2014
Lyme Disease
Solomon C, Shapiro E. Lyme Disease. New England Journal Of Medicine 2014, 370: 1724-1731. PMID: 24785207, PMCID: PMC4487875, DOI: 10.1056/nejmcp1314325.Peer-Reviewed Original Research
2009
A RANDOMIZED, PLACEBO-CONTROLLED TRIAL OF REPEATED IV ANTIBIOTIC THERAPY FOR LYME ENCEPHALOPATHY PROLONGED LYME DISEASE TREATMENT: ENOUGH IS ENOUGH
Marques A, Shaw P, Schmid C, Steere A, Kaplan R, Hassett A, Shapiro E, Wormser G. A RANDOMIZED, PLACEBO-CONTROLLED TRIAL OF REPEATED IV ANTIBIOTIC THERAPY FOR LYME ENCEPHALOPATHY PROLONGED LYME DISEASE TREATMENT: ENOUGH IS ENOUGH. Neurology 2009, 72: 383-386. PMID: 19171842, DOI: 10.1212/01.wnl.0000343855.45704.7c.Peer-Reviewed Original Research
2007
A Critical Appraisal of “Chronic Lyme Disease”
Feder HM, Johnson BJ, O'Connell S, Shapiro ED, Steere AC, Wormser GP, Agger W, Artsob H, Auwaerter P, Dumler J, Bakken J, Bockenstedt L, Green J, Dattwyler R, Munoz J, Nadelman R, Schwartz I, Draper T, McSweegan E, Halperin J, Klempner M, Krause P, Mead P, Morshed M, Porwancher R, Radolf J, Smith R, Sood S, Weinstein A, Wong S, Zemel L. A Critical Appraisal of “Chronic Lyme Disease”. New England Journal Of Medicine 2007, 357: 1422-1430. PMID: 17914043, DOI: 10.1056/nejmra072023.Peer-Reviewed Original ResearchConceptsAcute Lyme diseaseChronic Lyme diseaseLyme diseasePersistent painNeurocognitive symptomsCommon tick-borne infectionSerious public health problemPublic health problemTick-borne infectionsBorrelia burgdorferi sensu strictoBurgdorferi sensu strictoHealth problemsDiseasePainPatientsSymptomsFatigueInfectionDiagnosis
2006
The Clinical Assessment, Treatment, and Prevention of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis: Clinical Practice Guidelines by the Infectious Diseases Society of America
Wormser GP, Dattwyler RJ, Shapiro ED, Halperin JJ, Steere AC, Klempner MS, Krause PJ, Bakken JS, Strle F, Stanek G, Bockenstedt L, Fish D, Dumler JS, Nadelman RB. The Clinical Assessment, Treatment, and Prevention of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis: Clinical Practice Guidelines by the Infectious Diseases Society of America. Clinical Infectious Diseases 2006, 43: 1089-1134. PMID: 17029130, DOI: 10.1086/508667.Peer-Reviewed Original ResearchConceptsInfectious Diseases SocietyHuman granulocytic anaplasmosisDiseases SocietyLyme diseasePost-Lyme disease syndromeGranulocytic anaplasmosisPrevious treatment guidelinesManagement of patientsClinical practice guidelinesEvidence-based guidelinesHealth care providersTickborne infectionTreatment guidelinesClinical manifestationsAntimicrobial therapyClinical assessmentPractice guidelinesCare providersDisease syndromeExpert panelDiseasePreventionPatientsTherapyInfection
2004
Effectiveness Over Time of Varicella Vaccine
Vázquez M, LaRussa PS, Gershon AA, Niccolai LM, Muehlenbein CE, Steinberg SP, Shapiro ED. Effectiveness Over Time of Varicella Vaccine. JAMA 2004, 291: 851-855. PMID: 14970064, DOI: 10.1001/jama.291.7.851.Peer-Reviewed Original ResearchConceptsTime of vaccinationVaricella vaccineVaccine effectivenessCase subjectsPolymerase chain reaction test resultsVaricella-zoster virus DNACase-control studyReaction test resultsReports of outbreaksFirst yearBreakthrough diseaseImmunized groupsActive surveillancePossible confoundersPediatric practiceVaccinationVaccineVirus DNAMonthsMost casesGroup practiceChickenpoxAgeYear 2Year 1Case-control studies of the effectiveness of vaccines: validity and assessment of potential bias
Shapiro ED. Case-control studies of the effectiveness of vaccines: validity and assessment of potential bias. The Pediatric Infectious Disease Journal 2004, 23: 127-131. PMID: 14872178, DOI: 10.1097/01.inf.0000109248.32907.1d.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, BacterialBacterial CapsulesBiasCase-Control StudiesChild, PreschoolConfidence IntervalsFemaleHaemophilus InfectionsHaemophilus influenzae type bHaemophilus VaccinesHumansImmunityImmunization ScheduleInfantMalePolysaccharides, BacterialProbabilityReference ValuesReproducibility of ResultsSensitivity and SpecificityTreatment OutcomeVaccinationConceptsEffectiveness of vaccinesCase-control studyInvasive Hib infectionsHib vaccinePneumococcal infectionHib infectionsInvasive infectionsHaemophilus influenzae type bInvasive pneumococcal infectionsInfluenzae type bMonths of ageIdentical study designOverall 34Study 74S. pneumoniaeStreptococcus pneumoniaeVaccineInfectionStudy designHibType BPneumoniaeValid methodCasesPotential bias
