2025
Nonparametric Estimation of the Potential Impact Fraction and the Population Attributable Fraction With Individual‐Level and Aggregated Data
Chan C, Zepeda‐Tello R, Camacho‐García‐Formentí D, Cudhea F, Meza R, Rodrigues E, Spiegelman D, Barrientos‐Gutierrez T, Zhou X. Nonparametric Estimation of the Potential Impact Fraction and the Population Attributable Fraction With Individual‐Level and Aggregated Data. Statistics In Medicine 2025, 44: e70214. PMID: 40798868, DOI: 10.1002/sim.70214.Peer-Reviewed Original ResearchConceptsDistributional assumptionsFinite sample performanceImpact of distributional assumptionsPotential impact fractionNonparametric estimationSample performanceDistributional violationsPopulation attributable fractionImpact fractionNonparametric methodsSimulation studyContinuous exposure dataPopulation impact fractionsAttributable fractionSugar-sweetened beverage consumptionIncidence of type 2 diabetesAssumptionsExposure distributionEstimationAggregate dataBeverage consumptionNonparametricType 2 diabetesIndividual-levelTarget population
2022
Cardiovascular Risk Factors Mediate the Long-Term Maternal Risk Associated With Hypertensive Disorders of Pregnancy
Stuart JJ, Tanz LJ, Rimm EB, Spiegelman D, Missmer SA, Mukamal KJ, Rexrode KM, Rich-Edwards JW. Cardiovascular Risk Factors Mediate the Long-Term Maternal Risk Associated With Hypertensive Disorders of Pregnancy. Journal Of The American College Of Cardiology 2022, 79: 1901-1913. PMID: 35550687, PMCID: PMC9176211, DOI: 10.1016/j.jacc.2022.03.335.Peer-Reviewed Original ResearchConceptsCVD risk factorsRates of CVDHealth Study IIRisk of CVDBody mass indexGestational hypertensionType 2 diabetesRisk factorsChronic hypertensionHypertensive disordersMass indexNurses' Health Study IIPrepregnancy body mass indexHistory of HDPCardiovascular risk factorsOverweight/obesityProportional hazards modelIncident CVDCVD preventionNormotensive pregnanciesFirst pregnancyPotential confoundersParental historyHypertensionHazards model
2019
Substituting brown rice for white rice on diabetes risk factors in India: a randomised controlled trial
Malik V, Sudha V, Wedick N, RamyaBai M, Vijayalakshmi P, Lakshmipriya N, Gayathri R, Kokila A, Jones C, Hong B, Li R, Krishnaswamy K, Anjana R, Spiegelman D, Willett W, Hu F, Mohan V. Substituting brown rice for white rice on diabetes risk factors in India: a randomised controlled trial. British Journal Of Nutrition 2019, 121: 1389-1397. PMID: 31006420, PMCID: PMC6948352, DOI: 10.1017/s000711451900076x.Peer-Reviewed Original ResearchConceptsBrown rice groupMetabolic syndromePrimary outcomeRisk factorsHigh-sensitivity C-reactive proteinRandomised cross-over trialT2D risk factorsDiabetes risk factorsC-reactive proteinCross-over trialType 2 diabetesWhite rice groupMeals/dHs-CRPSecondary outcomesElevated BMIWashout periodInsulin resistanceBlood glucoseEpidemiological evidenceWhite riceT2D riskUrban South IndiaBMISyndrome
2018
Cashew Nut Consumption Increases HDL Cholesterol and Reduces Systolic Blood Pressure in Asian Indians with Type 2 Diabetes: A 12-Week Randomized Controlled Trial
Mohan V, Gayathri R, Jaacks LM, Lakshmipriya N, Anjana RM, Spiegelman D, Jeevan RG, Balasubramaniam KK, Shobana S, Jayanthan M, Gopinath V, Divya S, Kavitha V, Vijayalakshmi P, Bai R M, Unnikrishnan R, Sudha V, Krishnaswamy K, Salas-Salvadó J, Willett WC. Cashew Nut Consumption Increases HDL Cholesterol and Reduces Systolic Blood Pressure in Asian Indians with Type 2 Diabetes: A 12-Week Randomized Controlled Trial. Journal Of Nutrition 2018, 148: 63-69. PMID: 29378038, DOI: 10.1093/jn/nxx001.Peer-Reviewed Original ResearchConceptsSystolic blood pressureBlood pressureNut consumptionBody weightAsian IndiansHDL cholesterolDiabetic dietNut supplementationSelf-reported dietary intakeStandard diabetic dietClinical Trials RegistryHDL cholesterol concentrationsPlasma HDL cholesterolType 2 diabetesCashew nut consumptionBlood lipidsControlled TrialsTrials RegistryGlycemic variablesLipid variablesDietary intakeIntervention groupLipid profileCardiovascular diseaseRobust variance estimation
2017
A Mixed-Methods Study on Acceptability, Tolerability, and Substitution of Brown Rice for White Rice to Lower Blood Glucose Levels among Nigerian Adults
Adebamowo SN, Eseyin O, Yilme S, Adeyemi D, Willett WC, Hu FB, Spiegelman D, Adebamowo CA, Initiative T. A Mixed-Methods Study on Acceptability, Tolerability, and Substitution of Brown Rice for White Rice to Lower Blood Glucose Levels among Nigerian Adults. Frontiers In Nutrition 2017, 4: 33. PMID: 28775984, PMCID: PMC5517499, DOI: 10.3389/fnut.2017.00033.Peer-Reviewed Original ResearchBody mass indexGlucose levelsTwo-hour postprandial blood glucoseMean body mass indexLarge-scale intervention trialsPostprandial glucose levelsPostprandial blood glucoseBlood sugar levelsTimes/weekType 2 diabetesBlood glucose levelsFocus group discussionsWhole grain productsBrown rice mealLong-term trialsBrown rice consumptionConsumption of mealsMass indexIntervention trialsMean ageBlood glucoseNigerian adultsWhite riceMetabolic disordersLower risk
2013
Preventing the global burden of type 2 diabetes by improving the quality of staple foods: The Global Nutrition and Epidemiologic Transition Initiative
Mattei J, Malik V, Wedick N, Spiegelman D, Hu F, Willett W, Campos H. Preventing the global burden of type 2 diabetes by improving the quality of staple foods: The Global Nutrition and Epidemiologic Transition Initiative. The FASEB Journal 2013, 27: 1055.23-1055.23. DOI: 10.1096/fasebj.27.1_supplement.1055.23.Peer-Reviewed Original ResearchType 2 diabetesEpidemiological transitionNutrition transitionOverall death rateCause of deathDiabetes preventionMedian ageFood balance sheetsHigh-income countriesGlobal burdenEpidemic proportionsDiabetesAppropriate interventionsDeath ratePercent energyLife expectancyPilot dataAdverse changesTraditional foodsIntakeGlobal nutritionNutritionFoodGlobal research effortStaple food
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