Lauren A. Baldassarre, MD, FACC
Associate Professor of Medicine (Cardiovascular Medicine)Cards
About
Research
Publications
2025
Integration and Potential Applications of Cardiovascular Computed Tomography in Cardio-Oncology
Erbay M, Manubolu V, Stein-Merlob A, Ferencik M, Mamas M, Lopez-Mattei J, Baldassarre L, Budoff M, Yang E. Integration and Potential Applications of Cardiovascular Computed Tomography in Cardio-Oncology. Current Cardiology Reports 2025, 27: 51. PMID: 39932640, PMCID: PMC11814013, DOI: 10.1007/s11886-025-02206-x.Peer-Reviewed Original ResearchConceptsRadiation-induced cardiovascular diseaseCoronary artery diseaseCardiovascular diseaseCardiac massComputed tomographyArtery diseaseChest CT scans of patientsCT scans of patientsIncreased risk of CVDInvasive coronary angiographyRisk of cardiovascular diseaseRisk of complicationsScans of patientsCardiovascular computed tomographySeverity of cardiovascular diseaseNon-invasive imaging toolMonitoring of disease progressionManifestations of diseaseAsymptomatic patientsCardiac deteriorationIschemia evaluationCoronary angiographyPericardial diseaseCardiac changesRisk stratificationDiagnosis of cancer therapy-related cardiovascular toxicities: A multimodality integrative approach and future developments
Travers S, Alexandre J, Baldassarre L, Salem J, Mirabel M. Diagnosis of cancer therapy-related cardiovascular toxicities: A multimodality integrative approach and future developments. Archives Of Cardiovascular Diseases 2025, 118: 185-198. PMID: 39947997, DOI: 10.1016/j.acvd.2024.12.012.Peer-Reviewed Original ResearchConceptsCardio-oncologyCardiovascular toxicityCardiovascular imagingMultimodality cardiovascular imagingCancer risk factorsIncrease diagnostic accuracyPrognostic stratificationNatriuretic peptideSerum biomarkersTherapy schemesDiagnostic accuracyCancer therapyRhythm disordersRisk factorsCardiovascular diseaseBiomarkersMultimodal integrated approachCancerOmics approachesToxicityRhythmTherapyTroponinSerumDiagnosisHow to Use Imaging: Complex Cases of Atherosclerosis, Myocardial Inflammation, and Cardiomyopathy in Cardio-Oncology
Khattab M, Baig M, Zarif T, Barac A, Ferencik M, Henry M, Lopez-Mattei J, Redheuil A, Salem J, Scherrer-Crosbie M, Yang E, Baldassarre L. How to Use Imaging: Complex Cases of Atherosclerosis, Myocardial Inflammation, and Cardiomyopathy in Cardio-Oncology. Circulation Cardiovascular Imaging 2025, 18: e015981. PMID: 39772610, DOI: 10.1161/circimaging.124.015981.Peer-Reviewed Original ResearchConceptsCardio-oncologyCases of atherosclerosisCardiac magnetic resonance imagingCoronary computed tomography angiographySingle-photon emission computed tomographyImmune checkpoint inhibitorsLeft ventricular dysfunctionMultimodality cardiac imagingTyrosine kinase inhibitorsCardiac imaging modalitiesComputed tomography angiographyRisk of cardiovascular diseaseEmission computed tomographyPositron emission tomographyMagnetic resonance imagingCheckpoint inhibitorsVentricular dysfunctionMyocardial inflammationCoronary vasospasmAccelerated atherosclerosisKinase inhibitorsPatient populationDiagnosing such pathologiesCancer therapyCardiac imagingSecondary hemochromatosis in a patient with supraventricular tachycardia and new decompensated heart failure
Baig M, Tysarowski M, Ruiz D, Fuss C, Baldassarre L. Secondary hemochromatosis in a patient with supraventricular tachycardia and new decompensated heart failure. Journal Of Cardiovascular Magnetic Resonance 2025, 27: 101736. DOI: 10.1016/j.jocmr.2024.101736.Peer-Reviewed Original ResearchMulti-echo bSSFP for human cardiac DMI on a clinical 3T MRI scanner
Xiang J, de Graaf R, De Feyter H, Thomas M, Baldassarre L, Kwan J, Peters D. Multi-echo bSSFP for human cardiac DMI on a clinical 3T MRI scanner. Journal Of Cardiovascular Magnetic Resonance 2025, 27: 101295. DOI: 10.1016/j.jocmr.2024.101295.Peer-Reviewed Original ResearchCardiac MRI predicts mortality in patients with autoimmune rheumatic diseases
Csecs I, Tysarowski M, Baldassarre L, Feher A. Cardiac MRI predicts mortality in patients with autoimmune rheumatic diseases. Journal Of Cardiovascular Magnetic Resonance 2025, 27: 101317. DOI: 10.1016/j.jocmr.2024.101317.Peer-Reviewed Original ResearchProspective evaluation of ICI myocarditis: late gadolinium enhancement predicts mortality
Tysarowski M, Khattab M, Zarif T, Kwan J, Baldassarre L. Prospective evaluation of ICI myocarditis: late gadolinium enhancement predicts mortality. Journal Of Cardiovascular Magnetic Resonance 2025, 27: 101249. DOI: 10.1016/j.jocmr.2024.101249.Peer-Reviewed Original Research
2024
Adverse cardiovascular events and cardiac imaging findings in patients on immune checkpoint inhibitors
Kwan J, Shen M, Akhlaghi N, Hu J, Mora R, Cross J, Jiang M, Mankbadi M, Wang P, Zaman S, Lee S, Im Y, Feher A, Liu Y, S. S, Tao W, Wei W, Baldassarre L. Adverse cardiovascular events and cardiac imaging findings in patients on immune checkpoint inhibitors. PLOS ONE 2024, 19: e0314555. PMID: 39621799, PMCID: PMC11611253, DOI: 10.1371/journal.pone.0314555.Peer-Reviewed Original ResearchConceptsAdverse cardiovascular eventsICI therapyCardiac magnetic resonanceIncreased risk of mortalityICI initiationIncreased riskRisk of mortalityCentral nervous systemVentricular dysfunctionCancer patients treated with ICIsCardiovascular eventsLeft ventricular late gadolinium enhancementMortality benefitCardiovascular riskAbnormal left ventricular ejection fractionPatients treated with ICIsLeft ventricular ejection fractionCentral nervous system malignanciesRisk of adverse cardiovascular eventsImmune checkpoint inhibitorsRight ventricular dysfunctionGlobal longitudinal strainVentricular ejection fractionLeft ventricular dysfunctionMultimodality cardiac imagingDiastolic dysfunction evaluation by cardiovascular magnetic resonance derived E, a, e’: Comparison to echocardiography
Lamy J, Xiang J, Shah N, Kwan J, Kim Y, Upadhyaya K, Reinhardt S, Meadows J, McNamara R, Baldassarre L, Peters D. Diastolic dysfunction evaluation by cardiovascular magnetic resonance derived E, a, e’: Comparison to echocardiography. Physiological Reports 2024, 12: e70078. PMID: 39604208, PMCID: PMC11602526, DOI: 10.14814/phy2.70078.Peer-Reviewed Original ResearchConceptsCardiovascular magnetic resonanceTransthoracic echocardiographyDiastolic dysfunctionDiastolic functionDiagnostic accuracy of cardiovascular magnetic resonanceEvaluate diastolic dysfunctionCardiovascular magnetic resonance imagingLeft atrial volumeMitral annular velocityHealthy age-matched subjectsComparison to echocardiographyMitral inflow velocityEvaluate diastolic functionAge-matched subjectsPresence of DDAtrial volumeDD gradeFirst-lineAnnular velocityDiagnostic accuracyImaging modalitiesMagnetic resonanceEchocardiographyALLTransthoracicAdvanced Imaging Modalities in Cardiotoxicity: The Roles of Cardiac CT, MRI, and PET in Cardio-oncology
Arbune A, Khattab M, Henry M, Baldassarre L. Advanced Imaging Modalities in Cardiotoxicity: The Roles of Cardiac CT, MRI, and PET in Cardio-oncology. Current Treatment Options In Cardiovascular Medicine 2024, 27: 5. DOI: 10.1007/s11936-024-01061-3.Peer-Reviewed Original ResearchImmune checkpoint inhibitorsBaseline risk stratificationCardiac computed tomographyCardiac magnetic resonanceAdvanced cardiac imaging modalitiesPositron emission tomographyCardiac imaging modalitiesCoronary artery calciumRisk stratificationCardio-oncologyImaging modalitiesCardiac massEvaluate immune checkpoint inhibitorsImmune checkpoint inhibitor myocarditisImmune checkpoint inhibitor therapyAdvanced cardiac imaging techniquesCardiac positron emission tomographyDiagnosis of cardiotoxicityNoninvasive diagnostic testCardiac imaging techniquesRisk stratification toolCardio-oncology patientsAdvanced imaging modalitiesCoronary flow reserveImaging techniques
Clinical Trials
Current Trials
Advanced Cardiovascular Magnetic Resonance for Detection of Programmed Cell Death Protein-1 Deficient Myocarditis
HIC ID2000023943RolePrincipal InvestigatorPrimary Completion Date10/29/2024Recruiting Participants
Academic Achievements & Community Involvement
Clinical Care
Overview
Lauren Baldassarre, MD, is a cardiologist at Yale Medicine and director of the Cardio-Oncology Program at the Yale Cancer Center.
