2025
The global, regional, and national burden attributable to low bone mineral density, 1990–2020: an analysis of a modifiable risk factor from the Global Burden of Disease Study 2021
Collaborators G, Hsieh E, Bryazka D, Ong K, Rhinehart P, Cousin E, Hagins H, Cooper C, Cross M, Culbreth G, Dreinhoefer K, Halbout P, Kopec J, Nicholson S, Alhambra D, Woolf A, Vos T, Abate Y, Abd-Elsalam S, Abdoun M, Abouzid M, Abu-Gharbieh E, Aburuz S, Adepoju A, Adnani Q, Ahmad A, Ahmed H, Ahmed L, Al Hasan S, Alalwan T, Al-amer R, Alemi H, Ali A, Al-Worafi Y, Amani R, Anil A, Arabloo J, Aravkin A, Areda D, Aregawi B, Asghari-Jafarabadi M, Athari S, Azadnajafabad S, Azzam A, Badiye A, Bagheri N, Bagherieh S, Balogun S, Banach M, Barati S, Bhardwaj P, Bhaskar S, Bhatti G, Bustanji Y, Calina D, Chattu V, Abebe E, Chu D, Criqui M, Cruz-Martins N, Dadras O, Dai X, Dai Z, Soltani R, Dashti M, Dejenie T, Del Bo' C, Denova-Gutiérrez E, Devanbu V, Dewan S, Dhulipala V, Ekholuenetale M, Elmonem M, Etaee F, Fagbamigbe A, Fakhradiyev I, Fatehizadeh A, Feizkhah A, Fekadu G, Feyisa B, Fischer F, Gaipov A, Galluzzo L, Gebrehiwot M, Ghadirian F, Gill T, Gohari K, Golchin A, Gupta B, Gupta S, Hadi N, Haj-Mirzaian A, Hanif A, Harlianto N, Hasan I, Hasnain S, Hassan A, Hay S, He J, Heidari G, Hezam K, Hiraike Y, Hoogar P, Hu C, Ibitoye S, Iranmehr A, Ismail N, Iwagami M, Jafari-Khounigh A, Jakovljevic M, Jamshidi E, Jayapal S, Jayaram S, Jemere D, Jeong G, Joseph N, Joshua C, Jürisson M, Kadashetti V, Kalra S, Khafaie M, Khajuria H, Khan M, Khanali J, Khanmohammadi S, Khatatbeh M, Khateri S, Kim M, Korzh O, Krishan K, Kulimbet M, Kulkarni V, Kurniasari M, Lahariya C, Laksono T, Landires I, Latief K, Le T, Lee M, Lee W, Llanaj E, Malhotra K, Malik A, Martorell M, Maugeri A, Meles H, Merati M, Meretoja T, Mestrovic T, Mirahmadi A, Mohamed N, Mohammadian-Hafshejani A, Mokdad A, Monasta L, Moradi Y, Morovatdar N, Morrison S, Mostafavi E, Mousavi P, Mubarik S, Murray C, Muthu S, Naghavi M, Naghavi P, Natto Z, Nayak B, Nematollahi M, Nguyen D, Nguyen H, Nguyen V, Niazi R, Noman E, Nurrika D, Okonji O, Ordak M, Osman W, Ostadi Y, Padron-Monedero A, Pardhan S, Parija P, Parikh R, Patel J, Petermann-Rocha F, Pham H, Prates E, Qattea I, Rahimi M, Rahimi-Movaghar V, Rahman M, Rahmati M, Raimondo I, Ramasamy S, Rashedi S, Rashidi M, Rawaf S, Redwan E, Rezaei N, Saad A, Saeed U, Saghazadeh A, Sharif-Askari F, Sahebkar A, Saki M, Sakshaug J, Saleh M, Samodra Y, Samy A, Sanmarchi F, Saqib M, Schuermans A, Sethi Y, Seylani A, Shahwan M, Sham S, Shannawaz M, Sharfaei S, Sharma M, Shorofi S, Siddig E, Silva L, Singh J, Singh P, Soleimani H, Swain C, Tabatabai S, Tamuzi J, Oliaee R, Tavangar S, Teramoto M, Terefa D, Ticoalu J, Vaithinathan A, Vasankari T, Vaziri S, Wang F, Wang S, Xia J, Yonemoto N, Yu C, Zahir M, Zhao H, Zielińska M, Zitoun O, March L, Sanchez-Riera L. The global, regional, and national burden attributable to low bone mineral density, 1990–2020: an analysis of a modifiable risk factor from the Global Burden of Disease Study 2021. The Lancet Rheumatology 2025 PMID: 40972625, DOI: 10.1016/s2665-9913(25)00105-5.Peer-Reviewed Original ResearchDisability-adjusted life yearsLow bone mineral densityBone mineral densityModifiable risk factorsPopulation-based studyCategories of injuryGlobal burdenRoad injuriesMineral densityNational Health and Nutrition Examination SurveyProportion of in-hospital deathsHealth and Nutrition Examination SurveyMeta-analysis of population-based studiesRelative riskGlobal Burden of Disease StudyInjury-related burdenBurden of Disease StudyGlobal Burden of DiseasePopulation-attributable fractionBurden of fracturesEmergency department dataRelative risk of fractureNutrition Examination SurveyRisk Factors StudyRisk factors
