2025
Harnessing HIV clinics to deliver integrated hypertension care for People living with HIV in Uganda: A formative mixed methods study
Semitala F, Ayebare F, Kiggundu J, Kiwala C, Senfuma J, Mutungi G, Ssinabulya I, Kayima J, Muddu M, Spiegelman D, Schwartz J, Longenecker C, Katahoire A. Harnessing HIV clinics to deliver integrated hypertension care for People living with HIV in Uganda: A formative mixed methods study. PLOS Global Public Health 2025, 5: e0004701. PMID: 40465676, PMCID: PMC12136366, DOI: 10.1371/journal.pgph.0004701.Peer-Reviewed Original ResearchFragmented care deliveryHypertension careQualitative dataHIV clinicSub-Saharan AfricaCare deliveryConsolidated Framework for Implementation ResearchAnalyzed qualitative dataQualitative interviewsInterruptions due to side effectsSub-SaharanHIV servicesBlood pressureHealthcare accessNon-communicable diseasesMixed methods studyUgandaPeri-urban UgandaChronic careSystolic blood pressureHIV careImplementation researchPocket costsMedication accessAnalyzed quantitative dataPower and Sample Size Calculations for Cluster Randomized Hybrid Type 2 Effectiveness‐Implementation Studies
Owen M, Curran G, Smith J, Tedla Y, Cheng C, Spiegelman D. Power and Sample Size Calculations for Cluster Randomized Hybrid Type 2 Effectiveness‐Implementation Studies. Statistics In Medicine 2025, 44: e70015. PMID: 39930740, DOI: 10.1002/sim.70015.Peer-Reviewed Original ResearchConceptsHybrid type 2 effectiveness-implementation studySample size calculationCluster randomized trialCluster randomized designSize calculationImplementation research outcomesReduce cardiovascular diseaseIssue of multiple testingEffective outcomesImplementation outcomesCommunity interventionsControl blood pressureBinary outcomesOutcomes approachLiterature searchMultiple testingCardiovascular diseaseInterventionRandomized trialsStandard statistical methodsBlood pressureOutcomesType 2 studies
2024
Effects of a dietary intervention on cardiometabolic risk and food consumption in a workplace
Shrestha A, Tamrakar D, Ghinanju B, Shrestha D, Khadka P, Adhikari B, Shrestha J, Waiwa S, Pyakurel P, Bhandari N, Karmacharya B, Shrestha A, Shrestha R, Bhatta R, Malik V, Mattei J, Spiegelman D. Effects of a dietary intervention on cardiometabolic risk and food consumption in a workplace. PLOS ONE 2024, 19: e0301826. PMID: 38656951, PMCID: PMC11042715, DOI: 10.1371/journal.pone.0301826.Peer-Reviewed Original ResearchConceptsConsumption of whole grainsHealthy foodPre-post intervention studyWhole grainsMedian consumptionCardiovascular risk factor profileRisk factor profileBlood pressureWorksite settingWorksite interventionsUnhealthy foodsHealth programsMeasured blood pressurePre-hypertensionCardiometabolic riskDiastolic blood pressureIntervention studiesFactors dietPaired-t testFactor profileFasting glucose levelsDhulikhel HospitalHospital premisesEmployee healthHospital employees
2020
Cardiovascular disease trends in Nepal – An analysis of global burden of disease data 2017
Bhattarai S, Aryal A, Pyakurel M, Bajracharya S, Baral P, Citrin D, Cox H, Dhimal M, Fitzpatrick A, Jha AK, Jha N, Karmacharya BM, Koju R, Maharjan R, Oli N, Pyakurel P, Sapkota BP, Shrestha R, Shrestha S, Spiegelman D, Vaidya A, Shrestha A. Cardiovascular disease trends in Nepal – An analysis of global burden of disease data 2017. IJC Heart & Vasculature 2020, 30: 100602. PMID: 32775605, PMCID: PMC7399110, DOI: 10.1016/j.ijcha.2020.100602.Peer-Reviewed Original ResearchBurden of CVDCardiovascular diseaseGlobal burdenBlood pressureTotal DALYsRisk factorsDiet lowTotal deathsHigh low-density lipoprotein cholesterolHigher systolic blood pressureLow-density lipoprotein cholesterolMajor public health problemCardiovascular disease trendsPredominant cardiovascular diseasesCardiovascular disease incidenceDensity lipoprotein cholesterolSystolic blood pressureHigh blood pressureIschemic heart diseaseBody mass indexEvaluation's Global BurdenPublic health problemOlder age groupsLipoprotein cholesterolMiddle-income countriesThe Association of Cooking Fuel Use, Dietary Intake, and Blood Pressure among Rural Women in China
Bellows AL, Spiegelman D, Du S, Jaacks LM. The Association of Cooking Fuel Use, Dietary Intake, and Blood Pressure among Rural Women in China. International Journal Of Environmental Research And Public Health 2020, 17: 5516. PMID: 32751678, PMCID: PMC7432946, DOI: 10.3390/ijerph17155516.Peer-Reviewed Original ResearchConceptsBlood pressureHigh blood pressureHousehold air pollutionDietary intakeDiastolic blood pressureSystolic blood pressureRole of dietYears of ageFatty acid-rich foodsNonpregnant womenSolid fuel useLinear mixed effects modelsSolid cooking fuelsAdverse effectsIntakeWomenMixed effects modelsPossible mediationLower ratesCooking fuel useEffects modelRural womenCooking fuelAssociationDiet
