2025
Effectiveness of the TAK-003 dengue vaccine in adolescents during the 2024 outbreak in São Paulo, Brazil: a test-negative, case–control study
Ranzani O, Lazar Neto F, Mareto L, Brumatti T, de Oliveira R, da Silva P, Dos Santos E, D' Agostini T, De Paula R, Dean N, Ko A, Cummings D, Andrews J, Hitchings M, Croda J. Effectiveness of the TAK-003 dengue vaccine in adolescents during the 2024 outbreak in São Paulo, Brazil: a test-negative, case–control study. The Lancet Infectious Diseases 2025 PMID: 40845862, DOI: 10.1016/s1473-3099(25)00382-2.Peer-Reviewed Original ResearchAcute febrile illnessCase-control studyTAK-003Vaccine effectivenessSymptomatic dengueFirst doseSecond doseFebrile illnessDengue vaccineReal-world evidenceTest-negativeDays of symptom onsetTetravalent dengue vaccinePublic health challengeHigh-transmission settingsLogistic regression modelsDengue virus serotype 1National surveillance databaseSao PauloRT-PCR testHealth challengesSymptomatic diseaseGlobal health threatNS1 antigenSurveillance databaseGender differences in Leptospira exposure risk, perceptions of disease severity, and high-risk behaviours in Salvador, Brazil: A cross-sectional study
Delight E, Santiago D, Palma F, de Oliveira D, Souza F, Santana J, Hidano A, López Y, Reis M, Ko A, Marphatia A, Cremonese C, Costa F, Eyre M. Gender differences in Leptospira exposure risk, perceptions of disease severity, and high-risk behaviours in Salvador, Brazil: A cross-sectional study. PLOS Global Public Health 2025, 5: e0004786. PMID: 40577380, PMCID: PMC12204547, DOI: 10.1371/journal.pgph.0004786.Peer-Reviewed Original ResearchHigh-risk behaviorsUrban informal settlementsGender lensHealth promotion programsInformal settlementsGender identityHigh riskGender-neutralPerception of disease severityCross-sectional studySex-disaggregated analysesGender-specific riskLogistic regression modelsPromotion programsWalking barefootClimate hazardsGender differencesExposure riskEvidence gapsSalvadorGenderCross-sectional serosurveySurveillance dataAssociated with seropositivityWomen
2024
Factors associated with differential seropositivity to Leptospira interrogans and Leptospira kirschneri in a high transmission urban setting for leptospirosis in Brazil
de Oliveira D, Khalil H, Palma F, Santana R, Nery N, Quintero-Vélez J, Zeppelini C, do Sacramento G, Cruz J, Lustosa R, Ferreira I, Carvalho-Pereira T, Diggle P, Wunder E, Ko A, Lopez Y, Begon M, Reis M, Costa F. Factors associated with differential seropositivity to Leptospira interrogans and Leptospira kirschneri in a high transmission urban setting for leptospirosis in Brazil. PLOS Neglected Tropical Diseases 2024, 18: e0011292. PMID: 38758957, PMCID: PMC11139309, DOI: 10.1371/journal.pntd.0011292.Peer-Reviewed Original ResearchYears of ageResidents of low-income areasMultinomial logistic regression modelWork-related exposureEpidemiological patternsLow-income areasLogistic regression modelsInformal urban communitiesFactors associated with seropositivityCity of SalvadorPathogenic species of bacteriaUrban settingsUrban communities
2022
Leptospira Infection in Rural Areas of Urabá Region, Colombia: A Prospective Study.
Quintero-Vélez J, Rodas J, Rojas C, Ko A, Wunder E. Leptospira Infection in Rural Areas of Urabá Region, Colombia: A Prospective Study. American Journal Of Tropical Medicine And Hygiene 2022, 107: 1267-1277. PMID: 36375452, PMCID: PMC9768283, DOI: 10.4269/ajtmh.21-1103.Peer-Reviewed Original ResearchConceptsOutdoor occupationsLeptospira infectionProspective studyRisk factorsMultivariable modelLeptospira seroprevalenceLogistic regression modelsEco-epidemiological aspectsMultinomial logistic regression modelsMultivariable analysisSerologic testingPrimary exposureMale genderMicroscopic agglutinationPresence of ratsOlder ageRural areasLeptospira serogroupsInfectionSeroincidenceLeptospira speciesSeroprevalenceSerogroupsRegression modelsDirt floors
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