2025
The global, regional, and national burden attributable to low bone mineral density, 1990–2020: an analysis of a modifiable risk factor from the Global Burden of Disease Study 2021
Collaborators G, Hsieh E, Bryazka D, Ong K, Rhinehart P, Cousin E, Hagins H, Cooper C, Cross M, Culbreth G, Dreinhoefer K, Halbout P, Kopec J, Nicholson S, Alhambra D, Woolf A, Vos T, Abate Y, Abd-Elsalam S, Abdoun M, Abouzid M, Abu-Gharbieh E, Aburuz S, Adepoju A, Adnani Q, Ahmad A, Ahmed H, Ahmed L, Al Hasan S, Alalwan T, Al-amer R, Alemi H, Ali A, Al-Worafi Y, Amani R, Anil A, Arabloo J, Aravkin A, Areda D, Aregawi B, Asghari-Jafarabadi M, Athari S, Azadnajafabad S, Azzam A, Badiye A, Bagheri N, Bagherieh S, Balogun S, Banach M, Barati S, Bhardwaj P, Bhaskar S, Bhatti G, Bustanji Y, Calina D, Chattu V, Abebe E, Chu D, Criqui M, Cruz-Martins N, Dadras O, Dai X, Dai Z, Soltani R, Dashti M, Dejenie T, Del Bo' C, Denova-Gutiérrez E, Devanbu V, Dewan S, Dhulipala V, Ekholuenetale M, Elmonem M, Etaee F, Fagbamigbe A, Fakhradiyev I, Fatehizadeh A, Feizkhah A, Fekadu G, Feyisa B, Fischer F, Gaipov A, Galluzzo L, Gebrehiwot M, Ghadirian F, Gill T, Gohari K, Golchin A, Gupta B, Gupta S, Hadi N, Haj-Mirzaian A, Hanif A, Harlianto N, Hasan I, Hasnain S, Hassan A, Hay S, He J, Heidari G, Hezam K, Hiraike Y, Hoogar P, Hu C, Ibitoye S, Iranmehr A, Ismail N, Iwagami M, Jafari-Khounigh A, Jakovljevic M, Jamshidi E, Jayapal S, Jayaram S, Jemere D, Jeong G, Joseph N, Joshua C, Jürisson M, Kadashetti V, Kalra S, Khafaie M, Khajuria H, Khan M, Khanali J, Khanmohammadi S, Khatatbeh M, Khateri S, Kim M, Korzh O, Krishan K, Kulimbet M, Kulkarni V, Kurniasari M, Lahariya C, Laksono T, Landires I, Latief K, Le T, Lee M, Lee W, Llanaj E, Malhotra K, Malik A, Martorell M, Maugeri A, Meles H, Merati M, Meretoja T, Mestrovic T, Mirahmadi A, Mohamed N, Mohammadian-Hafshejani A, Mokdad A, Monasta L, Moradi Y, Morovatdar N, Morrison S, Mostafavi E, Mousavi P, Mubarik S, Murray C, Muthu S, Naghavi M, Naghavi P, Natto Z, Nayak B, Nematollahi M, Nguyen D, Nguyen H, Nguyen V, Niazi R, Noman E, Nurrika D, Okonji O, Ordak M, Osman W, Ostadi Y, Padron-Monedero A, Pardhan S, Parija P, Parikh R, Patel J, Petermann-Rocha F, Pham H, Prates E, Qattea I, Rahimi M, Rahimi-Movaghar V, Rahman M, Rahmati M, Raimondo I, Ramasamy S, Rashedi S, Rashidi M, Rawaf S, Redwan E, Rezaei N, Saad A, Saeed U, Saghazadeh A, Sharif-Askari F, Sahebkar A, Saki M, Sakshaug J, Saleh M, Samodra Y, Samy A, Sanmarchi F, Saqib M, Schuermans A, Sethi Y, Seylani A, Shahwan M, Sham S, Shannawaz M, Sharfaei S, Sharma M, Shorofi S, Siddig E, Silva L, Singh J, Singh P, Soleimani H, Swain C, Tabatabai S, Tamuzi J, Oliaee R, Tavangar S, Teramoto M, Terefa D, Ticoalu J, Vaithinathan A, Vasankari T, Vaziri S, Wang F, Wang S, Xia J, Yonemoto N, Yu C, Zahir M, Zhao H, Zielińska M, Zitoun O, March L, Sanchez-Riera L. The global, regional, and national burden attributable to low bone mineral density, 1990–2020: an analysis of a modifiable risk factor from the Global Burden of Disease Study 2021. The Lancet Rheumatology 2025 PMID: 40972625, DOI: 10.1016/s2665-9913(25)00105-5.Peer-Reviewed Original ResearchDisability-adjusted life yearsLow bone mineral densityBone mineral densityModifiable risk factorsPopulation-based studyCategories of injuryGlobal burdenRoad injuriesMineral densityNational Health and Nutrition Examination SurveyProportion of in-hospital deathsHealth and Nutrition Examination SurveyMeta-analysis of population-based studiesRelative riskGlobal Burden of Disease StudyInjury-related burdenBurden of Disease StudyGlobal Burden of DiseasePopulation-attributable fractionBurden of fracturesEmergency department dataRelative risk of fractureNutrition Examination SurveyRisk Factors StudyRisk factorsNon-communicable disease care for persons living with HIV in Peru: A national physician cross-sectional study
