2025
Topography and environmental deficiencies are associated with chikungunya virus exposure in urban informal settlements in Salvador, Brazil
Travis C, Argibay H, Pellizzaro M, de Oliveira D, Santana R, Palma F, Lustosa R, Santana J, Souza F, López Y, Reis M, Ko A, Diggle P, Ribeiro G, Begon M, Costa F, Khalil H, Eyre M. Topography and environmental deficiencies are associated with chikungunya virus exposure in urban informal settlements in Salvador, Brazil. PLOS Neglected Tropical Diseases 2025, 19: e0013477. PMID: 40911655, PMCID: PMC12440227, DOI: 10.1371/journal.pntd.0013477.Peer-Reviewed Original ResearchConceptsUrban informal settlementsPublic health burdenLow-income communitiesInformal settlementsGlobal public health burdenBinomial mixed-effects modelDegree of urbanisationHealth burdenMixed-effects modelsCHIKV seroprevalenceEnvironmental deficienciesReduced riskAssociated with seropositivityRisk factorsUrban communitiesMale sexBrazilian citiesRiskHouseholdsCommunityCHIKV seropositivityIndividualsEnvironmental factorsExposure patternsDomains individualsZika in Infants and Pregnancy (ZIP) study: results from a prospective international cohort study of prenatal Zika virus infection and adverse fetal and infant outcomes
Lebov J, Nason M, Stolka K, Ximenes R, Mussi-Pinhata M, Moye J, Zorrilla C, Velez Vega C, Cordero J, Scalabrin D, Ko A, Moreira M, Galvão L, Britt W, Marques E, Balmaseda A, Harris E, Arias J, Schultz-Cherry S, Garces A, Krebs N, Ochoa T, Ugarte-Gil C, Fogleman E, Gabriel E, Welton M, Irizarry C, de Moura Negrini S, Coutinho C, de Barros Miranda-Filho D, Montarroyos U, Cordeiro M, Gajewski A, Osorio J, Figueroa L. Zika in Infants and Pregnancy (ZIP) study: results from a prospective international cohort study of prenatal Zika virus infection and adverse fetal and infant outcomes. BMC Pregnancy And Childbirth 2025, 25: 903. PMID: 40885911, PMCID: PMC12399002, DOI: 10.1186/s12884-025-07774-y.Peer-Reviewed Original ResearchConceptsZika virus infectionZIKV exposureCongenital malformationsRelative riskInfant outcomesZika virusComposite endpointPrenatal Zika virus infectionPrimary analysisZika virus exposureSecondary analysisCo-primary analysisWeeks gestationPrimary endpointRNA testingProspective studyProspective cohortPregnant participantsWeeks postpartumPregnancyVirus infectionInfantsAdequate sample sizeInfant deathsPregnant peopleEffectiveness of the TAK-003 dengue vaccine in adolescents during the 2024 outbreak in São Paulo, Brazil: a test-negative, case–control study
Ranzani O, Lazar Neto F, Mareto L, Brumatti T, de Oliveira R, da Silva P, Dos Santos E, D' Agostini T, De Paula R, Dean N, Ko A, Cummings D, Andrews J, Hitchings M, Croda J. Effectiveness of the TAK-003 dengue vaccine in adolescents during the 2024 outbreak in São Paulo, Brazil: a test-negative, case–control study. The Lancet Infectious Diseases 2025 PMID: 40845862, DOI: 10.1016/s1473-3099(25)00382-2.Peer-Reviewed Original ResearchAcute febrile illnessCase-control studyTAK-003Vaccine effectivenessSymptomatic dengueFirst doseSecond doseFebrile illnessDengue vaccineReal-world evidenceTest-negativeDays of symptom onsetTetravalent dengue vaccinePublic health challengeHigh-transmission settingsLogistic regression modelsDengue virus serotype 1National surveillance databaseSao PauloRT-PCR testHealth challengesSymptomatic diseaseGlobal health threatNS1 antigenSurveillance databaseHematological and biochemical profiles, infection and habitat quality in an urban rat population
