2025
Estimating the Effects of Hypothetical Ambient PM2.5 Interventions on the Risk of Dementia Using the Parametric g-Formula in the UK Biobank Cohort
Lin C, Liu R, Sutton C, DeWan A, Forastiere L, Chen K. Estimating the Effects of Hypothetical Ambient PM2.5 Interventions on the Risk of Dementia Using the Parametric g-Formula in the UK Biobank Cohort. Environmental Health Perspectives 2025, 133: 047007. PMID: 40062909, PMCID: PMC12010936, DOI: 10.1289/ehp14723.Peer-Reviewed Original ResearchConceptsRisk of dementiaParametric g-formulaUK Biobank cohortG-formulaBiobank cohortLate lifeFree of dementiaUK Biobank participantsModifiable risk factorsParticulate matterAerodynamic diameter <Annual average standardBiobank participantsHypothetical interventionAmbient particulate matterNo interventionDementiaRisk differenceInterventionRisk factorsHealth benefitsPotential health benefitsCohortRiskParticipantsThe case-only design is a powerful approach to detect interactions but should be used with caution
Dong R, Wang G, DeWan A, Leal S. The case-only design is a powerful approach to detect interactions but should be used with caution. BMC Genomics 2025, 26: 222. PMID: 40050722, PMCID: PMC11884093, DOI: 10.1186/s12864-025-11318-1.Peer-Reviewed Original ResearchConceptsCase-only designRare disease assumptionType I error rateIncreased type I error ratesDisease prevalenceInvestigated type I errorComplex traitsInteraction termsInteraction effect sizesDetect interactionsCase-control designControlled type I error ratesSample sizeHigher disease prevalenceEffect sizeLow disease prevalenceType I errorPrevalenceExposure frequencyGenesType I andDesign studyEnvironmental factorsTraitsEnvironment interaction
2024
LDER-GE estimates phenotypic variance component of gene–environment interactions in human complex traits accurately with GE interaction summary statistics and full LD information
Dong Z, Jiang W, Li H, DeWan A, Zhao H. LDER-GE estimates phenotypic variance component of gene–environment interactions in human complex traits accurately with GE interaction summary statistics and full LD information. Briefings In Bioinformatics 2024, 25: bbae335. PMID: 38980374, PMCID: PMC11232466, DOI: 10.1093/bib/bbae335.Peer-Reviewed Original ResearchConceptsHuman complex traitsComplex traitsGene-environment interactionsGene-environmentLinkage disequilibriumPhenotypic variance componentsPhenotypic varianceProportion of phenotypic varianceSummary statisticsEuropean ancestry subjectsUK Biobank dataAssociation summary statisticsComplete linkage disequilibriumControlled type I error ratesLD informationLD matrixVariance componentsBiobank dataType I error rateEuropean ancestrySample size increaseGenetic effectsTraitsE-I pairsSimulation study
2023
Digital biobanks are underutilized in dermatology and create opportunities to reduce the burden of skin disease
Jumonville G, Hong D, Khan A, DeWan A, Leal S, Weng C, Petukhova L. Digital biobanks are underutilized in dermatology and create opportunities to reduce the burden of skin disease. British Journal Of Dermatology 2023, 190: 566-568. PMID: 37936310, PMCID: PMC10941321, DOI: 10.1093/bjd/ljad439.Peer-Reviewed Original ResearchConceptsBurden of skin diseaseGenetic architectureDiscover genesGenetic dataGene-environment interactionsClinical areasBiobank dataHealth dataMedical careDisease mechanismsGlobal burdenDisease relationshipsMedical interventionsDrug repurposingPharmacogenetic relationshipBiobankSkin diseasesGlobal burden of skin diseaseGenesKnowledge promisesAdverse eventsCareDermatologyHealthDiseaseMendelian randomization study of birthweight, gestational age, and risk of childhood acute lymphoblastic leukemia
Rogne T, DeWan A, Metayer C, Wiemels J, Ma X. Mendelian randomization study of birthweight, gestational age, and risk of childhood acute lymphoblastic leukemia. American Journal Of Obstetrics & Gynecology MFM 2023, 5: 101058. PMID: 37330008, DOI: 10.1016/j.ajogmf.2023.101058.Peer-Reviewed Original ResearchDyslipidemia and Risk of Preeclampsia: A Multiancestry Mendelian Randomization Study
Hosier H, Lipkind H, Rasheed H, DeWan A, Rogne T. Dyslipidemia and Risk of Preeclampsia: A Multiancestry Mendelian Randomization Study. Hypertension 2023, 80: 1067-1076. PMID: 36883459, DOI: 10.1161/hypertensionaha.122.20426.Peer-Reviewed Original ResearchConceptsRisk of preeclampsiaProtective effectCholesteryl Ester Transfer Protein InhibitionLack of effectMendelian randomization studyMendelian randomization analysisMaternal morbidityElevated HDLLeading causeLipid levelsObservational studyPreeclampsiaLipid measurementsReduced riskAncestry groupsPharmacological targetsRandomization studyHDLLDLRandomization analysisSingle nucleotide polymorphismsNew targetsDyslipidemiaRiskProtein inhibitionEarly-Onset Colorectal Cancer Somatic Gene Mutations by Population Subgroups.
