2025
Olive tree at the intersection of environment, public health, and One Health: a sustainable path to global wellbeing
Katsafadou A, Prodromou S, Aalizadeh R, White J, Thomaidis N, Vizirianakis I, Anastas P, Kyriakides T, Pastides H, Piscitelli P, Colao A, Thompson D, Vasiliou V. Olive tree at the intersection of environment, public health, and One Health: a sustainable path to global wellbeing. Frontiers In Public Health 2025, 13: 1658525. DOI: 10.3389/fpubh.2025.1658525.Peer-Reviewed Original ResearchOlive treesEnvironmental impactHuman healthOlive by-productsClimate change mitigationHealth benefitsSustainable agricultural practicesHuman health benefitsMonounsaturated fatty acidsOlive sectorGreenhouse gas emissionsBiodiversity supportEcosystem stewardshipBy-productsFeed additivesOlive oil cultivationAnimal nutritionCarbon sequestrationSoil conservationOlive oil productionSustainable agricultureFood productsLivestock healthAntioxidant propertiesEcological sustainabilitySynergistic toxicity in alcohol-associated liver disease and PFAS exposure
Stem A, Tieghi R, Chatzi V, Kleinstreuer N, Valvi D, Thompson D, Vasiliou V. Synergistic toxicity in alcohol-associated liver disease and PFAS exposure. Toxicological Sciences 2025, kfaf110. PMID: 40737496, DOI: 10.1093/toxsci/kfaf110.Peer-Reviewed Original ResearchAlcohol-associated liver diseaseLiver diseaseChronic ethanol intakeCentral mechanismsHepatotoxic effectsPolyfluoroalkyl substancesHigh-risk populationOxidative stressDysregulated lipid metabolismEthanol intakeLiver functionLiver injuryAcetaldehyde-induced cytotoxicityHepatic functionHepatocellular damageOxidative stress inductionLiver pathologyGlobal morbidityPathogenic pathwaysPolyfluoroalkyl substances exposuresExposure to polyfluoroalkyl substancesFatty acid oxidationHealthcare accessEffects of polyfluoroalkyl substancesMultiple mechanismsLessons learned from aldehyde dehydrogenases as non-P450 aldehyde-oxidizing enzymes: implications for the ‘exposome’ and human health
Lisgara A, Thompson D, Nebert D, Vasiliou V. Lessons learned from aldehyde dehydrogenases as non-P450 aldehyde-oxidizing enzymes: implications for the ‘exposome’ and human health. Expert Opinion On Drug Metabolism & Toxicology 2025, 21: 915-919. PMID: 40591371, DOI: 10.1080/17425255.2025.2524872.Peer-Reviewed Original ResearchConceptsAldehyde dehydrogenaseAldehyde-oxidizing enzymesNon-P450ALDH superfamilyNitric oxide-related speciesEnzymatic diversityGenetic screeningALDH polymorphismsCytochrome P450 enzymesRedox balancePrecise risk assessmentNeurodegenerative diseasesEnvironmental stressorsClinical implicationsDetoxication functionEnzymeP450 enzymesLifetime environmental exposuresTherapeutic targetPolymorphismCellular damageDehydrogenaseEnvironmental exposuresClinical relevanceHuman healthUpdate of the sideroflexin (SLC56) gene family
Katsafadou A, Nebert D, Krupenko S, Thompson D, Vasiliou V. Update of the sideroflexin (SLC56) gene family. Human Genomics 2025, 19: 69. PMID: 40542427, PMCID: PMC12180156, DOI: 10.1186/s40246-025-00779-w.Peer-Reviewed Original ResearchConceptsIron-sulfur cluster assemblyMitochondrial iron-regulatedMitochondrial iron homeostasisMitochondrial serine transporterMitochondrial transmembrane proteinOxidative phosphorylation disordersSolute carrier familyEukaryotic speciesOne-carbon metabolismMitochondrial researchGene familyModel organismsCellular homeostasisEvolutionary trajectoriesMitochondrial metabolismTransmembrane domainCongenital sideroblastic anemiaTransmembrane proteinsCarrier familySideroflexinHeme biosynthesisIron regulationCitrate metabolismMitochondrial functionSerine transportAdvancing translational exposomics: bridging genome, exposome and personalized medicine
