Discovery of a Widespread Polyamine–Low-Molecular-Weight Thiol Hybrid Pathway in Clostridioides difficile
Hunt R, Oh J, Jain A, Kuo T, Berardi D, Jian W, Song D, Wu Q, Goodman A, Palm N, Zimmermann M, Johnson C, Crawford J. Discovery of a Widespread Polyamine–Low-Molecular-Weight Thiol Hybrid Pathway in Clostridioides difficile. ACS Infectious Diseases 2025, 11: 2246-2264. PMID: 40671632, PMCID: PMC12403189, DOI: 10.1021/acsinfecdis.5c00286.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiogenic PolyaminesBiosynthetic PathwaysClostridioides difficileClostridium InfectionsColorectal NeoplasmsHumansMiceMicrobiotaSulfhydryl CompoundsConceptsLow-molecular-weight thiolsTwo-gene operonBacteroides uniformisExpression of polyaminesAssociated with diseaseColorectal cancerBiosynthesis genesCommunity-level changesClostridioides difficile infectionGut homeostasisGenetic screeningGI mucosal biopsiesRisk of colorectal cancerHybrid pathwayMicrobial metabolismHybrid metabolitesGastrointestinal (GI) tractClostridioides difficileDiverse collectionHost immunityMucosal biopsiesSevere inflammationGenesCationic metabolitesMucolytic agent
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