2025
Prevalence of metabolic syndrome in people living with HIV and its multi-organ damage: a prospective cohort study
Tang J, Chen L, Pan W, Lu L, Liu X, Zhang L, Zheng L, Song X, Guo F, Lv W, Cao W, Hsieh E, Li T. Prevalence of metabolic syndrome in people living with HIV and its multi-organ damage: a prospective cohort study. BMC Infectious Diseases 2025, 25: 351. PMID: 40075301, PMCID: PMC11905433, DOI: 10.1186/s12879-025-10735-7.Peer-Reviewed Original ResearchConceptsRisk factors of MetSFactors of MetSPooled Cohort EquationsProspective cohort studyAssociated with higher riskBone mineral densityGlobal scale-upMulti-organ damageRisk factorsAssociated with unfavorable health outcomesAntiretroviral therapyAlcohol consumptionCohort studyConclusionThe incidenceChina Diabetes SocietyPrevalence of metabolic syndromeScale-up of antiretroviral therapyMetabolic syndromeAssociated with multi-organ damageOrgan damageGlobal scale-up of antiretroviral therapyUnfavorable health outcomesIncidence of MetSLow HDL-C concentrationsAssociated with MetS
2023
Performance of a modified fracture risk assessment tool for fragility fracture prediction among older veterans living with HIV
Womack J, Murphy T, Leo-Summers L, Kidwai-Khan F, Skanderson M, Gill T, Gulanski B, Rodriguez-Barradas M, Tien P, Yin M, Hsieh E. Performance of a modified fracture risk assessment tool for fragility fracture prediction among older veterans living with HIV. AIDS 2023, 37: 1399-1407. PMID: 37070536, PMCID: PMC10329997, DOI: 10.1097/qad.0000000000003566.Peer-Reviewed Original ResearchConceptsFracture Risk Assessment ToolMajor osteoporotic fractureRisk assessment toolCohort studyHip fractureOsteoporotic fracturesVeterans Aging Cohort StudyAging Cohort StudyMultivariable logistic regressionType of fractureRace/ethnicityAssessment toolGlucocorticoid useHIV cohortFragility fracturesPrevious fractureRheumatoid arthritisSmoking statusFracture riskModest discriminationOlder veteransLogistic regressionOccurrence of fracturesHIVAlcohol useAssessing the contributions of modifiable risk factors to serious falls and fragility fractures among older persons living with HIV
Womack J, Murphy T, Leo‐Summers L, Bates J, Jarad S, Gill T, Hsieh E, Rodriguez‐Barradas M, Tien P, Yin M, Brandt C, Justice A. Assessing the contributions of modifiable risk factors to serious falls and fragility fractures among older persons living with HIV. Journal Of The American Geriatrics Society 2023, 71: 1891-1901. PMID: 36912153, PMCID: PMC10258163, DOI: 10.1111/jgs.18304.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAlcoholismCohort StudiesFractures, BoneFrailtyHIV InfectionsHumansRisk FactorsConceptsModifiable risk factorsFragility fracturesRisk factorsAlcohol use disorderSerious fallsPhysiologic frailtyAntiretroviral therapyOlder PWHUse disordersVeterans Aging Cohort StudyMeasures of multimorbidityAging Cohort StudyBody mass indexMultivariable logistic modelAverage attributable fractionSuccessful prevention programsKey risk factorsOpioid prescriptionsCohort studyMass indexModifiable factorsSixth decadeAttributable fractionElevated riskICD9 codesPrevalence of and risk factors for vertebral fracture and low bone mineral density among Peruvian women aging with HIV
Cabrera D, Cornejo M, Slotkin R, Pinedo Y, Yu W, Guan W, Garcia P, Hsieh E. Prevalence of and risk factors for vertebral fracture and low bone mineral density among Peruvian women aging with HIV. Archives Of Osteoporosis 2023, 18: 64. PMID: 37160770, PMCID: PMC10170032, DOI: 10.1007/s11657-023-01250-w.Peer-Reviewed Original ResearchConceptsBone mineral densityLow bone mineral densityThoracolumbar X-rayVertebral fracturesFemoral neckRisk factorsLumbar spineOsteoporosis treatmentTotal hipTreatment gapMineral densityTotal hip bone mineral densityPresence of VFsPeruvian womenTH bone mineral densityHip bone mineral densityFN bone mineral densityLower FN BMDSubset of patientsGenant semiquantitative methodLower femoral neckImportant treatment gapsKey risk factorsAntiretroviral therapyFRAX score
2021
Brief Report: Are Serious Falls Associated With Subsequent Fragility Fractures Among Veterans Living With HIV?