Carvalho-Pereira T, Pedra G, de Oliveira D, Souza F, Zeppelini C, Santos L, Couto R, Bahiense T, da Silva E, Begon M, Reis M, Ko A, Childs J, Costa F. Hematological and biochemical profiles, infection and habitat quality in an urban rat population. Scientific Reports 2025, 15: 26518. PMID: 40691241, PMCID: PMC12279998, DOI: 10.1038/s41598-025-09887-y.Peer-Reviewed Original ResearchConceptsRat serumComplete blood countT groupL. interrogansNo significant associationEosinophil deficiencyKidney imprintsPoor condition groupHelminth eggsBlood countEM-DGroup ratsRat groupsFecal samplesImmature neutrophilsDeficient groupMean intensitySpecific infectionsHealth profileRatsSignificant associationBlood samplesCorticosterone metabolitesInfectionHematological profileGender differences in Leptospira exposure risk, perceptions of disease severity, and high-risk behaviours in Salvador, Brazil: A cross-sectional study
Delight E, Santiago D, Palma F, de Oliveira D, Souza F, Santana J, Hidano A, López Y, Reis M, Ko A, Marphatia A, Cremonese C, Costa F, Eyre M. Gender differences in Leptospira exposure risk, perceptions of disease severity, and high-risk behaviours in Salvador, Brazil: A cross-sectional study. PLOS Global Public Health 2025, 5: e0004786. PMID: 40577380, PMCID: PMC12204547, DOI: 10.1371/journal.pgph.0004786.Peer-Reviewed Original ResearchHigh-risk behaviorsUrban informal settlementsGender lensHealth promotion programsInformal settlementsGender identityHigh riskGender-neutralPerception of disease severityCross-sectional studySex-disaggregated analysesGender-specific riskLogistic regression modelsPromotion programsWalking barefootClimate hazardsGender differencesExposure riskEvidence gapsSalvadorGenderCross-sectional serosurveySurveillance dataAssociated with seropositivityWomenType 2 immune responses are associated with less severe COVID-19 in a hospitalized cohort
Jayavelu N, Qi J, Milliren C, Ozonoff A, Liu S, Levy O, Baden L, Melamed E, McComsey G, Cairns C, Schaenman J, Shaw A, Hafler D, Corry D, Kheradmand F, Atkinson M, Brakenridge S, Higuita N, Metcalf J, Hough C, Messer W, Pulendran B, Nadeau K, Davis M, Geng L, Sesma A, Simon V, Krammer F, Bime C, Calfee C, Bosinger S, Eckalbar W, Steen H, Maecker H, Becker P, Augustine A, Holland S, Rosen L, Lee S, Vaysman T, Ozonoff A, Diray-Arce J, Chen J, Kho A, Milliren C, Hoch A, Chang A, McEnaney K, Barton B, Lentucci C, Murphy M, Saluvan M, Shaheen T, Liu S, Syphurs C, Albert M, Hayati A, Bryant R, Abraham J, Thomas S, Cooney M, Karoly M, Altman M, Jayavelu N, Presnell S, Kohr B, Jancsyk T, Arnett A, Peters B, Overton J, Vita R, Westendorf K, Overton J, Levy O, Steen H, van Zalm P, Fatou B, Smolen K, Viode A, van Haren S, Jha M, Stevenson D, Odumade O, Baden L, Mendez K, Lasky-Su J, Tong A, Rooks R, Desjardins M, Sherman A, Walsh S, Mitre X, Cauley J, Li X, Evans B, Montesano C, Licona J, Krauss J, Issa N, Chang J, Izaguirre N, Hutton S, Michelotti G, Wong K, Tebbutt S, Shannon C, Sekaly