2025
Prevalence of metabolic syndrome in people living with HIV and its multi-organ damage: a prospective cohort study
Tang J, Chen L, Pan W, Lu L, Liu X, Zhang L, Zheng L, Song X, Guo F, Lv W, Cao W, Hsieh E, Li T. Prevalence of metabolic syndrome in people living with HIV and its multi-organ damage: a prospective cohort study. BMC Infectious Diseases 2025, 25: 351. PMID: 40075301, PMCID: PMC11905433, DOI: 10.1186/s12879-025-10735-7.Peer-Reviewed Original ResearchMeSH KeywordsAdultChinaCohort StudiesFemaleHIV InfectionsHumansMaleMetabolic SyndromeMiddle AgedPrevalenceProspective StudiesRisk FactorsYoung AdultConceptsRisk factors of MetSFactors of MetSPooled Cohort EquationsProspective cohort studyAssociated with higher riskBone mineral densityGlobal scale-upMulti-organ damageRisk factorsAssociated with unfavorable health outcomesAntiretroviral therapyAlcohol consumptionCohort studyConclusionThe incidenceChina Diabetes SocietyPrevalence of metabolic syndromeScale-up of antiretroviral therapyMetabolic syndromeAssociated with multi-organ damageOrgan damageGlobal scale-up of antiretroviral therapyUnfavorable health outcomesIncidence of MetSLow HDL-C concentrationsAssociated with MetS
2020
Chinese registry of rheumatoid arthritis (CREDIT): III. The transition of disease activity during follow‐ups and predictors of achieving treatment target
Xiang Y, Wang Q, Li H, Duan X, Fang Y, Yang P, Li Q, Wu R, Huo Y, Shi X, Wu Z, Wang Y, Jiang N, Hsieh E, Li M, Tian X, Zeng X, co‐authors C. Chinese registry of rheumatoid arthritis (CREDIT): III. The transition of disease activity during follow‐ups and predictors of achieving treatment target. International Journal Of Rheumatic Diseases 2020, 23: 1719-1727. PMID: 33034424, DOI: 10.1111/1756-185x.13996.Peer-Reviewed Original ResearchConceptsBiologic disease-modifying anti-rheumatic drugsDisease activityTreatment responseChinese RegistryRheumatoid arthritisDisease-modifying anti-rheumatic drugsBaseline Disease Activity ScoreConventional DMARD therapyLower baseline DAS28Baseline disease activityDisease Activity ScoreAnti-rheumatic drugsBaseline DAS28DMARD therapyLDA ratesPrednisolone usageSynthetic DMARDsEarly RADisease durationActivity scoreTreatment strategiesTreatment targetsYounger agePatientsBaselineIncidence of hypertension among persons living with HIV in China: a multicenter cohort study
Fan H, Guo F, Hsieh E, Chen WT, Lv W, Han Y, Xie J, Li Y, Song X, Li T. Incidence of hypertension among persons living with HIV in China: a multicenter cohort study. BMC Public Health 2020, 20: 834. PMID: 32487185, PMCID: PMC7268367, DOI: 10.1186/s12889-020-08586-9.Peer-Reviewed Original ResearchConceptsIncidence of hypertensionAntiretroviral therapyChinese PLWHIncident hypertensionInitiation of ARTProspective longitudinal multicenter studyReceipt of ARTCox proportional hazards modelART-naïve patientsDetectable HIV viremiaMulticenter cohort studyCox regression analysisBody mass indexRecent viral loadLongitudinal multicenter studyProportional hazards modelHIV viremiaMedian followZidovudine exposureChronic comorbiditiesHIV careViral suppressionCohort studyConclusionsThe incidenceMass indexHIV-1 CRF01_AE subtype and HIV-1 DNA level among patients with chronic HIV-1 infection: a correlation study
Lyu T, Yue Y, Hsieh E, Han Y, Zhu T, Song X, Cao W, Lyu W, Wang J, Li T. HIV-1 CRF01_AE subtype and HIV-1 DNA level among patients with chronic HIV-1 infection: a correlation study. BMC Infectious Diseases 2020, 20: 66. PMID: 31964364, PMCID: PMC6975045, DOI: 10.1186/s12879-020-4785-6.Peer-Reviewed Original ResearchConceptsHIV-1 DNA levelsAntiretroviral therapyHIV-1 subtypesHIV-1 DNAHIV-1Copies/106 PBMCWeek 96Baseline predictorsDNA levelsSubtype groupsBaseline HIV-1 DNA levelsHigher HIV-1 DNA levelLower HIV-1 DNA levelsTotal HIV-1 DNA levelsChronic HIV-1 infectionHIV-1 DNA decayWeeks of ARTHIV-1-infected patientsLarge multi-centre studySuppressive antiretroviral therapyT-cell countsIndependent risk factorProportion of patientsHIV-1 infectionPeripheral blood samples
2013
Bone turnover and bone mineral density in HIV-1 infected Chinese taking highly active antiretroviral therapy –a prospective observational study
Zhang L, Su Y, Hsieh E, Xia W, Xie J, Han Y, Cao Y, Li Y, Song X, Zhu T, Li T, Yu W. Bone turnover and bone mineral density in HIV-1 infected Chinese taking highly active antiretroviral therapy –a prospective observational study. BMC Musculoskeletal Disorders 2013, 14: 224. PMID: 23899016, PMCID: PMC3734166, DOI: 10.1186/1471-2474-14-224.Peer-Reviewed Original ResearchConceptsBone mineral densityActive antiretroviral therapyBone turnoverHIV-1Parathyroid hormoneHealthy controlsMineral densityLumbar spineWeek 48Antiretroviral therapyΒ-CTXCollagen type 1 cross-linked C-telopeptideCross-linked C-telopeptideLong-term clinical implicationsImpact of HAARTInitiation of HAARTOnset of HAARTLow bone turnoverVitamin D levelsProspective observational studyHIV-1 infectionHigh bone turnoverHealthy control populationProcollagen type 1Annual percent decline
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