2025
Neuro- and social-cognition in schizotypal personality disorder and schizophrenia: A spectrum of severity
Goldstein K, Pietrzak R, Aladin S, Ng S, Chan C, Perez-Rodriguez M, Shafritz K, Kahn R, McClure M, Szeszko P, Hazlett E. Neuro- and social-cognition in schizotypal personality disorder and schizophrenia: A spectrum of severity. Psychiatry Research 2025, 348: 116445. PMID: 40117765, DOI: 10.1016/j.psychres.2025.116445.Peer-Reviewed Original ResearchSchizotypal personality disorderSocial cognitionPersonality disorderNegative symptomsNeuro-cognitiveSchizotypal personality disorder patientsCognitive impairmentCompared social cognitionSocial cognitive impairmentsSocial cognitive treatmentGeneral cognitive impairmentSocial-emotional cognitionGlobal cognitive impairmentProfile of clinical symptomsAssociated with greater reductionsCombined patient groupGender-matched healthy controlsNine-month follow-upSchizophrenia spectrumSchizophrenia patientsSchizophreniaDiagnostic groupsChange-over-timeCognitionGreater reductionsDifferentiating U.S. military women veterans with suicidal ideation, suicide attempts, and no suicidal ideation or attempts
Presseau C, Fischer I, Aunon F, Webermann A, Pietrzak R. Differentiating U.S. military women veterans with suicidal ideation, suicide attempts, and no suicidal ideation or attempts. Military Psychology 2025, ahead-of-print: 1-11. PMID: 40036151, DOI: 10.1080/08995605.2025.2472558.Peer-Reviewed Original ResearchSuicidal ideationWomen veteransActivities of daily livingSuicide risk groupSuicide-related outcomesLifetime suicidal ideationSubstance use disordersAdverse childhood experiencesU.S. women veteransDepressive disorderSI/SAIdeationChildhood experiencesIntervention effortsTrauma burdenInstrumental activities of daily livingSuicideVeteransMultinomial logistic regression analysisPost-hocDisordersExamined sociodemographicsHealth characteristicsDaily livingLogistic regression analysisVenous blood sampling for less invasive in vivo quantification of synaptic density with constant infusion of [18F]SynVesT-1 and PET
Asch R, Naganawa M, Moisieienko K, Weed M, Kapinos M, Zheng M, Hillmer A, Carson R, Pietrzak R, Esterlis I. Venous blood sampling for less invasive in vivo quantification of synaptic density with constant infusion of [18F]SynVesT-1 and PET. EJNMMI Research 2025, 15: 8. PMID: 39900828, PMCID: PMC11790547, DOI: 10.1186/s13550-025-01200-2.Peer-Reviewed Original ResearchPsychometric properties and socio-demographic correlates of the Connor-Davidson Resilience Scale in three large population-based cohorts including Danish and Icelandic adults
Didriksen M, Daníelsdottir H, Bjarnadóttir M, Overstreet C, Choi K, Christoffersen L, Mikkelsen C, Aspelund T, Hauksdóttir A, Thordardottir B, Jakobsdóttir J, Tómasson G, Erikstrup C, Aagaard B, Bruun M, Ullum H, Sørensen E, Fischer I, Pietrzak R, Gelernter J, Campbell-Sills L, Stein M, Werge T, Pedersen O, Valdimarsdóttir U, Ostrowski S, Schork A. Psychometric properties and socio-demographic correlates of the Connor-Davidson Resilience Scale in three large population-based cohorts including Danish and Icelandic adults. Journal Of Mood And Anxiety Disorders 2025, 100112. DOI: 10.1016/j.xjmad.2025.100112.Peer-Reviewed Original ResearchMeasures of psychological resilienceCD-RISC-10Connor-Davidson Resilience ScalePsychometric propertiesCD-RISC-10 scoresPsychological resilienceResilience ScalePopulation-based cohortExploratory factor analysisDepressive disorderDepressive symptomsLongitudinal stabilityInternal consistencyUnidimensional measureConstruct validitySocio-demographic correlatesFactor analysisPhysical healthLower scoresHigher scoresResilient cohortsDanish Blood Donor StudyIcelandic adultsDanish individualsBlood Donor StudyNegative Aging Stereotypes and Clinical Insomnia in Older U.S. Military Veterans
Boyle J, Fischer I, Bashian H, Moye J, Levy B, Pietrzak R. Negative Aging Stereotypes and Clinical Insomnia in Older U.S. Military Veterans. The Gerontologist 2025, gnaf036. PMID: 39878650, DOI: 10.1093/geront/gnaf036.Peer-Reviewed Original ResearchNegative age stereotypesAge stereotypesClinical insomniaEmotional agingInsomnia symptomsU.S. veteransAssociated with clinical insomniaNational Health and ResilienceEndorsement of negative stereotypesOlder United StatesMultivariate regression analysisU.S. military veteransNegative stereotypesClinical insomnia symptomsNegative perceptions of agingAssociated with significantly greater oddsNationally representative sampleImproving overall sleep qualityPerceptions of agingOverall sleep qualityRegression analysisVeterans StudyMilitary veteransOlder veteransInsomniaPrevalence of Moral Injury in Nationally Representative Samples of Combat Veterans, Healthcare Workers, and First Responders
