Adam Chekroud, PhD
Assistant Professor Adjunct, PsychiatryCards
About
Research
Publications
2025
Return on Investment of Enhanced Behavioral Health Services
Hawrilenko M, Smolka C, Ward E, Ambwani G, Brown M, Mohandas A, Paulus M, Krystal J, Chekroud A. Return on Investment of Enhanced Behavioral Health Services. JAMA Network Open 2025, 8: e2457834. PMID: 39908020, PMCID: PMC11800021, DOI: 10.1001/jamanetworkopen.2024.57834.Peer-Reviewed Original ResearchConceptsBehavioral health careBehavioral health servicesBehavioral health diagnosesHealth care costsHealth diagnosisBehavioral health benefitsProgram groupHealth servicesHealth careCare costsPhysical health care costsCohort studyMedical claimsMedical spendingBehavioral health appointmentsBehavioral health programsBehavioral health conditionsMental health diagnosesBehavioral health costsHealth benefitsDifference-in-differences analysisMedication risk scoreIn-person psychotherapyMedical cost savingsMedical management
2024
Illusory generalizability of clinical prediction models
Chekroud A, Hawrilenko M, Loho H, Bondar J, Gueorguieva R, Hasan A, Kambeitz J, Corlett P, Koutsouleris N, Krumholz H, Krystal J, Paulus M. Illusory generalizability of clinical prediction models. Science 2024, 383: 164-167. PMID: 38207039, DOI: 10.1126/science.adg8538.Peer-Reviewed Original Research
2023
Personalized symptom clusters that predict depression treatment outcomes: A replication of machine learning methods
Chen Y, Stewart J, Ge J, Cheng B, Chekroud A, Hellerstein D. Personalized symptom clusters that predict depression treatment outcomes: A replication of machine learning methods. Journal Of Affective Disorders Reports 2023, 11: 100470. DOI: 10.1016/j.jadr.2023.100470.Peer-Reviewed Original ResearchHamilton Rating ScaleSymptom clustersTreatment trajectoriesQuick InventoryTreatment outcomesDouble-blind clinical trialDepressive Symptomatology-Self ReportRating ScaleBest baseline predictorsHAM-D scoresDepression treatment outcomesAnxiety disorder diagnosisQIDS-SR16Depressive illnessEscitalopram monotherapyBaseline variablesClinical trialsBaseline predictorsTreatment efficacyUnipolar depressionDifferent treatment trajectoriesTreatment planLogistic regressionDisorder diagnosisDual treatmentBroadening the Use of Machine Learning in Psychiatry
Adkinson B, Chekroud A. Broadening the Use of Machine Learning in Psychiatry. Biological Psychiatry 2023, 93: 4-5. PMID: 36456077, DOI: 10.1016/j.biopsych.2022.10.006.Peer-Reviewed Original Research
2022
Clinical and Financial Outcomes Associated With a Workplace Mental Health Program Before and During the COVID-19 Pandemic
Bondar J, Morrow C, Gueorguieva R, Brown M, Hawrilenko M, Krystal JH, Corlett PR, Chekroud AM. Clinical and Financial Outcomes Associated With a Workplace Mental Health Program Before and During the COVID-19 Pandemic. JAMA Network Open 2022, 5: e2216349. PMID: 35679044, PMCID: PMC9185188, DOI: 10.1001/jamanetworkopen.2022.16349.Peer-Reviewed Original ResearchConceptsMental health programsHealth programsCohort studyLarge clinical effect sizesPatient Health Questionnaire-9Common mental health conditionsSheehan Disability ScaleClinical effect sizeMental health conditionsMental health symptomsCost of treatmentGeneralized anxiety disorderMental health difficultiesMental health benefitsWorkplace wellness programsCare navigationClinical improvementPrimary outcomeClinical benefitQuestionnaire-9Disability ScaleMedication managementLeast moderate anxietyMixed-effects regressionPerson psychotherapy
2021
Trends in inpatient care for psychiatric disorders in NHS hospitals across England, 1998/99–2019/20: an observational time series analysis
Degli Esposti M, Ziauddeen H, Bowes L, Reeves A, Chekroud A, Humphreys D, Ford T. Trends in inpatient care for psychiatric disorders in NHS hospitals across England, 1998/99–2019/20: an observational time series analysis. Social Psychiatry And Psychiatric Epidemiology 2021, 57: 993-1006. PMID: 34951652, PMCID: PMC8705084, DOI: 10.1007/s00127-021-02215-5.Peer-Reviewed Original ResearchConceptsObservational time series analysisPsychiatric disordersBed daysAdmission ratesHospital activityAge groupsNHS hospitalsBinomial regression modelsNegative binomial regression modelsInpatient psychiatric careMental health needsInpatient hospital activityHospital admissionRegression modelsInpatient carePsychiatric careHealth needsHospitalDisordersCareDepressionAdultsPronounced increaseSame periodChildrenParsing the antidepressant effects of non-invasive brain stimulation and pharmacotherapy: A symptom clustering approach on ELECT-TDCS
