2023
Environmental risk scores of persistent organic pollutants associate with higher ALS risk and shorter survival in a new Michigan case/control cohort
Goutman S, Boss J, Jang D, Mukherjee B, Richardson R, Batterman S, Feldman E. Environmental risk scores of persistent organic pollutants associate with higher ALS risk and shorter survival in a new Michigan case/control cohort. Journal Of Neurology Neurosurgery & Psychiatry 2023, 95: 241-248. PMID: 37758454, PMCID: PMC11060633, DOI: 10.1136/jnnp-2023-332121.Peer-Reviewed Original ResearchConceptsEnvironmental risk scoreAmyotrophic lateral sclerosis riskPersistent organic pollutantsALS riskInterquartile increaseHigher ALS riskAssociated with ALS riskModify disease riskOrganochlorine pesticidesAssociated with riskRisk reduction strategiesPersistent organic pollutant analysisIndividual persistent organic pollutantsPersistent organic pollutant mixturesHazard ratioDisease riskRisk scoreCase/control cohortEnvironmental exposuresControl participantsGenetic susceptibilityPolychlorinated biphenylsAlpha-hexachlorocyclohexaneOrganic pollutantsMortality rate
2019
High plasma concentrations of organic pollutants negatively impact survival in amyotrophic lateral sclerosis
Goutman S, Boss J, Patterson A, Mukherjee B, Batterman S, Feldman E. High plasma concentrations of organic pollutants negatively impact survival in amyotrophic lateral sclerosis. Journal Of Neurology Neurosurgery & Psychiatry 2019, 90: 907. PMID: 30760645, PMCID: PMC6625908, DOI: 10.1136/jnnp-2018-319785.Peer-Reviewed Original ResearchConceptsPersistent organic pollutantsPolychlorinated biphenylsHigh concentrations of persistent organic pollutantsAmyotrophic lateral sclerosisConcentrations of persistent organic pollutantsEffects of persistent organic pollutantsMeasurement of persistent organic pollutantsHazard rate of mortalitySymptom onset to diagnosisMedian diagnostic ageNegatively impacts survivalLowest quartileIndependent of ageOrganic pollutantsSummary measuresMedian timeClinical featuresMedical recordsRate of mortalityDiagnostic ageEnvironmental exposuresBulbar onsetALS diseaseCervical onsetPlasma concentrations