2025
The impact of orthopoxvirus vaccination and Mpox infection on cross-protective immunity: a multicohort observational study
Crandell J, Monteiro V, Pischel L, Fang Z, Conde L, Zhong Y, Lawres L, de Asis G, Maciel G, Zaleski A, Lira G, Higa L, Breban M, Vogels C, Caria J, Pinto A, Almeida V, Maltez F, Cordeiro R, Póvoas D, Grubaugh N, Aoun-Barakat L, Grifoni A, Sette A, Castineiras T, Chen S, Yildirim I, Vale A, Omer S, Lucas C. The impact of orthopoxvirus vaccination and Mpox infection on cross-protective immunity: a multicohort observational study. The Lancet Microbe 2025, 6: 101098. PMID: 40311645, DOI: 10.1016/j.lanmic.2025.101098.Peer-Reviewed Original ResearchT cellsAntigenic distanceMpox virusBreadth of immune responsesSmallpox vaccineThird-generation smallpox vaccineImmune responseObservational studyCross-reactive immune responsesT cell cross-reactivityT cell memoryT cell responsesImmune memory responseVaccina virusCross-neutralising activityFc-mediated functionsMucosal humoral responsesVirus neutralisation titresCross-reactive responsesCross-protectionCross-protective immunityCowpox virusNeutralising antibody titresAntibody effector functionsEffector functions
2022
Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19
Unterman A, Sumida TS, Nouri N, Yan X, Zhao AY, Gasque V, Schupp JC, Asashima H, Liu Y, Cosme C, Deng W, Chen M, Raredon MSB, Hoehn KB, Wang G, Wang Z, DeIuliis G, Ravindra NG, Li N, Castaldi C, Wong P, Fournier J, Bermejo S, Sharma L, Casanovas-Massana A, Vogels CBF, Wyllie AL, Grubaugh ND, Melillo A, Meng H, Stein Y, Minasyan M, Mohanty S, Ruff WE, Cohen I, Raddassi K, Niklason L, Ko A, Montgomery R, Farhadian S, Iwasaki A, Shaw A, van Dijk D, Zhao H, Kleinstein S, Hafler D, Kaminski N, Dela Cruz C. Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19. Nature Communications 2022, 13: 440. PMID: 35064122, PMCID: PMC8782894, DOI: 10.1038/s41467-021-27716-4.Peer-Reviewed Original ResearchMeSH KeywordsAdaptive ImmunityAgedAntibodies, Monoclonal, HumanizedCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCells, CulturedCOVID-19COVID-19 Drug TreatmentFemaleGene Expression ProfilingGene Expression RegulationHumansImmunity, InnateMaleReceptors, Antigen, B-CellReceptors, Antigen, T-CellRNA-SeqSARS-CoV-2Single-Cell AnalysisConceptsProgressive COVID-19B cell clonesSingle-cell analysisT cellsImmune responseMulti-omics single-cell analysisCOVID-19Cell clonesAdaptive immune interactionsSevere COVID-19Dynamic immune responsesGene expressionSARS-CoV-2 virusAdaptive immune systemSomatic hypermutation frequenciesCellular effectsProtein markersEffector CD8Immune signaturesProgressive diseaseHypermutation frequencyProgressive courseClassical monocytesClonesImmune interactions
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply