2025
Association of social relationships and genetic risk with frailty
Song W, Zhong W, Yan H, Li Z, Gao J, Wang X, Chen P, You F, Li C, Chen H, Xie J, Lv Y, Shi X, Mao C. Association of social relationships and genetic risk with frailty. American Journal Of Geriatric Psychiatry 2025 DOI: 10.1016/j.jagp.2025.02.015.Peer-Reviewed Original ResearchPolygenic risk scoresFrailty riskGenetic riskMendelian randomizationOlder adultsChinese Longitudinal Healthy Longevity SurveyTwo-sample Mendelian randomizationAssociations of social relationshipsSocial relationshipsEffects of social relationshipsSocial activitiesCox proportional hazards modelsIncreased frailty riskLongevity SurveyHigh frailty riskProportional hazards modelUnfavorable relationshipSocial supportTwo-time pointsRisk scoreFrailtyHazards modelGenetic susceptibilityAdditive interactionSingle-nucleotide[Association of urine cadmium levels with thyroid hormone levels among middle-aged and older adults aged 40-89 years in selected areas of China].
Wu C, Wang X, Chen Y, Li Z, Zhang Y, Wei Y, Wu B, Zhang W, Yang Z, Dong X, Hao R, Ye X, Wei L, Qu Y, Chu H, Lyu Y, Zhu Y, Xu D, Shi X. [Association of urine cadmium levels with thyroid hormone levels among middle-aged and older adults aged 40-89 years in selected areas of China]. Chinese Preventive Medicine 2025, 59: 209-215. PMID: 39938993, DOI: 10.3760/cma.j.cn112150-20240625-00500.Peer-Reviewed Original ResearchConceptsThyroid hormone levelsRestricted cubic splinesUrinary cadmium levelsHormone levelsUrinary cadmiumFasting venous bloodAssociated with T3Dose-response relationshipMiddle-agedMidstream urineCadmium levelsUrine cadmium levelsMixed effects modelsLinear mixed effects modelsPositive nonlinear associationOlder adultsMulti-stage stratified random sampling methodPhysical examinationUrinary creatinineVenous bloodDietary frequencyDisease statusEffects modelOne-unit increaseCubic splinesCorrigendum to “Wearing time and respiratory volume affect the filtration efficiency of masks against aerosols at different sizes” [Environ. Technol. Innov. 25 (2022) 102165]
Li X, Ding P, Deng F, Mao Y, Zhou L, Ding C, Wang Y, Luo Y, Zhou Y, MacIntyre C, Tang S, Xu D, Shi X. Corrigendum to “Wearing time and respiratory volume affect the filtration efficiency of masks against aerosols at different sizes” [Environ. Technol. Innov. 25 (2022) 102165]. Environmental Technology & Innovation 2025, 37: 104056. DOI: 10.1016/j.eti.2025.104056.Peer-Reviewed Original ResearchExposure profiles, determinants, and health risks of chemicals in personal care products among healthy older adults from the China BAPE study
Guo X, Qian J, Ren H, Ding E, Ma X, Zhang J, Qiu T, Lu Y, Sun P, Li C, Li C, Xu Y, Cao K, Lin X, Mao C, Tong S, Tang S, Shi X. Exposure profiles, determinants, and health risks of chemicals in personal care products among healthy older adults from the China BAPE study. Journal Of Hazardous Materials 2025, 488: 137365. PMID: 39869979, DOI: 10.1016/j.jhazmat.2025.137365.Peer-Reviewed Original ResearchConceptsPersonal care productsHealthy older adultsHealth risksOlder adultsExposure to ambient PM<sub>2.5</sub>Benzophenone-2Ambient PM<sub>2.5</sub>Care productsHealth risks associated with exposureRisks associated with exposureAssociated health risksRisk of chemicalsHealth risks of chemicalsIncreased physical activityAssessment of older adultsMinimal health risksPhysical well-beingPredominant chemicalsMedian concentrationsPhysical activityExposure assessmentExposure profilesRisk assessmentExposure levelsMethyl parabenAssociations of body mass index trajectories, weight change with mortality among the oldest old: do they differ from general older adults?