2018
Cashew Nut Consumption Increases HDL Cholesterol and Reduces Systolic Blood Pressure in Asian Indians with Type 2 Diabetes: A 12-Week Randomized Controlled Trial
Mohan V, Gayathri R, Jaacks LM, Lakshmipriya N, Anjana RM, Spiegelman D, Jeevan RG, Balasubramaniam KK, Shobana S, Jayanthan M, Gopinath V, Divya S, Kavitha V, Vijayalakshmi P, Bai R M, Unnikrishnan R, Sudha V, Krishnaswamy K, Salas-Salvadó J, Willett WC. Cashew Nut Consumption Increases HDL Cholesterol and Reduces Systolic Blood Pressure in Asian Indians with Type 2 Diabetes: A 12-Week Randomized Controlled Trial. Journal Of Nutrition 2018, 148: 63-69. PMID: 29378038, DOI: 10.1093/jn/nxx001.Peer-Reviewed Original ResearchConceptsSystolic blood pressureBlood pressureNut consumptionBody weightAsian IndiansHDL cholesterolDiabetic dietNut supplementationSelf-reported dietary intakeStandard diabetic dietClinical Trials RegistryHDL cholesterol concentrationsPlasma HDL cholesterolType 2 diabetesCashew nut consumptionBlood lipidsControlled TrialsTrials RegistryGlycemic variablesLipid variablesDietary intakeIntervention groupLipid profileCardiovascular diseaseRobust variance estimation
1999
Distribution of and Factors Associated With Serum Homocysteine Levels in Children: Child and Adolescent Trial for Cardiovascular Health
Osganian SK, Stampfer MJ, Spiegelman D, Rimm E, Cutler JA, Feldman HA, Montgomery DH, Webber LS, Lytle LA, Bausserman L, Nader PR. Distribution of and Factors Associated With Serum Homocysteine Levels in Children: Child and Adolescent Trial for Cardiovascular Health. JAMA 1999, 281: 1189-1196. PMID: 10199428, DOI: 10.1001/jama.281.13.1189.Peer-Reviewed Original ResearchConceptsSerum folic acidSystolic blood pressureHomocysteine levelsHomocysteine concentrationsCardiovascular diseaseSerum homocysteineAdolescent TrialBlood pressureSerum levelsFolic acidCardiovascular healthSerum total homocysteine concentrationsVitamin B12Mean homocysteine concentrationFuture cardiovascular diseaseVitamin B12 levelsSerum homocysteine concentrationsSchool-based cohortSerum homocysteine levelsTotal homocysteine concentrationsSerum lipid levelsBody mass indexCross-sectional analysisNonusers of multivitaminsB12 levels
1996
Birth weight and adult hypertension and obesity in women.
Curhan G, Chertow G, Willett W, Spiegelman D, Colditz G, Manson J, Speizer F, Stampfer M. Birth weight and adult hypertension and obesity in women. Circulation 1996, 94: 1310-5. PMID: 8822985, DOI: 10.1161/01.cir.94.6.1310.Peer-Reviewed Original ResearchConceptsAge-adjusted odds ratioHealth Study IIBody mass indexBirth weightYears of ageOdds ratioNHS IMass indexNurses' Health Study INurses' Health Study IIAdult body mass indexHealth Study INHS II cohortDevelopment of hypertensionLow birth weightPhysician-diagnosed hypertensionRisk of hypertensionHigh birth weightEarly life exposureAdult hypertensionNHS IIBlood pressureLowest quintileRisk factorsLife exposureProspective study of oral contraceptives and hypertension among women in the United States.
Chasan-Taber L, Willett W, Manson J, Spiegelman D, Hunter D, Curhan G, Colditz G, Stampfer M. Prospective study of oral contraceptives and hypertension among women in the United States. Circulation 1996, 94: 483-9. PMID: 8759093, DOI: 10.1161/01.cir.94.3.483.Peer-Reviewed Original ResearchConceptsOral contraceptivesBody mass indexMass indexRelative riskFamily historyAge-adjusted relative riskPast usersHigh-dose pillsMultivariate relative riskOral contraceptive useProspective cohort studyRisk of hypertensionCoronary heart diseaseRisk of developmentLow-dose formulationsCurrent usersMicrograms estrogenHypertensive effectCohort studyEffect of ageBlood pressureAlcohol intakeCigarette smokingIncident casesProspective study
1992
Absolute fat mass, percent body fat, and body-fat distribution: which is the real determinant of blood pressure and serum glucose?
Spiegelman D, Israel R, Bouchard C, Willett W. Absolute fat mass, percent body fat, and body-fat distribution: which is the real determinant of blood pressure and serum glucose? American Journal Of Clinical Nutrition 1992, 55: 1033-1044. PMID: 1595574, DOI: 10.1093/ajcn/55.6.1033.Peer-Reviewed Original ResearchConceptsBody mass indexBlood pressurePercent body fatAbsolute fat massFat massSerum glucoseBody fatBlood glucoseDiastolic blood pressureBody fat distributionCigarette smoking statusCurrent cigarette smoking statusRegional fat distributionMultiple skinfold thicknessesRelative fat massMass indexFat distributionOverall body massSkinfold thicknessBody compositionStudy centersGold standardHip girthStrongest predictorUnderwater weighing
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply