2022
Exposure to heavy metals and hormone levels in midlife women: The Study of Women's Health Across the Nation (SWAN)
Wang X, Ding N, Harlow S, Randolph J, Mukherjee B, Gold E, Park S. Exposure to heavy metals and hormone levels in midlife women: The Study of Women's Health Across the Nation (SWAN). Environmental Pollution 2022, 317: 120740. PMID: 36436662, PMCID: PMC9897061, DOI: 10.1016/j.envpol.2022.120740.Peer-Reviewed Original ResearchConceptsUrinary metal concentrationsExposure to heavy metalsHeavy metalsMetal concentrationsStudy of Women's HealthAssociation of heavy metalsEnvironmental heavy metal exposureHeavy metal exposureSex hormone-binding globulinFollicle-stimulating hormoneWomen's HealthBayesian kernel machine regressionAssociated with E<sub>2</sub>, TMidlife womenKernel machine regressionMetal exposureSerum hormone levelsMetal mixturesHealth-related factorsNation Multi-Pollutant StudyCalculate percent changesCadmiumHormone levelsProspective cohort studyLinear mixed effects modelsPrediction of telomere length and telomere attrition using a genetic risk score: The multi-ethnic study of atherosclerosis (MESA)
Castro-Diehl C, Smith J, Zhao W, Wang X, Mukherjee B, Seeman T, Needham B. Prediction of telomere length and telomere attrition using a genetic risk score: The multi-ethnic study of atherosclerosis (MESA). Frontiers In Aging 2022, 3: 1021051. PMID: 36304436, PMCID: PMC9592760, DOI: 10.3389/fragi.2022.1021051.Peer-Reviewed Original ResearchMulti-Ethnic Study of AtherosclerosisGenetic risk scoreMulti-Ethnic StudyGenome-wide association studiesStudy of AtherosclerosisAssociated with TLEuropean ancestry genome-wide association studiesEuropean ancestryRisk scoreTL-associated genetic variantsShorter TLEuropean ancestry populationsPredictive of telomere lengthHispanic participantsRace/ethnic groupsLinear mixed effects modelsShorter telomere lengthMixed effects modelsAfrican AmericansTelomere attritionExam 1Association studiesRelative TLTelomere lengthT/S ratioMaternal blood metal concentrations are associated with C-reactive protein and cell adhesion molecules among pregnant women in Puerto Rico
Kim C, Cathey A, Watkins D, Mukherjee B, Rosario-Pabón Z, Vélez-Vega C, Alshawabkeh A, Cordero J, Meeker J. Maternal blood metal concentrations are associated with C-reactive protein and cell adhesion molecules among pregnant women in Puerto Rico. Environmental Epidemiology 2022, 6: e214. PMID: 35975168, PMCID: PMC9374188, DOI: 10.1097/ee9.0000000000000214.Peer-Reviewed Original ResearchVascular cell adhesion moleculeC-reactive proteinLevels of C-reactive proteinAssociated with C-reactive proteinCell adhesion moleculesAdverse birth outcomesIntercellular adhesion moleculeFetal sexAdhesion moleculesBirth outcomesPregnant womenLinear mixed effects modelsVisit 3Visit 1Maternal C-reactive proteinCustomized Luminex assaySignificant associationBlood samplesPositive associationPrenatal metal exposureWeeks gestationLuminex assayMale fetusesBirth cohortAssessed associationsMaternal blood metal concentrations are associated with matrix metalloproteinases (MMPs) among pregnant women in Puerto Rico