Sarigiannis D, Karakitsios S, Anesti O, Stem A, Valvi D, Sumner S, Chatzi L, Snyder M, Thompson D, Vasiliou V. Advancing translational exposomics: bridging genome, exposome and personalized medicine. Human Genomics 2025, 19: 48. PMID: 40307849, PMCID: PMC12044731, DOI: 10.1186/s40246-025-00761-6.Peer-Reviewed Original ResearchConceptsExposome-wide association studyBridge genomicsLifestyle exposuresEnhancing causal inferencePublic health decision-makingEnvironmental health researchHealth decision-makingMulti-omics technologiesGenomic variationGenomic dataAssociation studiesHealth outcomesBioinformatics approachHealth researchPrecision preventionGenetic variabilityExposome dataExposure-response relationshipMulti-OmicsGenomeInternal exposomeVulnerable populationsComplex diseasesDisease phenotypePublic health4.09 Aldehyde Dehydrogenases
Vasiliou V, Lisgara A, Krupenko S, Krupenko N, Alayyoub M, Petersen D, Thompson D. 4.09 Aldehyde Dehydrogenases. 2025, 183-210. DOI: 10.1016/b978-0-323-95488-4.00287-4.Peer-Reviewed Original ResearchAldehyde dehydrogenaseTransgenic knockout mouse modelLate-onset Alzheimer's diseaseAldehyde dehydrogenase superfamilyAldehyde dehydrogenase geneNAD(P)+-dependent enzymesType II hyperprolinemiaHuman genomeDehydrogenase geneKnockout mouse modelPoor cancer prognosisExogenous aldehydesMolecular basisSpastic paraplegiaPhysiological processesAlzheimer's diseaseDe Barsy syndromeClinical phenotypeSjogren-Larsson syndromeGenesCancer stem cellsDehydrogenaseEnzyme inactivationEnzymeBarsy syndrome
2024
CYP2E1 in 1,4-dioxane metabolism and liver toxicity: insights from CYP2E1 knockout mice study
Wang Y, Charkoftaki G, Orlicky D, Davidson E, Aalizadeh R, Sun N, Ginsberg G, Thompson D, Vasiliou V, Chen Y. CYP2E1 in 1,4-dioxane metabolism and liver toxicity: insights from CYP2E1 knockout mice study. Archives Of Toxicology 2024, 98: 3241-3257. PMID: 39192018, PMCID: PMC11500436, DOI: 10.1007/s00204-024-03811-5.Peer-Reviewed Original ResearchCYP2E1-null miceLiver toxicityDrinking waterOxidative DNA damageLiver carcinogenAbstract1,4-DioxaneDNA damage repair responseImpaired DNA damage repairWater contaminationOxidative stressElevated oxidative stressEnvironmental pollutionKnockout mouse studiesDamage repair responseCYP2E1-nullMale wildtypeWT miceDNA damageDX exposureRisk assessmentRedox dysregulationCYP2E1 inductionLiver oxidative stressHigh dosesMouse studiesThe European Union Ban on Microplastics Includes Artificial Turf Crumb Rubber Infill: Other Nations Should Follow Suit
Zuccaro P, Thompson D, de Boer J, Llompart M, Watterson A, Bilott R, Birnbaum L, Vasiliou V. The European Union Ban on Microplastics Includes Artificial Turf Crumb Rubber Infill: Other Nations Should Follow Suit. Environmental Science And Technology 2024, 58: 2591-2594. PMID: 38301275, DOI: 10.1021/acs.est.4c00047.Peer-Reviewed Original Research1,4-Dioxane
Stouffer A, Erickson C, Krick M, Chen Y, Ginsberg G, Loch-Caruso R, Jones R, Madrigal J, Thompson D, Vasliou V. 1,4-Dioxane. 2024, 843-849. DOI: 10.1016/b978-0-12-824315-2.00831-9.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsPersistent environmental contaminationEnvironmental contaminationEnvironmental behaviorEnvironmental releaseChemical intermediatesWater solubilityPotential negative health effectsDioxaneRecent decadesSoilConsumer productsGroundwaterContaminationHealth effectsSolventSolubilityIntermediatesNegative health effectsStabilizerManagementUsesProductsUseToxicityExposure
2023
Multi-omics profiling reveals cellular pathways and functions regulated by ALDH1B1 in colon cancer cells
Wang Y, Popovic Z, Charkoftaki G, Garcia-Milian R, Lam T, Thompson D, Chen Y, Vasiliou V. Multi-omics profiling reveals cellular pathways and functions regulated by ALDH1B1 in colon cancer cells. Chemico-Biological Interactions 2023, 384: 110714. PMID: 37716420, PMCID: PMC10807983, DOI: 10.1016/j.cbi.2023.110714.Peer-Reviewed Original ResearchColon cancer cellsCellular stress response pathwaysStress response pathwaysMulti-omics analysisCancer cellsSecond messenger signalingMulti-omics profilingNew molecular informationFunctional annotationCellular functionsResponse pathwaysKinase signalingCellular pathwaysColon adenocarcinoma cell lineHuman colon adenocarcinoma cell lineApoptosis signalingEnrichment analysisAldehyde dehydrogenase 1B1Molecular signaturesAdenocarcinoma cell lineMolecular informationSignalingNovel targetProtein expressionCell linesAn AI-powered patient triage platform for future viral outbreaks using COVID-19 as a disease model