2024
BoneScore: A natural language processing algorithm to extract bone mineral density data from DXA scans
Fodeh S, Wang R, Murphy T, Kidwai-Khan F, Leo-Summers L, Tessier-Sherman B, Hsieh E, Womack J. BoneScore: A natural language processing algorithm to extract bone mineral density data from DXA scans. Health Informatics Journal 2024, 30: 14604582241295930. PMID: 39526751, PMCID: PMC11872221, DOI: 10.1177/14604582241295930.Peer-Reviewed Original ResearchConceptsT-score valuesT-scoreNLP algorithmsDXA scansFemoral neck T-scoreNatural language processing algorithmsBone mineral density dataLanguage processing algorithmsBone mineral densityExtract annotationsRegular expressionsTest dataProcessing algorithmsDXA reportsMineral densityAlgorithmMultivariate linear regressionClinical face validityRisk factorsPresence of informationDXANLPClinical validationClinical expertsAccuracy
2023
Prevalence of and risk factors for vertebral fracture and low bone mineral density among Peruvian women aging with HIV
Cabrera D, Cornejo M, Slotkin R, Pinedo Y, Yu W, Guan W, Garcia P, Hsieh E. Prevalence of and risk factors for vertebral fracture and low bone mineral density among Peruvian women aging with HIV. Archives Of Osteoporosis 2023, 18: 64. PMID: 37160770, PMCID: PMC10170032, DOI: 10.1007/s11657-023-01250-w.Peer-Reviewed Original ResearchConceptsBone mineral densityLow bone mineral densityThoracolumbar X-rayVertebral fracturesFemoral neckRisk factorsLumbar spineOsteoporosis treatmentTotal hipTreatment gapMineral densityTotal hip bone mineral densityPresence of VFsPeruvian womenTH bone mineral densityHip bone mineral densityFN bone mineral densityLower FN BMDSubset of patientsGenant semiquantitative methodLower femoral neckImportant treatment gapsKey risk factorsAntiretroviral therapyFRAX score
2021
Changes in trabecular bone score and bone mineral density in Chinese HIV-Infected individuals after one year of antiretroviral therapy
Guan WM, Pan W, Yu W, Cao W, Lin Q, Zhang ZZ, Song XJ, Li YL, Tian JP, Xu Y, Li TS, Hsieh E. Changes in trabecular bone score and bone mineral density in Chinese HIV-Infected individuals after one year of antiretroviral therapy. Journal Of Orthopaedic Translation 2021, 29: 72-77. PMID: 34094860, PMCID: PMC8164002, DOI: 10.1016/j.jot.2021.04.002.Peer-Reviewed Original ResearchTrabecular bone scoreBone mineral densityDual-energy X-ray absorptiometryLPV/rAntiretroviral therapyART initiationLower BMIBone scoreRisk factorsMineral densityBone microarchitectureBaseline TBSHuman immunodeficiency virus (HIV) infectionNormal bone mineral densityBone damageDifferent antiretroviral agentsHIV treatment historyImpaired bone microarchitectureLower baseline CD4Immunodeficiency virus infectionTraditional risk factorsClinicians additional informationX-ray absorptiometryKey risk factorsBaseline CD4Bone mineral density and microarchitecture among Chinese patients with rheumatoid arthritis: a cross-sectional study with HRpQCT
