2025
Learn-As-you-GO (LAGO) trials: optimizing treatments and preventing trial failure through ongoing learning
Bing A, Spiegelman D, Nevo D, Lok J. Learn-As-you-GO (LAGO) trials: optimizing treatments and preventing trial failure through ongoing learning. Biometrics 2025, 81: ujaf061. PMID: 40407021, PMCID: PMC12099308, DOI: 10.1093/biomtc/ujaf061.Peer-Reviewed Original ResearchConceptsIntervention packageBinary outcomesIntervention effectsConditional mean modelsOptimal intervention packagesOverall intervention effectContinuous outcomesComplex intervention packagesConfidence bandsInterval estimationImplementation trialLarge-scale intervention trialsMean modelIntervention trialsHypothesis testingInterventionStandard statistical methodsOutcomesTrialsConfidenceTheory
2017
A Mixed-Methods Study on Acceptability, Tolerability, and Substitution of Brown Rice for White Rice to Lower Blood Glucose Levels among Nigerian Adults
Adebamowo SN, Eseyin O, Yilme S, Adeyemi D, Willett WC, Hu FB, Spiegelman D, Adebamowo CA, Initiative T. A Mixed-Methods Study on Acceptability, Tolerability, and Substitution of Brown Rice for White Rice to Lower Blood Glucose Levels among Nigerian Adults. Frontiers In Nutrition 2017, 4: 33. PMID: 28775984, PMCID: PMC5517499, DOI: 10.3389/fnut.2017.00033.Peer-Reviewed Original ResearchBody mass indexGlucose levelsTwo-hour postprandial blood glucoseMean body mass indexLarge-scale intervention trialsPostprandial glucose levelsPostprandial blood glucoseBlood sugar levelsTimes/weekType 2 diabetesBlood glucose levelsFocus group discussionsWhole grain productsBrown rice mealLong-term trialsBrown rice consumptionConsumption of mealsMass indexIntervention trialsMean ageBlood glucoseNigerian adultsWhite riceMetabolic disordersLower risk
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