Charkoftaki G, Aalizadeh R, Santos-Neto A, Tan W, Davidson E, Nikolopoulou V, Wang Y, Thompson B, Furnary T, Chen Y, Wunder E, Coppi A, Schulz W, Iwasaki A, Pierce R, Cruz C, Desir G, Kaminski N, Farhadian S, Veselkov K, Datta R, Campbell M, Thomaidis N, Ko A, Thompson D, Vasiliou V. An AI-powered patient triage platform for future viral outbreaks using COVID-19 as a disease model. Human Genomics 2023, 17: 80. PMID: 37641126, PMCID: PMC10463861, DOI: 10.1186/s40246-023-00521-4.Peer-Reviewed Original ResearchConceptsCOVID-19 patientsDisease severityViral outbreaksFuture viral outbreaksLength of hospitalizationIntensive care unitWorse disease prognosisLife-threatening illnessEffective medical interventionsCOVID-19Clinical decision treeGlucuronic acid metabolitesNew potential biomarkersHospitalization lengthCare unitComorbidity dataSerotonin levelsDisease progressionHealthy controlsPatient outcomesDisease prognosisPatient transferPatientsHealthcare resourcesPotential biomarkersAlzheimer’s disease: using gene/protein network machine learning for molecule discovery in olive oil
Rita L, Neumann N, Laponogov I, Gonzalez G, Veselkov D, Pratico D, Aalizadeh R, Thomaidis N, Thompson D, Vasiliou V, Veselkov K. Alzheimer’s disease: using gene/protein network machine learning for molecule discovery in olive oil. Human Genomics 2023, 17: 57. PMID: 37420280, PMCID: PMC10327379, DOI: 10.1186/s40246-023-00503-6.Peer-Reviewed Original Research
2022
Assessing extraction-analysis methodology to detect fluorotelomer alcohols (FTOH), a class of perfluoroalkyl and polyfluoroalkyl substances (PFAS), in artificial turf fibers and crumb rubber infill
Zuccaro P, Licato J, Davidson E, Thompson D, Vasiliou V. Assessing extraction-analysis methodology to detect fluorotelomer alcohols (FTOH), a class of perfluoroalkyl and polyfluoroalkyl substances (PFAS), in artificial turf fibers and crumb rubber infill. Case Studies In Chemical And Environmental Engineering 2022, 7: 100280. PMID: 37575658, PMCID: PMC10423336, DOI: 10.1016/j.cscee.2022.100280.Peer-Reviewed Original ResearchUse of clinical chemistry health outcomes and PFAS chain length to predict 28-day rodent oral toxicity
Bellia G, Bilott R, Sun N, Thompson D, Vasiliou V. Use of clinical chemistry health outcomes and PFAS chain length to predict 28-day rodent oral toxicity. Toxicology Methods 2022, 33: 378-387. PMID: 36446747, PMCID: PMC10625160, DOI: 10.1080/15376516.2022.2150591.Peer-Reviewed Original ResearchProteomic profiling reveals an association between ALDH and oxidative phosphorylation and DNA damage repair pathways in human colon adenocarcinoma stem cells
Wang Y, Chen Y, Garcia-Milian R, Golla JP, Charkoftaki G, Lam TT, Thompson DC, Vasiliou V. Proteomic profiling reveals an association between ALDH and oxidative phosphorylation and DNA damage repair pathways in human colon adenocarcinoma stem cells. Chemico-Biological Interactions 2022, 368: 110175. PMID: 36162455, PMCID: PMC9891852, DOI: 10.1016/j.cbi.2022.110175.Peer-Reviewed Original ResearchConceptsCancer stem cellsProteomic profilingOxidative phosphorylationLabel-free quantitative proteomic analysisDNA damage repair pathwaysQuantitative proteomic analysisAldehyde dehydrogenase familyColon cancer stem cellsCOLO320DM cellsStem cellsNucleotide excision repairDamage repair pathwaysIngenuity Pathway AnalysisCell populationsProteomic analysisProteomic datasetsDehydrogenase familyMetabolic switchProteomic studiesRepair pathwaysCellular pathwaysALDH enzymatic activityCellular survivalExcision repairALDH activityArtificial turf and crumb rubber infill: An international policy review concerning the current state of regulations
Zuccaro P, Thompson D, de Boer J, Watterson A, Wang Q, Tang S, Shi X, Llompart M, Ratola N, Vasiliou V. Artificial turf and crumb rubber infill: An international policy review concerning the current state of regulations. Environmental Challenges 2022, 9: 100620. PMID: 36644410, PMCID: PMC9838222, DOI: 10.1016/j.envc.2022.100620.Peer-Reviewed Original ResearchEuropean UnionOnline archivesPolicy reviewNotable policiesPolicy reportsAgency officialsDirect policyGovernmental policiesMost policiesUnited NationsEnvironmental policyRespective countriesPolicyGovernmental agenciesRegulatory approachesUnited KingdomCountriesUnited StatesUnionHealth researchPublicGrey literatureEnvironmental health risksCountry regulationsSurveillance measuresOxidative stress, glutathione, and CYP2E1 in 1,4-dioxane liver cytotoxicity and genotoxicity: insights from animal models
