2025
Impact of RSVpreF vaccination on reducing the burden of respiratory syncytial virus in infants and older adults
Du Z, Pandey A, Moghadas S, Bai Y, Wang L, Matrajt L, Singer B, Galvani A. Impact of RSVpreF vaccination on reducing the burden of respiratory syncytial virus in infants and older adults. Nature Medicine 2025, 31: 647-652. PMID: 39789324, PMCID: PMC11835734, DOI: 10.1038/s41591-024-03431-7.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusSyncytial virusRSV diseaseImpact of vaccinationBurden of respiratory syncytial virusVaccination of pregnant womenRSV-related mortalityProtein-based vaccinesVaccination of older adultsRSV vaccinePregnant womenSeasonal influenzaVaccine uptake ratesInfant hospitalizationClinical trialsPrefusion FHospital costsInfantsHealth burdenAdult immunizationVaccineOlder adultsHospitalEnhanced uptakeHigh-income countries
2024
Impact and cost-effectiveness analyses of vaccination for prevention of respiratory syncytial virus disease among older adults in Ontario: A Canadian Immunization Research Network (CIRN) study
Shoukat A, Bawden C, Röst G, LeBlanc J, Galvani A, Langley J, Moghadas S. Impact and cost-effectiveness analyses of vaccination for prevention of respiratory syncytial virus disease among older adults in Ontario: A Canadian Immunization Research Network (CIRN) study. Vaccine 2024, 42: 1768-1776. PMID: 38368226, DOI: 10.1016/j.vaccine.2024.02.041.Peer-Reviewed Original ResearchIncremental cost-effectiveness ratioQuality-adjusted life yearsLong-term care homesCommunity-dwelling older adultsCanadian Immunization Research NetworkIncremental cost-effectiveness ratio valuesResidents of long-term care homesRSV diseaseOlder adultsBurden of RSV diseaseRespiratory syncytial virus diseaseNo-vaccination scenarioRSV-related hospitalisationNo vaccinesRespiratory syncytial virusVaccination programBudget impactSocietal perspectiveCost-effectiveness ratioReduction of hospitalizationInfluenza vaccineRSV seasonSyncytial virusHealth benefitsAnalysis of vaccination
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