Shen X, DeWan A, Johnson C. Early-Onset Colorectal Cancer Somatic Gene Mutations by Population Subgroups. Cancer Discovery 2023, 13: 530-531. PMID: 36855917, DOI: 10.1158/2159-8290.cd-22-1464.Peer-Reviewed Original ResearchRare-variant association analysis reveals known and new age-related hearing loss genes
Cornejo-Sanchez D, Li G, Fabiha T, Wang R, Acharya A, Everard J, Kadlubowska M, Huang Y, Schrauwen I, Wang G, DeWan A, Leal S. Rare-variant association analysis reveals known and new age-related hearing loss genes. European Journal Of Human Genetics 2023, 31: 638-647. PMID: 36788145, PMCID: PMC10250305, DOI: 10.1038/s41431-023-01302-2.Peer-Reviewed Original ResearchType 2 cytokine genes as allergic asthma risk factors after viral bronchiolitis in early childhood
Dong Z, Myklebust Å, Johnsen I, Jartti T, Døllner H, Risnes K, DeWan A. Type 2 cytokine genes as allergic asthma risk factors after viral bronchiolitis in early childhood. Frontiers In Immunology 2023, 13: 1054119. PMID: 36685501, PMCID: PMC9852873, DOI: 10.3389/fimmu.2022.1054119.Peer-Reviewed Original ResearchConceptsAllergic asthmaViral bronchiolitisRisk factorsViral infectionDetailed lung function testsAllergic asthma developmentHistory of bronchiolitisHuman Metapneumovirus InfectionVariable airway obstructionAsthma risk factorsType 2 cytokinesDevelopment of asthmaLung function testsGenetic variantsCohort of childrenSpecific viral infectionsEarly childhoodType 2 cytokine genesSchool agePotential candidate targetAirway obstructionMetapneumovirus infectionMedian ageAsthma developmentFunction testsPaired Indoor and Outdoor Nitrogen Dioxide Associated With Childhood Asthma Outcomes in a Mixed Rural-Urban Setting: A Feasibility Study
Wi C, Gent J, Bublitz J, King K, Ryu E, Sorrentino K, Plano J, McKay L, Porcher J, Wheeler P, Chiarella S, DeWan A, Pollitt K, Sheares B, Leaderer B, Juhn Y. Paired Indoor and Outdoor Nitrogen Dioxide Associated With Childhood Asthma Outcomes in a Mixed Rural-Urban Setting: A Feasibility Study. Journal Of Primary Care & Community Health 2023, 14: 21501319231173813. PMID: 37243352, PMCID: PMC10226331, DOI: 10.1177/21501319231173813.Peer-Reviewed Original ResearchConceptsAsthma control statusControl statusAsthma diaryRural-urban settingOutdoor NOChildhood asthma outcomesProspective cohort studySocioeconomic statusLow socioeconomic statusSmall feasibility studyAsthma exacerbationsOlmsted CountyPersistent asthmaAsthma outcomesCohort studyChildhood asthmaRural-urban communityLarger sample sizeAsthmaStudy periodHealth effectsFeasibility studyWeeksStatusLow threshold
2022
Preimplantation genetic testing for aneuploidy: challenges in clinical practice
Yang H, DeWan A, Desai M, Vermund S. Preimplantation genetic testing for aneuploidy: challenges in clinical practice. Human Genomics 2022, 16: 69. PMID: 36536471, PMCID: PMC9764701, DOI: 10.1186/s40246-022-00442-8.Peer-Reviewed Original ResearchConceptsPreimplantation genetic testingGenetic testingFetal disordersReproductive centerClinical practiceDefinitive guidelinesDrug AdministrationScreening testCurrent professional guidelinesDisease riskDiagnostic testsMosaic embryosProfessional guidelinesBlastocyst stagePGTAneuploidyAppropriate agenciesGenetic disease riskGuidelinesPatientsAdministrationCirculating miRNAs in the first trimester and pregnancy complications: a systematic review
