2021
On cross-ancestry cancer polygenic risk scores
Fritsche L, Ma Y, Zhang D, Salvatore M, Lee S, Zhou X, Mukherjee B. On cross-ancestry cancer polygenic risk scores. PLOS Genetics 2021, 17: e1009670. PMID: 34529658, PMCID: PMC8445431, DOI: 10.1371/journal.pgen.1009670.Peer-Reviewed Original ResearchConceptsPolygenic risk scoresGenome-wide association studiesProstate cancer polygenic risk scoresPolygenic risk score distributionRecruitment of diverse participantsAncestry groupsPolygenic risk score methodsRisk scoreNon-genetic risk factorsElectronic health recordsBreast cancer casesHealth recordsUK BiobankGWAS effortsDisease risk assessmentCancer casesAssociation studiesGenetic dataEuropean ancestryPersonalized risk stratificationSummary statisticsRisk factorsAncestryDiverse participantsField of cancer
2017
Explaining Disparities in Ovarian Cancer Incidence Rates between Women of African and European Ancestry: The Role of Genetic Factors
Mullins M, Mukherjee B, Wu A, Pike M, Pharoah P, Berchuck A, Pearce C. Explaining Disparities in Ovarian Cancer Incidence Rates between Women of African and European Ancestry: The Role of Genetic Factors. Cancer Epidemiology Biomarkers & Prevention 2017, 26: 433-434. DOI: 10.1158/1055-9965.epi-17-0030.Peer-Reviewed Original ResearchGenetic risk scoreOvarian cancer incidence ratesNon-Hispanic White (NHWPopulation attributable risk percentCollaborative Oncological Gene-environment StudyCancer incidence ratesNon-genetic risk factorsIncidence rateAfrican AmericansAssociated with ovarian cancer riskOvarian Cancer Association ConsortiumOophorectomy ratesRisk of ovarian cancerAncestry groupsOvarian cancer riskAttributable risk percentNon-genetic riskGene-environment studiesOvarian cancerSingle nucleotide polymorphismsRisk factorsConditional logistic regressionGRS quintileRisk percentLowest quintile