Goerigk S, Padberg F, Chekroud A, Kambeitz J, Bühner M, Brunoni A. Parsing the antidepressant effects of non-invasive brain stimulation and pharmacotherapy: A symptom clustering approach on ELECT-TDCS. Brain Stimulation 2021, 14: 906-912. PMID: 34048940, DOI: 10.1016/j.brs.2021.05.008.Peer-Reviewed Original ResearchConceptsTranscranial direct current stimulationNon-invasive brain stimulationDepressive symptomsBrain stimulationEfficacy of tDCSCore depressive symptomsLinear mixed regression modelsDepressive symptom clustersConsiderable inter-individual variabilityDirect current stimulationEscitalopram 20Antidepressant effectsAntidepressant efficacyInter-individual variabilityAtypical symptomsDepressed patientsMixed regression modelsInsomnia symptomsTDCS sessionsPharmacotherapyEscitalopramSymptomsPlaceboSymptom clustersCurrent stimulationThe promise of machine learning in predicting treatment outcomes in psychiatry
Chekroud A, Bondar J, Delgadillo J, Doherty G, Wasil A, Fokkema M, Cohen Z, Belgrave D, DeRubeis R, Iniesta R, Dwyer D, Choi K. The promise of machine learning in predicting treatment outcomes in psychiatry. World Psychiatry 2021, 20: 154-170. PMID: 34002503, PMCID: PMC8129866, DOI: 10.1002/wps.20882.Peer-Reviewed Original Research
2020
Convergent molecular, cellular, and cortical neuroimaging signatures of major depressive disorder
Anderson KM, Collins MA, Kong R, Fang K, Li J, He T, Chekroud AM, Yeo BTT, Holmes AJ. Convergent molecular, cellular, and cortical neuroimaging signatures of major depressive disorder. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 25138-25149. PMID: 32958675, PMCID: PMC7547155, DOI: 10.1073/pnas.2008004117.Peer-Reviewed Original ResearchMeSH KeywordsAstrocytesAutopsyBrainCerebral CortexDepressive Disorder, MajorFemaleGene Expression ProfilingGene Expression RegulationGene OntologyGene Regulatory NetworksGenome-Wide Association StudyGenomicsHumansInterneuronsMaleMultifactorial InheritanceNeuroimagingSignal TransductionSingle-Cell AnalysisSomatostatinConceptsGenome-wide association studiesTranscriptional dataTranscriptional correlatesMajor depressive disorderCorrelates of depressionGene transcriptionSpecific genesGene expressionGene dysregulationIntegrative analysisBiological pathwaysAssociation studiesExpression dataGenesMolecular pathwaysCortical gene expressionDepressive disorderEx vivo geneCells associatesIntegrated analysisVivo geneBiological systemsRegulationPathwayUK BiobankPrecision non-implantable neuromodulation therapies: a perspective for the depressed brain
Borrione L, Bellini H, Razza L, Avila A, Baeken C, Brem A, Busatto G, Carvalho A, Chekroud A, Daskalakis Z, Deng Z, Downar J, Gattaz W, Loo C, Lotufo P, da Graça M. Martin M, McClintock S, O’Shea J, Padberg F, Passos I, Salum G, Vanderhasselt M, Fraguas R, Benseñor I, Valiengo L, Brunoni A. Precision non-implantable neuromodulation therapies: a perspective for the depressed brain. Brazilian Journal Of Psychiatry 2020, 42: 403-419. PMID: 32187319, PMCID: PMC7430385, DOI: 10.1590/1516-4446-2019-0741.Peer-Reviewed Original ResearchConceptsMajor depressive disorderSide effectsCurrent first-line treatmentMultiple medication trialsMagnetic seizure therapyFirst-line treatmentCognitive side effectsTranscranial direct current stimulationTranscranial magnetic stimulationDirect current stimulationCognitive behavioral therapyCost-effectiveness analysisClinical respondersSeizure therapyElectroconvulsive therapyMedication trialsPathophysiological mechanismsClinical trialsDepressed patientsDepressive disorderDepressed brainMagnetic stimulationNeuromodulation techniquesCurrent stimulationTherapy
Academic Achievements & Community Involvement
News
News
- January 12, 2024Source: Yale News
Quest for Personalized Medicine Hits a Snag
- June 09, 2022
Workplace Mental Health Program Evaluated for Clinical and Financial Benefits
- February 13, 2022
Thorne Prize Winner April Koh, YC ’16, Recognized for Success
- January 27, 2020Source: Nature
How Founding a Company Compares to Graduate School