2025
Topography and environmental deficiencies are associated with chikungunya virus exposure in urban informal settlements in Salvador, Brazil
Travis C, Argibay H, Pellizzaro M, de Oliveira D, Santana R, Palma F, Lustosa R, Santana J, Souza F, López Y, Reis M, Ko A, Diggle P, Ribeiro G, Begon M, Costa F, Khalil H, Eyre M. Topography and environmental deficiencies are associated with chikungunya virus exposure in urban informal settlements in Salvador, Brazil. PLOS Neglected Tropical Diseases 2025, 19: e0013477. PMID: 40911655, PMCID: PMC12440227, DOI: 10.1371/journal.pntd.0013477.Peer-Reviewed Original ResearchConceptsUrban informal settlementsPublic health burdenLow-income communitiesInformal settlementsGlobal public health burdenBinomial mixed-effects modelDegree of urbanisationHealth burdenMixed-effects modelsCHIKV seroprevalenceEnvironmental deficienciesReduced riskAssociated with seropositivityRisk factorsUrban communitiesMale sexBrazilian citiesRiskHouseholdsCommunityCHIKV seropositivityIndividualsEnvironmental factorsExposure patternsDomains individuals
2022
Linking rattiness, geography and environmental degradation to spillover Leptospira infections in marginalised urban settings: An eco-epidemiological community-based cohort study in Brazil
Eyre MT, Souza FN, Carvalho-Pereira T, Nery N, de Oliveira D, Cruz JS, Sacramento GA, Khalil H, Wunder EA, Hacker KP, Hagan JE, Childs JE, Reis MG, Begon M, Diggle PJ, Ko AI, Giorgi E, Costa F. Linking rattiness, geography and environmental degradation to spillover Leptospira infections in marginalised urban settings: An eco-epidemiological community-based cohort study in Brazil. ELife 2022, 11: e73120. PMID: 36111781, PMCID: PMC9560157, DOI: 10.7554/elife.73120.Peer-Reviewed Original ResearchConceptsInfection riskSignificant global public health burdenCommunity-based cohort studyGlobal public health burdenPublic health burdenAgents of leptospirosisExposure of interestYears of agePublic health interventionsHigh-risk communitiesJoint spatial modellingZoonotic spilloverCohort studyHuman infection riskMale genderSerological evidenceHealth burdenLeptospira infectionLeptospiral infectionInfection rateHealth interventionsEco-epidemiological studiesHealth surveillanceFundação de Amparo à PesquisaOswaldo Cruz Foundation
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