R, Fourati S, McComsey G, Harris P, Sieg S, Ribeiro S, Cairns C, Haddad E, Kutzler M, Bernui M, Cusimano G, Connors J, Woloszczuk K, Joyner D, Edwards C, Lee E, Lin E, Melnyk N, Powell D, Kim J, Goonewardene I, Simmons B, Smith C, Martens M, Croen B, Semenza N, Bell M, Furukawa S, McLin R, Tegos G, Rogowski B, Mege N, Ulring K, Schearer P, Sheidy J, Nagle C, Seyfert-Margolis V, Rouphael N, Bosinger S, Boddapati A, Tharp G, Pellegrini K, Johnson B, Panganiban B, Huerta C, Anderson E, Samaha H, Sevransky J, Bristow L, Beagle E, Cowan D, Hamilton S, Hodder T, Bechnak A, Cheng A, Mehta A, Ciric C, Spainhour C, Carter E, Scherer E, Usher J, Hellmeister K, Hussaini L, Hewitt L, Mcnair N, Ribeiro S, Wimalasena S, Fernandez-Sesma A, Simon V, Krammer F, Van Bakel H, Kim-Schulze S, Reiche A, Qi J, Lee B, Carreño J, Singh G, Raskin A, Tcheou J, Khalil Z, van de Guchte A, Farrugia K, Khan Z, Kelly G, Srivastava K, Eaker L, Bermúdez-González M, Mulder L, Beach K, Saksena M, Altman D, Kojic E, Sominsky L, Azad A, Bielak D, Kawabata H, Yellin T, Fried M, Sullivan L, Morris S, Kleiner G, Stadlbauer D, Dutta J, Xie H, Patel M, Nie K, Rahman A, Messer W, Hough C, Siegel S, Sullivan P, Lu Z, Brunton A, Strand M, Lyski Z, Coulter F, Micheleti C, Maecker H, Pulendran B, Nadeau K, Rosenberg-Hasson Y, Leipold M, Sigal N, Rogers A, Fernandes A, Manohar M, Do E, Chang I, Lee A, Blish C, Din H, Roque J, Geng L, Artandi M, Davis M, Ahuja N, Yang S, Chinthrajah S, Hagan T, Reed E, Schaenman J, Salehi-Rad R, Rivera A, Pickering H, Sen S, Elashoff D, Ward D, Brook J, Sanchez E, Llamas M, Perdomo C, Magyar C, Fulcher J, Erle D, Calfee C, Hendrickson C, Kangelaris K, Nguyen V, Lee D, Chak S, Ghale R, Gonzalez A, Jauregui A, Leroux C, Altamirano L, Rashid A, Willmore A, Woodruff P, Krummel M, Carrillo S, Ward A, Langelier C, Patel R, Wilson M, Dandekar R, Alvarenga B, Rajan J, Eckalbar W, Schroeder A, Fragiadakis G, Tsitsiklis A, Mick E, Guerrero Y, Love C, Maliskova L, Adkisson M, Leligdowicz A, Beagle A, Rao A, Sigman A, Samad B, Curiel C, Shaw C, Tietje-Ulrich G, Milush J, Singer J, Vasquez J, Tang K, Betancourt L, Santhosh L, Pierce L, Paz M, Matthay M, Thakur N, Rodriguez N, Sutter N, Jones N, Sinha P, Prasad P, Lota R, Rashid S, Asthana S, Bhide S, Lea T, Abe-Jones Y, Hafler D, Montgomery R, Shaw A, Kleinstein S, Gygi J, Pawar S, Konstorum A, Chen E, Cotsapas C, Wang X, Xu L, Dela Cruz C, Iwasaki A, Mohanty S, Nelson A, Zhao Y, Farhadian S, Asashima H, Chaudhary O, Coppi A, Fournier J, Muenker M, Nelson A, Raddassi K, Rainone M, Ruff W, Salahuddin S, Shulz W, Vijayakumar P, Wang H, Wunder E, Young H, Ko A, Wang X, Duchen D, Esserman D, Guan L, Brito A, Rothman J, Grubaugh N, Corry D, Kheradmand F, Song L, Nelson E, Metcalf J, Higuita N, Sinko L, Booth J, Drevets D, Brown B, Kraft M, Bime C, Mosier J, Erickson H, Schunk R, Kimura H, Conway M, Francisco D, Molzahn A, Wilson C, Schunk R, Hughes T, Sierra B, Atkinson M, Brakenridge S, Ungaro R, Manning B, Moldawer L, Oberhaus J, Guirgis F, Borresen B, Anderson M, Ehrlich L, Melamed E, Maguire C, Wylie D, Rousseau J, Hurley K, Geltman J, Siles N, Rogers J, Augustine A, Diray-Arce J, Haddad E, Sekaly R, Kraft M, Woodruff P, Erle D, Ehrlich L, Montgomery R, Becker P, Altman