Maguen S, Griffin B, Pietrzak R, McLean C, Hamblen J, Norman S. Prevalence of Moral Injury in Nationally Representative Samples of Combat Veterans, Healthcare Workers, and First Responders. Journal Of General Internal Medicine 2025, 1-7. PMID: 39881119, DOI: 10.1007/s11606-024-09337-x.Peer-Reviewed Original ResearchNationally representative sampleHealthcare workersRepresentative sampleMoral injuryDesignCross-sectional surveyPrevalence of moral injuryFirst respondersExposure to PMIEsMoral injury symptomsCombat veteransHigh-risk populationHigh-risk groupInjury eventsInjury exposureHealthcareVeteransWell-beingOccupational differencesRespondentsPMIEsPrevalenceWorkersComplex decisionsClinicInjuryCriminal Justice System Involvement Among U.S. Military Veterans: Prevalence, Correlates, and Mental Health Burden
Meisler A, Gianoli M, Pietrzak R. Criminal Justice System Involvement Among U.S. Military Veterans: Prevalence, Correlates, and Mental Health Burden. Criminal Justice And Behavior 2025, 52: 555-570. DOI: 10.1177/00938548241313383.Peer-Reviewed Original ResearchJustice system involvementU.S. military veteransMilitary veteransLifetime substance use disorderSubstance use disordersCriminal justice system involvementCurrent substance useAdverse childhood experiencesMental health burdenAssociated with current substance useSuicidal ideationLifetime traumaPopulation-based findingsTreatment utilizationCumulative traumaU.S. veteransSubstance useChildhood experiencesVeteransNationally representative sampleRepresentative sampleSystem involvementRacial/ethnic minoritiesIdeationHealth burdenResilience and Vulnerability: Suicide-Specific Cognitions in a Nationally Representative Sample of US Military Veterans.
Fischer I, Nichter B, Trachik B, Bryan C, Pietrzak R. Resilience and Vulnerability: Suicide-Specific Cognitions in a Nationally Representative Sample of US Military Veterans. The Primary Care Companion For CNS Disorders 2025, 27 PMID: 39823445, DOI: 10.4088/pcc.24m03821.Peer-Reviewed Original ResearchConceptsSuicide-specific cognitionsNationally representative sampleUS military veteransSuicide riskMilitary veteransActivities of daily livingNational Health and ResilienceSample of US military veteransSuicide Cognitions ScalePrevalence of veteransPositive psychological traitsReduce suicide riskAdverse childhood experiencesDaily livingPsychosocial characteristicsSocial supportVeterans StudyUS veteransSuicidal behaviorSuicidal ideationCognitive scalesRepresentative samplePsychological traitsElevated riskSocial connectednessSocial Determinants of Health and Suicide-Related Outcomes
Na P, Shin J, Kwak H, Lee J, Jester D, Bandara P, Kim J, Moutier C, Pietrzak R, Oquendo M, Jeste D. Social Determinants of Health and Suicide-Related Outcomes. JAMA Psychiatry 2025, 82 PMID: 39745761, DOI: 10.1001/jamapsychiatry.2024.4241.Peer-Reviewed Original ResearchSocial determinants of healthSuicide mortalitySuicide-related outcomesAssociation of social determinants of healthRisk of suicide mortalityPrevent suicideAssociated with suicide mortalitySuicidal ideationHomeless individualsMeta-analysesDeterminants of healthSuicide riskRisk factorsPublic health policiesSuicide attemptsIncarcerated female youthIntimate partner violenceSexual minority statusPrevalence of lifetime suicidal ideationIncreased suicide riskExperiences of childhood abuseSocial determinantsWeb of ScienceResearch SynthesesTailored interventions
2024
Prevalence, correlates, and mental and physical health burden of cardiovascular disease in older U.S. military veterans