Subramanian A, Weiss D, Nyhan K, Dewan A, Jukic A. Circulating miRNAs in the first trimester and pregnancy complications: a systematic review. Epigenetics 2022, 18: 2152615. PMID: 36503407, PMCID: PMC9980650, DOI: 10.1080/15592294.2022.2152615.Peer-Reviewed Original ResearchConceptsPregnancy complicationsSystematic reviewFirst trimesterMiR-520hPlacental originMiR-518bFuture pregnancy complicationsMost pregnancy complicationsFirst-trimester serumFirst trimester biomarkersPotential early biomarkersGestational hypertensionPreterm birthPlacental pathologyEarly biomarkersComplicationsEarly placentationPotential biomarkersPlasma miRNAsPreeclampsiaMiR-125bEarly detectionBiomarkersMiR-365aMost evidence
2020
Body mass index and risk of dying from a bloodstream infection: A Mendelian randomization study
Rogne T, Solligård E, Burgess S, Brumpton BM, Paulsen J, Prescott HC, Mohus RM, Gustad LT, Mehl A, Åsvold BO, DeWan AT, Damås JK. Body mass index and risk of dying from a bloodstream infection: A Mendelian randomization study. PLOS Medicine 2020, 17: e1003413. PMID: 33196656, PMCID: PMC7668585, DOI: 10.1371/journal.pmed.1003413.Peer-Reviewed Original ResearchConceptsBody mass indexHigher body mass indexBloodstream infectionsBSI incidenceBSI mortalityHazard ratioMass indexGeneral populationPopulation-based cohortAnalysis of patientsTerms of mortalityMendelian randomization studyTraditional epidemiological studiesMendelian randomization analysisObesity paradoxMean ageObservational studyEpidemiological studiesRandomization studyCausal associationSepsisMortalityPatientsInfectionRandomization analysisDiscovery and Mediation Analysis of Cross-Phenotype Associations Between Asthma and Body Mass Index in 12q13.2
Salinas YD, Wang Z, DeWan AT. Discovery and Mediation Analysis of Cross-Phenotype Associations Between Asthma and Body Mass Index in 12q13.2. American Journal Of Epidemiology 2020, 190: 85-94. PMID: 32700739, PMCID: PMC7784522, DOI: 10.1093/aje/kwaa144.Peer-Reviewed Original ResearchConceptsBody mass indexMass indexComorbidity of asthmaWhite British subjectsCross-phenotype associationsAdult asthmaAsthma diagnosisAsthmaConfounder adjustmentAsthma associationsBMI associationsMediation analysisLimited evidenceCandidate gene studiesBMIObesityUK BiobankAssociationDiagnosisTwin studiesAgeFurther characterizationComorbiditiesConfoundersThe Role of FER rs4957796 in the Risk of Developing and Dying from a Bloodstream Infection: A 23-Year Follow-up of the Population-based Nord-Trøndelag Health Study
Rogne T, Damås JK, Flatby HM, Åsvold BO, DeWan AT, Solligård E. The Role of FER rs4957796 in the Risk of Developing and Dying from a Bloodstream Infection: A 23-Year Follow-up of the Population-based Nord-Trøndelag Health Study. Clinical Infectious Diseases 2020, 73: e297-e303. PMID: 32699877, PMCID: PMC8282309, DOI: 10.1093/cid/ciaa786.Peer-Reviewed Original ResearchConceptsBloodstream infectionsHUNT StudyCC genotypePopulation-based HUNT StudyBloodstream infection incidenceBloodstream infection patientsTotal study populationTerms of mortalityInfection patientsSepsis mortalityCase fatalityImmunoregulatory roleDiagnosis codesProspective dataStudy populationTT genotypeBlood samplesInfection incidencePatientsC alleleInfectionMajor causeHealth lossMortalitySingle nucleotide polymorphisms
