsRisk factors of MetSFactors of MetSPooled Cohort EquationsProspective cohort studyAssociated with higher riskBone mineral densityGlobal scale-upMulti-organ damageRisk factorsAssociated with unfavorable health outcomesAntiretroviral therapyAlcohol consumptionCohort studyConclusionThe incidenceChina Diabetes SocietyPrevalence of metabolic syndromeScale-up of antiretroviral therapyMetabolic syndromeAssociated with multi-organ damageOrgan damageGlobal scale-up of antiretroviral therapyUnfavorable health outcomesIncidence of MetSLow HDL-C concentrationsAssociated with MetS
2020
Time to sputum culture conversion and its predictors among patients with multidrug-resistant tuberculosis in Hangzhou, China
Li Q, Lu M, Hsieh E, Wu L, Wu Y, Wang M, Wang L, Zhao G, Xie L, Qian HZ. Time to sputum culture conversion and its predictors among patients with multidrug-resistant tuberculosis in Hangzhou, China. Medicine 2020, 99: e23649. PMID: 33327347, PMCID: PMC7738096, DOI: 10.1097/md.0000000000023649.Peer-Reviewed Original ResearchConceptsInitial sputum culture conversionSputum culture conversionPoor treatment outcomesSuccessful treatment outcomeTreatment outcomesCulture conversionMDR-TBMultidrug-resistant tuberculosis patientsCox proportional hazards regressionMDR-TB treatmentMDR-TB patientsRetrospective cohort studyKaplan-Meier methodTreatment success rateInitiation of treatmentMultidrug-resistant tuberculosisProportional hazards regressionConsecutive negative culturesRisk of transmissionCohort studyTuberculosis patientsTreatment failureHazards regressionOutpatient treatmentInpatient treatment
2019
Earlier Onset in Autosomal Dominant Hypophosphatemic Rickets of R179 than R176 Mutations in Fibroblast Growth Factor 23: Report of 20 Chinese Cases and Review of the Literature
Liu C, Zhao Z, Wang O, Li M, Xing X, Hsieh E, Fukumoto S, Jiang Y, Xia W. Earlier Onset in Autosomal Dominant Hypophosphatemic Rickets of R179 than R176 Mutations in Fibroblast Growth Factor 23: Report of 20 Chinese Cases and Review of the Literature. Calcified Tissue International 2019, 105: 476-486. PMID: 31486862, DOI: 10.1007/s00223-019-00597-y.Peer-Reviewed Original ResearchConceptsAutosomal dominant hypophosphatemic ricketsLower extremity deformitiesDominant hypophosphatemic ricketsExtremity deformitiesOnset ageHypophosphatemic ricketsFibroblast growth factor 23Growth factor 23Onset of diseaseRU/mLHistory of ricketsEarlier onset ageAge of onsetRare hereditary disorderPg/mLGenotype-phenotype correlationI-FGF23Symptomatic patientsFactor 23More patientsSerum phosphateClinical manifestationsLaboratory examinationsOvert symptomsMutation carriersShort-term acceptability of female condom use among low-fee female sex workers in China: a follow-up study
Zhou C, Hsieh E, Rou K, Tillman J, Dong W, Feng XX, Yang YZ, Yang YJ, Sun XG, Zang HJ, Wu YZ, Wu Z. Short-term acceptability of female condom use among low-fee female sex workers in China: a follow-up study. BMC Women's Health 2019, 19: 77. PMID: 31200702, PMCID: PMC6570840, DOI: 10.1186/s12905-019-0773-7.Peer-Reviewed Original ResearchConceptsFemale condomCondom useFC useRegular clientsMale condom useOne-month followFemale sex workersFemale condom useFollow-up questionnaireShort-term acceptabilityEligible participantsResultsA totalMore frequent useBaseline questionnairePast monthLogistic regressionOne monthSex workersAppropriate candidatesFollowCondomsPrimary school educationFrequent useParticipantsQuestionnaire
2018
Lumbar Vertebrae Morphological Analysis and an Additional Approach for Vertebrae Identification in Lumbar Spine DXA Images
Guan W, Yu W, Lin Q, Zhang Z, Du G, Tian J, Xu Y, Hsieh E. Lumbar Vertebrae Morphological Analysis and an Additional Approach for Vertebrae Identification in Lumbar Spine DXA Images. Journal Of Clinical Densitometry 2018, 23: 395-402. PMID: 30425005, PMCID: PMC6520202, DOI: 10.1016/j.jocd.2018.09.004.Peer-Reviewed Original ResearchConceptsLumbar spine DXA imagesDual-energy X-ray absorptiometrySpine DXA imagesYr of ageDXA imagesAge strataLumbar vertebraeProportion of patientsLarge tertiary hospitalBone mineral densityX-ray absorptiometryDiagnosis of osteoporosisAdult patientsKey anatomic featuresTertiary hospitalMean ageChinese patientsMineral densityBilateral pediclesChi-square analysisLarge cohortProportion of individualsIliac crestPatientsAnatomic features
2016
Longitudinal increase in vitamin D binding protein levels after initiation of tenofovir/lamivudine/efavirenz among individuals with HIV
