2024
Modelling the epidemiological and economic impact of digital adherence technologies with differentiated care for tuberculosis treatment in Ethiopia
Goscé L, Tadesse A, Foster N, van Kalmthout K, van Rest J, van der Wal J, Harker M, Madden N, Abdurhman T, Gadissa D, Bedru A, Dube T, Alacapa J, Mganga A, Deyanova N, Charalambous S, Letta T, Jerene D, White R, Fielding K, Houben R, McQuaid C. Modelling the epidemiological and economic impact of digital adherence technologies with differentiated care for tuberculosis treatment in Ethiopia. BMJ Global Health 2024, 9: e016997. PMID: 39653521, PMCID: PMC11628985, DOI: 10.1136/bmjgh-2024-016997.Peer-Reviewed Original ResearchConceptsDigital adherence technologiesHealthcare providersTB deathsPatient cost savingsStandard of careAdherence technologiesLabelling interventionsEpidemiological impactASCENT trialDifferentiated careMedication labelsIncident TBImprove tuberculosisProvider costsTB incidenceCareTB episodeProvidersCompartmental transmission modelPotential long-termCost of treatmentInterventionTreatment completionHealthcareEpidemiological benefitsAdjunctive N-Acetylcysteine and Lung Function in Pulmonary Tuberculosis.
Wallis R, Sabi I, Lalashowi J, Bakuli A, Mapamba D, Olomi W, Siyame E, Ngaraguza B, Chimbe O, Charalambous S, Rachow A, Ivanova O, Zurba L, Myombe B, Kunambi R, Hoelscher M, Ntinginya N, Churchyard G. Adjunctive N-Acetylcysteine and Lung Function in Pulmonary Tuberculosis. NEJM Evidence 2024, 3: evidoa2300332. PMID: 39189858, DOI: 10.1056/evidoa2300332.Peer-Reviewed Original ResearchConceptsWhole blood glutathione levelsLung functionN-acetylcysteinePulmonary tuberculosisCulture conversionSecondary outcomesGlutathione levelsEffect of N-acetylcysteineTuberculosis treatment outcomesOutcome of lung functionOral N-acetylcysteineRecovery of lung functionAdjunctive N-acetylcysteineAssociated with improved recoveryN-acetylcysteine treatmentPermanent lung injuryFar-advanced tuberculosisSputum cultureStandard therapyNAC administrationAdverse eventsLung injuryGlobal health concernCohort studyClinical evaluation
2023
“It’s about time they taught us”: a qualitative study evaluating the barriers to finding and screening child contacts under five at risk for TB in Gauteng Province, South Africa from the provider and caregiver perspectives
Munedzimwe F, Chetty-Makkan C, Mukora R, Charalambous S, Turner K, Chihota V. “It’s about time they taught us”: a qualitative study evaluating the barriers to finding and screening child contacts under five at risk for TB in Gauteng Province, South Africa from the provider and caregiver perspectives. BMC Health Services Research 2023, 23: 1415. PMID: 38102646, PMCID: PMC10722712, DOI: 10.1186/s12913-023-10359-0.Peer-Reviewed Original ResearchConceptsTB preventive treatmentTB prevention strategiesIsoniazid preventive therapyTB staffSemi-structured questionnaireTB transmissionFacility staffPrevention strategiesPrimary health clinicsPrevention of tuberculosisEnd TB goalChild contactsYears of ageFacility observationsSemi-structured interview guidePreventive therapyTB preventionTB screeningTB treatmentPreventive servicesPreventive treatmentEkurhuleni DistrictHealth clinicsHigh riskCaregiver perspectives