M, Fourati S. Type 2 immune responses are associated with less severe COVID-19 in a hospitalized cohort. Journal Of Allergy And Clinical Immunology Global 2025, 4: 100515. PMID: 40709330, PMCID: PMC12284355, DOI: 10.1016/j.jacig.2025.100515.Peer-Reviewed Original ResearchT2 immune responseClinical outcomesVirus loadImmune responseSARS-CoV-2Primary siteSusceptibility to respiratory viral infectionsType 2 immune responsesAntibody titersCellular markersPrimary site of infectionSeverity of respiratory illnessRespiratory viral infectionsIL-13 levelsDegree of respiratory supportAssociated with less severe COVID-19Site of infectionLow virus loadSevere COVID-19Effects of SARS-CoV-2Severe coronavirus diseaseDiagnosis of asthmaRespiratory supportCoronavirus severe acute respiratory syndrome coronavirus 2Blood cytometryAdverse fetal and perinatal outcomes associated with Zika virus infection during pregnancy: an individual participant data meta-analysis
Consortium T, Pérez E, Ticona J, Alger J, Aranda C, Niño A, Ansusinha E, Araújo T, Arias J, Nieto L, Ávila M, Bardají A, Mojica C, Benedetti A, Bertozzi A, Bethencourt S, Blackmon K, Aburto V, Brasil P, Brickley E, Britt W, Broutet N, Buekens P, Cabié A, Cabrera-Gaytán D, Cachay R, Cafferata M, Caicedo-Castro I, Calle J, Calvet G, Campbell H, Campos M, Carabali M, Cerigo H, Cordon C, Corrêa J, Costa F, Coutinho C, Cunha A, Cure C, Damen J, Daza M, De la Hoz Siegler I, DeBiasi R, Debray T, de Jong V, Delgado-López C, Duarte G, Miranda G, Eckert V, Eickmann S, Ellis E, Estofolete C, Bolaños L, Fléchelles O, Fong K, Gomes M, Fuller T, Fumadó V, Funk A, Galvão L, Gama G, Gérardin P, Gibbons L, Goncé A, Gonzalez A, Gotuzzo E, Grajales-Muñiz C, Gustafson P, Hamdan T, Harris E, Harrison C, Hcini N, Hofer C, Holband N, Sánchez C, Huerta I, Hurtado I, Inwani I, Isaac D, Jaenisch T, João E, Juliana A, Pereira J, Kara E, Kim C, Ko A, Krebs N, LaBeaud A, Lake-Burger H, Lebov J, Leo Y, Levis B, Lima T, Ling S, Lopez-Medina E, Lorenzo C, Macpherson C, Manders O, Marbán-Castro E, de Azevedo Marques E, Martelli C, Martinez-Espinosa F, González G, Matta G, Máttar S, Maxwell L, McCracken J, Melo A, Menéndez C, Reyes M, Montoya M, de Barros Miranda-Filho D, Montarroyos U, Moons K, Moreira M, Moye J, Mulkey S, Muñoz-Medina J, Munoz J, Mussi-Pinhata M, Negrini S, Nery N, Velásquez J, Nielsen K, Njenga M, Noël T, Nogueira M, Ochoa T, Oliveira C, Osoro E, Souto E, Parra-Saavedra M, Passos S, Rosado L, Coêlho B, Petra P, Pomar L, Prata-Barbosa A, Rabe I, Reis M, Casas A, Rojas D, Rosenberger K, Villarroel P, Clemente N, Cortes M, Sayers J, Scalabrin D, Schuler-Faccini L, Schultz-Cherry S, Segurado A, Short K, Shreedhar P, Silva A, Silva R, Silva V, de Siqueira I, Sohan K, Soriano-Arandes A, Soria-Segarra C, da Costa P, Tami A, Tavares J, Teixeira M, Terry R, Thein T, Thwin S, Tobian F, Rodríguez V, Trejos I, Turchi M, Ugarte-Gil C, Valencia-Prado M, Vallejos-Parás A, Vasconselos Z, da Veiga A, Viñuela-Benéitez C, Vouga M, Wei Y, Westcott J, Widdowson M, Ximenes R, Zorrilla C. Adverse fetal and perinatal outcomes associated with Zika virus infection during pregnancy: an individual participant data meta-analysis. EClinicalMedicine 2025, 83: 103231. PMID: 40630619, PMCID: PMC12235389, DOI: 