2019
RE: “RACIAL AND ETHNIC DIFFERENCES IN SOCIOECONOMIC POSITION AND RISK OF CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA”
Spector L, DeWan A, Pankratz N, Turcotte L, Yang J, Scheurer M. RE: “RACIAL AND ETHNIC DIFFERENCES IN SOCIOECONOMIC POSITION AND RISK OF CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA”. American Journal Of Epidemiology 2019, 188: 1192-1193. PMID: 30924856, PMCID: PMC10410092, DOI: 10.1093/aje/kwz075.Peer-Reviewed Original Research
2018
MendelProb: probability and sample size calculations for Mendelian studies of exome and whole genome sequence data
He Z, Wang L, DeWan A, Leal S. MendelProb: probability and sample size calculations for Mendelian studies of exome and whole genome sequence data. Bioinformatics 2018, 35: 529-531. PMID: 30032240, PMCID: PMC6397596, DOI: 10.1093/bioinformatics/bty542.Peer-Reviewed Original ResearchFamily‐based study reveals decreased abundance of sputum Granulicatella in asthmatics
Wang L, de Ángel Solá D, Mao Y, Bielecki P, Zhu Y, Sun Z, Shan L, Flavell R, Bazzy‐Asaad A, DeWan A. Family‐based study reveals decreased abundance of sputum Granulicatella in asthmatics. Allergy 2018, 73: 1918-1921. PMID: 29862523, PMCID: PMC6586473, DOI: 10.1111/all.13493.Peer-Reviewed Original ResearchGene-Gene and Gene-Environment Interactions
DeWan AT. Gene-Gene and Gene-Environment Interactions. Methods In Molecular Biology 2018, 1793: 89-110. PMID: 29876893, DOI: 10.1007/978-1-4939-7868-7_7.BooksConceptsComplex traitsGene-environment interactionsGenome-wide interaction analysisGenetic variantsGenetic architectureDense panelMultiple test correctionGene-GeneTest correctionExplicit testsTraitsHigher-order interactionsRare frequencyInteraction analysisVariantsInteractionSmall effect sizesReplicationInteraction resultsOrder interactionsGWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q24.21
Wiemels JL, Walsh KM, de Smith AJ, Metayer C, Gonseth S, Hansen HM, Francis SS, Ojha J, Smirnov I, Barcellos L, Xiao X, Morimoto L, McKean-Cowdin R, Wang R, Yu H, Hoh J, DeWan AT, Ma X. GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q24.21. Nature Communications 2018, 9: 286. PMID: 29348612, PMCID: PMC5773513, DOI: 10.1038/s41467-017-02596-9.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentCaliforniaChild, PreschoolChromosomes, Human, Pair 17Chromosomes, Human, Pair 8FemaleGene FrequencyGenetic Predisposition to DiseaseGenome-Wide Association StudyHispanic or LatinoHumansInfantInfant, NewbornMalePolymorphism, Single NucleotidePrecursor Cell Lymphoblastic Leukemia-LymphomaRisk FactorsConceptsNew risk lociRisk lociGenome-wide association studiesGrowth regulation pathwaysGenetic associationAcute lymphoblastic leukemiaNovel genetic associationsChildhood acute lymphoblastic leukemiaGenetic Epidemiology ResearchTranscription factorsStrong genetic associationGene expressionAssociation studiesLymphocyte developmentMYC oncogeneChromosome 17q12Oncology GroupLymphoblastic leukemiaLociChildren's Oncology GroupCalifornia Childhood Leukemia StudyChildhood Leukemia StudyStructural contactsYear of birthNon-Latino whites
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