Slotkin R, Granda D, Cabrera D, Benites C, Garcia P, Hsieh E. Non-communicable disease care for persons living with HIV in Peru: A national physician cross-sectional study. PLOS Global Public Health 2025, 5: e0004846. PMID: 40758733, PMCID: PMC12321123, DOI: 10.1371/journal.pgph.0004846.Peer-Reviewed Original ResearchNon-communicable diseasesCare guidelinesHIV physiciansNon-communicable disease screeningNon-communicable disease careHepatitis ProgramSystems-level barriersRisk factorsModifiable risk factorsCross-sectional studyProvider confidenceCoordinated referralsPractice characteristicsScreening frequencyNational HIVPhysician confidencePhysician registrySurvey domainsPhysician educationTelephone surveyAlcohol usePhysiciansHIV populationProvidersCause of morbidityPrevalence of metabolic syndrome in people living with HIV and its multi-organ damage: a prospective cohort study
Tang J, Chen L, Pan W, Lu L, Liu X, Zhang L, Zheng L, Song X, Guo F, Lv W, Cao W, Hsieh E, Li T. Prevalence of metabolic syndrome in people living with HIV and its multi-organ damage: a prospective cohort study. BMC Infectious Diseases 2025, 25: 351. PMID: 40075301, PMCID: PMC11905433, DOI: 10.1186/s12879-025-10735-7.Peer-Reviewed Original ResearchConceptsRisk factors of MetSFactors of MetSPooled Cohort EquationsProspective cohort studyAssociated with higher riskBone mineral densityGlobal scale-upMulti-organ damageRisk factorsAssociated with unfavorable health outcomesAntiretroviral therapyAlcohol consumptionCohort studyConclusionThe incidenceChina Diabetes SocietyPrevalence of metabolic syndromeScale-up of antiretroviral therapyMetabolic syndromeAssociated with multi-organ damageOrgan damageGlobal scale-up of antiretroviral therapyUnfavorable health outcomesIncidence of MetSLow HDL-C concentrationsAssociated with MetS
2024
BoneScore: A natural language processing algorithm to extract bone mineral density data from DXA scans
Fodeh S, Wang R, Murphy T, Kidwai-Khan F, Leo-Summers L, Tessier-Sherman B, Hsieh E, Womack J. BoneScore: A natural language processing algorithm to extract bone mineral density data from DXA scans. Health Informatics Journal 2024, 30: 14604582241295930. PMID: 39526751, PMCID: PMC11872221, DOI: 10.1177/14604582241295930.Peer-Reviewed Original ResearchConceptsT-score valuesT-scoreNLP algorithmsDXA scansFemoral neck T-scoreNatural language processing algorithmsBone mineral density dataLanguage processing algorithmsBone mineral densityExtract annotationsRegular expressionsTest dataProcessing algorithmsDXA reportsMineral densityAlgorithmMultivariate linear regressionClinical face validityRisk factorsPresence of informationDXANLPClinical validationClinical expertsAccuracy
2023
Assessing the contributions of modifiable risk factors to serious falls and fragility fractures among older persons living with HIV