Womack JA, Murphy TE, Ramsey C, Bathulapalli H, Leo-Summers L, Smith AC, Bates J, Jarad S, Gill TM, Hsieh E, Rodriguez-Barradas MC, Tien PC, Yin MT, Brandt C, Justice AC. Brief Report: Are Serious Falls Associated With Subsequent Fragility Fractures Among Veterans Living With HIV? JAIDS Journal Of Acquired Immune Deficiency Syndromes 2021, 88: 192-196. PMID: 34506360, PMCID: PMC8513792, DOI: 10.1097/qai.0000000000002752.Peer-Reviewed Original ResearchConceptsSubsequent fragility fracturesFragility fracturesAntiretroviral therapySerious fallsRisk factorsVeterans Aging Cohort StudyAging Cohort StudyMultivariable logistic regressionUpper arm fracturesMiddle-aged populationYears of ageAlcohol use disorderCohort studyHip fractureVertebral fracturesArm fracturesInjury codesICD9 codesGeneral populationUse disordersLogistic regressionIntegrase inhibitorsOlder adultsRadiology reportsHIV
2020
HIV/AIDS Among Female Sex Workers in China: Epidemiology and Recent Prevention Strategies
Zhang H, Hsieh E, Wang L, Liao S. HIV/AIDS Among Female Sex Workers in China: Epidemiology and Recent Prevention Strategies. Current HIV/AIDS Reports 2020, 17: 151-160. PMID: 32030600, PMCID: PMC9675938, DOI: 10.1007/s11904-019-00477-y.BooksConceptsFemale sex workersSex workersHIV prevalenceRisk factorsPrevention strategiesRecent prevention strategiesEpidemiology of HIVHIV prevention strategiesNational HIV prevalenceNational prevention programsCondom use practicesNew risk factorsSpread of HIVSex workHIV/AIDSRegional levelHIV infectionHIV transmissionSexual practicesHIV preventionHIV riskMale condomsPrevalence ratesReviewThis reviewPrevention programsHIV-1 CRF01_AE subtype and HIV-1 DNA level among patients with chronic HIV-1 infection: a correlation study
Lyu T, Yue Y, Hsieh E, Han Y, Zhu T, Song X, Cao W, Lyu W, Wang J, Li T. HIV-1 CRF01_AE subtype and HIV-1 DNA level among patients with chronic HIV-1 infection: a correlation study. BMC Infectious Diseases 2020, 20: 66. PMID: 31964364, PMCID: PMC6975045, DOI: 10.1186/s12879-020-4785-6.Peer-Reviewed Original ResearchConceptsHIV-1 DNA levelsAntiretroviral therapyHIV-1 subtypesHIV-1 DNAHIV-1Copies/106 PBMCWeek 96Baseline predictorsDNA levelsSubtype groupsBaseline HIV-1 DNA levelsHigher HIV-1 DNA levelLower HIV-1 DNA levelsTotal HIV-1 DNA levelsChronic HIV-1 infectionHIV-1 DNA decayWeeks of ARTHIV-1-infected patientsLarge multi-centre studySuppressive antiretroviral therapyT-cell countsIndependent risk factorProportion of patientsHIV-1 infectionPeripheral blood samples
2018
Vertebral fractures among breast cancer survivors in China: a cross-sectional study of prevalence and health services gaps
Hsieh E, Wang Q, Zhang R, Niu X, Xia W, Fraenkel L, Insogna KL, Li J, Smith JS, Zhou C, Qiao YL, Zhang P. Vertebral fractures among breast cancer survivors in China: a cross-sectional study of prevalence and health services gaps. BMC Cancer 2018, 18: 104. PMID: 29378534, PMCID: PMC5789645, DOI: 10.1186/s12885-018-4014-5.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsVertebral fracturesCancer survivorsCross-sectional studyBreast cancerBone lossCancer treatment-induced bone lossHealthy community-dwelling postmenopausal womenProgesterone receptor-positive breast cancerHealth servicesBreast cancer survivor cohortCommunity-dwelling postmenopausal womenFracture-related risk factorsPeking Vertebral Fracture StudyTreatment-induced bone lossReceptor-positive breast cancerChinese breast cancer survivorsCancer survivor cohortLarge cancer hospitalThoracolumbar X-rayVitamin D supplementsPrevalent vertebral fracturesBone density scanInitiation of treatmentAdjusted odds ratio
2017
Cardiovascular disease risk among Chinese antiretroviral-naïve adults with advanced HIV disease
Guo F, Hsieh E, Lv W, Han Y, Xie J, Li Y, Song X, Li T. Cardiovascular disease risk among Chinese antiretroviral-naïve adults with advanced HIV disease. BMC Infectious Diseases 2017, 17: 287. PMID: 28427339, PMCID: PMC5397830, DOI: 10.1186/s12879-017-2358-0.Peer-Reviewed Original ResearchConceptsCVD risk factorsFramingham risk scoreRisk factorsRisk scoreCVD riskAtherosclerotic cardiovascular disease risk scoreCommon CVD risk factorsCardiovascular disease risk scoreAdvanced HIV diseaseD risk scoreTreatment-naïve HIVLipid-Lowering TherapyPrevalence of hypertensionRisk factor treatmentBurden of CVDCardiovascular disease riskTreatment-naïve individualsMulticenter clinical trialAntiretroviral-naïve adultsDisease risk scoreRoutine clinical assessmentHIV providersAdverse eventsBackgroundCardiovascular diseaseHIV disease