2001
Position for Newborn Sleep: Associations with Parents' Perceptions of Their Nursery Experience
Colson E, Bergman D, Shapiro E, Leventhal J. Position for Newborn Sleep: Associations with Parents' Perceptions of Their Nursery Experience. Birth 2001, 28: 249-253. PMID: 11903213, DOI: 10.1046/j.1523-536x.2001.00249.x.Peer-Reviewed Original ResearchConceptsSupine positionSudden infant death syndromeUrban primary care centerPrimary care centersWell-child visitsInfant death syndromeCause of deathCurrent American AcademyInfant sleeping positionPercent of parentsPostpartum hospitalInner-city parentsHealthy infantsPostpartum periodProne positionCare centerPediatrics recommendationsDeath syndromeInner-city settingsNewborn sleepSleeping positionInfant sleepInfantsAmerican AcademyPostpartum experiencesThe Effectiveness of the Varicella Vaccine in Clinical Practice
Vázquez M, LaRussa P, Gershon A, Steinberg S, Freudigman K, Shapiro E. The Effectiveness of the Varicella Vaccine in Clinical Practice. New England Journal Of Medicine 2001, 344: 955-960. PMID: 11274621, DOI: 10.1056/nejm200103293441302.Peer-Reviewed Original ResearchConceptsVaricella-zoster virusVaricella vaccinePolymerase chain reactionMild diseasePediatric practiceClinical practicePositive PCR testCase-control studyConditional logistic regressionPotential casesUnvaccinated childrenPotential confoundersActive surveillanceSevere diseaseChickenpoxDay 3VaccineLogistic regressionPCR testDiseaseChain reactionChildrenResearch assistantsIllnessVirusWILLINGNESS OF DIRECTORS OF CHILD CARE CENTERS TO CARE FOR CHILDREN WITH CHRONIC INFECTIONS
Juhn Y, Shapiro E, McCarthy P, Freudigman K. WILLINGNESS OF DIRECTORS OF CHILD CARE CENTERS TO CARE FOR CHILDREN WITH CHRONIC INFECTIONS. The Pediatric Infectious Disease Journal 2001, 20: 77-79. PMID: 11176573, DOI: 10.1097/00006454-200101000-00016.Peer-Reviewed Original Research
2000
Varicella vaccine revisited
LaRussa P, Steinberg S, Shapiro E, Vazquez M, Gershon A. Varicella vaccine revisited. Nature Medicine 2000, 6: 1299-1299. PMID: 11100089, DOI: 10.1038/82070.Commentaries, Editorials and LettersViral strain identification in varicella vaccinees with disseminated rashes
LARUSSA P, STEINBERG S, SHAPIRO E, VAZQUEZ M, GERSHON A. Viral strain identification in varicella vaccinees with disseminated rashes. The Pediatric Infectious Disease Journal 2000, 19: 1037-1039. PMID: 11099082, DOI: 10.1097/00006454-200011000-00002.Peer-Reviewed Original ResearchConceptsVaricella-zoster virusBreakthrough varicellaVaccine strainVaricella vaccineVaccine-strain varicella-zoster virusWild-type VZV infectionLive attenuated varicella vaccineAttenuated varicella vaccineRecipients of vaccineOka vaccine strainDisseminated rashNatural varicellaVesicular rashPostvaccination periodVZV infectionClinical pictureZosteriform rashGeneralized rashSkin lesionsVaccine virusVaricellaRashZosterVaccineesWild-type virusThe Scholarship of Application
Shapiro E, Coleman D. The Scholarship of Application. Academic Medicine 2000, 75: 895-898. PMID: 10995610, DOI: 10.1097/00001888-200009000-00010.Peer-Reviewed Original ResearchLyme Disease
Shapiro E, Gerber M. Lyme Disease. Clinical Infectious Diseases 2000, 31: 533-542. PMID: 10987718, DOI: 10.1086/313982.Peer-Reviewed Original ResearchConceptsLyme diseaseCommon vector borne diseaseSeventh cranial nerve palsyOnly nonspecific symptomsCranial nerve palsyAnnular rashNerve palsyNonspecific symptomsAseptic meningitisSymptomatic infectionFrequent manifestationCommon causeActual morbidityPossible diagnosisSerological testsMost personsDiseaseBorrelia burgdorferiSymptomsVector borne diseasesBorne diseasesFrequent useManifestationsUnited StatesCausePractice Guidelines for the Treatment of Lyme Disease