Jin S, Li M, Wang Q, Zeng X, Xia W, Yu W, Guan W, Hsieh E. Bone mineral density and microarchitecture among Chinese patients with rheumatoid arthritis: a cross-sectional study with HRpQCT. Arthritis Research & Therapy 2021, 23: 127. PMID: 33894786, PMCID: PMC8067377, DOI: 10.1186/s13075-021-02503-0.Peer-Reviewed Original ResearchConceptsBone mineral densityRheumatoid arthritisRisk of fractureCross-sectional studyMineral densityFragility fracturesDistal radiusHealthy controlsBone microarchitectureBone strengthHigh-resolution peripheral quantitative computed tomographySex-matched healthy controlsPeripheral quantitative computed tomographyDual-energy X-ray absorptiometryVolumetric bone mineral densityFemale reproductive factorsRA-related characteristicsThoracolumbar X-rayTraditional risk factorsQuantitative computed tomographyX-ray absorptiometryCortical bone thicknessThin cortical boneGroup of ageChinese RegistryLong-term trabecular bone score and bone mineral density changes in Chinese antiretroviral-treated HIV-infected individuals
Guan W, Pan W, Yu W, Cao W, Lin Q, Zhang Z, Song X, Li Y, Tian J, Xu Y, Li T, Hsieh E. Long-term trabecular bone score and bone mineral density changes in Chinese antiretroviral-treated HIV-infected individuals. Archives Of Osteoporosis 2021, 16: 41. PMID: 33624129, PMCID: PMC9675940, DOI: 10.1007/s11657-021-00890-0.Peer-Reviewed Original ResearchConceptsTrabecular bone scoreBone mineral densityTH bone mineral densityNormal bone mineral densityAntiretroviral therapyBone scoreART initiationFemoral neckMineral densityBone microarchitectureTotal hip (TH) BMDLumbar spine (LS) BMDBone mineral density changesFN bone mineral densityLarge tertiary care hospitalRetrospective chart reviewTertiary care hospitalMineral density changesMean percent decreaseResultsFour hundred fiftyPercent decreaseAdult PWHChart reviewCare hospitalBMD changes
2020
Age‐, Site‐, and Sex‐Specific Normative Centile Curves for HR‐pQCT‐Derived Microarchitectural and Bone Strength Parameters in a Chinese Mainland Population
Yu F, Xu Y, Hou Y, Lin Y, Jiajue R, Jiang Y, Wang O, Li M, Xing X, Zhang L, Qin L, Hsieh E, Xia W. Age‐, Site‐, and Sex‐Specific Normative Centile Curves for HR‐pQCT‐Derived Microarchitectural and Bone Strength Parameters in a Chinese Mainland Population. Journal Of Bone And Mineral Research 2020, 35: 2159-2170. PMID: 32564403, PMCID: PMC9719438, DOI: 10.1002/jbmr.4116.Peer-Reviewed Original ResearchConceptsHigh-resolution peripheral quantitative computed tomographyPeripheral quantitative computed tomographyVolumetric bone mineral densityCortical bone lossHR-pQCT parametersBone mineral densityHealthy Chinese menNormative reference rangesQuantitative computed tomographyHR-pQCT scansLatest-generation scannersYears of ageHR-pQCT measuresFracture risk assessmentBone strength parametersDifferent disease statesBone lossCortical porosityMineral densityBone microarchitectureEarly diagnosisComputed tomographyChinese menReference rangeNutritional status
2018
Lumbar Vertebrae Morphological Analysis and an Additional Approach for Vertebrae Identification in Lumbar Spine DXA Images