Womack J, Murphy T, Leo‐Summers L, Bates J, Jarad S, Gill T, Hsieh E, Rodriguez‐Barradas M, Tien P, Yin M, Brandt C, Justice A. Assessing the contributions of modifiable risk factors to serious falls and fragility fractures among older persons living with HIV. Journal Of The American Geriatrics Society 2023, 71: 1891-1901. PMID: 36912153, PMCID: PMC10258163, DOI: 10.1111/jgs.18304.Peer-Reviewed Original ResearchConceptsModifiable risk factorsFragility fracturesRisk factorsAlcohol use disorderSerious fallsPhysiologic frailtyAntiretroviral therapyOlder PWHUse disordersVeterans Aging Cohort StudyMeasures of multimorbidityAging Cohort StudyBody mass indexMultivariable logistic modelAverage attributable fractionSuccessful prevention programsKey risk factorsOpioid prescriptionsCohort studyMass indexModifiable factorsSixth decadeAttributable fractionElevated riskICD9 codesPrevalence of and risk factors for vertebral fracture and low bone mineral density among Peruvian women aging with HIV
Cabrera D, Cornejo M, Slotkin R, Pinedo Y, Yu W, Guan W, Garcia P, Hsieh E. Prevalence of and risk factors for vertebral fracture and low bone mineral density among Peruvian women aging with HIV. Archives Of Osteoporosis 2023, 18: 64. PMID: 37160770, PMCID: PMC10170032, DOI: 10.1007/s11657-023-01250-w.Peer-Reviewed Original ResearchConceptsBone mineral densityLow bone mineral densityThoracolumbar X-rayVertebral fracturesFemoral neckRisk factorsLumbar spineOsteoporosis treatmentTotal hipTreatment gapMineral densityTotal hip bone mineral densityPresence of VFsPeruvian womenTH bone mineral densityHip bone mineral densityFN bone mineral densityLower FN BMDSubset of patientsGenant semiquantitative methodLower femoral neckImportant treatment gapsKey risk factorsAntiretroviral therapyFRAX score
2021
Brief Report: Are Serious Falls Associated With Subsequent Fragility Fractures Among Veterans Living With HIV?
Womack JA, Murphy TE, Ramsey C, Bathulapalli H, Leo-Summers L, Smith AC, Bates J, Jarad S, Gill TM, Hsieh E, Rodriguez-Barradas MC, Tien PC, Yin MT, Brandt C, Justice AC. Brief Report: Are Serious Falls Associated With Subsequent Fragility Fractures Among Veterans Living With HIV? JAIDS Journal Of Acquired Immune Deficiency Syndromes 2021, 88: 192-196. PMID: 34506360, PMCID: PMC8513792, DOI: 10.1097/qai.0000000000002752.Peer-Reviewed Original ResearchConceptsSubsequent fragility fracturesFragility fracturesAntiretroviral therapySerious fallsRisk factorsVeterans Aging Cohort StudyAging Cohort StudyMultivariable logistic regressionUpper arm fracturesMiddle-aged populationYears of ageAlcohol use disorderCohort studyHip fractureVertebral fracturesArm fracturesInjury codesICD9 codesGeneral populationUse disordersLogistic regressionIntegrase inhibitorsOlder adultsRadiology reportsHIVChanges in trabecular bone score and bone mineral density in Chinese HIV-Infected individuals after one year of antiretroviral therapy
Guan WM, Pan W, Yu W, Cao W, Lin Q, Zhang ZZ, Song XJ, Li YL, Tian JP, Xu Y, Li TS, Hsieh E. Changes in trabecular bone score and bone mineral density in Chinese HIV-Infected individuals after one year of antiretroviral therapy. Journal Of Orthopaedic Translation 2021, 29: 72-77. PMID: 34094860, PMCID: PMC8164002, DOI: 10.1016/j.jot.2021.04.002.Peer-Reviewed Original ResearchTrabecular bone scoreBone mineral densityDual-energy X-ray absorptiometryLPV/rAntiretroviral therapyART initiationLower BMIBone scoreRisk factorsMineral densityBone microarchitectureBaseline TBSHuman immunodeficiency virus (HIV) infectionNormal bone mineral densityBone damageDifferent antiretroviral agentsHIV treatment historyImpaired bone microarchitectureLower baseline CD4Immunodeficiency virus infectionTraditional risk factorsClinicians additional informationX-ray absorptiometryKey risk factorsBaseline CD4Validation of a six-item dietary calcium screening tool among HIV patients in China