Hsieh E, Fraenkel L, Han Y, Xia W, Insogna KL, Yin MT, Zhu T, Cheng X, Li T. Longitudinal increase in vitamin D binding protein levels after initiation of tenofovir/lamivudine/efavirenz among individuals with HIV. AIDS 2016, 30: 1935-1942. PMID: 27124896, PMCID: PMC4949136, DOI: 10.1097/qad.0000000000001131.Peer-Reviewed Original ResearchConceptsTenofovir disoproxil fumarateVitamin DProcollagen type 1 N-terminal propeptideInitiation of TDFTenofovir/lamivudine/efavirenzVitamin D binding protein (VDBP) levelsCollagen type 1 cross-linked C-telopeptideIntact parathyroid hormone levelsCross-linked C-telopeptideIntact parathyroid hormoneParathyroid hormone levelsTotal procollagen type 1 N-terminal propeptideBinding protein levelsProtein levelsMulticenter clinical trialPlasma samplesOngoing multicenter clinical trialsN-terminal propeptideClinical characteristicsParathyroid hormoneBone lossFormation markersDisoproxil fumarateC-telopeptideBone resorptionExploring HIV-related stigma among HIV-infected men who have sex with men in Beijing, China: a correlation study
Li Z, Hsieh E, Morano JP, Sheng Y. Exploring HIV-related stigma among HIV-infected men who have sex with men in Beijing, China: a correlation study. AIDS Care 2016, 28: 1394-1401. PMID: 27137205, PMCID: PMC5069196, DOI: 10.1080/09540121.2016.1179713.Peer-Reviewed Original ResearchConceptsHIV transmissionHIV stigmaStigma scoresPoor self-rated health statusBerger HIV Stigma ScaleSelf-rated health statusHIV-positive MSMIncidence of HIVMultivariable linear regression modelsHuman immunodeficiency virusLevels of HIVHIV Stigma ScaleAdverse health outcomesCross-sectional survey studySocial support networksAntiretroviral therapyHIV statusOpportunistic infectionsImmunodeficiency virusPoor adherenceSocio-demographic characteristicsRisk factorsStudy populationHIVHealth outcomes
2014
Increased bone resorption during tenofovir plus lopinavir/ritonavir therapy in Chinese individuals with HIV
Hsieh E, Fraenkel L, Xia W, Hu YY, Han Y, Insogna K, Yin MT, Xie J, Zhu T, Li T. Increased bone resorption during tenofovir plus lopinavir/ritonavir therapy in Chinese individuals with HIV. Osteoporosis International 2014, 26: 1035-1044. PMID: 25224293, PMCID: PMC4334679, DOI: 10.1007/s00198-014-2874-3.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusLopinavir/ritonavirBone turnover markersBone resorption marker levelsResorption marker levelsNon-Chinese populationsAntiretroviral therapyTreatment failureImmunodeficiency virusMarker levelsSkeletal metabolismC-terminal cross-linking telopeptideLopinavir/ritonavir therapyTreatment-naïve patientsFirst-line therapyBone resorption markersProcollagen type 1Multi-center trialPlasma samplesChinese individualsN-terminal propeptideType 1 collagenRitonavir therapyTurnover markersResorption markers
2013
Bone turnover and bone mineral density in HIV-1 infected Chinese taking highly active antiretroviral therapy –a prospective observational study
Zhang L, Su Y, Hsieh E, Xia W, Xie J, Han Y, Cao Y, Li Y, Song X, Zhu T, Li T, Yu W. Bone turnover and bone mineral density in HIV-1 infected Chinese taking highly active antiretroviral therapy –a prospective observational study. BMC Musculoskeletal Disorders 2013, 14: 224. PMID: 23899016, PMCID: PMC3734166, DOI: 10.1186/1471-2474-14-224.Peer-Reviewed Original ResearchConceptsBone mineral densityActive antiretroviral therapyBone turnoverHIV-1Parathyroid hormoneHealthy controlsMineral densityLumbar spineWeek 48Antiretroviral therapyΒ-CTXCollagen type 1 cross-linked C-telopeptideCross-linked C-telopeptideLong-term clinical implicationsImpact of HAARTInitiation of HAARTOnset of HAARTLow bone turnoverVitamin D levelsProspective observational studyHIV-1 infectionHigh bone turnoverHealthy control populationProcollagen type 1Annual percent decline
2008
Male midwives: preferred managers of sexually transmitted infections in men in developing countries?
Hsieh EJ, García PJ, Roca SL. Male midwives: preferred managers of sexually transmitted infections in men in developing countries? BULL PAN AM HEALTH ORGAN 2008, 24: 271-5. PMID: 19133176, DOI: 10.1590/s1020-49892008001000007.Peer-Reviewed Original ResearchMeSH KeywordsAdultAttitudeCase ManagementCultureData CollectionDeveloping CountriesFemaleGender IdentityHumansMaleMenMiddle AgedMidwiferyMulticenter Studies as TopicPatient Acceptance of Health CarePatient Care TeamPatient Education as TopicPeruPractice ManagementRegistriesSalaries and Fringe BenefitsSexually Transmitted DiseasesUrban HealthYoung AdultConceptsMale patientsSTI casesSTI managementPrivate practiceReproductive health servicesReproductive health careHealth care providersHealth services researchNumber of midwivesIntervention trialsCare providersHealth servicesDoor surveyMedical officesHealth careCities of PeruType of practiceAreas of PeruMidwivesPatientsClinical positionsServices researchInfectionDemographicsFemale counterparts
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