Zika in Infants and Pregnancy (ZIP) study: results from a prospective international cohort study of prenatal Zika virus infection and adverse fetal and infant outcomes
Lebov J, Nason M, Stolka K, Ximenes R, Mussi-Pinhata M, Moye J, Zorrilla C, Velez Vega C, Cordero J, Scalabrin D, Ko A, Moreira M, Galvão L, Britt W, Marques E, Balmaseda A, Harris E, Arias J, Schultz-Cherry S, Garces A, Krebs N, Ochoa T, Ugarte-Gil C, Fogleman E, Gabriel E, Welton M, Irizarry C, de Moura Negrini S, Coutinho C, de Barros Miranda-Filho D, Montarroyos U, Cordeiro M, Gajewski A, Osorio J, Figueroa L. Zika in Infants and Pregnancy (ZIP) study: results from a prospective international cohort study of prenatal Zika virus infection and adverse fetal and infant outcomes. BMC Pregnancy And Childbirth 2025, 25: 903. PMID: 40885911, PMCID: PMC12399002, DOI: 10.1186/s12884-025-07774-y.Peer-Reviewed Original ResearchConceptsZika virus infectionZIKV exposureCongenital malformationsRelative riskInfant outcomesZika virusComposite endpointPrenatal Zika virus infectionPrimary analysisZika virus exposureSecondary analysisCo-primary analysisWeeks gestationPrimary endpointRNA testingProspective studyProspective cohortPregnant participantsWeeks postpartumPregnancyVirus infectionInfantsAdequate sample sizeInfant deathsPregnant peopleAdverse fetal and perinatal outcomes associated with Zika virus infection during pregnancy: an individual participant data meta-analysis
Consortium T, Pérez E, Ticona J, Alger J, Aranda C, Niño A, Ansusinha E, Araújo T, Arias J, Nieto L, Ávila M, Bardají A, Mojica C, Benedetti A, Bertozzi A, Bethencourt S, Blackmon K, Aburto V, Brasil P, Brickley E, Britt W, Broutet N, Buekens P, Cabié A, Cabrera-Gaytán D, Cachay R, Cafferata M, Caicedo-Castro I, Calle J, Calvet G, Campbell H, Campos M, Carabali M, Cerigo H, Cordon C, Corrêa J, Costa F, Coutinho C, Cunha A, Cure C, Damen J, Daza M, De la Hoz Siegler I, DeBiasi R, Debray T, de Jong V, Delgado-López C, Duarte G, Miranda G, Eckert V, Eickmann S, Ellis E, Estofolete C, Bolaños L, Fléchelles O, Fong K, Gomes M, Fuller T, Fumadó V, Funk A, Galvão L, Gama G, Gérardin P, Gibbons L, Goncé A, Gonzalez A, Gotuzzo E, Grajales-Muñiz C, Gustafson P, Hamdan T, Harris E, Harrison C, Hcini N, Hofer C, Holband N, Sánchez C, Huerta I, Hurtado I, Inwani I, Isaac D, Jaenisch T, João E, Juliana A, Pereira J, Kara E, Kim C, Ko A, Krebs N, LaBeaud A, Lake-Burger H, Lebov J, Leo Y, Levis B, Lima T, Ling S, Lopez-Medina E, Lorenzo C, Macpherson C, Manders O, Marbán-Castro E, de Azevedo Marques E, Martelli C, Martinez-Espinosa F, González G, Matta G, Máttar S, Maxwell L, McCracken J, Melo A, Menéndez C, Reyes M, Montoya M, de Barros Miranda-Filho D, Montarroyos U, Moons K, Moreira M, Moye J, Mulkey S, Muñoz-Medina J, Munoz J, Mussi-Pinhata M, Negrini S, Nery N, Velásquez J, Nielsen K, Njenga M, Noël T, Nogueira M, Ochoa T, Oliveira C, Osoro E, Souto E, Parra-Saavedra M, Passos S, Rosado L, Coêlho B, Petra P, Pomar L, Prata-Barbosa A, Rabe I, Reis M, Casas A, Rojas D, Rosenberger K, Villarroel P, Clemente N, Cortes M, Sayers J, Scalabrin D, Schuler-Faccini L, Schultz-Cherry S, Segurado A, Short K, Shreedhar P, Silva A, Silva R, Silva V, de Siqueira I, Sohan K, Soriano-Arandes A, Soria-Segarra C, da Costa P, Tami A, Tavares J, Teixeira M, Terry R, Thein T, Thwin S, Tobian F, Rodríguez V, Trejos I, Turchi M, Ugarte-Gil C, Valencia-Prado M, Vallejos-Parás A, Vasconselos Z, da Veiga A, Viñuela-Benéitez C, Vouga M, Wei Y, Westcott J, Widdowson M, Ximenes R, Zorrilla C. Adverse fetal and perinatal outcomes associated with Zika virus infection during pregnancy: an individual participant data meta-analysis. EClinicalMedicine 2025, 83: 103231. PMID: 40630619, PMCID: PMC12235389, DOI: 10.1016/j.eclinm.2025.103231.Peer-Reviewed Original ResearchIPD-MAIPD meta-analysisMeta-analysisIndividual Participant Data Meta-AnalysisPregnant individualsParticipant data meta-analysisInternational health organisationsOne-stage meta-analysisZika virus infectionExploration of heterogeneityRisk of adverse outcomesData Meta-AnalysisWomen of reproductive ageAdverse pregnancy outcomesZika virusRisk of congenital malformationsOutcome prevalenceSurveillance-based studyRelative riskStandardised definitionsHealth OrganisationRisk estimatesMeta-analysesSystematic searchPrimary outcome
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