Philip Corlett, PhD
Associate Professor of PsychiatryCards
About
Research
Publications
2025
Depth inversion illusion and its relationship to positive symptoms in clinical and non-clinical voice hearers
Erickson M, Li C, Bansal S, Waltz J, Corlett P, Gold J. Depth inversion illusion and its relationship to positive symptoms in clinical and non-clinical voice hearers. Cognitive Neuropsychiatry 2025, ahead-of-print: 1-12. PMID: 39969991, DOI: 10.1080/13546805.2025.2467974.Peer-Reviewed Original ResearchPositive symptomsHealthy control subjectsAssociated with positive symptomsEnhanced perception of stimuliDepth inversion illusionsNon-clinical voice hearersVisual illusionsPerception of stimuliIllusion taskSymptom severityModulation of sensory informationPsychiatric illnessInversion illusionsIllusion perceptionVoice hearersMental illnessEnhanced perceptionSensory informationSymptomsControl subjectsPSZIllnessIllusionSchizophreniaDelusionsA generalized reward processing deficit pathway to negative symptoms across diagnostic boundaries
Spilka M, Millman Z, Waltz J, Walker E, Levin J, Powers A, Corlett P, Schiffman J, Gold J, Silverstein S, Ellman L, Mittal V, Woods S, Zinbarg R, Strauss G. A generalized reward processing deficit pathway to negative symptoms across diagnostic boundaries. Psychological Medicine 2025, 55: e6. PMID: 39901872, DOI: 10.1017/s003329172400326x.Peer-Reviewed Original ResearchConceptsNegative symptomsDiagnostic boundariesPsychiatric diagnosisTransdiagnostic sample of youthProcessing profilesEffort-cost computationsPositive valence systemsElevated negative symptomsHelp-seeking participantsClinical high riskClinical group membershipSample of youthHedonic reactivityTransdiagnostic sampleCHR criteriaNeurobiological mechanismsPsychosis riskSubgroup of participantsBehavioral tasksClinical interviewPsychiatric disordersClinical participantsValence systemsGroup membershipDiagnostic classificationN-methyl-d-aspartate receptor hypofunction causes recurrent and transient failures of perceptual inference
Weilnhammer V, Rothkirch M, Yilmaz D, Fritsch M, Ptasczynski L, Reichenbach K, Roediger L, Corlett P, Sterzer P. N-methyl-d-aspartate receptor hypofunction causes recurrent and transient failures of perceptual inference. Brain 2025, awaf011. PMID: 39821016, DOI: 10.1093/brain/awaf011.Peer-Reviewed Original ResearchN-methyl-D-aspartate receptorsN-methyl-D-aspartateN-methyl-D-aspartate receptor hypofunctionS-ketamineSymptoms of schizophreniaDissociation of perceptionsHealthy human participantsExternal sensory signalsReceptor hypofunctionSensory signalsNMDAR hypofunctionPerceptual inferenceCase-control studyInternal predictionsHuman participantsPlacebo-controlledDouble-blindCross-over experimentHypofunctionSchizophreniaParanoidPerceptionSCZRevisiting the Defeatist Performance Belief Scale in Adults With Schizophrenia and Youth at Clinical High-Risk for Psychosis: A Comprehensive Psychometric Analysis
Luther L, Ahmed A, Grant P, Granholm E, Gold J, Williams T, Pratt D, Holden J, Walker E, Arnold L, Ellman L, Mittal V, Zinbarg R, Silverstein S, Corlett P, Powers A, Woods S, Waltz J, Schiffman J, Strauss G. Revisiting the Defeatist Performance Belief Scale in Adults With Schizophrenia and Youth at Clinical High-Risk for Psychosis: A Comprehensive Psychometric Analysis. Schizophrenia Bulletin 2025, sbae220. PMID: 39749462, DOI: 10.1093/schbul/sbae220.Peer-Reviewed Original ResearchDefeatist performance beliefsSchizophrenia spectrum groupClinical high riskNegative symptomsFactor structureCognitive model of negative symptomsMechanisms of negative symptomsModel of negative symptomsNegative symptom improvementNegative symptoms treatmentPhase of psychosisFactor analysisComprehensive psychometric analysisConfirmatory factor analysisExploratory factor analysisPositive symptomsCHR samplesPerformance beliefsMeasurement invarianceDiscriminant validityConvergent validityPsychometric propertiesCognitive modelUnidimensional modelBeliefs ScaleTranslational Models for Psychosis
Corlett P. Translational Models for Psychosis. 2025, 209-214. DOI: 10.1093/med/9780197640654.003.0017.Peer-Reviewed Original Research
2024