Tseng LY, Xie W, Pan W, Lyu H, Yu Z, Shi W, He Y, Chen W, Li T, Hsieh E. Validation of a six-item dietary calcium screening tool among HIV patients in China. Public Health Nutrition 2021, 24: 4786-4795. PMID: 33820577, PMCID: PMC8600937, DOI: 10.1017/s1368980021001427.Peer-Reviewed Original ResearchConceptsSix-item toolAdjacent quartilesClinical practiceScreening toolClinical risk factorsFollow-up screeningModerate relative validityTime-point studyHIV patientsAverage BMIBone healthMean ageOutpatient settingNutritional assessmentRisk factorsRoutine screeningDietary CaHealthy dietDisease preventionHIVFurther assessmentRelative validityAdequate CaChinese individualsTarget populationKnowledge and Impact of COVID-19 on Middle-Aged and Older People Living with HIV in Lima, Peru
Diaz MM, Cabrera DM, Gil-Zacarias M, Ramirez V, Saavedra M, Cárcamo C, Hsieh E, Garcia PJ. Knowledge and Impact of COVID-19 on Middle-Aged and Older People Living with HIV in Lima, Peru. Journal Of The International Association Of Providers Of AIDS Care (JIAPAC) 2021, 20: 23259582211056760. PMID: 34870508, PMCID: PMC8655474, DOI: 10.1177/23259582211056760.Peer-Reviewed Original ResearchConceptsLow educational levelCOVID-19Large HIV clinicMajority of PWHCross-sectional telephone surveyHealthcare systemCOVID-19 symptomsHealth impactsHigher COVID-19 case ratesEducational levelMental health impactCOVID-19 case ratesHIV clinicOlder PWHFemale sexRisk factorsPWHMedical careCase ratesNationwide quarantineOlder peopleVulnerable populationsTelephone surveySocioeconomic supportHIV
2020
Factors Associated With Renal Involvement in Primary Sjögren's Syndrome: A Meta-Analysis
Hong R, Xu D, Hsieh E, Xiang Y, Zhao J, Wang Q, Tian X, Li M, Zhao Y, Zeng X. Factors Associated With Renal Involvement in Primary Sjögren's Syndrome: A Meta-Analysis. Frontiers In Medicine 2020, 7: 614482. PMID: 33324667, PMCID: PMC7726424, DOI: 10.3389/fmed.2020.614482.Peer-Reviewed Original ResearchPrimary Sjögren's syndromeAnti-SSB antibodiesRenal involvementSjögren's syndromeLarge-scale prospective cohort studyLabial salivary gland biopsyAnti-SSA antibodiesChronic renal diseaseProspective cohort studyNewcastle-Ottawa ScaleFurther risk factorsSalivary gland biopsyOdds ratio valuesWeb of ScienceFixed-effects modelRenal impairmentCohort studyCritical complicationsDry eyePS patientsRenal diseaseRheumatoid factorCochrane LibraryRisk factorsGland biopsyLongitudinal change in bone mineral density among Chinese individuals with HIV after initiation of antiretroviral therapy
Guo F, Song X, Li Y, Guan W, Pan W, Yu W, Li T, Hsieh E. Longitudinal change in bone mineral density among Chinese individuals with HIV after initiation of antiretroviral therapy. Osteoporosis International 2020, 32: 321-332. PMID: 32803316, PMCID: PMC9509525, DOI: 10.1007/s00198-020-05584-w.Peer-Reviewed Original ResearchConceptsTenofovir disoproxil fumarateLong-term clinical managementBone mineral density lossMineral density lossAntiretroviral therapyDisoproxil fumarateClinical managementRisk factorsGreater bone mineral density lossInitiation of TDFDual-energy x-ray absorptiometry testingHIV-specific parametersNon-TDF groupUndetectable viral loadOutpatient HIV clinicRelated risk factorsLarge tertiary hospitalBone mineral densityDensity lossAntiretroviral initiationTDF groupWeek 96HIV clinicWeek 48HIV diagnosisHIV/AIDS Among Female Sex Workers in China: Epidemiology and Recent Prevention Strategies
