2025
Household practices and infrastructure associated with high Plasmodium falciparum infection rates among children under five years old in Northern Uganda
Echodu R, Ajolorwot S, Aryemo F, Nyeko C, Okot J, Iwiru T, Nakiwu V, Bei A, DeBlasio M, Turyasingura N, Zhang E, Parikh S. Household practices and infrastructure associated with high Plasmodium falciparum infection rates among children under five years old in Northern Uganda. Malaria Journal 2025, 24: 181. PMID: 40484941, PMCID: PMC12145591, DOI: 10.1186/s12936-025-05288-8.Peer-Reviewed Original ResearchConceptsIndoor residual sprayingArtemisinin-based combination therapyMalaria prevalenceCoverage of indoor residual sprayingPlasmodium falciparum infection rateIndoor residual spraying coverageEffective malaria preventionHighest malaria prevalenceInsecticide-treated netsConclusionA high prevalenceReduce malaria prevalenceHealth-seeking behaviorYears of ageMalaria preventionCombination therapyInsecticidal netsPlasmodium falciparumGovernment health centersBed netsMethodsA cross-sectional surveyPositive prevalenceResidual sprayingUntreated netsPre-tested questionnaireMosquito nets
2023
Ex vivo RSA and pfkelch13 targeted-amplicon deep sequencing reveal parasites susceptibility to artemisinin in Senegal, 2017
Yade M, Dièye B, Coppée R, Mbaye A, Diallo M, Diongue K, Bailly J, Mama A, Fall A, Thiaw A, Ndiaye I, Ndiaye T, Gaye A, Tine A, Diédhiou Y, Mbaye A, Doderer-Lang C, Garba M, Bei A, Ménard D, Ndiaye D. Ex vivo RSA and pfkelch13 targeted-amplicon deep sequencing reveal parasites susceptibility to artemisinin in Senegal, 2017. Malaria Journal 2023, 22: 167. PMID: 37237307, PMCID: PMC10223908, DOI: 10.1186/s12936-023-04588-1.Peer-Reviewed Original ResearchConceptsRing-stage survival assayART resistancePlasmodium falciparum isolatesMost malaria deathsLong-term useCurative treatmentCombination therapyMalaria deathsMinor variantsFalciparum isolatesPfkelch13 geneSurvival assaysParasite susceptibilityResultsAll samplesPfKelch13Spread of parasitesSaharan AfricaExMain determinantsIsolatesTherapySusceptibilityDeep sequencing approach
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