2016
Exploring HIV-related stigma among HIV-infected men who have sex with men in Beijing, China: a correlation study
Li Z, Hsieh E, Morano JP, Sheng Y. Exploring HIV-related stigma among HIV-infected men who have sex with men in Beijing, China: a correlation study. AIDS Care 2016, 28: 1394-1401. PMID: 27137205, PMCID: PMC5069196, DOI: 10.1080/09540121.2016.1179713.Peer-Reviewed Original ResearchConceptsHIV transmissionHIV stigmaStigma scoresPoor self-rated health statusBerger HIV Stigma ScaleSelf-rated health statusHIV-positive MSMIncidence of HIVMultivariable linear regression modelsHuman immunodeficiency virusLevels of HIVHIV Stigma ScaleAdverse health outcomesCross-sectional survey studySocial support networksAntiretroviral therapyHIV statusOpportunistic infectionsImmunodeficiency virusPoor adherenceSocio-demographic characteristicsRisk factorsStudy populationHIVHealth outcomes
2014
Body Mass Index and Breast Cancer Defined by Biological Receptor Status in Pre-Menopausal and Post-Menopausal Women: A Multicenter Study in China
Li J, Huang Y, Zhang BN, Fan JH, Huang R, Zhang P, Wang SL, Zheng S, Zhang B, Yang HJ, Xie XM, Tang ZH, Li H, He JJ, Hsieh E, Qiao YL, Li JY. Body Mass Index and Breast Cancer Defined by Biological Receptor Status in Pre-Menopausal and Post-Menopausal Women: A Multicenter Study in China. PLOS ONE 2014, 9: e87224. PMID: 24489874, PMCID: PMC3906138, DOI: 10.1371/journal.pone.0087224.Peer-Reviewed Original ResearchConceptsBody mass indexPost-menopausal womenHigher Body Mass IndexReceptor statusBreast cancerLogistic regression modelsMass indexBMI dataMultivariate logistic regression modelBreast cancer patientsRank correlation analysisEstrogen metabolism pathwayBreast cancer casesFisher's exact testChi-square testPre-MenopausalMedical chartsPathologic featuresRegression modelsEligible casesMulticenter studyCancer patientsRisk factorsCancer casesExact test
2010
Human papillomavirus infection in female sex workers in Lima, Peru
Montano SM, Hsieh EJ, Calderón M, Ton TG, Quijano E, Solari V, Zunt JR. Human papillomavirus infection in female sex workers in Lima, Peru. Sexually Transmitted Infections 2010, 87: 81. PMID: 20813720, PMCID: PMC3501137, DOI: 10.1136/sti.2010.043315.Peer-Reviewed Original ResearchMeSH KeywordsCross-Sectional StudiesFemaleHumansPapillomavirus InfectionsPeruPrevalenceRisk FactorsSex WorkConceptsFemale sex workersHuman papillomavirus infectionHPV infectionPapillomavirus infectionHPV typesBrothel-based female sex workersHigh-risk HPV infectionHigh-risk HPV typesMore HPV typesSex workersPrevalence of coinfectionCross-sectional studyCervical swabsRisk factorsHigh prevalenceBlood specimensLower riskYounger ageInfectionPrevalenceSex work practicesSexual characteristicsHPVCoinfectionSwabs
2003
Low prevalence and increased household clustering of Mycobacterium tuberculosis infection in high altitude villages in Peru.
Olender S, Saito M, Apgar J, Gillenwater K, BAUTISTA CT, LESCANO AG, Moro P, Caviedes L, HSIEH EJ, GILMAN RH. Low prevalence and increased household clustering of Mycobacterium tuberculosis infection in high altitude villages in Peru. American Journal Of Tropical Medicine And Hygiene 2003, 68: 721-7. PMID: 12887034, DOI: 10.4269/ajtmh.2003.68.721.Peer-Reviewed Original ResearchConceptsBacille Calmette-Guerin (BCG) vaccinationTuberculin skin test (TST) positivityTST-positive individualsSkin test positivityMycobacterium tuberculosis infectionHigh-altitude villagesTuberculosis patientsTuberculosis infectionTest positivityPrevalence ratesLow prevalenceRelative hypoxiaHousehold clusteringMycobacterium tuberculosisSea level areaPrevalenceTuberculosisInfectionHigh altitudePatientsVaccination
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