Zhang H, Hsieh E, Wang L, Liao S. HIV/AIDS Among Female Sex Workers in China: Epidemiology and Recent Prevention Strategies. Current HIV/AIDS Reports 2020, 17: 151-160. PMID: 32030600, PMCID: PMC9675938, DOI: 10.1007/s11904-019-00477-y.BooksConceptsFemale sex workersSex workersHIV prevalenceRisk factorsPrevention strategiesRecent prevention strategiesEpidemiology of HIVHIV prevention strategiesNational HIV prevalenceNational prevention programsCondom use practicesNew risk factorsSpread of HIVSex workHIV/AIDSRegional levelHIV infectionHIV transmissionSexual practicesHIV preventionHIV riskMale condomsPrevalence ratesReviewThis reviewPrevention programsOsteoporosis Knowledge and Health Beliefs Among Female Community Leaders in Peru
Sava M, Tseng LY, Valderrama M, Mabey D, García PJ, Hsieh E. Osteoporosis Knowledge and Health Beliefs Among Female Community Leaders in Peru. Women's Health Reports 2020, 1: 47-54. PMID: 33786472, PMCID: PMC7784789, DOI: 10.1089/whr.2019.0005.Peer-Reviewed Original ResearchOsteoporosis knowledgeFemale community leadersCalcium intakeHealth beliefsImportant modifiable risk factorHealth motivationOsteoporosis Health Belief ScaleOsteoporosis prevention programsModifiable risk factorsPrevalence of osteoporosisBody mass indexOsteoporosis Knowledge TestBenefits of exerciseBone mineral lossCross-sectional studyHealth Belief ScaleHigher health motivationPostmenopausal womenMass indexMean ageRisk factorsLatin American populationsPhysical activityPeriurban settingsHigh school education
2019
Increased Fragility Fracture Rates in Older Men With Osteomyelitis
Hsieh E, Shiau S, Nolan O, Gibert CL, Bedimo RJ, Rodriguez-Barradas MC, Justice AC, Womack JA, Yin MT. Increased Fragility Fracture Rates in Older Men With Osteomyelitis. Clinical Infectious Diseases 2019, 69: 1239-1242. PMID: 30715288, PMCID: PMC6743834, DOI: 10.1093/cid/ciz077.Peer-Reviewed Original Research
2017
Cardiovascular disease risk among Chinese antiretroviral-naïve adults with advanced HIV disease
Guo F, Hsieh E, Lv W, Han Y, Xie J, Li Y, Song X, Li T. Cardiovascular disease risk among Chinese antiretroviral-naïve adults with advanced HIV disease. BMC Infectious Diseases 2017, 17: 287. PMID: 28427339, PMCID: PMC5397830, DOI: 10.1186/s12879-017-2358-0.Peer-Reviewed Original ResearchConceptsCVD risk factorsFramingham risk scoreRisk factorsRisk scoreCVD riskAtherosclerotic cardiovascular disease risk scoreCommon CVD risk factorsCardiovascular disease risk scoreAdvanced HIV diseaseD risk scoreTreatment-naïve HIVLipid-Lowering TherapyPrevalence of hypertensionRisk factor treatmentBurden of CVDCardiovascular disease riskTreatment-naïve individualsMulticenter clinical trialAntiretroviral-naïve adultsDisease risk scoreRoutine clinical assessmentHIV providersAdverse eventsBackgroundCardiovascular diseaseHIV disease
2016
Exploring HIV-related stigma among HIV-infected men who have sex with men in Beijing, China: a correlation study