10.1016/j.eclinm.2025.103231.Peer-Reviewed Original ResearchIPD-MAIPD meta-analysisMeta-analysisIndividual Participant Data Meta-AnalysisPregnant individualsParticipant data meta-analysisInternational health organisationsOne-stage meta-analysisZika virus infectionExploration of heterogeneityRisk of adverse outcomesData Meta-AnalysisWomen of reproductive ageAdverse pregnancy outcomesZika virusRisk of congenital malformationsOutcome prevalenceSurveillance-based studyRelative riskStandardised definitionsHealth OrganisationRisk estimatesMeta-analysesSystematic searchPrimary outcomeProceedings of the second annual dengue endgame summit: A call to action
Hardy C, Bahr L, Rothman A, Anderson K, Barba-Spaeth G, Weiskopf D, Ooi E, Marques E, Bonsignori M, Barrett A, Kirkpatrick B, Castanha P, Hamins-Puertolas M, Christofferson R, Dimopoulos G, Oliveira F, Chiang L, Ko A, Gunale B, Kulkarni P, Perkins T, Dorigatti I, Stewart T, Shaw J, Johansson M, Thomas S, Waickman A. Proceedings of the second annual dengue endgame summit: A call to action. PLOS Neglected Tropical Diseases 2025, 19: e0013028. PMID: 40294026, PMCID: PMC12036847, DOI: 10.1371/journal.pntd.0013028.Peer-Reviewed Original ResearchZika virus: advancing a priority research agenda for preparedness and response
Lackritz E, Ng L, Marques E, Rabe I, Bourne N, Staples J, Méndez-Rico J, Harris E, Brault A, Ko A, Beasley D, Leighton T, Wilder-Smith A, Ostrowsky J, Mehr A, Ulrich A, Velayudhan R, Golding J, Fay P, Cehovin A, Moua N, Moore K, Osterholm M, Barrett A, Workgroup Z, Waldorf K, Barrett A, Beasley D, Bennie J, Bourne N, Brault A, Cehovin A, Coelho C, Diamond M, Emperador D, Faria N, Fay P, Golding J, Harris E, Hasanin N, Jaenisch T, Ko A, Lackritz E, Leighton T, Leo Y, Mehr A, Memish Z, Méndez-Rico J, Moore K, Mura M, Ng L, Osterholm M, Ostrowsky J, Peeling R, Rabe I, Salje H, Staples J, Thomas S, Ulrich A, Vanhomwegen J, Wongsawat J. Zika virus: advancing a priority research agenda for preparedness and response. The Lancet Infectious Diseases 2025, 25: e390-e401. PMID: 40024263, DOI: 10.1016/s1473-3099(24)00794-1.Peer-Reviewed Original ResearchRole of non-human primate models in accelerating research and developing countermeasures against Zika virus infection
Li A, Coffey L, Mohr E, Raper J, Chahroudi A, Ausderau K, Aliota M, Friedrich T, Mitzey A, Koenig M, Golos T, Jaeger H, Roberts V, Lo J, Smith J, Hirsch A, Streblow D, Newman C, O’Connor D, Lackritz E, Van Rompay K, Waldorf K, Workgroup Z, Waldorf K, Barrett A, Beasley D, Bennie J, Bourne N, Brault A, Cehovin A, Coelho C, Diamond M, Emperador D, Faria N, Fay P, Golding J, Harris E, Hasanin N, Jaenisch T, Ko A, Lackritz E, Leighton T, Leo Y, Mehr A, Memish Z, Méndez-Rico J, Moore K, Mura M, Ng L, Osterholm M, Ostrowsky J, Peeling R, Rabe I, Salje H, Staples J, Thomas S, Ulrich A, Vanhomwegen J, Wongsawat J. Role of non-human primate models in accelerating research and developing countermeasures against Zika virus infection. The Lancet Microbe 2025, 6: 101030. PMID: 40024258, PMCID: PMC12145256, DOI: 10.1016/j.lanmic.2024.101030.Peer-Reviewed Original ResearchNon-human primate modelZika virus infectionZika virus researchPrimate modelVirus infectionCases of congenital microcephalyFetal brain injuryLaboratory-confirmed casesGestational ageZika virus strainsBrain injuryPerinatal complicationsZika virus epidemicTesting medical countermeasuresCongenital microcephalyGlobal health concernVirus researchDevelopmental abnormalitiesZika virusVirus strainsMedical countermeasuresCongenital brain injuryInfectionZikaVirus epidemicSpecimen and data sharing to advance research and development on Zika virus