Qi L, Chen C, Zhou J, Liu S, Wang J, Wei Y, Shi W, Li Y, Zhang T, Lv Y, Shi X. Associations of body mass index trajectories, weight change with mortality among the oldest old: do they differ from general older adults? Science Bulletin 2025 PMID: 39966069, DOI: 10.1016/j.scib.2025.01.040.Peer-Reviewed Original ResearchSand and dust storms: a growing global health threat calls for international health studies to support policy action
Li T, Cohen A, Krzyzanowski M, Zhang C, Gumy S, Mudu P, Pant P, Liu Q, Kan H, Tong S, Chen S, Kang U, Basart S, Touré N, Al-Hemoud A, Rudich Y, Tobias A, Querol X, Khomsi K, Samara F, Hashizume M, Stafoggia M, Malkawi M, Wang S, Zhou M, Shi X, Jiang G, Shen H. Sand and dust storms: a growing global health threat calls for international health studies to support policy action. The Lancet Planetary Health 2025, 9: e34-e40. PMID: 39855230, PMCID: PMC11755727, DOI: 10.1016/s2542-5196(24)00308-5.Peer-Reviewed Original ResearchIntegrated healthy lifestyle even in late-life mitigates cognitive decline risk across varied genetic susceptibility
Wang J, Chen C, Zhou J, Xu Z, Xu L, Li X, Zhong Z, Lv Y, Shi X. Integrated healthy lifestyle even in late-life mitigates cognitive decline risk across varied genetic susceptibility. Nature Communications 2025, 16: 539. PMID: 39789005, PMCID: PMC11718162, DOI: 10.1038/s41467-024-55763-0.Peer-Reviewed Original ResearchConceptsFavorable lifestyleRate of cognitive declineGenetic riskCognitive declineUnfavorable lifestyleHealthy lifestyleAssociations of combined lifestyle factorsChinese Longitudinal Healthy Longevity SurveyCombined lifestyle factorsHigh genetic riskDimensions of cognitionCognitive decline riskAccelerated cognitive declineLongevity SurveyLifestyle factorsCognitive domainsLate-lifeOlder adultsCognitive functionDeclining riskLifestyleGenetic susceptibilityGenetic factorsRiskCognitionAir Pollution and Cognitive Impairment Among the Chinese Elderly Population: An Analysis of the Chinese Longitudinal Healthy Longevity Survey (CLHLS)
Zhu Q, Lyu Y, Huang K, Zhou J, Wang W, Steenland K, Chang H, Ebelt S, Shi X, Liu Y. Air Pollution and Cognitive Impairment Among the Chinese Elderly Population: An Analysis of the Chinese Longitudinal Healthy Longevity Survey (CLHLS). GeoHealth 2025, 9: e2024gh001023. PMID: 39776607, PMCID: PMC11705411, DOI: 10.1029/2024gh001023.Peer-Reviewed Original ResearchChinese Longitudinal Health Longevity SurveyWarm-season O<sub>3</sub>Chinese elderly populationAssociated with cognitive impairmentLongevity SurveyCognitive impairmentLinear mixed-effects modelsChinese Longitudinal Healthy Longevity SurveyAir pollutionAssociation of air pollutionMixed-effects modelsAverage NO<sub>2</sub>Average PM<sub>2.5</sub>Elderly populationSingle-pollutant modelsMulti-pollutant modelsLogistic regression modelsCMMSE scoresControl Action PlanAir pollution preventionStudy participantsGaseous air pollutantsFollow-up visitRandom interceptPositive association
2024
Black Carbon Air Pollution and Incident Mortality Among the Advance-Aged Adults in China: A Prospective Cohort Study
Zhu A, Kan H, Shi X, Zeng Y, Ji J. Black Carbon Air Pollution and Incident Mortality Among the Advance-Aged Adults in China: A Prospective Cohort Study. The Journals Of Gerontology Series A 2024, 80: glae302. PMID: 39716384, PMCID: PMC11897793, DOI: 10.1093/gerona/glae302.Peer-Reviewed Original ResearchConceptsProspective cohort studyNonaccidental mortalityChinese Longitudinal Healthy Longevity SurveyMortality riskCohort studyBlack carbonLow physical activityBC exposurePM2.5 componentsHighest effect estimatesAverage BCImprove public healthCox proportional hazards modelsPhysical activityLongevity SurveyPM2.5 exposure concentrationsFine particulate matterProportional hazards modelIncident mortalityStratified analysisPredictors of mortalityEffect estimatesRural populationDemographic covariatesPublic healthApplication of multi-angle spaceborne observations in characterizing the long-term particulate organic carbon pollution in China
Hang Y, Pu Q, Zhu Q, Meng X, Jin Z, Liang F, Tian H, Li T, Wang T, Cao J, Fu Q, Dey S, Li S, Huang K, Kan H, Shi X, Liu Y. Application of multi-angle spaceborne observations in characterizing the long-term particulate organic carbon pollution in China. The Science Of The Total Environment 2024, 958: 177883. PMID: 39647193, PMCID: PMC11824872, DOI: 10.1016/j.scitotenv.2024.177883.Peer-Reviewed Original ResearchOC/EC ratioOC concentrationsIndustrial activitiesOverall PM<sub>2.5</sub> concentration. PCross-validation R<sup>2</sup>Air pollution control policiesPollution source contributionsAir quality policiesBeijing-Tianjin-Hebei regionPollution control policiesChemistry transport model simulationsBeijing-Tianjin-HebeiEvaluating air quality policiesLand use informationElevating OC levelNorth China PlainTransport model simulationsAmbient PMFenwei PlainFire seasonSource contributionsBiomass burningForest firesOC trendsBiogenic emissionsEvaluation of various mass spectrometry mode based on gas chromatography for quantifying the polycyclic aromatic hydrocarbon metabolites in human urine
Bao S, Qian J, Qiu T, Jiang W, Gu W, Qu Y, Bai X, Yu X, Jiang Y, Tang S, Lv Y, Shi X, Lu Y. Evaluation of various mass spectrometry mode based on gas chromatography for quantifying the polycyclic aromatic hydrocarbon metabolites in human urine. Journal Of Chromatography A 2024, 1739: 465521. PMID: 39566290, DOI: 10.1016/j.chroma.2024.465521.Peer-Reviewed Original ResearchElectron ionizationHuman urinePolycyclic aromatic hydrocarbonsGas chromatographyOH-PAHsHydroxylated polycyclic aromatic hydrocarbonsTandem mass spectrometryRange of compoundsMethod validation criteriaMass spectrometry technologyAromatic hydrocarbonsMass spectrometryHuman exposure to polycyclic aromatic hydrocarbonsExposure to polycyclic aromatic hydrocarbonsPolycyclic aromatic hydrocarbon metabolitesNational human biomonitoring programSample volumeHuman biomonitoring programsHuman biological monitoringIonizationBiomonitoring programsUrine samplesHydrocarbon metabolitesBiological monitoringMinute concentrationsCorrigendum to ‘Heavy metals and metalloids exposure and liver function in Chinese adults - A nationally representative cross-sectional study’ [Environ. Res. 252-P2 (2024) 118653]
Wang S, Lyu Y, Ji S, Liu N, Wu B, Zhao F, Li Z, Qu Y, Zhu Y, Xie L, Li Y, Zhang Z, Song H, Hu X, Qiu Y, Zheng X, Zhang W, Yang Y, Li F, Cai J, Zhu Y, Cao Z, Tan F, Shi X. Corrigendum to ‘Heavy metals and metalloids exposure and liver function in Chinese adults - A nationally representative cross-sectional study’ [Environ. Res. 252-P2 (2024) 118653]. Environmental Research 2024, 262: 120178. PMID: 39438182, DOI: 10.1016/j.envres.2024.120178.Peer-Reviewed Original ResearchBurden of non-communicable diseases due to population ageing in China: challenges to healthcare delivery and long term care services
Lv Y, Fan L, Zhou J, Ding E, Shen J, Tang S, He Y, Shi X. Burden of non-communicable diseases due to population ageing in China: challenges to healthcare delivery and long term care services. The BMJ 2024, 387: e076529. PMID: 39424307, PMCID: PMC11484826, DOI: 10.1136/bmj-2023-076529.Peer-Reviewed Original ResearchSocial isolation and likelihood of becoming centenarians: evidence from the Chinese longitudinal healthy longevity survey
Li Y, Jigeer G, Lv Y, Wang K, Peng Y, Sun L, Shi X, Gao X. Social isolation and likelihood of becoming centenarians: evidence from the Chinese longitudinal healthy longevity survey. BMC Geriatrics 2024, 24: 839. PMID: 39407128, PMCID: PMC11476547, DOI: 10.1186/s12877-024-05417-z.Peer-Reviewed Original ResearchConceptsChinese Longitudinal Healthy Longevity SurveySocial isolationLongevity SurveyAssociated with health outcomesHigher social isolation scoresConditional logistic regression modelsOldest-old peopleProspective nested case-control studyPublic health initiativesSocial isolation scoresOldest-old populationNested case-control studyDegree of social isolationLogistic regression modelsCase-control studyBackgroundSocial isolationHealth initiativesHealth outcomesLifestyle factorsCommunity-basedNever smokersOlder adultsYear of entryInverse associationIsolation scoresLeisure-time activities and disability among Chinese community-dwelling oldest old: evidence from the Chinese Longitudinal Healthy Longevity Study