Li Z, Hsieh E, Morano JP, Sheng Y. Exploring HIV-related stigma among HIV-infected men who have sex with men in Beijing, China: a correlation study. AIDS Care 2016, 28: 1394-1401. PMID: 27137205, PMCID: PMC5069196, DOI: 10.1080/09540121.2016.1179713.Peer-Reviewed Original ResearchConceptsHIV transmissionHIV stigmaStigma scoresPoor self-rated health statusBerger HIV Stigma ScaleSelf-rated health statusHIV-positive MSMIncidence of HIVMultivariable linear regression modelsHuman immunodeficiency virusLevels of HIVHIV Stigma ScaleAdverse health outcomesCross-sectional survey studySocial support networksAntiretroviral therapyHIV statusOpportunistic infectionsImmunodeficiency virusPoor adherenceSocio-demographic characteristicsRisk factorsStudy populationHIVHealth outcomesWhich HIV patients should be screened for osteoporosis
Alvarez E, Belloso WH, Boyd MA, Inkaya AÇ, Hsieh E, Kambugu A, Kaminski G, Martinez E, Stellbrink HJ, Walmsley S, Brown TT, Mallon PW. Which HIV patients should be screened for osteoporosis. Current Opinion In HIV And AIDS 2016, 11: 268-276. PMID: 26895510, DOI: 10.1097/coh.0000000000000269.Peer-Reviewed Original ResearchConceptsBone mineral densityLow bone mineral densityFracture Risk Assessment ToolMeasurement of BMDDual-energy X-ray absorptiometryEnergy X-ray absorptiometryImpact of comorbiditiesManagement of osteoporosisTenofovir disoproxil fumarateX-ray absorptiometryLong-term managementRisk assessment toolHIV physiciansHIV patientsConsensus guidelinesDisoproxil fumaratePhysicians' knowledgeRisk factorsMineral densityCare differsGeneral populationClinical approachPLWHOverall risk estimationSubstance abuse
2014
Body Mass Index and Breast Cancer Defined by Biological Receptor Status in Pre-Menopausal and Post-Menopausal Women: A Multicenter Study in China
Li J, Huang Y, Zhang BN, Fan JH, Huang R, Zhang P, Wang SL, Zheng S, Zhang B, Yang HJ, Xie XM, Tang ZH, Li H, He JJ, Hsieh E, Qiao YL, Li JY. Body Mass Index and Breast Cancer Defined by Biological Receptor Status in Pre-Menopausal and Post-Menopausal Women: A Multicenter Study in China. PLOS ONE 2014, 9: e87224. PMID: 24489874, PMCID: PMC3906138, DOI: 10.1371/journal.pone.0087224.Peer-Reviewed Original ResearchConceptsBody mass indexPost-menopausal womenHigher Body Mass IndexReceptor statusBreast cancerLogistic regression modelsMass indexBMI dataMultivariate logistic regression modelBreast cancer patientsRank correlation analysisEstrogen metabolism pathwayBreast cancer casesFisher's exact testChi-square testPre-MenopausalMedical chartsPathologic featuresRegression modelsEligible casesMulticenter studyCancer patientsRisk factorsCancer casesExact test
2010
Human papillomavirus infection in female sex workers in Lima, Peru
Montano SM, Hsieh EJ, Calderón M, Ton TG, Quijano E, Solari V, Zunt JR. Human papillomavirus infection in female sex workers in Lima, Peru. Sexually Transmitted Infections 2010, 87: 81. PMID: 20813720, PMCID: PMC3501137, DOI: 10.1136/sti.2010.043315.Peer-Reviewed Original ResearchConceptsFemale sex workersHuman papillomavirus infectionHPV infectionPapillomavirus infectionHPV typesBrothel-based female sex workersHigh-risk HPV infectionHigh-risk HPV typesMore HPV typesSex workersPrevalence of coinfectionCross-sectional studyCervical swabsRisk factorsHigh prevalenceBlood specimensLower riskYounger ageInfectionPrevalenceSex work practicesSexual characteristicsHPVCoinfectionSwabs
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply