2016
Decreased Anti-Tumor Cytotoxic Immunity among Microsatellite-Stable Colon Cancers from African Americans
Basa R, Davies V, Li X, Murali B, Shah J, Yang B, Li S, Khan M, Tian M, Tejada R, Hassan A, Washington A, Mukherjee B, Carethers J, McGuire K. Decreased Anti-Tumor Cytotoxic Immunity among Microsatellite-Stable Colon Cancers from African Americans. PLOS ONE 2016, 11: e0156660. PMID: 27310868, PMCID: PMC4911070, DOI: 10.1371/journal.pone.0156660.Peer-Reviewed Original ResearchConceptsGranzyme B+ cellsColorectal cancerCytotoxic immunityB+ cellsAnti-tumor cytotoxic T lymphocytesColon cancerMicrosatellite-stable colon cancerCytotoxic T lymphocytesIL-17 expressionWilcoxon rank sum testProtection to patientsAfrican American colorectal cancerRank sum testTwo-sample Wilcoxon rank-sum testCD57+CD8+Invasive borderCytotoxic markersNo significant differenceT lymphocytesColon tumorsDescriptive summary statisticsImmune biomarkersTumor samplesImmune cytotoxicity
2013
Interaction of Fatty Acid Genotype and Diet on Changes in Colonic Fatty Acids in a Mediterranean Diet Intervention Study
Porenta S, Ko Y, Raskin L, Gruber S, Mukherjee B, Baylin A, Ren J, Djuric Z. Interaction of Fatty Acid Genotype and Diet on Changes in Colonic Fatty Acids in a Mediterranean Diet Intervention Study. Cancer Prevention Research 2013, 6: 1212-1221. PMID: 24022589, PMCID: PMC3840911, DOI: 10.1158/1940-6207.capr-13-0131.Peer-Reviewed Original ResearchConceptsFatty acid desaturaseHealthy Eating dietArachidonic acid concentrationIntake of n-3Fatty acid desaturase genotypeIncreased risk of colon cancerN-6 fatty acidsEating dietsIntake of n-6 fatty acidsRisk of colon cancerFatty acid desaturase gene clusterDietary fat intakeColon cancer riskSerum eicosapentaenoic acidDiet intervention studyInteraction of polymorphismsSerum arachidonic acidFatty acid desaturase geneFatty acidsSingle-nucleotide polymorphismsFat intakeN-3N-6Colon cancerAssociated with genotypeFADS genotype affects change in fatty acid levels after a Mediterranean dietary intervention
Djuric Z, Porenta S, Ren J, Ko Y, Baylin A, Mukherjee B, Gruber S. FADS genotype affects change in fatty acid levels after a Mediterranean dietary intervention. The FASEB Journal 2013, 27: 372.5-372.5. DOI: 10.1096/fasebj.27.1_supplement.372.5.Peer-Reviewed Original ResearchFatty acid levelsProstaglandin E2Allele carriersColonic mucosaFADS genotypesIntake of n-3Increased colon cancer riskIntake of n-6 fatty acidsMediterranean dietary interventionAcid levelsColon cancer riskMinor allele carriersSerum arachidonic acidFatty acidsFatty acid desaturaseN-6 fatty acid levelsPro-inflammatory eicosanoidsColon cancerDietary interventionFADS clusterN-9 fatty acidsCancer riskMediterranean dietLowered intakeN-6 fatty acids