2025
Nonparametric Estimation of the Potential Impact Fraction and the Population Attributable Fraction With Individual‐Level and Aggregated Data
Chan C, Zepeda‐Tello R, Camacho‐García‐Formentí D, Cudhea F, Meza R, Rodrigues E, Spiegelman D, Barrientos‐Gutierrez T, Zhou X. Nonparametric Estimation of the Potential Impact Fraction and the Population Attributable Fraction With Individual‐Level and Aggregated Data. Statistics In Medicine 2025, 44: e70214. PMID: 40798868, DOI: 10.1002/sim.70214.Peer-Reviewed Original ResearchConceptsDistributional assumptionsFinite sample performanceImpact of distributional assumptionsPotential impact fractionNonparametric estimationSample performanceDistributional violationsPopulation attributable fractionImpact fractionNonparametric methodsSimulation studyContinuous exposure dataPopulation impact fractionsAttributable fractionSugar-sweetened beverage consumptionIncidence of type 2 diabetesAssumptionsExposure distributionEstimationAggregate dataBeverage consumptionNonparametricType 2 diabetesIndividual-levelTarget population
2021
Estimating the natural indirect effect and the mediation proportion via the product method
Cheng C, Spiegelman D, Li F. Estimating the natural indirect effect and the mediation proportion via the product method. BMC Medical Research Methodology 2021, 21: 253. PMID: 34800985, PMCID: PMC8606099, DOI: 10.1186/s12874-021-01425-4.Peer-Reviewed Original ResearchConceptsInterval estimatorsApproximate estimatorExact estimatorMultivariate delta methodFinite sample performanceProduct methodNon-negligible biasBinary outcomesRare outcome assumptionExact expressionDelta methodVariance estimationEmpirical performanceEstimatorCommon data typesBootstrap approachBinary mediatorNatural indirect effectSample size
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