Cardio-oncology is a relatively new field that helps patients manage the cardiac side effects of therapies they’re receiving for cancer treatment (such as chemotherapy, radiation and immunotherapy). The goal of the cardio-oncology program is to diagnose and treat those side effects as early as possible.
Dr. Baldassarre first became interested in cardio-oncology during her cardiology fellowship, and she decided to pursue and complete an additional year of fellowship training at the Memorial Sloan Kettering Cancer Center in New York City. That fellowship focused on advanced cardiac imaging with cardiac MRI and caring for cancer patients with cardiac questions or complications. It was a way for Dr. Baldassarre to combine her interests in women’s heart disease and cardiac imaging, and introduced her to the field of cardio-oncology. In 2013, she arrived at Yale Medicine and became the director of the cardio-oncology program in 2015.
As the director, Dr. Baldassarre’s goals have been to offer care to any patient who might benefit from cardiovascular risk assessment and monitoring not only at the main hospital, but also at Yale Medicine satellite sites, and to expand research and clinical trials that investigate ways to diagnose cardiac complications from cancer earlier.
When meeting with new patients, Dr. Baldassarre takes a thorough history and physical and completes a cardiovascular risk assessment based on the type of cancer therapy they will be receiving. Patients can also expect to undergo some cardiac imaging as part of that risk assessment.
“I really hope to be able to put patients at ease,” says Dr. Baldassarre. “I know that patients are concerned especially when they’re going through so much already.” She walks them through established monitoring and treatments protocols, which may be used to prevent complications or treat them, if they do arise.
In addition to seeing patients, Dr. Baldassarre researches the cardiac side effects of immunotherapy, one of the most promising therapies for cancer. She is also an associate professor (cardiology) at Yale Medicine.
Clinical Specialties
Fact Sheets
CT Scan for Coronary Artery Disease
Learn More on Yale MedicineChronic Total Occlusion (CTO)
Learn More on Yale MedicineCoronary Artery Disease (CAD)
Learn More on Yale MedicineHeart Disease in Women
Learn More on Yale Medicine
Board Certifications
Cardiovascular Computed Tomography
- Certification Organization
- AB of Nuclear Cardiology
- Original Certification Date
- 2016
Cardiovascular Computed Tomography
- Certification Organization
- Certification Board of Cardiovascular Computed Tomography
- Original Certification Date
- 2012
Yale Medicine News
News & Links
News
- September 18, 2024
Drs. Gallegos and Akintoye Named New Leaders of Yale’s Advanced Cardiac Imaging Fellowship Program
- July 24, 2024
Yale Department of Internal Medicine Faculty Promotions and Appointments (July 2024)
- April 01, 2024
Yale Faculty Present Groundbreaking Clinical Research at the 2024 American College of Cardiology Scientific Sessions
- June 09, 2023
Five faculty members receive Innovative Project Award for sarcoidosis research
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Cardiovascular Medicine
15 York Street, PO Box 208017
New Haven, CT 06520-8017
United States
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