Zhong W, Wang X, Liang F, Song W, Chen Z, Li Z, Shen Q, Shen D, Nan Y, Xiang J, Li C, Ye Z, Huang H, Wang J, Lv Y, Shi X, Mao C. Leisure-time activities and disability among Chinese community-dwelling oldest old: evidence from the Chinese Longitudinal Healthy Longevity Study. European Journal Of Public Health 2024, 34: 1177-1183. PMID: 39254527, PMCID: PMC11631485, DOI: 10.1093/eurpub/ckae129.Peer-Reviewed Original ResearchLeisure-time activitiesRisk of disabilityOlder adultsChinese Longitudinal Healthy Longevity StudyChinese Longitudinal Healthy Longevity SurveyActivities of daily livingChinese community-dwellingCox proportional hazards modelsPublic health problemLeisure-timeLongevity SurveyAcceleration of population agingCommunity-dwellingProportional hazards modelDaily livingPhysical performanceWatching TVHealth problemsFrequent engagementDaily activitiesAffecting disabilityDisabilityHazards modelPopulation agingLongevity StudyExposome-Wide Ranking to Uncover Environmental Chemicals Associated with Dyslipidemia: A Panel Study in Healthy Older Chinese Adults from the BAPE Study.
Ding E, Deng F, Fang J, Liu J, Yan W, Yao Q, Miao K, Wang Y, Sun P, Li C, Liu Y, Dong H, Dong L, Zhang X, Lu Y, Lin X, Ding C, Li T, Shi Y, Cai Y, Liu X, Godri Pollitt K, Ji J, Tong S, Tang S, Shi X. Exposome-Wide Ranking to Uncover Environmental Chemicals Associated with Dyslipidemia: A Panel Study in Healthy Older Chinese Adults from the BAPE Study. Environmental Health Perspectives 2024, 132: 97005. PMID: 39240788, PMCID: PMC11379127, DOI: 10.1289/ehp13864.Peer-Reviewed Original ResearchConceptsDyslipidemia markersCardiovascular diseaseMulti-omicsMarkers of dyslipidemiaExamination of cytokinesMeasurement of cytokinesSerum lipidomeSystemic inflammationMulti-omics profilingCardiac functionDyslipidemiaPrimary preventionClinical measuresSerumChinese adultsBlood transcriptomeImpact spectraCytokinesExposome-wide association studyInflammationMarkersBiomolecular pathwaysAssociationHealthy older adultsElectrocardiogramAssociation of daytime-only, nighttime-only, compound heatwaves with preterm birth by urban-rural and regional socioeconomic status in China
Guo Y, Chen P, Xie Y, Wang Y, Mu Y, Zhou R, Niu Y, Shi X, Zhu J, Liang J, Liu Q. Association of daytime-only, nighttime-only, compound heatwaves with preterm birth by urban-rural and regional socioeconomic status in China. ISEE Conference Abstracts 2024, 2024 DOI: 10.1289/isee.2024.0175.Peer-Reviewed Original ResearchFuture high temperature aggravate ozone-attributable deaths and spatial variation under China's carbon neutrality scenario limiting global warming to 2℃
Chen C, Qiu Y, Li T, Shi X. Future high temperature aggravate ozone-attributable deaths and spatial variation under China's carbon neutrality scenario limiting global warming to 2℃. ISEE Conference Abstracts 2024, 2024 DOI: 10.1289/isee.2024.0380.Peer-Reviewed Original ResearchDisparities of heat wave-related preterm birth in climate types — China, 2012-2019
Guo Y, Xie Y, Wei X, Guo C, Chen P, Wang Y, Mu Y, Shi X, Zhu J, Liang J, Liu Q. Disparities of heat wave-related preterm birth in climate types — China, 2012-2019. ISEE Conference Abstracts 2024, 2024 DOI: 10.1289/isee.2024.1648.Peer-Reviewed Original ResearchHigh temperature and hospitalisations for kidney disease spectrum in China during 2013–2019: Vulnerable populations and geographic differentials
Wang Y, Wang S, Shi W, Fan L, Zhang Y, Chen C, Wang J, Fang J, Tong S, Shi X, Wu S. High temperature and hospitalisations for kidney disease spectrum in China during 2013–2019: Vulnerable populations and geographic differentials. ISEE Conference Abstracts 2024, 2024 DOI: 10.1289/isee.2024.0439.Peer-Reviewed Original Research
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