Wang Y, Charkoftaki G, Davidson E, Orlicky D, Tanguay R, Thompson D, Vasiliou V, Chen Y. Oxidative stress, glutathione, and CYP2E1 in 1,4-dioxane liver cytotoxicity and genotoxicity: insights from animal models. Current Opinion In Environmental Science & Health 2022, 29: 100389. PMID: 37483863, PMCID: PMC10361651, DOI: 10.1016/j.coesh.2022.100389.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsOxidative stressUnique mouse modelRelevant low dosesDirect genotoxic effectsLiver cytotoxicityCYP2E1 activationMouse modelAnimal modelsHuman studiesCarcinogenic pathwaysLiver carcinogenicityLow dosesCausal roleGenotoxic effectsHuman exposureUndetermined mechanismPublic healthCarcinogenicityLiver genotoxicityDrinking water contaminantsMechanistic dataGenotoxicityFuture animalCytotoxicityCYP2E1Liver metabolomics identifies bile acid profile changes at early stages of alcoholic liver disease in mice
Charkoftaki G, Tan WY, Berrios-Carcamo P, Orlicky DJ, Golla JP, Garcia-Milian R, Aalizadeh R, Thomaidis NS, Thompson DC, Vasiliou V. Liver metabolomics identifies bile acid profile changes at early stages of alcoholic liver disease in mice. Chemico-Biological Interactions 2022, 360: 109931. PMID: 35429548, PMCID: PMC9364420, DOI: 10.1016/j.cbi.2022.109931.Peer-Reviewed Original ResearchConceptsAlcoholic liver diseaseEthanol-consuming miceAlcohol consumptionLiver diseaseDevelopment of ALDBile acid changesChronic alcohol drinkingChronic alcohol consumptionLieber-DeCarli dietAlcohol-induced alterationsGlobal healthcare problemBile acid biosynthesisAlcohol drinkingLiver histopathologyTissue injuryClinical consequencesUntargeted metabolomics analysisEarly stagesComplex pathologyMinimal changesUntargeted metabolomics approachEarly onsetHealthcare problemMiceLiverOxidative stress induces inflammation of lens cells and triggers immune surveillance of ocular tissues
Thompson B, Davidson EA, Chen Y, Orlicky DJ, Thompson DC, Vasiliou V. Oxidative stress induces inflammation of lens cells and triggers immune surveillance of ocular tissues. Chemico-Biological Interactions 2022, 355: 109804. PMID: 35123994, PMCID: PMC9136680, DOI: 10.1016/j.cbi.2022.109804.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcysteineAnimalsButhionine SulfoximineCell LineChemokine CCL7CytokinesDown-RegulationEpithelial CellsEpithelial-Mesenchymal TransitionEyeGlutamate-Cysteine LigaseImmunity, InnateLens, CrystallineLeukocytesMiceMice, Inbred C57BLMice, KnockoutOxidative StressReactive Oxygen SpeciesUp-RegulationConceptsPosterior capsule opacificationCytokine expressionKO miceImmune surveillanceOxidative stressLens epithelial cellsOcular structuresLens cellsDevelopment of PCOEpithelial cellsInnate immune cellsExpression of cytokinesEx vivo inductionOcular surface tissuesExpression of markersImmune response genesCON miceControl miceCapsule opacificationImmune cellsPostnatal dayΑ-SMAMouse modelOcular tissuesVivo induction
2020
Interplay between APC and ALDH1B1 in a newly developed mouse model of colorectal cancer
Golla JP, Kandyliari A, Tan WY, Chen Y, Orlicky DJ, Thompson DC, Shah YM, Vasiliou V. Interplay between APC and ALDH1B1 in a newly developed mouse model of colorectal cancer. Chemico-Biological Interactions 2020, 331: 109274. PMID: 33007288, PMCID: PMC9201852, DOI: 10.1016/j.cbi.2020.109274.Peer-Reviewed Original ResearchConceptsColorectal cancerColonic adenomasPresent preliminary studyMouse modelConsecutive daysLarge colonic adenomaPresence of adenomasApc mouse modelColon tumor growthMouse xenograft modelColon epithelial cellsFurther mechanistic studiesCancer mortalityKO miceLeading causeColorectal adenomasCRC developmentImmunohistochemical analysisXenograft modelTumor growthColorectal tumorigenesisAdenomasExpression scoreMale ApcMice
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