2023
Environmental risk scores of persistent organic pollutants associate with higher ALS risk and shorter survival in a new Michigan case/control cohort
Goutman S, Boss J, Jang D, Mukherjee B, Richardson R, Batterman S, Feldman E. Environmental risk scores of persistent organic pollutants associate with higher ALS risk and shorter survival in a new Michigan case/control cohort. Journal Of Neurology Neurosurgery & Psychiatry 2023, 95: 241-248. PMID: 37758454, PMCID: PMC11060633, DOI: 10.1136/jnnp-2023-332121.Peer-Reviewed Original ResearchConceptsEnvironmental risk scoreAmyotrophic lateral sclerosis riskPersistent organic pollutantsALS riskInterquartile increaseHigher ALS riskAssociated with ALS riskModify disease riskOrganochlorine pesticidesAssociated with riskRisk reduction strategiesPersistent organic pollutant analysisIndividual persistent organic pollutantsPersistent organic pollutant mixturesHazard ratioDisease riskRisk scoreCase/control cohortEnvironmental exposuresControl participantsGenetic susceptibilityPolychlorinated biphenylsAlpha-hexachlorocyclohexaneOrganic pollutantsMortality rate
2016
Association of Environmental Toxins With Amyotrophic Lateral Sclerosis
Su F, Goutman S, Chernyak S, Mukherjee B, Callaghan B, Batterman S, Feldman E. Association of Environmental Toxins With Amyotrophic Lateral Sclerosis. JAMA Neurology 2016, 73: 803-11. PMID: 27159543, PMCID: PMC5032145, DOI: 10.1001/jamaneurol.2016.0594.Peer-Reviewed Original ResearchMeSH KeywordsAgedAmyotrophic Lateral SclerosisCase-Control StudiesEnvironmental ExposureEnvironmental PollutantsFemaleGas Chromatography-Mass SpectrometryHumansMaleMichiganMiddle AgedMultivariate AnalysisOccupational ExposureOdds RatioOutcome Assessment, Health CareRetrospective StudiesRisk FactorsSurveys and QuestionnairesConceptsBrominated flame retardantsPersistent environmental pollutantsResidential exposureOrganochlorine pesticidesPolychlorinated biphenylsOdds of ALSAssociation of occupational exposureDisease risk factorsExposure time windowsEnvironmental pollutionRisk factorsModifiable risk factorsMultivariate modelOccupational exposureLogistic regression modelsCase-control studySurvey dataFamily history of amyotrophic lateral sclerosisExposure windowsIncreased oddsFamily historyAssociated with amyotrophic lateral sclerosisHistory of amyotrophic lateral sclerosisRegression modelsMilitary service