Delusional Unreality and Predictive Processing
Castiello S, Rossi-Goldthorpe R, Fan S, Kenney J, Waltz J, Erickson M, Bansal S, Gold J, Corlett P. Delusional Unreality and Predictive Processing. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2024 PMID: 39710316, DOI: 10.1016/j.bpsc.2024.12.006.Peer-Reviewed Original ResearchHealthy control participantsSense of unrealityPeters Delusions InventoryAssociated with delusionsDelusion-like beliefsPrediction error processingImpact of psychosisUnreal experiencesPrediction processDelusions InventoryExtinction learningKamin blockingEsoteric beliefsDelusional ideationClinical delusionsPhenomenological psychopathologistsControl participantsDelusionsSchizophreniaLearning tasksError processHealthy participantsAssess symptomsParticipant groupsKaminParanoid and teleological thinking give rise to distinct social hallucinations in vision
Castiello S, Ongchoco J, van Buren B, Scholl B, Corlett P. Paranoid and teleological thinking give rise to distinct social hallucinations in vision. Communications Psychology 2024, 2: 117. PMID: 39690258, PMCID: PMC11652377, DOI: 10.1038/s44271-024-00163-9.Peer-Reviewed Original ResearchDiffering Pattern of Mismatch Negativity Responses in Clinical and Nonclinical Voice Hearers Challenge Predictive Coding Accounts of Psychosis
Erickson M, Bansal S, Li C, Waltz J, Corlett P, Gold J. Differing Pattern of Mismatch Negativity Responses in Clinical and Nonclinical Voice Hearers Challenge Predictive Coding Accounts of Psychosis. Biological Psychiatry Global Open Science 2024, 5: 100394. PMID: 39526022, PMCID: PMC11550737, DOI: 10.1016/j.bpsgos.2024.100394.Peer-Reviewed Original ResearchHealthy comparison subjectsReduced mismatch negativityPrediction error signalsPositive symptomsMismatch negativityDeviant typesPredictive coding accountPresence of hallucinationsMismatch negativity paradigmAuditory memory tracesComparison subjectsCoding accountMemory tracesPsychiatric illnessMMN responseVoice hearersRepetitive positioningError signalDuration conditionsHallucinationsHigher-levelDMMNDifferent patternsSymptomsPSZAn Integrated theory of false insights and beliefs under psychedelics
McGovern H, Grimmer H, Doss M, Hutchinson B, Timmermann C, Lyon A, Corlett P, Laukkonen R. An Integrated theory of false insights and beliefs under psychedelics. Communications Psychology 2024, 2: 69. PMID: 39242747, PMCID: PMC11332244, DOI: 10.1038/s44271-024-00120-6.Peer-Reviewed Original ResearchLesions to the mediodorsal thalamus, but not orbitofrontal cortex, enhance volatility beliefs linked to paranoia
Suthaharan P, Thompson S, Rossi-Goldthorpe R, Rudebeck P, Walton M, Chakraborty S, Noonan M, Costa V, Murray E, Mathys C, Groman S, Mitchell A, Taylor J, Corlett P, Chang S. Lesions to the mediodorsal thalamus, but not orbitofrontal cortex, enhance volatility beliefs linked to paranoia. Cell Reports 2024, 43: 114355. PMID: 38870010, PMCID: PMC11231991, DOI: 10.1016/j.celrep.2024.114355.Peer-Reviewed Original ResearchOrbitofrontal cortexMediodorsal thalamusReward learning rateAssociated with paranoiaExcitotoxic lesionsBrain regionsUnoperated monkeysAction selectionAdaptive behaviorParanoiaBelief updatingMDmcMeaningful changeCortexThalamusBeliefsLearning rateRobust to variabilityCompare performanceRewardBehaviorBrainMonkeysAction policiesPerception
Clinical Trials
Current Trials
Song-making In a Group (SING)
HIC ID2000026376RolePrincipal InvestigatorPrimary Completion Date08/31/2024Recruiting ParticipantsTeen Brain and Behavior Study
HIC ID1111009332RoleSub InvestigatorPrimary Completion Date12/21/2022Recruiting ParticipantsGenderBothAge13 years - 17 years
Academic Achievements & Community Involvement
News
News
- December 17, 2024Source: YaleNews
Paranoia May Be, In Part, a Visual Problem
- November 15, 2024
Corlett Speaks at 'Artificial Intelligence and Mental Health' Conference in Shanghai
- August 12, 2024Source: Yale News
Insights & Outcomes: Sea scorpions, delusions, and forensics-related stress
- June 14, 2024Source: YaleNews
New Insights Into the Brain Regions Involved in Paranoia
Get In Touch
Contacts
Mailing Address
Psychiatry
34 Park St., CNRU
New Haven, CT 06519
United States