2016
Decreased Anti-Tumor Cytotoxic Immunity among Microsatellite-Stable Colon Cancers from African Americans
Basa R, Davies V, Li X, Murali B, Shah J, Yang B, Li S, Khan M, Tian M, Tejada R, Hassan A, Washington A, Mukherjee B, Carethers J, McGuire K. Decreased Anti-Tumor Cytotoxic Immunity among Microsatellite-Stable Colon Cancers from African Americans. PLOS ONE 2016, 11: e0156660. PMID: 27310868, PMCID: PMC4911070, DOI: 10.1371/journal.pone.0156660.Peer-Reviewed Original ResearchConceptsGranzyme B+ cellsColorectal cancerCytotoxic immunityB+ cellsAnti-tumor cytotoxic T lymphocytesColon cancerMicrosatellite-stable colon cancerCytotoxic T lymphocytesIL-17 expressionWilcoxon rank sum testProtection to patientsAfrican American colorectal cancerRank sum testTwo-sample Wilcoxon rank-sum testCD57+CD8+Invasive borderCytotoxic markersNo significant differenceT lymphocytesColon tumorsDescriptive summary statisticsImmune biomarkersTumor samplesImmune cytotoxicity
1996
Prostate-specific membrane antigen: a novel folate hydrolase in human prostatic carcinoma cells.
Pinto J, Suffoletto B, Berzin T, Qiao C, Lin S, Tong W, May F, Mukherjee B, Heston W. Prostate-specific membrane antigen: a novel folate hydrolase in human prostatic carcinoma cells. Clinical Cancer Research 1996, 2: 1445-51. PMID: 9816319.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, SurfaceCarboxypeptidasesCell FractionationCell MembraneFolic AcidGamma-Glutamyl HydrolaseGlutamate Carboxypeptidase IIHumansHydrogen-Ion ConcentrationHydrolasesImmunohistochemistryMaleMethotrexatePolyglutamic AcidProstatic NeoplasmsPteroylpolyglutamic AcidsSubstrate SpecificityTumor Cells, CulturedConceptsFolate hydrolase activityProtein prostate-specific membrane antigenHuman prostate cancerPC-3 cellsProstate cancerMembrane-bound enzymeHydrolase activityMonoclonal antibodiesLNCaP cellsTransfection of PC-3 cellsResistance to methotrexate therapyClass II membrane proteinHuman prostate cancer cell linesTreatment of prostate cancerMembrane fractionProstate cancer cell linesHuman prostate carcinoma cellsLNCaP cell membranesProstate-specific membraneHuman prostate adenocarcinoma cellsPhase 3 trialProstate carcinoma cellsProstate adenocarcinoma cellsAbsence of thiol reagentsEukaryotic expression vector