Guan W, Yu W, Lin Q, Zhang Z, Du G, Tian J, Xu Y, Hsieh E. Lumbar Vertebrae Morphological Analysis and an Additional Approach for Vertebrae Identification in Lumbar Spine DXA Images. Journal Of Clinical Densitometry 2018, 23: 395-402. PMID: 30425005, PMCID: PMC6520202, DOI: 10.1016/j.jocd.2018.09.004.Peer-Reviewed Original ResearchConceptsLumbar spine DXA imagesDual-energy X-ray absorptiometrySpine DXA imagesYr of ageDXA imagesAge strataLumbar vertebraeProportion of patientsLarge tertiary hospitalBone mineral densityX-ray absorptiometryDiagnosis of osteoporosisAdult patientsKey anatomic featuresTertiary hospitalMean ageChinese patientsMineral densityBilateral pediclesChi-square analysisLarge cohortProportion of individualsIliac crestPatientsAnatomic featuresContinued Interest and Controversy: Vitamin D in HIV
Hsieh E, Yin MT. Continued Interest and Controversy: Vitamin D in HIV. Current HIV/AIDS Reports 2018, 15: 199-211. PMID: 29713871, PMCID: PMC6003869, DOI: 10.1007/s11904-018-0401-4.BooksConceptsVitD deficiencyVitD supplementationExtra-skeletal outcomesSetting of HIVSubgroup of HIVBone mineral densityRecent FindingsRecent studiesART regimensD deficiencyClinical outcomesPoor outcomeSummaryFurther researchVitamin DChronic diseasesClinical trialsDifferent demographic strataMineral densityClinical roleHIVGreater riskDemographic strataSignificant heterogeneityOutcomesRiskSupplementation
2016
Which HIV patients should be screened for osteoporosis
Alvarez E, Belloso WH, Boyd MA, Inkaya AÇ, Hsieh E, Kambugu A, Kaminski G, Martinez E, Stellbrink HJ, Walmsley S, Brown TT, Mallon PW. Which HIV patients should be screened for osteoporosis. Current Opinion In HIV And AIDS 2016, 11: 268-276. PMID: 26895510, DOI: 10.1097/coh.0000000000000269.Peer-Reviewed Original ResearchConceptsBone mineral densityLow bone mineral densityFracture Risk Assessment ToolMeasurement of BMDDual-energy X-ray absorptiometryEnergy X-ray absorptiometryImpact of comorbiditiesManagement of osteoporosisTenofovir disoproxil fumarateX-ray absorptiometryLong-term managementRisk assessment toolHIV physiciansHIV patientsConsensus guidelinesDisoproxil fumaratePhysicians' knowledgeRisk factorsMineral densityCare differsGeneral populationClinical approachPLWHOverall risk estimationSubstance abuse
2013
Bone turnover and bone mineral density in HIV-1 infected Chinese taking highly active antiretroviral therapy –a prospective observational study
Zhang L, Su Y, Hsieh E, Xia W, Xie J, Han Y, Cao Y, Li Y, Song X, Zhu T, Li T, Yu W. Bone turnover and bone mineral density in HIV-1 infected Chinese taking highly active antiretroviral therapy –a prospective observational study. BMC Musculoskeletal Disorders 2013, 14: 224. PMID: 23899016, PMCID: PMC3734166, DOI: 10.1186/1471-2474-14-224.Peer-Reviewed Original ResearchConceptsBone mineral densityActive antiretroviral therapyBone turnoverHIV-1Parathyroid hormoneHealthy controlsMineral densityLumbar spineWeek 48Antiretroviral therapyΒ-CTXCollagen type 1 cross-linked C-telopeptideCross-linked C-telopeptideLong-term clinical implicationsImpact of HAARTInitiation of HAARTOnset of HAARTLow bone turnoverVitamin D levelsProspective observational studyHIV-1 infectionHigh bone turnoverHealthy control populationProcollagen type 1Annual percent decline
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