2025
Senescence Cell Induction Methods Display Diverse Metabolic Reprogramming and Reveal an Underpinning Serine/Taurine Reductive Metabolic Phenotype
Berardi D, Farrell G, AlSultan A, McCulloch A, Hall N, Sousa R, Jimenez M, Selman C, Bellantuono I, Johnson C, Rattray Z, Rattray N. Senescence Cell Induction Methods Display Diverse Metabolic Reprogramming and Reveal an Underpinning Serine/Taurine Reductive Metabolic Phenotype. Aging Cell 2025, 24: e70127. PMID: 40530891, PMCID: PMC12341781, DOI: 10.1111/acel.70127.Peer-Reviewed Original ResearchSenescence inductionLabel-free proteomicsDNA damage markersRedox circuitsCell inductionImpaired proteostasisP21 levelsTherapeutic strategiesCellular phenotypesMetabolic phenotypeMetabolic reprogrammingProteomic heterogeneityMetabolic shiftSenescence markersProteomic profilingMetabolic processesSenescence biomarkersDamage markersProtein levelsSenescenceSubphenotypesSenescence modelInfluence cellsPhenotypeInduction
2020
Sex Differences in Colon Cancer Metabolism Reveal A Novel Subphenotype
Cai Y, Rattray NJW, Zhang Q, Mironova V, Santos-Neto A, Hsu KS, Rattray Z, Cross JR, Zhang Y, Paty PB, Khan SA, Johnson CH. Sex Differences in Colon Cancer Metabolism Reveal A Novel Subphenotype. Scientific Reports 2020, 10: 4905. PMID: 32184446, PMCID: PMC7078199, DOI: 10.1038/s41598-020-61851-0.Peer-Reviewed Original ResearchConceptsRight-sided colon cancerColorectal cancerCRC patientsColon cancer metabolismPoor clinical outcomePatient colon tumorsAsparagine synthetase expressionNovel subphenotypesClinical outcomesAmino acid uptakePoor survivalLower incidenceAnatomic locationHigh incidenceTherapeutic targetColon cancerCancer Genomic AtlasClinical importanceColon tumorsTumor progressionAberrant metabolismNormal tissuesPatientsSubphenotypesAcid uptake
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