Peeling R, Fongwen N, Guzman M, Méndez-Rico J, Avumegah M, Jaenisch T, Lackritz E, Workgroup Z, Waldorf K, Barrett A, Beasley D, Bennie J, Bourne N, Brault A, Cehovin A, Coelho C, Diamond M, Emperador D, Faria N, Fay P, Golding J, Harris E, Hasanin N, Ko A, Leighton T, Leo Y, Mehr A, Memish Z, Moore K, Mura M, Ng L, Osterholm M, Ostrowsky J, Rabe I, Salje H, Staples J, Thomas S, Ulrich A, Vanhomwegen J, Wongsawat J. Specimen and data sharing to advance research and development on Zika virus. The Lancet Microbe 2025, 6: 101057. PMID: 40024261, DOI: 10.1016/j.lanmic.2024.101057.Peer-Reviewed Original ResearchZika virus vaccines and monoclonal antibodies: a priority agenda for research and development
Ostrowsky J, Katzelnick L, Bourne N, Barrett A, Thomas S, Diamond M, Beasley D, Harris E, Wilder-Smith A, Leighton T, Mehr A, Moua N, Ulrich A, Cehovin A, Fay P, Golding J, Moore K, Osterholm M, Lackritz E, Workgroup Z, Waldorf K, Barrett A, Beasley D, Bennie J, Bourne N, Brault A, Cehovin A, Coelho C, Diamond M, Emperador D, Faria N, Fay P, Golding J, Harris E, Hasanin N, Jaenisch T, Ko A, Lackritz E, Leighton T, Leo Y, Mehr A, Memish Z, Méndez-Rico J, Moore K, Mura M, Ng L, Osterholm M, Ostrowsky J, Peeling R, Rabe I, Salje H, Staples J, Thomas S, Ulrich A, Vanhomwegen J, Wongsawat J. Zika virus vaccines and monoclonal antibodies: a priority agenda for research and development. The Lancet Infectious Diseases 2025, 25: e402-e415. PMID: 40024262, PMCID: PMC12356332, DOI: 10.1016/s1473-3099(24)00750-3.Peer-Reviewed Original ResearchSocial mixing patterns of United States healthcare personnel at a quaternary health center: a prospective observational study
Pischel L, Aguolu O, Ahmed N, Campbell M, Borg R, Duckwall C, Willebrand K, Zaleski A, Paintsil E, Muenker M, Malik A, Kiti M, Warren J, Jenness S, Lopman B, Belsky J, Martinello R, Yildirim I, Ko A, Omer S. Social mixing patterns of United States healthcare personnel at a quaternary health center: a prospective observational study. Infection Control And Hospital Epidemiology 2025, 46: 289-297. PMID: 39880795, PMCID: PMC11883655, DOI: 10.1017/ice.2024.234.Peer-Reviewed Original ResearchHealthcare personnelUnited States healthcare systemStates healthcare systemCOVID-19 pandemicNurse aidesContact diariesHealth centersHealthcare systemWorking-age populationImaging technologistsLow-contact groupNursesRegression modelsPandemic responseWork environmentSocial contactCOVID-19Job typeThree-hundredWorking daysDiaryParticipantsPersonnelInfectious disease transmissionContact groupP-271. Contact Patterns of United States Health Care Workers at Quaternary Health Center: Stability of contacts during the post-pandemic era
Pischel L, Aguolu O, Ahmed N, Campbell M, Borg R, Duckwall C, Willebrand K, Paintsil E, Muenker M, Malik A, Kiti M, Jenness S, Lopman B, Belsky J, Martinello R, Yildirim I, Ko A, Omer S. P-271. Contact Patterns of United States Health Care Workers at Quaternary Health Center: Stability of contacts during the post-pandemic era. Open Forum Infectious Diseases 2025, 12: ofae631.475. PMCID: PMC11777566, DOI: 10.1093/ofid/ofae631.475.Peer-Reviewed Original ResearchHealth care workersHealth care worker participationCare workersUnited States health care systemStates health care systemAge rangeHealth care systemHealth care workers' contactsLinear regressionHealth centersCare systemChi-square testCOVID-19 pandemic responseContact diariesEpidemiological researchParticipants' jobsWorking-age populationWorking ageConfidence intervalsImaging technologistsParticipantsPandemic responseSocial workersWork environmentWorking days
2024
Two Mosquito Salivary Antigens Demonstrate Promise as Biomarkers of Recent Exposure to Plasmodium falciparum–Infected Mosquito Bites
Lapidus S, Goheen M, Sy M, Deme A, Ndiaye I, Diedhiou Y, Mbaye A, Hagadorn K, Sene S, Pouye M, Thiam L, Ba A, Guerra N, Mbengue A, Raduwan H, Gagnon J, Vigan-Womas I, Parikh S, Ko A, Ndiaye D, Fikrig E, Chuang Y, Bei A. Two Mosquito Salivary Antigens Demonstrate Promise as Biomarkers of Recent Exposure to Plasmodium falciparum–Infected Mosquito Bites. The Journal Of Infectious Diseases 2024, 231: e570-e581. PMID: 39475423, PMCID: PMC11911913, DOI: 10.1093/infdis/jiae525.Peer-Reviewed Original ResearchModerate transmission areasMosquito salivary proteinsModerately endemic areaAntibody responseMosquito exposureTransmission seasonP. falciparum infectionMalaria transmission seasonMalaria transmission intensityExposure to infectious mosquitoesMosquito bitesEntomological inoculation rateEndemic areasHuman immune responseInfected mosquito bitesTransmission areasDecline 3 monthsNo antibody responseExposure to infected mosquitoesP. falciparumControl cohortExposure to mosquitoesBead-based assayImmune responseSalivary proteinsDisentangling the influence of reservoir abundance and pathogen shedding on zoonotic spillover of the Leptospira agent in urban informal settlements
Soni N, Eyre M, Souza F, Diggle P, Ko A, Begon M, Pickup R, Childs J, Khalil H, Carvalho-Pereira T, Pertile A, Carvalho M, de Oliveira D, Nery N, Giorgi E, Costa F. Disentangling the influence of reservoir abundance and pathogen shedding on zoonotic spillover of the Leptospira agent in urban informal settlements. Frontiers In Public Health 2024, 12: 1447592. PMID: 39360250, PMCID: PMC11445007, DOI: 10.3389/fpubh.2024.1447592.Peer-Reviewed Original ResearchRat abundanceReservoir abundanceAbundance of ratsEnvironmentally transmitted diseasesVegetation land coverInfection riskSexually mature ratsHuman infection riskLive trapsUrban informal settlementsZoonotic spilloverLand coverSpatial variationHydrological factorsValley bottomTrack plateAbundanceHuman riskShedding rateMature ratsEco-epidemiological studiesLeptospira infectionSpillover transmissionSpatial distributionInformal settlementsSeverity-dependent test-seeking behaviors and test-negative designs: impact on estimated vaccine effectiveness and utility of analytic and design choices
Amin A, Hitchings M, Ranzani O, Andrews J, Cummings D, Ko A, Croda J, Dean N. Severity-dependent test-seeking behaviors and test-negative designs: impact on estimated vaccine effectiveness and utility of analytic and design choices. American Journal Of Epidemiology 2024, 194: 1855-1862. PMID: 39191656, PMCID: PMC12234220, DOI: 10.1093/aje/kwae303.Peer-Reviewed Original ResearchHuman antibodies in Mexico and Brazil neutralizing tick-borne flaviviruses
Cervantes Rincón T, Kapoor T, Keeffe J, Simonelli L, Hoffmann H, Agudelo M, Jurado A, Peace A, Lee Y, Gazumyan A, Guidetti F, Cantergiani J, Cena B, Bianchini F, Tamagnini E, Moro S, Svoboda P, Costa F, Reis M, Ko A, Fallon B, Avila-Rios S, Reyes-Téran G, Rice C, Nussenzweig M, Bjorkman P, Ruzek D, Varani L, MacDonald M, Robbiani D. Human antibodies in Mexico and Brazil neutralizing tick-borne flaviviruses. Cell Reports 2024, 43: 114298. PMID: 38819991, PMCID: PMC11832053, DOI: 10.1016/j.celrep.2024.114298.Peer-Reviewed Original ResearchPowassan virusEnvelope domain IIIYellow fever virusZika virusFever virusSerological neutralizing activityTemperate regionsDengue virusTicksTropical areasInfect humansLineage IMosquito-borne flavivirusNeutralizing activityHuman antibodiesVirusNeurological illnessBrazilFlavivirusesP002P003Human diseasesQuality of life among residents of informal urban settlements during the COVID-19 pandemic in Salvador, Brazil
Mogaji H, Nery N, Argibay H, Cruz J, Carneiro I, Lustosa R, Ko A, Costa F, Begon M, Khalil H. Quality of life among residents of informal urban settlements during the COVID-19 pandemic in Salvador, Brazil. BMJ Public Health 2024, 2: e000572. PMID: 40018243, PMCID: PMC11812815, DOI: 10.1136/bmjph-2023-000572.Peer-Reviewed Original ResearchHealth-related quality of lifePhysical health scoresHealth scoresQuality of lifeHealth-related quality of life of residentsCross-sectional analysis of dataMental health scoresHealth-related qualityResults Most participantsMixed-effects regression modelsCross-sectional analysisCOVID-19 pandemicOlder age groupsPhysical healthOlder adultsDisadvantaged populationsOlder participantsMental challengesFood insecuritySlum communitiesMarginalised populationsCity of SalvadorAged 5Analysis of dataCreation of economic opportunitiesFactors associated with differential seropositivity to Leptospira interrogans and Leptospira kirschneri in a high transmission urban setting for leptospirosis in Brazil
de Oliveira D, Khalil H, Palma F, Santana R, Nery N, Quintero-Vélez J, Zeppelini C, do Sacramento G, Cruz J, Lustosa R, Ferreira I, Carvalho-Pereira T, Diggle P, Wunder E, Ko A, Lopez Y, Begon M, Reis M, Costa F. Factors associated with differential seropositivity to Leptospira interrogans and Leptospira kirschneri in a high transmission urban setting for leptospirosis in Brazil. PLOS Neglected Tropical Diseases 2024, 18: e0011292. PMID: 38758957, PMCID: PMC11139309, DOI: 10.1371/journal.pntd.0011292.Peer-Reviewed Original ResearchYears of ageResidents of low-income areasMultinomial logistic regression modelWork-related exposureEpidemiological patternsLow-income areasLogistic regression modelsInformal urban communitiesFactors associated with seropositivityCity of SalvadorPathogenic species of bacteriaUrban settingsUrban communities
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