Wormser G, Nadelman R, Dattwyler R, Dennis D, Shapiro E, Steere A, Rush T, Rahn D, Coyle P, Persing D, Fish D, Luft B. Practice Guidelines for the Treatment of Lyme Disease. Clinical Infectious Diseases 2000, 31: s1-s14. PMID: 10982743, DOI: 10.1086/314053.Peer-Reviewed Original ResearchProspective cohort study of children born to human immunodeficiency virus-infected mothers, 1985 through 1997: trends in the risk of vertical transmission, mortality and acquired immunodeficiency syndrome indicator diseases in the era before highly active antiretroviral therapy
SIMPSON J, SHAPIRO E, ANDIMAN W. Prospective cohort study of children born to human immunodeficiency virus-infected mothers, 1985 through 1997: trends in the risk of vertical transmission, mortality and acquired immunodeficiency syndrome indicator diseases in the era before highly active antiretroviral therapy. The Pediatric Infectious Disease Journal 2000, 19: 618-624. PMID: 10917219, DOI: 10.1097/00006454-200007000-00007.Peer-Reviewed Original ResearchConceptsAIDS indicator diseasesMonths of ageIndicator diseasesInfected childrenVertical transmissionCohort studyHuman immunodeficiency virus-infected mothersMycobacterium avium complex diseaseActive antiretroviral therapyHIV infection statusPerson monthsProspective cohort studyPneumocystis carinii pneumoniaLongitudinal cohort studyRate of deathIntroduction of treatmentTime of deathRates of diseaseAntiretroviral therapyHIV infectionCarinii pneumoniaPregnant womenAntiretroviral drugsHIV-1HIVGroup-Specific Antibody Levels Surrounding Invasive Pneumococcal Illness in Children Infected with Human Immunodeficiency Virus
King J, Borkowsky W, Mahidhara N, Madore D, Shapiro E, Rutstein R, Tan T, Farley J, Dankner W, Nachman S, Simoes E, Flynn P, Clemens J, Hamilton R. Group-Specific Antibody Levels Surrounding Invasive Pneumococcal Illness in Children Infected with Human Immunodeficiency Virus. The Journal Of Infectious Diseases 2000, 181: 1817-1821. PMID: 10823792, DOI: 10.1086/315441.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusAntibody levelsSerum samplesPneumococcal illnessImmunodeficiency virusPneumococcal antibody levelsGeometric mean levelsAntibody valuesPneumococcal serotypesIgG antibodiesGroup 4Mean levelsSeroresponsesIllnessChildrenWeeksSerotypesVirusLevelsSerorespondersELISAAntibodies
1999
Pneumococcal vaccines: history, current status, and future directions
Butler J, Shapiro E, Carlone G. Pneumococcal vaccines: history, current status, and future directions. The American Journal Of Medicine 1999, 107: 69-76. PMID: 10451012, DOI: 10.1016/s0002-9343(99)00105-9.Peer-Reviewed Original ResearchConceptsPneumococcal polysaccharide vaccinePolysaccharide vaccinePneumococcal infectionCertain underlying medical conditionsSerious pneumococcal diseaseCommunity-acquired pneumoniaPneumococcal conjugate vaccineUnderlying medical conditionsAnti-pneumococcal antibodiesLarger efficacy trialPrevention of infectionDrug-resistant strainsImmunocompetent childrenPneumococcal diseasePneumococcal vaccineBacterial meningitisConjugate vaccineCase fatalityDNA vaccineInvasive infectionsPneumococcal polysaccharideEfficacy trialsImmune responseMedical conditionsHigh risk
1998
Lyme Arthritis in Children: Clinical Epidemiology and Long-term Outcomes
Gerber M, Zemel L, Shapiro E. Lyme Arthritis in Children: Clinical Epidemiology and Long-term Outcomes. Pediatrics 1998, 102: 905-908. PMID: 9755263, DOI: 10.1542/peds.102.4.905.Peer-Reviewed Original ResearchConceptsLong-term outcomesLyme arthritisAppropriate antimicrobial therapyAntimicrobial therapyClinical epidemiologyLyme diseaseMean white blood cell countWhite blood cell countNewington Children's HospitalCells/mm3Pediatric rheumatology clinicTime of diagnosisEarly Lyme diseaseErythrocyte sedimentation rateLong-term followOnset of symptomsBlood cell countStructured telephone interviewActive arthritisChronic arthritisRheumatology clinicArthroscopic synovectomyInitial diagnosisChildren's HospitalTelephone followEffectiveness of pneumococcal vaccine
Butler J, Spika J, Nichol K, Shapiro E, Breinan R. Effectiveness of pneumococcal vaccine. The Lancet 1998, 351: 1961. PMID: 9654289, DOI: 10.1016/s0140-6736(05)78647-5.Peer-Reviewed Original ResearchLyme Disease
Shapiro E. Lyme Disease. Pediatrics In Review 1998, 19: 147-154. PMID: 9584524, DOI: 10.1542/pir.19-5-147.Peer-Reviewed Original Research