Arechiga C, Yang R, Pietrzak R. Prevalence, correlates, and mental and physical health burden of cardiovascular disease in older U.S. military veterans. PLOS Mental Health 2024, 1: e0000192. DOI: 10.1371/journal.pmen.0000192.Peer-Reviewed Original ResearchHealth burden of cardiovascular diseaseOlder U.S. veteransBurden of cardiovascular diseaseMental health conditionsU.S. military veteransHealth conditionsAssociated with cardiovascular diseaseMilitary veteransCardiovascular diseasePopulation-based sample of veteransU.S. veteransNational Health and ResilienceIncreased risk of CVDOlder military veteransPhysical health variablesPhysical health burdenAssociation of cardiovascular diseasePopulation-based samplePrevalence of cardiovascular diseaseSample of veteransNationally representative sampleRisk of cardiovascular diseaseDiagnosis of hypertensionSelf-report assessmentsCross-sectional sampleIdentifying transdiagnostic traumatic stress reactions in U.S. military veterans: A nationally representative study
Pugach C, Adams S, Wisco B, Pietrzak R. Identifying transdiagnostic traumatic stress reactions in U.S. military veterans: A nationally representative study. Journal Of Traumatic Stress 2024 PMID: 39682069, DOI: 10.1002/jts.23119.Peer-Reviewed Original ResearchPosttraumatic stress disorderTraumatic stress reactionsU.S. military veteransDysphoric arousalMilitary veteransSelf-reported posttraumatic stress disorderPosttraumatic stress disorder symptomsNational Health and ResilienceStress reactionsComorbid psychopathologyPsychopathological symptomsGeneralized anxietyStress disorderDiagnostic subtypesVeterans StudyDepressive symptomsLatent class analysisTrauma historySymptom differencesU.S. veteransPsychopathologyMental functioningPsychosocial correlatesArousalFunctional impairmentSex Differences in PTSD Among US Military Veterans: Role of Trauma, Coping, and Social Factors.
Yang R, Fischer I, Na P, Mazure C, Pietrzak R. Sex Differences in PTSD Among US Military Veterans: Role of Trauma, Coping, and Social Factors. The Journal Of Clinical Psychiatry 2024, 86 PMID: 39700385, DOI: 10.4088/jcp.24br15621.Peer-Reviewed Original ResearchHappiness in US military veterans: Results from a nationally representative study
Kang H, Fischer I, Na P, Pietrzak R. Happiness in US military veterans: Results from a nationally representative study. PLOS ONE 2024, 19: e0313609. PMID: 39661580, PMCID: PMC11633995, DOI: 10.1371/journal.pone.0313609.Peer-Reviewed Original ResearchConceptsUS military veteransMilitary veteransNational Health and ResilienceWhole Health approachEmotional stabilityMean happiness scoreWell-beingPerception of well-beingSeverity of depressive symptomsNationally representative sampleCorrelates of happinessMeasures of optimismVeterans' perceptionsPsychosocial characteristicsVeterans StudySubjective well-beingDepressive symptomsHealth approachRepresentative sampleHigher optimismVeteransHappiness scoresGreater happinessAnalyzed dataUS DepartmentPsychometric properties, factor structure, and functional correlates of the PTSD checklist for DSM-5 in a U.S. national sample of older veterans
Cook J, Bovin M, Günak M, Lawrence K, Pietrzak R. Psychometric properties, factor structure, and functional correlates of the PTSD checklist for DSM-5 in a U.S. national sample of older veterans. International Psychogeriatrics 2024, 37: 100027. PMID: 40086904, DOI: 10.1016/j.inpsyc.2024.100027.Peer-Reviewed Original ResearchPosttraumatic stress disorderPosttraumatic Stress Disorder ChecklistDSM-5PCL-5Psychometric propertiesOlder veteransSymptoms of posttraumatic stress disorderSubthreshold posttraumatic stress disorderAdult trauma exposurePCL-5 scoresMeasure PTSD symptomsSample of older veteransExcellent internal consistencyRates of childhoodNationally representative web-based surveyU.S. national sampleAssociated with measuresDysphoric symptomsPTSD symptomsStress disorderTrauma exposureFactor structureCommunity-dwelling older veteransAssessment measuresInternal consistencyPosttraumatic Stress Disorder, Obesity, and Accelerated Epigenetic Aging Among US Military Veterans
Fischer I, Na P, Nagamatsu S, Jeste D, Cabrera-Mendoza B, Montalvo-Ortiz J, Krystal J, Polimanti R, Gelernter J, Pietrzak R. Posttraumatic Stress Disorder, Obesity, and Accelerated Epigenetic Aging Among US Military Veterans. JAMA Psychiatry 2024, 81: 1276-1277. PMID: 39476130, PMCID: PMC11581715, DOI: 10.1001/jamapsychiatry.2024.3403.Peer-Reviewed Original ResearchAssociation of clerical burden and EHR frustration with burnout and career intentions among physician faculty in an urban academic health system
