2025
The case-only design is a powerful approach to detect interactions but should be used with caution
Dong R, Wang G, DeWan A, Leal S. The case-only design is a powerful approach to detect interactions but should be used with caution. BMC Genomics 2025, 26: 222. PMID: 40050722, PMCID: PMC11884093, DOI: 10.1186/s12864-025-11318-1.Peer-Reviewed Original ResearchMeSH KeywordsCase-Control StudiesComputer SimulationGene-Environment InteractionHumansModels, GeneticPrevalenceResearch DesignSample SizeConceptsCase-only designRare disease assumptionType I error rateIncreased type I error ratesDisease prevalenceInvestigated type I errorComplex traitsInteraction termsInteraction effect sizesDetect interactionsCase-control designControlled type I error ratesSample sizeHigher disease prevalenceEffect sizeLow disease prevalenceType I errorPrevalenceExposure frequencyGenesType I andDesign studyEnvironmental factorsTraitsEnvironment interaction
2010
PDE11A associations with asthma: Results of a genome-wide association scan
DeWan AT, Triche EW, Xu X, Hsu LI, Zhao C, Belanger K, Hellenbrand K, Willis-Owen SA, Moffatt M, Cookson WO, Himes BE, Weiss ST, Gauderman WJ, Baurley JW, Gilliland F, Wilk JB, O’Connor G, Strachan DP, Hoh J, Bracken MB. PDE11A associations with asthma: Results of a genome-wide association scan. Journal Of Allergy And Clinical Immunology 2010, 126: 871-873.e9. PMID: 20920776, PMCID: PMC3133448, DOI: 10.1016/j.jaci.2010.06.051.Peer-Reviewed Original Research
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