Kim C, Cathey A, Watkins D, Mukherjee B, Rosario-Pabón Z, Vélez-Vega C, Alshawabkeh A, Cordero J, Meeker J. Maternal blood metal concentrations are associated with matrix metalloproteinases (MMPs) among pregnant women in Puerto Rico. Environmental Research 2022, 209: 112874. PMID: 35123972, PMCID: PMC10443181, DOI: 10.1016/j.envres.2022.112874.Peer-Reviewed Original ResearchConceptsBlood metal concentrationsAdverse birth outcomesMetal concentrationsAssociated with matrix metalloproteinasesMatrix metalloproteinasesBirth outcomesFetal sexHealthy pregnancyLinear mixed effects modelsUterine remodelingPregnant womenFemale fetusesExposure to heavy metalsHeavy metal exposureCustomized Luminex assayFetal sex effectLevels of inflammatory cytokinesTrimester of pregnancyBlood metal levelsMetal levelsHeavy metalsMetal exposureMeasured blood concentrationsLuminex assayMale fetuses
2021
Individual and joint effects of phthalate metabolites on biomarkers of oxidative stress among pregnant women in Puerto Rico
Cathey A, Eaton J, Ashrap P, Watkins D, Rosario Z, Vega C, Alshawabkeh A, Cordero J, Mukherjee B, Meeker J. Individual and joint effects of phthalate metabolites on biomarkers of oxidative stress among pregnant women in Puerto Rico. Environment International 2021, 154: 106565. PMID: 33882432, PMCID: PMC9923976, DOI: 10.1016/j.envint.2021.106565.Peer-Reviewed Original ResearchConceptsBayesian kernel machine regressionPhthalate metabolitesEnvironmental risk scoreBiomarkers of oxidative stressPregnant womenPhthalate mixtureBayesian kernel machine regression analysisEffects of phthalate metabolitesOxidative stressIndividual phthalate metabolitesLipid oxidative stressUrinary biomarker measurementsKernel machine regressionAdverse birth outcomesPuerto Rico TestsiteOxidative stress biomarkersChemical fractionationContamination threatLongitudinal birth cohortPhthalate compoundsLinear mixed effects modelsBirth outcomesOxidative stress mechanismsStudy visitsPhthalate exposure
2020
Urinary metal mixtures and longitudinal changes in glucose homeostasis: The Study of Women’s Health Across the Nation (SWAN)
Wang X, Mukherjee B, Karvonen-Gutierrez C, Herman W, Batterman S, Harlow S, Park S. Urinary metal mixtures and longitudinal changes in glucose homeostasis: The Study of Women’s Health Across the Nation (SWAN). Environment International 2020, 145: 106109. PMID: 32927284, PMCID: PMC7577932, DOI: 10.1016/j.envint.2020.106109.Peer-Reviewed Original ResearchConceptsEnvironmental risk scoreStudy of Women's HealthWomen's HealthExposure to metal mixturesElevated diabetes riskAssociated with lower HOMA-IRUrinary metal mixtureLongitudinal changesMetal mixturesHOMA-BYears of follow-upRate of changeHOMA-IRAdaptive elastic-netStandard deviation increaseDiabetes riskLinear mixed effects modelsLower HOMA-IRRandom interceptMixed effects modelsRisk scoreAssociated with higher HOMA-IRMetal mixture effectsEpidemiological studiesDeviation increaseUrinary trace metals in association with fetal ultrasound measures during pregnancy
Kim S, Meeker J, Aung M, Yu Y, Mukherjee B, Cantonwine D, McElrath T, Ferguson K. Urinary trace metals in association with fetal ultrasound measures during pregnancy. Environmental Epidemiology 2020, 4: e075. PMID: 32201854, PMCID: PMC7083213, DOI: 10.1097/ee9.0000000000000075.Peer-Reviewed Original ResearchEstimated fetal weightBirth weightFetal weightZ-scoreAssociated with higher birth weightHead circumference z-scoreAssociated with low birth weightMeasures of fetal growthFetal ultrasound measurementsLength z-scoreLow birth weightHigh birth weightMeasured abdominal circumferenceGestational ageFetal growthAbdominal circumferenceHead circumferenceInterquartile range increaseEssential metalsLIFECODES birth cohortFemur lengthGrowth outcomesUltrasound measurementsLinear mixed effects modelsBirth cohort