Ripp J, Pietrzak R, de Guillebon E, Peccoralo L. Association of clerical burden and EHR frustration with burnout and career intentions among physician faculty in an urban academic health system. International Journal Of Medical Informatics 2024, 195: 105740. PMID: 39644795, DOI: 10.1016/j.ijmedinf.2024.105740.Peer-Reviewed Original ResearchElectronic health recordsClerical burdenAssociated with greater likelihoodPhysician facultyHealth systemEHR timeUrban academic health systemClerical timeGreater likelihoodOdds of burnoutAssociated with lower oddsAcademic health systemMultivariate logistic regression analysisHealth recordsLogistic regression analysisHospital-based departmentsInstitution-wide surveyLower oddsHealthy workforceHealthcare systemDemographic characteristicsNew York CityBurnoutCareer intentionsPhysiciansExamining Methylation at the Intersection of Genetic Risk To Alzheimer’s Disease And Alcohol Use Disorder
Pathak G, Pietrzak R, Levey D, Montalvo‐Ortiz J, Kranzler H, Gelernter J, Polimanti R. Examining Methylation at the Intersection of Genetic Risk To Alzheimer’s Disease And Alcohol Use Disorder. Alzheimer's & Dementia 2024, 20: e086508. PMCID: PMC11710760, DOI: 10.1002/alz.086508.Peer-Reviewed Original ResearchEpigenome-wide association studiesGenetic susceptibility to ADSusceptibility to ADCpG sitesPolygenic scoresAD pathogenesisAlzheimer's diseaseTOPMed reference panelEuropean ancestry participantsIllumina EPIC arrayBrain lipid metabolismCpG associationsAssociation studiesIdentified genesGenotype dataGenetic ancestryImprove statistical powerReference panelAncestry participantsEPIC arrayBonferroni significanceCpGMethylation intensityAlcohol use disorder diagnosisRisk of neurodegenerationExamining Methylation at the Intersection of Genetic Risk To Alzheimer's Disease And Alcohol Use Disorder
Pathak G, Pietrzak R, Levey D, Montalvo‐Ortiz J, Kranzler H, Gelernter J, Polimanti R. Examining Methylation at the Intersection of Genetic Risk To Alzheimer's Disease And Alcohol Use Disorder. Alzheimer's & Dementia 2024, 20: e093693. PMCID: PMC11712840, DOI: 10.1002/alz.093693.Peer-Reviewed Original ResearchEpigenome-wide association studiesGenetic susceptibility to ADSusceptibility to ADCpG sitesPolygenic scoresAD pathogenesisAlzheimer's diseaseTOPMed reference panelEuropean ancestry participantsIllumina EPIC arrayBrain lipid metabolismCpG associationsAssociation studiesIdentified genesGenotype dataGenetic ancestryImprove statistical powerReference panelAncestry participantsEPIC arrayBonferroni significanceCpGMethylation intensityAlcohol use disorder diagnosisRisk of neurodegenerationTraumatic Brain Injury in U.S. Veterans: Prevalence and Associations with Physical, Mental, and Cognitive Health
Karr J, Rippey C, Hubert T, Stein M, Adams T, Pietrzak R. Traumatic Brain Injury in U.S. Veterans: Prevalence and Associations with Physical, Mental, and Cognitive Health. Archives Of Physical Medicine And Rehabilitation 2024 PMID: 39613218, DOI: 10.1016/j.apmr.2024.11.010.Peer-Reviewed Original ResearchPosttraumatic stress disorderAlcohol use disorderDrug use disordersTraumatic brain injuryActivities of daily livingInstrumental activities of daily livingU.S. veteransAnxiety disordersSuicidal ideationUse disorderHealth conditionsPrevalence of traumatic brain injuryU.S. military veteransBrain injuryActivities of daily living disabilitySelf-reported health professional diagnosisOdds of mild cognitive impairmentU.S. veteran populationMental health conditionsMild cognitive impairmentPhysical health conditionsDepressive disorderStress disorderAssociated with higher oddsSuicide attemptsTrauma-related nightmares among U.S. veterans: Findings from a nationally representative study
Worley C, Meshberg-Cohen S, Fischer I, Pietrzak R. Trauma-related nightmares among U.S. veterans: Findings from a nationally representative study. Sleep Medicine 2024, 126: 159-166. PMID: 39672095, DOI: 10.1016/j.sleep.2024.11.031.Peer-Reviewed Original ResearchTrauma-related nightmaresNationally representative sampleSuicidal ideationTreatment of trauma-related nightmaresRepresentative sampleAssociated with adverse mental healthExposure to adverse childhood eventsTrauma-exposed veteransAssociated with elevated oddsAdverse mental healthIncreased suicide riskNationally representative studyAdverse childhood eventsUS military veteransTransdiagnostic assessmentNightmare severityTrauma exposureHealth historySociodemographic factorsMental healthSuicide riskTrauma typesPsychiatric conditionsSociodemographic characteristicsPsychosocial functioning
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