2025
Estimated Effectiveness of Nirsevimab Against Respiratory Syncytial Virus
Xu H, Aparicio C, Wats A, Araujo B, Pitzer V, Warren J, Shapiro E, Niccolai L, Weinberger D, Oliveira C. Estimated Effectiveness of Nirsevimab Against Respiratory Syncytial Virus. JAMA Network Open 2025, 8: e250380. PMID: 40063022, PMCID: PMC11894488, DOI: 10.1001/jamanetworkopen.2025.0380.Peer-Reviewed Original ResearchConceptsRSV-positive casesCase-control studyRSV infectionLRTI-associated hospitalizationsWeeks postimmunizationLong-acting monoclonal antibodiesTest-negative case-control studyClinical settingRespiratory syncytial virusMultivariate logistic regressionYale New Haven Health SystemRSV diseaseEmergency department dataState immunization registryRSV seasonSyncytial virusNirsevimabPolymerase chain reactionClinical trialsLRTIInfantsPotential confoundersMonoclonal antibodiesBroader outcomesDisease severity
2001
The Effectiveness of the Varicella Vaccine in Clinical Practice
Vázquez M, LaRussa P, Gershon A, Steinberg S, Freudigman K, Shapiro E. The Effectiveness of the Varicella Vaccine in Clinical Practice. New England Journal Of Medicine 2001, 344: 955-960. PMID: 11274621, DOI: 10.1056/nejm200103293441302.Peer-Reviewed Original ResearchConceptsVaricella-zoster virusVaricella vaccinePolymerase chain reactionMild diseasePediatric practiceClinical practicePositive PCR testCase-control studyConditional logistic regressionPotential casesUnvaccinated childrenPotential confoundersActive surveillanceSevere diseaseChickenpoxDay 3VaccineLogistic regressionPCR testDiseaseChain reactionChildrenResearch assistantsIllnessVirus
1986
Does breast-feeding protect against infections in infants less than 3 months of age?
Leventhal J, Shapiro E, Aten C, Berg A, Egerter S. Does breast-feeding protect against infections in infants less than 3 months of age? Pediatrics 1986, 78: 896-903. PMID: 3093969, DOI: 10.1542/peds.78.5.896.Peer-Reviewed Original ResearchConceptsCase-control pairsSurveillance biasOdds ratioProtective effectYale-New Haven HospitalBreast-feeding protectsPotential surveillance biasTime of hospitalizationSeverity of illnessBreast-fed infantsCase-control studyApparent protective effectMonths of ageLogistic regression modelsDays of ageMild illnessInfectious illnessPotential confoundersHealthy childrenMedical conditionsStratified resultsSerious illnessInfantsIllnessInfection
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